Mutagenetix > Incidental Mutation

Incidental Mutation 'R0538:Smarca2'

49657

Institutional Source

Beutler Lab

Gene Symbol

Smarca2

Ensembl Gene

ENSMUSG00000024921

Gene Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

Synonyms

Snf2l2, brm, 2610209L14Rik

MMRRC Submission

038730-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0538 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

26582578-26755721 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 26668762 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Asparagine at position 920 (K920N)

Ref Sequence

ENSEMBL: ENSMUSP00000135017 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025862] [ENSMUST00000099537] [ENSMUST00000176030] [ENSMUST00000176769]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000025862
AA Change: K978N

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000025862
Gene: ENSMUSG00000024921
AA Change: K978N

Domain	Start	End	E-Value	Type
low complexity region	11	58	N/A	INTRINSIC
low complexity region	98	113	N/A	INTRINSIC
low complexity region	135	154	N/A	INTRINSIC
QLQ	172	208	2.58e-13	SMART
low complexity region	216	264	N/A	INTRINSIC
low complexity region	290	314	N/A	INTRINSIC
low complexity region	394	405	N/A	INTRINSIC
HSA	447	519	1.44e-28	SMART
low complexity region	559	579	N/A	INTRINSIC
BRK	601	645	1.9e-19	SMART
DEXDc	731	923	1.34e-36	SMART
Blast:DEXDc	934	966	8e-10	BLAST
low complexity region	1005	1014	N/A	INTRINSIC
HELICc	1091	1175	3.84e-23	SMART
low complexity region	1233	1248	N/A	INTRINSIC
SnAC	1269	1337	7.29e-28	SMART
low complexity region	1344	1366	N/A	INTRINSIC
BROMO	1391	1501	3.13e-41	SMART
low complexity region	1502	1524	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1564	1576	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000099537
AA Change: K978N

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000097135
Gene: ENSMUSG00000024921
AA Change: K978N

Domain	Start	End	E-Value	Type
low complexity region	11	58	N/A	INTRINSIC
low complexity region	98	113	N/A	INTRINSIC
low complexity region	135	154	N/A	INTRINSIC
QLQ	172	208	2.58e-13	SMART
low complexity region	216	264	N/A	INTRINSIC
low complexity region	290	314	N/A	INTRINSIC
low complexity region	394	405	N/A	INTRINSIC
HSA	447	519	1.44e-28	SMART
low complexity region	559	579	N/A	INTRINSIC
BRK	601	645	1.9e-19	SMART
DEXDc	731	923	1.34e-36	SMART
Blast:DEXDc	934	966	7e-10	BLAST
low complexity region	1005	1014	N/A	INTRINSIC
HELICc	1091	1175	3.84e-23	SMART
low complexity region	1233	1248	N/A	INTRINSIC
SnAC	1269	1337	7.29e-28	SMART
low complexity region	1344	1366	N/A	INTRINSIC
PDB:2DAT\|A	1389	1410	1e-6	PDB
low complexity region	1480	1508	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000175935

Predicted Effect

possibly damaging
Transcript: ENSMUST00000176030
AA Change: K978N

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000135784
Gene: ENSMUSG00000024921
AA Change: K978N

Domain	Start	End	E-Value	Type
low complexity region	11	58	N/A	INTRINSIC
low complexity region	98	113	N/A	INTRINSIC
low complexity region	135	154	N/A	INTRINSIC
QLQ	172	208	2.58e-13	SMART
low complexity region	216	264	N/A	INTRINSIC
low complexity region	290	314	N/A	INTRINSIC
low complexity region	394	405	N/A	INTRINSIC
HSA	447	519	1.44e-28	SMART
low complexity region	559	579	N/A	INTRINSIC
BRK	601	645	1.9e-19	SMART
DEXDc	731	923	1.34e-36	SMART
Blast:DEXDc	934	966	8e-10	BLAST
low complexity region	1005	1014	N/A	INTRINSIC
HELICc	1091	1175	3.84e-23	SMART
low complexity region	1233	1248	N/A	INTRINSIC
SnAC	1269	1337	7.29e-28	SMART
low complexity region	1344	1366	N/A	INTRINSIC
BROMO	1391	1519	1.74e-39	SMART
low complexity region	1520	1542	N/A	INTRINSIC
low complexity region	1544	1558	N/A	INTRINSIC
low complexity region	1582	1594	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000176769
AA Change: K920N

