Incidental Mutation 'R6217:Ticam1'
ID 503808
Institutional Source Beutler Lab
Gene Symbol Ticam1
Ensembl Gene ENSMUSG00000047123
Gene Name TIR domain containing adaptor molecule 1
Synonyms Trif, TICAM-1
MMRRC Submission 044350-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6217 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 56576462-56583767 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 56577730 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 455 (I455N)
Ref Sequence ENSEMBL: ENSMUSP00000055104 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058136]
AlphaFold Q80UF7
Predicted Effect probably damaging
Transcript: ENSMUST00000058136
AA Change: I455N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000055104
Gene: ENSMUSG00000047123
AA Change: I455N

DomainStartEndE-ValueType
PDB:4BSX|D 5 153 3e-52 PDB
low complexity region 345 384 N/A INTRINSIC
SCOP:d1fyva_ 386 491 8e-3 SMART
PDB:2M1X|A 391 547 1e-74 PDB
Pfam:RHIM 610 698 4.7e-13 PFAM
Meta Mutation Damage Score 0.5211 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 97% (59/61)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
PHENOTYPE: Homozygous null mice are viable but exhibit abnormalities of the innate immune system. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abraxas2 G A 7: 132,476,694 (GRCm39) A145T probably damaging Het
Adamts20 T C 15: 94,236,596 (GRCm39) D808G probably benign Het
Ankdd1a C T 9: 65,415,343 (GRCm39) A227T possibly damaging Het
Arsk T A 13: 76,239,935 (GRCm39) Q46L unknown Het
Asnsd1 A G 1: 53,387,187 (GRCm39) F147L probably benign Het
Atp5f1a T A 18: 77,869,056 (GRCm39) S427T probably benign Het
Atp6v1b2 A C 8: 69,562,530 (GRCm39) probably null Het
AU021092 T A 16: 5,030,050 (GRCm39) T322S possibly damaging Het
Bcl7c A T 7: 127,307,698 (GRCm39) M1K probably null Het
Cacna1i T C 15: 80,273,333 (GRCm39) V1673A probably damaging Het
Ccdc146 A T 5: 21,522,900 (GRCm39) probably null Het
Cdc7 A G 5: 107,120,660 (GRCm39) D122G probably damaging Het
Cfap46 CCTTCTTCT CCTTCT 7: 139,218,816 (GRCm39) probably benign Het
Chd3 T A 11: 69,236,361 (GRCm39) Q1950L probably damaging Het
Cutc T C 19: 43,748,436 (GRCm39) L111S probably damaging Het
Cyp2j6 A G 4: 96,406,398 (GRCm39) F458L probably damaging Het
Ddhd1 T C 14: 45,856,971 (GRCm39) probably null Het
Dstyk T C 1: 132,387,677 (GRCm39) S804P probably damaging Het
Ech1 A G 7: 28,531,261 (GRCm39) D283G possibly damaging Het
Exosc10 A G 4: 148,666,768 (GRCm39) probably null Het
Fancg A C 4: 43,010,084 (GRCm39) V5G probably benign Het
Fbxo11 A G 17: 88,316,332 (GRCm39) V394A probably benign Het
Fcmr C T 1: 130,806,060 (GRCm39) R339W probably damaging Het
Fhip2b T C 14: 70,829,198 (GRCm39) probably null Het
Fsip2 T A 2: 82,818,762 (GRCm39) L4832M possibly damaging Het
Gab1 A G 8: 81,518,237 (GRCm39) V125A possibly damaging Het
Gabrr1 A T 4: 33,149,026 (GRCm39) probably null Het
Gon4l T C 3: 88,799,968 (GRCm39) V871A possibly damaging Het
Hspg2 A G 4: 137,267,559 (GRCm39) T2056A probably damaging Het
Lrrc3 T A 10: 77,736,843 (GRCm39) T198S probably benign Het
Lsamp A T 16: 41,954,675 (GRCm39) E174V possibly damaging Het
Ltbr C T 6: 125,284,417 (GRCm39) V342M probably damaging Het
Muc16 A T 9: 18,566,742 (GRCm39) S1926T unknown Het
Ntn1 C A 11: 68,104,158 (GRCm39) V497F possibly damaging Het
Or2ag18 A T 7: 106,405,279 (GRCm39) L130Q probably damaging Het
Or5k17 T C 16: 58,746,877 (GRCm39) D19G probably benign Het
Or8g22 A T 9: 38,958,039 (GRCm39) *270R probably null Het
Osmr T C 15: 6,853,047 (GRCm39) Y615C probably damaging Het
Pcdhgb2 T C 18: 37,823,054 (GRCm39) V15A possibly damaging Het
Pkd2l2 A G 18: 34,547,733 (GRCm39) N162S probably benign Het
Ppp1r12a G A 10: 108,076,045 (GRCm39) probably null Het
Prss59 G A 6: 40,903,019 (GRCm39) P118S possibly damaging Het
Prtg C T 9: 72,812,076 (GRCm39) P899S probably damaging Het
Ptprn A T 1: 75,224,810 (GRCm39) S912R probably damaging Het
Rex2 A G 4: 147,141,931 (GRCm39) T140A possibly damaging Het
Ryr2 T G 13: 11,848,964 (GRCm39) D339A probably damaging Het
Sf3b1 C T 1: 55,046,677 (GRCm39) R289H probably damaging Het
Slc17a9 A G 2: 180,379,455 (GRCm39) D309G probably benign Het
