Incidental Mutation 'IGL01133:Or10z1'
ID 50325
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10z1
Ensembl Gene ENSMUSG00000050788
Gene Name olfactory receptor family 10 subfamily Z member 1
Synonyms MOR267-6, Olfr419, GA_x6K02T2P20D-20891507-20892448
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # IGL01133
Quality Score
Status
Chromosome 1
Chromosomal Location 174077455-174078542 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 174078092 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 134 (S134G)
Ref Sequence ENSEMBL: ENSMUSP00000149512 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027817] [ENSMUST00000061990] [ENSMUST00000214725]
AlphaFold E9Q0Y7
Predicted Effect probably benign
Transcript: ENSMUST00000027817
SMART Domains Protein: ENSMUSP00000027817
Gene: ENSMUSG00000026532

DomainStartEndE-ValueType
SPEC 55 153 3.62e-11 SMART
SPEC 159 259 1.84e-26 SMART
SPEC 265 365 1.56e-24 SMART
SPEC 371 471 8.35e-25 SMART
SPEC 477 577 1.19e-29 SMART
SPEC 583 682 2.43e-26 SMART
SPEC 688 788 1.3e-26 SMART
SPEC 794 894 1.66e-28 SMART
SPEC 900 1077 5.03e-19 SMART
SH3 978 1033 2.98e-15 SMART
SPEC 1083 1178 2.57e-16 SMART
SPEC 1184 1284 1.15e-27 SMART
SPEC 1290 1390 7.05e-23 SMART
SPEC 1396 1495 6.04e-22 SMART
SPEC 1501 1602 1.15e-27 SMART
SPEC 1608 1708 5.46e-29 SMART
SPEC 1714 1814 1.08e-32 SMART
SPEC 1820 1921 2.17e-23 SMART
SPEC 1927 2028 2.19e-19 SMART
SPEC 2042 2142 3.87e-11 SMART
SPEC 2156 2253 9.77e-8 SMART
low complexity region 2307 2318 N/A INTRINSIC
efhand_Ca_insen 2346 2414 2.37e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000061990
AA Change: S134G

PolyPhen 2 Score 0.415 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000050893
Gene: ENSMUSG00000050788
AA Change: S134G

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.4e-53 PFAM
Pfam:7tm_1 41 290 3.2e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156092
Predicted Effect probably benign
Transcript: ENSMUST00000214725
AA Change: S134G