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000135017
Gene: ENSMUSG00000024921
AA Change: K920N

Domain	Start	End	E-Value	Type
low complexity region	11	58	N/A	INTRINSIC
low complexity region	98	113	N/A	INTRINSIC
low complexity region	135	154	N/A	INTRINSIC
QLQ	172	208	2.58e-13	SMART
low complexity region	216	264	N/A	INTRINSIC
low complexity region	290	314	N/A	INTRINSIC
low complexity region	394	405	N/A	INTRINSIC
HSA	447	519	1.44e-28	SMART
low complexity region	559	579	N/A	INTRINSIC
BRK	601	645	1.9e-19	SMART
DEXDc	731	908	4.18e-24	SMART
low complexity region	947	956	N/A	INTRINSIC
HELICc	1033	1117	3.84e-23	SMART
low complexity region	1175	1190	N/A	INTRINSIC
SnAC	1211	1279	7.29e-28	SMART
low complexity region	1286	1308	N/A	INTRINSIC
BROMO	1333	1443	3.13e-41	SMART
low complexity region	1444	1466	N/A	INTRINSIC
low complexity region	1468	1482	N/A	INTRINSIC
low complexity region	1506	1518	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000208303
AA Change: K222N

Meta Mutation Damage Score

0.8692

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.3%
20x: 92.7%

Validation Efficiency

98% (126/129)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]
PHENOTYPE: Mice homozygous for a targeted mutation in this gene may exhibit infertility and a slightly increased body weight in some genetic backgrounds. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 129 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930578I07Rik	A	T	14: 67,175,823 (GRCm39)	H6L	unknown	Het
Abca13	G	A	11: 9,217,622 (GRCm39)		probably null	Het
Acad12	C	T	5: 121,745,511 (GRCm39)	R260Q	possibly damaging	Het
Actn1	G	A	12: 80,306,874 (GRCm39)		probably benign	Het
Acvrl1	A	G	15: 101,034,030 (GRCm39)	T182A	probably damaging	Het
Adam23	T	C	1: 63,607,003 (GRCm39)		probably benign	Het
Adamtsl1	A	T	4: 86,261,358 (GRCm39)	T1190S	probably benign	Het
Adh6b	A	T	3: 138,063,411 (GRCm39)	Y330F	probably benign	Het
Ak7	A	G	12: 105,732,876 (GRCm39)	E540G	probably damaging	Het
Akr1c19	T	A	13: 4,287,099 (GRCm39)	L106Q	probably damaging	Het
Ankrd12	A	T	17: 66,356,847 (GRCm39)	S57T	probably damaging	Het
Aoc3	G	A	11: 101,222,964 (GRCm39)	R400Q	possibly damaging	Het
Arel1	A	T	12: 84,988,611 (GRCm39)	I46N	probably damaging	Het
Armc5	A	G	7: 127,843,463 (GRCm39)	D752G	probably damaging	Het
Atp11b	T	C	3: 35,891,163 (GRCm39)	V812A	probably damaging	Het
Axin1	A	G	17: 26,403,215 (GRCm39)	H131R	possibly damaging	Het
Bpifb3	A	G	2: 153,765,789 (GRCm39)	E184G	probably benign	Het
Cacna2d2	T	C	9: 107,401,582 (GRCm39)		probably benign	Het
Catsperd	T	C	17: 56,969,828 (GRCm39)	F641L	probably benign	Het
Ccdc83	A	C	7: 89,877,591 (GRCm39)	L284V	probably damaging	Het
Ccn2	T	A	10: 24,472,364 (GRCm39)	C136S	probably damaging	Het
