Incidental Mutation 'R6395:Dennd2c'
ID 514702
Institutional Source Beutler Lab
Gene Symbol Dennd2c
Ensembl Gene ENSMUSG00000007379
Gene Name DENN domain containing 2C
Synonyms A930010I20Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6395 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 103009954-103077054 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 103056540 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134008 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172288] [ENSMUST00000173206]
AlphaFold no structure available at present
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166143
Predicted Effect probably null
Transcript: ENSMUST00000172288
SMART Domains Protein: ENSMUSP00000127187
Gene: ENSMUSG00000007379

DomainStartEndE-ValueType
uDENN 481 571 1.01e-25 SMART
DENN 578 762 3.36e-77 SMART
dDENN 806 873 1.15e-20 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173037
Predicted Effect probably null
Transcript: ENSMUST00000173206
SMART Domains Protein: ENSMUSP00000134008
Gene: ENSMUSG00000007379

DomainStartEndE-ValueType
uDENN 424 514 1.01e-25 SMART
DENN 521 705 3.36e-77 SMART
dDENN 749 816 1.15e-20 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174060
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174486
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.6%
  • 20x: 98.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actc1 C A 2: 113,879,731 (GRCm39) E243* probably null Het
Ahi1 T C 10: 20,855,491 (GRCm39) I600T possibly damaging Het
Apob A G 12: 8,058,507 (GRCm39) T2330A probably benign Het
Cabin1 A T 10: 75,582,576 (GRCm39) M280K probably benign Het
Ccdc117 T C 11: 5,484,762 (GRCm39) probably null Het
Cct8 G T 16: 87,283,364 (GRCm39) Y292* probably null Het
Celf1 A G 2: 90,834,203 (GRCm39) I165V probably benign Het
Cenpc1 A T 5: 86,183,429 (GRCm39) N453K probably benign Het
Chst10 T C 1: 38,910,770 (GRCm39) I131M probably damaging Het
Cltc A G 11: 86,616,006 (GRCm39) I420T probably damaging Het
Cspg4b T G 13: 113,506,003 (GRCm39) C2377W probably damaging Het
Dact3 A C 7: 16,617,086 (GRCm39) Q95P probably damaging Het
Dock2 G T 11: 34,182,874 (GRCm39) H1586Q probably damaging Het
Dst T C 1: 34,221,771 (GRCm39) M2525T probably benign Het
Egflam T C 15: 7,261,176 (GRCm39) H786R probably damaging Het
Eml6 T C 11: 29,759,321 (GRCm39) T811A probably benign Het
Epha1 T C 6: 42,343,106 (GRCm39) T148A probably damaging Het
Fsip1 A C 2: 118,067,406 (GRCm39) S306A probably damaging Het
Gga2 A T 7: 121,607,661 (GRCm39) probably null Het
Gm10801 C CGTT 2: 98,494,152 (GRCm39) probably benign Het
Gm9837 T A 11: 53,360,885 (GRCm39) probably benign Het
Gnl2 A T 4: 124,940,058 (GRCm39) Q310L probably damaging Het
H2-M1 T C 17: 36,982,701 (GRCm39) D53G probably benign Het
Hmcn2 T A 2: 31,259,269 (GRCm39) D1036E probably damaging Het
Htr3a A T 9: 48,811,871 (GRCm39) D381E probably benign Het
Igdcc4 G A 9: 65,042,400 (GRCm39) G106R probably damaging Het