PolyPhen 2 Score 0.415 (Sensitivity: 0.89; Specificity: 0.90)
Meta Mutation Damage Score 0.1580 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,834,475 (GRCm39) V124I probably damaging Het
Adam4 T C 12: 81,468,220 (GRCm39) T134A possibly damaging Het
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Cartpt T G 13: 100,036,548 (GRCm39) I67L probably benign Het
Cc2d1a G T 8: 84,870,033 (GRCm39) H161N probably benign Het
Ccer1 T C 10: 97,530,401 (GRCm39) F355L probably benign Het
Cert1 A G 13: 96,751,310 (GRCm39) E320G probably damaging Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Cfap299 T C 5: 98,646,240 (GRCm39) probably null Het
Cfap36 A C 11: 29,184,414 (GRCm39) V114G probably damaging Het
Cyp2b9 G A 7: 25,909,660 (GRCm39) G476D probably damaging Het
Eif3l T C 15: 78,961,120 (GRCm39) Y58H possibly damaging Het
Gapvd1 T C 2: 34,615,410 (GRCm39) Y411C probably damaging Het
Gm27029 G T 11: 101,302,786 (GRCm39) F236L possibly damaging Het
Golga1 T C 2: 38,913,484 (GRCm39) T501A probably benign Het
Heg1 C T 16: 33,547,657 (GRCm39) H815Y probably benign Het
Krt1 A T 15: 101,756,628 (GRCm39) D298E probably damaging Het
Mecr T A 4: 131,570,907 (GRCm39) S32T probably benign Het
Med1 A T 11: 98,048,812 (GRCm39) Y661* probably null Het
Pla2g12b G T 10: 59,252,239 (GRCm39) A37S probably benign Het
Plekha7 G T 7: 115,744,476 (GRCm39) probably null Het
Ralgapa1 T C 12: 55,689,133 (GRCm39) I1989V probably damaging Het
Ralgapa1 T C 12: 55,689,144 (GRCm39) H1938R probably damaging Het
Sanbr A T 11: 23,545,434 (GRCm39) D486E probably damaging Het
Sec31b A G 19: 44,515,480 (GRCm39) F309S probably damaging Het
Serpina3a T C 12: 104,087,758 (GRCm39) I227T probably benign Het
Slc1a3 A G 15: 8,675,171 (GRCm39) I278T probably damaging Het
Slc1a3 T C 15: 8,680,477 (GRCm39) Y127C probably damaging Het
Spen T C 4: 141,217,212 (GRCm39) K449R unknown Het
Thoc2l A G 5: 104,665,528 (GRCm39) T17A probably benign Het
Tmem130 A G 5: 144,689,255 (GRCm39) S129P probably damaging Het
Trim68 A T 7: 102,328,348 (GRCm39) probably null Het
Vdac3-ps1 T C 13: 18,206,034 (GRCm39) noncoding transcript Het
Vmn2r75 A G 7: 85,797,240 (GRCm39) probably benign Het
Zbtb9 G T 17: 27,193,985 (GRCm39) probably benign Het
Zfp568 T A 7: 29,687,233 (GRCm39) probably null Het
Other mutations in Or10z1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01765:Or10z1 APN 1 174,077,703 (GRCm39) missense probably damaging 1.00
IGL02718:Or10z1 APN 1 174,078,273 (GRCm39) nonsense probably null
IGL03208:Or10z1 APN 1 174,077,959 (GRCm39) missense probably damaging 1.00
BB009:Or10z1 UTSW 1 174,078,260 (GRCm39) missense probably benign 0.00
BB019:Or10z1 UTSW 1 174,078,260 (GRCm39) missense probably benign 0.00
R1406:Or10z1 UTSW 1 174,078,427 (GRCm39) missense possibly damaging 0.51
R1406:Or10z1 UTSW 1 174,078,427 (GRCm39) missense possibly damaging 0.51
R1760:Or10z1 UTSW 1 174,077,926 (GRCm39) missense probably damaging 0.99
R2138:Or10z1 UTSW 1 174,078,302 (GRCm39) splice site probably null
R2139:Or10z1 UTSW 1 174,078,302 (GRCm39) splice site probably null
R2869:Or10z1 UTSW 1 174,078,092 (GRCm39) missense probably benign 0.41
R2869:Or10z1 UTSW 1 174,078,092 (GRCm39) missense probably benign 0.41
R2871:Or10z1 UTSW 1 174,078,092 (GRCm39) missense probably benign 0.41
R2871:Or10z1 UTSW 1 174,078,092 (GRCm39) missense probably benign 0.41
R2872:Or10z1 UTSW 1 174,078,092 (GRCm39) missense probably benign 0.41
R2872:Or10z1 UTSW 1 174,078,092 (GRCm39) missense probably benign 0.41
R2873:Or10z1 UTSW 1 174,078,092 (GRCm39) missense probably benign 0.41
R2874:Or10z1 UTSW 1 174,078,092 (GRCm39) missense probably benign 0.41
R3854:Or10z1 UTSW 1 174,077,716 (GRCm39) missense probably damaging 1.00
R4614:Or10z1 UTSW 1 174,078,188 (GRCm39) missense possibly damaging 0.93
R4858:Or10z1 UTSW 1 174,078,262 (GRCm39) missense probably damaging 1.00
R5015:Or10z1 UTSW 1 174,078,448 (GRCm39) missense possibly damaging 0.91
R5138:Or10z1 UTSW 1 174,078,395 (GRCm39) missense probably damaging 0.97
R5296:Or10z1 UTSW 1 174,078,322 (GRCm39) missense possibly damaging 0.75
R5369:Or10z1 UTSW 1 174,078,007 (GRCm39) missense probably damaging 1.00
R6285:Or10z1 UTSW 1 174,078,395 (GRCm39) missense possibly damaging 0.62
R7655:Or10z1 UTSW 1 174,077,784 (GRCm39) missense probably damaging 1.00
R7656:Or10z1 UTSW 1 174,077,784 (GRCm39) missense probably damaging 1.00
R7753:Or10z1 UTSW 1 174,078,236 (GRCm39) missense probably benign 0.01
R7932:Or10z1 UTSW 1 174,078,260 (GRCm39) missense probably benign 0.00
R8179:Or10z1 UTSW 1 174,078,130 (GRCm39) missense possibly damaging 0.75
R9336:Or10z1 UTSW 1 174,077,679 (GRCm39) missense probably damaging 1.00
R9758:Or10z1 UTSW 1 174,077,902 (GRCm39) missense probably damaging 1.00
Posted On 2013-06-21