Incidental Mutation 'IGL01133:Zfp568'
ID 51626
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp568
Ensembl Gene ENSMUSG00000074221
Gene Name zinc finger protein 568
Synonyms chato, LOC381866
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01133
Quality Score
Status
Chromosome 7
Chromosomal Location 29683380-29727707 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 29687233 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147124 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074322] [ENSMUST00000146074] [ENSMUST00000148442] [ENSMUST00000177931] [ENSMUST00000207940]
AlphaFold E9PYI1
Predicted Effect probably null
Transcript: ENSMUST00000074322
SMART Domains Protein: ENSMUSP00000073930
Gene: ENSMUSG00000074221

DomainStartEndE-ValueType
KRAB 34 94 2.73e-39 SMART
KRAB 124 184 2.01e-28 SMART
ZnF_C2H2 363 385 7.78e-3 SMART
ZnF_C2H2 391 413 3.95e-4 SMART
ZnF_C2H2 419 441 3.44e-4 SMART
ZnF_C2H2 447 469 2.2e-2 SMART
ZnF_C2H2 475 497 6.67e-2 SMART
ZnF_C2H2 503 525 6.32e-3 SMART
ZnF_C2H2 531 553 4.87e-4 SMART
ZnF_C2H2 559 581 2.09e-3 SMART
ZnF_C2H2 587 609 2.95e-3 SMART
ZnF_C2H2 615 637 3.69e-4 SMART
ZnF_C2H2 643 665 1.12e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000146074
SMART Domains Protein: ENSMUSP00000118823
Gene: ENSMUSG00000074221

DomainStartEndE-ValueType
KRAB 34 94 2.73e-39 SMART
KRAB 123 183 2.01e-28 SMART
ZnF_C2H2 362 384 7.78e-3 SMART
ZnF_C2H2 390 412 3.95e-4 SMART
ZnF_C2H2 418 440 3.44e-4 SMART
ZnF_C2H2 446 468 2.2e-2 SMART
ZnF_C2H2 474 496 6.67e-2 SMART
ZnF_C2H2 502 524 6.32e-3 SMART
ZnF_C2H2 530 552 4.87e-4 SMART
ZnF_C2H2 558 580 2.09e-3 SMART
ZnF_C2H2 586 608 2.95e-3 SMART
ZnF_C2H2 614 636 3.69e-4 SMART
ZnF_C2H2 642 664 1.12e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000148442
SMART Domains Protein: ENSMUSP00000118387
Gene: ENSMUSG00000074221

DomainStartEndE-ValueType
KRAB 34 94 2.73e-39 SMART
KRAB 124 184 2.01e-28 SMART
ZnF_C2H2 363 385 7.78e-3 SMART
ZnF_C2H2 391 413 3.95e-4 SMART
ZnF_C2H2 419 441 3.44e-4 SMART
ZnF_C2H2 447 469 2.2e-2 SMART
ZnF_C2H2 475 497 6.67e-2 SMART
ZnF_C2H2 503 525 6.32e-3 SMART
ZnF_C2H2 531 553 4.87e-4 SMART
ZnF_C2H2 559 581 2.09e-3 SMART
ZnF_C2H2 587 609 2.95e-3 SMART
ZnF_C2H2 615 637 3.69e-4 SMART
ZnF_C2H2 643 665 1.12e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000177931
SMART Domains Protein: ENSMUSP00000137438
Gene: ENSMUSG00000074221