Igfbp2 A G 1: 72,864,078 (GRCm39) T114A probably damaging Het
Ints14 A G 9: 64,885,406 (GRCm39) probably null Het
Kcnt1 T A 2: 25,799,251 (GRCm39) M906K possibly damaging Het
Kif13a C T 13: 46,905,931 (GRCm39) V671M possibly damaging Het
Lars2 A G 9: 123,200,990 (GRCm39) Q18R probably benign Het
Mndal C T 1: 173,698,999 (GRCm39) C222Y possibly damaging Het
Msto1 C T 3: 88,812,781 (GRCm39) A1854V possibly damaging Het
Musk G A 4: 58,286,169 (GRCm39) G20R probably benign Het
Or6c215 G T 10: 129,638,013 (GRCm39) P127Q probably damaging Het
Oxct1 G T 15: 4,056,309 (GRCm39) S19I possibly damaging Het
Papss2 G A 19: 32,641,876 (GRCm39) G517D probably damaging Het
Parp14 T C 16: 35,676,918 (GRCm39) S1017G probably benign Het
Pde2a A G 7: 101,150,242 (GRCm39) Q227R probably benign Het
Pdlim5 G T 3: 142,020,183 (GRCm39) P92Q probably damaging Het
Pkd1l3 C T 8: 110,350,595 (GRCm39) T480I probably benign Het
Pla2g4c C T 7: 13,077,933 (GRCm39) T357I probably benign Het
Ppp3ca A G 3: 136,583,531 (GRCm39) R213G possibly damaging Het
Pramel18 G A 4: 101,767,189 (GRCm39) R146H probably benign Het
Prrc1 C T 18: 57,495,619 (GRCm39) S32L probably null Het
Prss47 C T 13: 65,197,116 (GRCm39) V207I probably benign Het
Prtg G A 9: 72,819,414 (GRCm39) V1136I possibly damaging Het
Psmb8 T A 17: 34,418,265 (GRCm39) M69K possibly damaging Het
Rb1 A T 14: 73,436,636 (GRCm39) D876E probably damaging Het
Rnasel T C 1: 153,637,867 (GRCm39) M680T probably damaging Het
Rnf111 G T 9: 70,383,692 (GRCm39) N80K possibly damaging Het
Senp1 C T 15: 97,946,074 (GRCm39) C557Y probably damaging Het
Serpina3a A T 12: 104,082,710 (GRCm39) Y161F probably damaging Het
Serpinb11 A T 1: 107,299,781 (GRCm39) probably null Het
Sgpl1 C A 10: 60,947,936 (GRCm39) probably null Het
Slc37a4 A G 9: 44,310,576 (GRCm39) Y60C probably damaging Het
Slc38a10 A G 11: 120,015,208 (GRCm39) S381P probably benign Het
Slc5a7 C T 17: 54,585,849 (GRCm39) V323I probably damaging Het
Slco1a7 T A 6: 141,668,818 (GRCm39) probably null Het
Smarcal1 A T 1: 72,655,716 (GRCm39) E665V possibly damaging Het
Specc1 C A 11: 62,023,164 (GRCm39) N736K probably damaging Het
Tas2r121 T C 6: 132,677,495 (GRCm39) Y159C probably benign Het
Tex54 A G 19: 8,718,462 (GRCm39) D68G probably benign Het
Trank1 A G 9: 111,196,268 (GRCm39) I1431V probably damaging Het
Ttll6 T C 11: 96,047,414 (GRCm39) V671A probably benign Het
Ttn A T 2: 76,748,931 (GRCm39) probably benign Het
Uimc1 T C 13: 55,188,389 (GRCm39) T557A possibly damaging Het
Uri1 C A 7: 37,661,974 (GRCm39) V446L probably benign Het
Vpreb1b C T 16: 17,798,771 (GRCm39) R86C probably damaging Het
Vwa8 A G 14: 79,331,184 (GRCm39) K1231E probably benign Het
Xcr1 G A 9: 123,684,854 (GRCm39) R303C probably damaging Het
Zfp619 C A 7: 39,186,454 (GRCm39) A828E possibly damaging Het
Zfp687 T C 3: 94,915,049 (GRCm39) S1151G possibly damaging Het
Other mutations in Dennd2c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01763:Dennd2c APN 3 103,064,224 (GRCm39) missense probably damaging 1.00