Ccnt2	T	A	1: 127,730,902 (GRCm39)	V593E	probably damaging	Het
Cd53	T	A	3: 106,669,444 (GRCm39)	I185F	probably benign	Het
Cep350	A	T	1: 155,724,366 (GRCm39)	D3077E	possibly damaging	Het
Ces1h	C	A	8: 94,083,628 (GRCm39)		probably null	Het
Chrna3	T	A	9: 54,923,290 (GRCm39)	T173S	probably benign	Het
Clca4b	T	C	3: 144,627,717 (GRCm39)	D418G	probably benign	Het
Col11a2	T	C	17: 34,270,302 (GRCm39)		probably benign	Het
Coq2	T	A	5: 100,815,889 (GRCm39)	I97F	possibly damaging	Het
Cr2	A	G	1: 194,842,667 (GRCm39)		probably benign	Het
D2hgdh	A	G	1: 93,754,099 (GRCm39)	Y24C	probably damaging	Het
D630045J12Rik	G	A	6: 38,168,628 (GRCm39)	R974C	probably damaging	Het
Dach1	A	G	14: 98,140,715 (GRCm39)	V429A	possibly damaging	Het
Ddr1	G	A	17: 35,995,899 (GRCm39)	T660I	probably damaging	Het
Dlg1	A	C	16: 31,615,682 (GRCm39)		probably null	Het
Dmbt1	T	C	7: 130,651,631 (GRCm39)		probably benign	Het
Dmxl2	A	T	9: 54,301,120 (GRCm39)	D2330E	probably benign	Het
Dnai4	T	C	4: 102,953,815 (GRCm39)	N128S	possibly damaging	Het
Doc2a	A	G	7: 126,447,983 (GRCm39)	T5A	probably benign	Het
Dock2	G	A	11: 34,595,545 (GRCm39)		probably benign	Het
Dok4	T	A	8: 95,591,866 (GRCm39)	Y290F	probably damaging	Het
Dop1a	A	G	9: 86,367,550 (GRCm39)	D11G	probably damaging	Het
E230025N22Rik	T	C	18: 36,821,987 (GRCm39)	H235R	probably benign	Het
Ear6	A	G	14: 52,091,909 (GRCm39)	D152G	probably damaging	Het
Ecscr	T	A	18: 35,846,689 (GRCm39)		probably benign	Het
Eml6	A	T	11: 29,710,010 (GRCm39)		probably benign	Het
Epha4	T	A	1: 77,365,178 (GRCm39)	Q607L	probably damaging	Het
Exoc4	A	G	6: 33,948,998 (GRCm39)	N947S	probably benign	Het
Flg	A	G	3: 93,186,767 (GRCm39)	E73G	probably damaging	Het
Fndc1	C	T	17: 8,003,173 (GRCm39)		probably benign	Het
Gad1-ps	T	C	10: 99,280,854 (GRCm39)		noncoding transcript	Het
Gata6	A	G	18: 11,064,771 (GRCm39)	T528A	probably benign	Het
Gjd4	T	C	18: 9,280,244 (GRCm39)	E278G	probably benign	Het
Gm20091	T	A	10: 96,244,864 (GRCm39)		noncoding transcript	Het
Gnb3	G	A	6: 124,812,659 (GRCm39)	Q266*	probably null	Het
Grm3	A	G	5: 9,562,446 (GRCm39)	V468A	possibly damaging	Het
Igf1r	C	T	7: 67,857,574 (GRCm39)	R1085C	probably damaging	Het
Igsf10	T	C	3: 59,227,527 (GRCm39)	T2049A	probably damaging	Het
Jak3	A	T	8: 72,138,126 (GRCm39)	D859V	probably benign	Het
Kcnb2	G	T	1: 15,783,108 (GRCm39)		probably benign	Het
Kcnh3	G	A	15: 99,138,839 (GRCm39)	G858D	probably benign	Het
Kif1a	C	A	1: 92,971,360 (GRCm39)	R1006L	probably damaging	Het
Klhl23	C	T	2: 69,654,757 (GRCm39)	A209V	probably benign	Het
Mapk13	T	C	17: 28,994,229 (GRCm39)	Y104H	probably damaging	Het
Mbd4	A	G	6: 115,826,443 (GRCm39)	S183P	probably damaging	Het
Mga	T	C	2: 119,750,187 (GRCm39)		probably null	Het
Mipol1	G	A	12: 57,461,197 (GRCm39)		probably null	Het
Mmp14	A	G	14: 54,676,166 (GRCm39)	T299A	possibly damaging	Het
