Incidental Mutation 'R6465:Ints10'
ID 517777
Institutional Source Beutler Lab
Gene Symbol Ints10
Ensembl Gene ENSMUSG00000031864
Gene Name integrator complex subunit 10
Synonyms 4921521J11Rik
MMRRC Submission 044598-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6465 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 69245729-69282062 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 69260188 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 304 (N304S)
Ref Sequence ENSEMBL: ENSMUSP00000105871 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034328] [ENSMUST00000070713] [ENSMUST00000110241] [ENSMUST00000110242]
AlphaFold Q8K2A7
Predicted Effect probably benign
Transcript: ENSMUST00000034328
AA Change: N304S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000034328
Gene: ENSMUSG00000031864
AA Change: N304S

DomainStartEndE-ValueType
low complexity region 132 138 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000070713
AA Change: N304S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000069908
Gene: ENSMUSG00000031864
AA Change: N304S

DomainStartEndE-ValueType
low complexity region 132 138 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110241
AA Change: N304S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000105870
Gene: ENSMUSG00000031864
AA Change: N304S

DomainStartEndE-ValueType
low complexity region 132 138 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110242
AA Change: N304S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000105871
Gene: ENSMUSG00000031864
AA Change: N304S

DomainStartEndE-ValueType
low complexity region 132 138 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140309
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.8%
  • 20x: 93.1%
Validation Efficiency 95% (40/42)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 G A 6: 128,518,041 (GRCm39) T1415I probably damaging Het
Acvr2b T A 9: 119,262,369 (GRCm39) W461R probably damaging Het
Adam23 G T 1: 63,605,827 (GRCm39) C637F probably damaging Het
Apol8 T G 15: 77,634,148 (GRCm39) T143P probably benign Het
Bfsp1 A C 2: 143,699,975 (GRCm39) probably null Het
Cytl1 T C 5: 37,895,014 (GRCm39) V99A probably benign Het
Dock2 A T 11: 34,453,413 (GRCm39) V793E probably damaging Het
Fxyd5 G T 7: 30,737,305 (GRCm39) T81K probably damaging Het
Gcm1 A G 9: 77,972,151 (GRCm39) Y364C probably damaging Het
Get3 A T 8: 85,745,194 (GRCm39) M291K probably benign Het
Haghl T C 17: 26,002,793 (GRCm39) N190S possibly damaging Het
Inpp5j C A 11: 3,452,293 (GRCm39) R319L possibly damaging Het
Isoc1 T A 18: 58,804,328 (GRCm39) C119S probably damaging Het
Klhl18 A G 9: 110,257,988 (GRCm39) M414T probably benign Het
Krtap2-4 A G 11: 99,505,585 (GRCm39) probably benign Het
Krtap3-1 G A 11: 99,457,277 (GRCm39) P45S possibly damaging Het
Mroh2a GCCC GC 1: 88,159,979 (GRCm39) probably null Het
Myo7a A G 7: 97,711,887 (GRCm39) V1754A possibly damaging Het
Nedd4l T A 18: 65,288,335 (GRCm39) D119E probably benign Het
Nsun7 T C 5: 66,452,929 (GRCm39) V548A probably benign Het
Or5m12 A T 2: 85,734,883 (GRCm39) S172T probably benign Het
Or6b6 A T 7: 106,571,419 (GRCm39) V44E possibly damaging Het
Parvg A G 15: 84,213,141 (GRCm39) D127G probably damaging Het
Pate13 A T 9: 35,819,921 (GRCm39) N25Y possibly damaging Het
Piezo2 T A 18: 63,174,734 (GRCm39) M2007L possibly damaging Het
Pou2f3 A C 9: 43,051,162 (GRCm39) F175V probably damaging Het
Ptprn2 T C 12: 117,233,209 (GRCm39) I958T probably damaging Het
Pwwp2b T C 7: 138,835,951 (GRCm39) V464A probably benign Het
Pzp A G 6: 128,468,582 (GRCm39) Y982H probably damaging Het
Rad17 T A 13: 100,773,588 (GRCm39) N202I probably benign Het
Rtel1 T A 2: 180,977,733 (GRCm39) D271E possibly damaging Het
Sos2 T C 12: 69,643,549 (GRCm39) S943G probably benign Het