IGL01791:Dennd2c APN 3 103,073,741 (GRCm39) missense probably benign 0.19
IGL02100:Dennd2c APN 3 103,060,991 (GRCm39) missense probably damaging 0.98
IGL02119:Dennd2c APN 3 103,044,559 (GRCm39) missense probably damaging 0.99
IGL02395:Dennd2c APN 3 103,065,081 (GRCm39) missense probably benign 0.00
IGL02631:Dennd2c APN 3 103,063,387 (GRCm39) missense possibly damaging 0.56
IGL02895:Dennd2c APN 3 103,044,519 (GRCm39) missense possibly damaging 0.76
convolution UTSW 3 103,063,423 (GRCm39) missense probably damaging 1.00
Resolution UTSW 3 103,040,661 (GRCm39) missense possibly damaging 0.51
R1749:Dennd2c UTSW 3 103,039,352 (GRCm39) missense possibly damaging 0.92
R1931:Dennd2c UTSW 3 103,040,568 (GRCm39) missense probably benign 0.32
R1964:Dennd2c UTSW 3 103,073,807 (GRCm39) missense probably damaging 1.00
R1972:Dennd2c UTSW 3 103,039,014 (GRCm39) missense probably benign 0.01
R1973:Dennd2c UTSW 3 103,039,014 (GRCm39) missense probably benign 0.01
R2025:Dennd2c UTSW 3 103,039,005 (GRCm39) missense possibly damaging 0.71
R2350:Dennd2c UTSW 3 103,039,317 (GRCm39) missense probably benign 0.00
R2373:Dennd2c UTSW 3 103,064,158 (GRCm39) missense probably damaging 0.99
R4555:Dennd2c UTSW 3 103,039,202 (GRCm39) missense probably benign 0.00
R4916:Dennd2c UTSW 3 103,039,140 (GRCm39) missense probably benign 0.00
R5560:Dennd2c UTSW 3 103,068,871 (GRCm39) missense probably damaging 1.00
R6291:Dennd2c UTSW 3 103,038,925 (GRCm39) nonsense probably null
R6567:Dennd2c UTSW 3 103,039,335 (GRCm39) missense probably benign 0.02
R6681:Dennd2c UTSW 3 103,038,977 (GRCm39) missense probably benign 0.01
R7106:Dennd2c UTSW 3 103,038,893 (GRCm39) missense possibly damaging 0.82
R7162:Dennd2c UTSW 3 103,063,423 (GRCm39) missense probably damaging 1.00
R7514:Dennd2c UTSW 3 103,070,378 (GRCm39) missense probably benign 0.00
R7591:Dennd2c UTSW 3 103,040,661 (GRCm39) missense possibly damaging 0.51
R7698:Dennd2c UTSW 3 103,072,359 (GRCm39) missense possibly damaging 0.65
R8069:Dennd2c UTSW 3 103,072,446 (GRCm39) missense probably damaging 1.00
R8086:Dennd2c UTSW 3 103,040,661 (GRCm39) missense possibly damaging 0.51
R8247:Dennd2c UTSW 3 103,059,637 (GRCm39) missense probably damaging 0.99
R8347:Dennd2c UTSW 3 103,065,025 (GRCm39) missense probably damaging 0.99
R8829:Dennd2c UTSW 3 103,059,720 (GRCm39) critical splice donor site probably null
R8832:Dennd2c UTSW 3 103,059,720 (GRCm39) critical splice donor site probably null
R9131:Dennd2c UTSW 3 103,065,031 (GRCm39) missense probably damaging 1.00
R9332:Dennd2c UTSW 3 103,038,877 (GRCm39) missense probably benign 0.01
R9350:Dennd2c UTSW 3 103,039,308 (GRCm39) missense possibly damaging 0.79
R9520:Dennd2c UTSW 3 103,044,484 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CGTTACAGATCGCCACAAGC -3'
(R):5'- TTTGTGAGACAGGCAGAGC -3'

Sequencing Primer
(F):5'- CGCTTGGCACAGCTGCAG -3'
(R):5'- GTGTTAACAACAGCCAGGC -3'
Posted On 2018-05-04