Slc4a10 A G 2: 62,134,295 (GRCm39) R1004G probably benign Het
Sprr2f A T 3: 92,273,366 (GRCm39) Q55L unknown Het
Syne1 C T 10: 5,243,761 (GRCm39) G2801D probably benign Het
Tenm3 A T 8: 48,746,700 (GRCm39) V1026D probably damaging Het
Tmem161b A G 13: 84,399,363 (GRCm39) I6M possibly damaging Het
Ubn1 A G 16: 4,895,096 (GRCm39) E714G probably damaging Het
Ush2a T G 1: 188,475,651 (GRCm39) probably null Het
Usp19 G A 9: 108,377,343 (GRCm39) V874M probably damaging Het
Vmn2r106 T C 17: 20,488,501 (GRCm39) T633A probably benign Het
Vmn2r75 A T 7: 85,815,375 (GRCm39) probably benign Het
Zfyve27 T C 19: 42,178,016 (GRCm39) V386A probably damaging Het
Zscan20 A T 4: 128,498,327 (GRCm39) W24R probably damaging Het
Other mutations in Ticam1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02160:Ticam1 APN 17 56,577,560 (GRCm39) missense possibly damaging 0.80
IGL02164:Ticam1 APN 17 56,577,019 (GRCm39) missense unknown
Lps2 UTSW 17 56,576,969 (GRCm39) frame shift probably null
Pangu UTSW 17 56,276,693 (GRCm38) critical splice donor site probably benign
Yue UTSW 17 56,578,339 (GRCm39) missense probably benign 0.06
R0930:Ticam1 UTSW 17 56,578,687 (GRCm39) missense probably damaging 1.00
R0930:Ticam1 UTSW 17 56,577,226 (GRCm39) missense unknown
R1509:Ticam1 UTSW 17 56,578,113 (GRCm39) missense probably benign 0.43
R1837:Ticam1 UTSW 17 56,577,799 (GRCm39) missense possibly damaging 0.87
R1863:Ticam1 UTSW 17 56,578,436 (GRCm39) missense probably damaging 1.00
R1867:Ticam1 UTSW 17 56,578,718 (GRCm39) missense probably benign 0.01
R1872:Ticam1 UTSW 17 56,578,897 (GRCm39) missense probably benign 0.00
R1893:Ticam1 UTSW 17 56,578,894 (GRCm39) missense probably benign 0.36
R1980:Ticam1 UTSW 17 56,578,555 (GRCm39) missense probably damaging 0.99
R1981:Ticam1 UTSW 17 56,578,555 (GRCm39) missense probably damaging 0.99
R1982:Ticam1 UTSW 17 56,578,555 (GRCm39) missense probably damaging 0.99
R2263:Ticam1 UTSW 17 56,578,888 (GRCm39) missense possibly damaging 0.95
R2513:Ticam1 UTSW 17 56,578,612 (GRCm39) missense possibly damaging 0.61
R4294:Ticam1 UTSW 17 56,578,339 (GRCm39) missense probably benign 0.06
R4888:Ticam1 UTSW 17 56,578,642 (GRCm39) missense probably damaging 0.98
R4982:Ticam1 UTSW 17 56,579,020 (GRCm39) missense probably benign 0.10
R5396:Ticam1 UTSW 17 56,578,117 (GRCm39) missense probably benign 0.02
R5604:Ticam1 UTSW 17 56,578,756 (GRCm39) missense probably benign 0.13
R5641:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5647:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5648:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5657:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5770:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5771:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5964:Ticam1 UTSW 17 56,578,703 (GRCm39) missense probably damaging 0.99
R5974:Ticam1 UTSW 17 56,578,178 (GRCm39) missense probably benign
R6983:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6984:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6985:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6986:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6987:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6988:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6989:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R7029:Ticam1 UTSW 17 56,578,154 (GRCm39) missense possibly damaging 0.51
R7684:Ticam1 UTSW 17 56,576,984 (GRCm39) missense unknown
R7755:Ticam1 UTSW 17 56,577,182 (GRCm39) missense unknown
R7885:Ticam1 UTSW 17 56,578,067 (GRCm39) missense probably benign 0.04
R8021:Ticam1 UTSW 17 56,577,089 (GRCm39) missense unknown
R8414:Ticam1 UTSW 17 56,578,340 (GRCm39) missense probably benign 0.00
R8822:Ticam1 UTSW 17 56,578,444 (GRCm39) missense probably damaging 1.00
R9442:Ticam1 UTSW 17 56,577,428 (GRCm39) missense probably benign 0.00
R9521:Ticam1 UTSW 17 56,578,388 (GRCm39) missense probably benign 0.07
V8831:Ticam1 UTSW 17 56,576,969 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- TGTTCATCCAGCCACACAATG -3'
(R):5'- CCTGTTTTGGACCACTCAGAAAC -3'

Sequencing Primer
(F):5'- GCTGTGGAGCAGTCTGG -3'
(R):5'- GTTTTGGACCACTCAGAAACATCTG -3'
Posted On 2018-02-27