Tdpoz6 A G 3: 93,600,303 (GRCm39) I22T probably damaging Het
Tm9sf2 A G 14: 122,378,619 (GRCm39) H241R probably benign Het
Ttc8 A G 12: 98,930,829 (GRCm39) E291G probably damaging Het
Unc93a2 G T 17: 7,641,842 (GRCm39) T202K probably damaging Het
Wfikkn1 A G 17: 26,097,692 (GRCm39) C211R probably damaging Het
Ylpm1 T A 12: 85,096,576 (GRCm39) D1219E probably damaging Het
Zc3hav1 T C 6: 38,308,784 (GRCm39) Y586C possibly damaging Het
Zcchc4 T A 5: 52,976,618 (GRCm39) F471I probably benign Het
Zfp719 C A 7: 43,240,108 (GRCm39) Y565* probably null Het
Other mutations in Ints10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00743:Ints10 APN 8 69,271,985 (GRCm39) missense probably damaging 1.00
IGL00964:Ints10 APN 8 69,264,638 (GRCm39) missense probably damaging 1.00
IGL02326:Ints10 APN 8 69,257,485 (GRCm39) missense probably damaging 0.99
R0012:Ints10 UTSW 8 69,260,127 (GRCm39) missense probably benign 0.01
R0112:Ints10 UTSW 8 69,279,954 (GRCm39) missense probably damaging 0.99
R1302:Ints10 UTSW 8 69,279,964 (GRCm39) missense probably damaging 1.00
R1462:Ints10 UTSW 8 69,260,296 (GRCm39) splice site probably benign
R1540:Ints10 UTSW 8 69,249,365 (GRCm39) splice site probably benign
R1592:Ints10 UTSW 8 69,255,555 (GRCm39) missense possibly damaging 0.69
R1845:Ints10 UTSW 8 69,247,323 (GRCm39) missense probably damaging 1.00
R2144:Ints10 UTSW 8 69,249,457 (GRCm39) missense probably damaging 1.00
R2323:Ints10 UTSW 8 69,271,997 (GRCm39) missense probably benign 0.09
R3765:Ints10 UTSW 8 69,277,771 (GRCm39) missense possibly damaging 0.78
R3910:Ints10 UTSW 8 69,266,272 (GRCm39) missense probably damaging 0.96
R3912:Ints10 UTSW 8 69,266,272 (GRCm39) missense probably damaging 0.96
R3913:Ints10 UTSW 8 69,266,272 (GRCm39) missense probably damaging 0.96
R4050:Ints10 UTSW 8 69,280,003 (GRCm39) missense probably damaging 1.00
R4151:Ints10 UTSW 8 69,247,250 (GRCm39) splice site probably null
R4607:Ints10 UTSW 8 69,263,271 (GRCm39) missense probably damaging 1.00
R4608:Ints10 UTSW 8 69,263,271 (GRCm39) missense probably damaging 1.00
R4881:Ints10 UTSW 8 69,263,256 (GRCm39) missense probably benign 0.08
R4911:Ints10 UTSW 8 69,279,964 (GRCm39) missense probably damaging 0.98
R5255:Ints10 UTSW 8 69,246,624 (GRCm39) start gained probably benign
R5331:Ints10 UTSW 8 69,273,472 (GRCm39) splice site probably null
R5461:Ints10 UTSW 8 69,246,693 (GRCm39) missense possibly damaging 0.59
R5740:Ints10 UTSW 8 69,257,574 (GRCm39) missense probably damaging 0.96
R5741:Ints10 UTSW 8 69,257,574 (GRCm39) missense probably damaging 0.96
R6128:Ints10 UTSW 8 69,274,904 (GRCm39) critical splice donor site probably null
R6868:Ints10 UTSW 8 69,250,450 (GRCm39) missense probably damaging 1.00
R6983:Ints10 UTSW 8 69,246,703 (GRCm39) missense probably damaging 1.00
R7076:Ints10 UTSW 8 69,249,403 (GRCm39) nonsense probably null
R7216:Ints10 UTSW 8 69,274,809 (GRCm39) missense probably damaging 0.96
R7652:Ints10 UTSW 8 69,277,771 (GRCm39) missense possibly damaging 0.78
R8134:Ints10 UTSW 8 69,255,638 (GRCm39) nonsense probably null
R8176:Ints10 UTSW 8 69,255,603 (GRCm39) missense probably damaging 1.00
R8185:Ints10 UTSW 8 69,249,370 (GRCm39) missense possibly damaging 0.51
R8964:Ints10 UTSW 8 69,264,631 (GRCm39) missense probably benign
R9015:Ints10 UTSW 8 69,260,139 (GRCm39) missense probably benign 0.00
R9256:Ints10 UTSW 8 69,261,129 (GRCm39) missense possibly damaging 0.93
R9320:Ints10 UTSW 8 69,279,951 (GRCm39) missense probably damaging 0.98
R9372:Ints10 UTSW 8 69,271,967 (GRCm39) missense probably damaging 1.00
X0027:Ints10 UTSW 8 69,261,126 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- AAGTCTCATACCTGCTTGCC -3'
(R):5'- TGAGAACTGGCACTACCCTG -3'

Sequencing Primer
(F):5'- CATACCTGCTTGCCTCTGG -3'
(R):5'- TTAATCCCTCAGCACTGGTGGAG -3'
Posted On 2018-05-21