DomainStartEndE-ValueType
KRAB 34 94 2.73e-39 SMART
KRAB 123 183 2.01e-28 SMART
ZnF_C2H2 362 384 7.78e-3 SMART
ZnF_C2H2 390 412 3.95e-4 SMART
ZnF_C2H2 418 440 3.44e-4 SMART
ZnF_C2H2 446 468 2.2e-2 SMART
ZnF_C2H2 474 496 6.67e-2 SMART
ZnF_C2H2 502 524 6.32e-3 SMART
ZnF_C2H2 530 552 4.87e-4 SMART
ZnF_C2H2 558 580 2.09e-3 SMART
ZnF_C2H2 586 608 2.95e-3 SMART
ZnF_C2H2 614 636 3.69e-4 SMART
ZnF_C2H2 642 664 1.12e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000207940
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209185
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mutants are embryonic lethal with growth arrest around E8.5-9.0. Mutant embryo shows shortened anterior-posterior axial extension with defects in somites and midline structures including open gut tube, cardia bifida, and failure to closeneural tube. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,834,475 (GRCm39) V124I probably damaging Het
Adam4 T C 12: 81,468,220 (GRCm39) T134A possibly damaging Het
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Cartpt T G 13: 100,036,548 (GRCm39) I67L probably benign Het
Cc2d1a G T 8: 84,870,033 (GRCm39) H161N probably benign Het
Ccer1 T C 10: 97,530,401 (GRCm39) F355L probably benign Het
Cert1 A G 13: 96,751,310 (GRCm39) E320G probably damaging Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Cfap299 T C 5: 98,646,240 (GRCm39) probably null Het
Cfap36 A C 11: 29,184,414 (GRCm39) V114G probably damaging Het
Cyp2b9 G A 7: 25,909,660 (GRCm39) G476D probably damaging Het
Eif3l T C 15: 78,961,120 (GRCm39) Y58H possibly damaging Het
Gapvd1 T C 2: 34,615,410 (GRCm39) Y411C probably damaging Het
Gm27029 G T 11: 101,302,786 (GRCm39) F236L possibly damaging Het
Golga1 T C 2: 38,913,484 (GRCm39) T501A probably benign Het
Heg1 C T 16: 33,547,657 (GRCm39) H815Y probably benign Het
Krt1 A T 15: 101,756,628 (GRCm39) D298E probably damaging Het
Mecr T A 4: 131,570,907 (GRCm39) S32T probably benign Het
Med1 A T 11: 98,048,812 (GRCm39) Y661* probably null Het
Or10z1 T C 1: 174,078,092 (GRCm39) S134G probably benign Het
Pla2g12b G T 10: 59,252,239 (GRCm39) A37S probably benign Het
Plekha7 G T 7: 115,744,476 (GRCm39) probably null Het
Ralgapa1 T C 12: 55,689,133 (GRCm39) I1989V probably damaging Het
Ralgapa1 T C 12: 55,689,144 (GRCm39) H1938R probably damaging Het
Sanbr A T 11: 23,545,434 (GRCm39) D486E probably damaging Het
Sec31b A G 19: 44,515,480 (GRCm39) F309S probably damaging Het
Serpina3a T C 12: 104,087,758 (GRCm39) I227T probably benign Het
Slc1a3 A G 15: 8,675,171 (GRCm39) I278T probably damaging Het
Slc1a3 T C 15: 8,680,477 (GRCm39) Y127C probably damaging Het
Spen T C 4: 141,217,212 (GRCm39) K449R unknown Het
Thoc2l A G 5: 104,665,528 (GRCm39) T17A probably benign Het
Tmem130 A G 5: 144,689,255 (GRCm39) S129P probably damaging Het
Trim68 A T 7: 102,328,348 (GRCm39) probably null Het
Vdac3-ps1 T C 13: 18,206,034 (GRCm39) noncoding transcript Het
Vmn2r75 A G 7: 85,797,240 (GRCm39) probably benign Het
Zbtb9 G T 17: 27,193,985 (GRCm39) probably benign Het
Other mutations in Zfp568
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00573:Zfp568 APN 7 29,721,865 (GRCm39) missense possibly damaging 0.66
IGL00792:Zfp568 APN 7 29,714,497 (GRCm39) missense probably benign 0.00
IGL01330:Zfp568 APN 7 29,721,702 (GRCm39) missense probably benign 0.01
IGL03157:Zfp568 APN 7 29,722,189 (GRCm39) missense probably damaging 1.00
R0739:Zfp568 UTSW 7 29,722,746 (GRCm39) missense probably damaging 1.00
R1051:Zfp568 UTSW 7 29,721,954 (GRCm39) nonsense probably null
R1967:Zfp568 UTSW 7 29,688,513 (GRCm39) missense probably damaging 0.99
R2038:Zfp568 UTSW 7 29,688,507 (GRCm39) missense probably null 1.00
R3874:Zfp568 UTSW 7 29,722,821 (GRCm39) missense probably damaging 1.00
R4438:Zfp568 UTSW 7 29,721,721 (GRCm39) missense probably benign
R4584:Zfp568 UTSW 7 29,697,617 (GRCm39) missense probably benign 0.04
R4667:Zfp568 UTSW 7 29,722,702 (GRCm39) missense probably damaging 1.00
R4669:Zfp568 UTSW 7 29,722,702 (GRCm39) missense probably damaging 1.00
R4773:Zfp568 UTSW 7 29,697,195 (GRCm39) missense probably damaging 1.00
R4791:Zfp568 UTSW 7 29,714,608 (GRCm39) missense probably damaging 1.00
R5250:Zfp568 UTSW 7 29,716,655 (GRCm39) missense probably benign 0.12
R5541:Zfp568 UTSW 7 29,722,301 (GRCm39) missense possibly damaging 0.81
R5956:Zfp568 UTSW 7 29,697,288 (GRCm39) missense probably damaging 1.00
R6444:Zfp568 UTSW 7 29,716,682 (GRCm39) missense probably benign 0.01
R6600:Zfp568 UTSW 7 29,721,948 (GRCm39) missense possibly damaging 0.71
R7299:Zfp568 UTSW 7 29,716,669 (GRCm39) missense probably benign 0.34
R7316:Zfp568 UTSW 7 29,721,681 (GRCm39) missense possibly damaging 0.95
R7562:Zfp568 UTSW 7 29,722,681 (GRCm39) missense probably benign 0.04
R7664:Zfp568 UTSW 7 29,721,715 (GRCm39) missense probably benign
R7672:Zfp568 UTSW 7 29,697,212 (GRCm39) missense probably damaging 0.99
R7759:Zfp568 UTSW 7 29,722,839 (GRCm39) missense possibly damaging 0.66
R7790:Zfp568 UTSW 7 29,722,150 (GRCm39) missense probably damaging 1.00
R7811:Zfp568 UTSW 7 29,697,295 (GRCm39) missense possibly damaging 0.95
R8110:Zfp568 UTSW 7 29,722,551 (GRCm39) missense probably damaging 1.00
R8194:Zfp568 UTSW 7 29,722,758 (GRCm39) missense probably damaging 1.00
R8254:Zfp568 UTSW 7 29,714,558 (GRCm39) missense probably benign 0.22
R8319:Zfp568 UTSW 7 29,697,629 (GRCm39) missense possibly damaging 0.72
R8836:Zfp568 UTSW 7 29,722,459 (GRCm39) missense probably damaging 0.98
R8902:Zfp568 UTSW 7 29,713,307 (GRCm39) missense probably benign 0.08
R8978:Zfp568 UTSW 7 29,716,683 (GRCm39) missense probably benign 0.01
R9676:Zfp568 UTSW 7 29,721,823 (GRCm39) missense probably benign 0.18
Posted On 2013-06-21