Mmrn1	A	G	6: 60,953,453 (GRCm39)	E578G	probably benign	Het
Mov10l1	G	A	15: 88,879,063 (GRCm39)	C193Y	possibly damaging	Het
Mppe1	A	G	18: 67,370,548 (GRCm39)	C50R	probably damaging	Het
Msantd1	C	A	5: 35,075,069 (GRCm39)	R44S	probably damaging	Het
Myt1l	T	C	12: 29,892,570 (GRCm39)	V69A	possibly damaging	Het
Nav1	A	T	1: 135,392,430 (GRCm39)		probably benign	Het
Ncan	A	G	8: 70,561,252 (GRCm39)	S572P	possibly damaging	Het
Nck2	T	C	1: 43,608,304 (GRCm39)		probably benign	Het
Nemf	A	T	12: 69,403,088 (GRCm39)	D31E	probably damaging	Het
Nlrp12	T	C	7: 3,297,892 (GRCm39)	D93G	possibly damaging	Het
Nsmaf	A	T	4: 6,419,930 (GRCm39)		probably null	Het
Nup98	T	C	7: 101,835,892 (GRCm39)	T184A	probably damaging	Het
Oog2	C	A	4: 143,922,654 (GRCm39)	Y306*	probably null	Het
Or13a18	A	T	7: 140,190,297 (GRCm39)	N73Y	probably damaging	Het
Or6ae1	A	T	7: 139,742,144 (GRCm39)	S240T	probably damaging	Het
Or6b2b	A	T	1: 92,419,055 (GRCm39)	C141S	possibly damaging	Het
Osmr	A	G	15: 6,871,419 (GRCm39)		probably benign	Het
P2rx6	A	G	16: 17,386,162 (GRCm39)	N275S	probably benign	Het
Pbxip1	G	T	3: 89,354,926 (GRCm39)	G482W	possibly damaging	Het
Pcsk4	T	G	10: 80,161,168 (GRCm39)	I249L	probably damaging	Het
Pou4f2	C	T	8: 79,162,291 (GRCm39)	G104E	probably damaging	Het
Pramel28	T	A	4: 143,691,653 (GRCm39)	T357S	possibly damaging	Het
Prkdc	G	T	16: 15,651,652 (GRCm39)	R3763L	probably damaging	Het
Ptpre	A	T	7: 135,265,044 (GRCm39)	I207F	probably damaging	Het
Rapgef3	A	T	15: 97,655,698 (GRCm39)		probably benign	Het
Rasgrp1	T	G	2: 117,115,428 (GRCm39)	K685T	probably benign	Het
Rnf148	C	T	6: 23,654,237 (GRCm39)	R253Q	probably damaging	Het
Rock1	T	C	18: 10,132,227 (GRCm39)	I241V	possibly damaging	Het
Rp1l1	T	G	14: 64,259,541 (GRCm39)	V61G	probably damaging	Het
Scin	A	C	12: 40,131,770 (GRCm39)	S255A	probably damaging	Het
Scn8a	A	T	15: 100,933,505 (GRCm39)	K1570*	probably null	Het
Sec14l4	A	C	11: 3,990,018 (GRCm39)	M106L	probably benign	Het
Sec63	G	A	10: 42,674,795 (GRCm39)	R226H	probably benign	Het
Septin2	T	A	1: 93,429,345 (GRCm39)	N271K	probably damaging	Het
Serac1	G	T	17: 6,099,101 (GRCm39)		probably benign	Het
Shc2	T	A	10: 79,465,974 (GRCm39)		probably benign	Het
Sipa1l1	T	A	12: 82,471,873 (GRCm39)	D1284E	probably benign	Het
Slc11a2	A	G	15: 100,306,097 (GRCm39)	L105P	probably damaging	Het
Slc1a3	T	A	15: 8,680,406 (GRCm39)	T151S	probably benign	Het
Sugp2	G	A	8: 70,711,598 (GRCm39)	E964K	probably damaging	Het
Tas2r122	A	C	6: 132,688,778 (GRCm39)	N38K	probably benign	Het
Tecpr1	G	A	5: 144,143,092 (GRCm39)	R730C	probably damaging	Het
Tent2	A	T	13: 93,312,123 (GRCm39)		probably benign	Het
Themis3	G	T	17: 66,900,265 (GRCm39)	N34K	possibly damaging	Het
Traf3ip1	A	G	1: 91,427,341 (GRCm39)	T104A	unknown	Het
Trappc11	A	G	8: 47,956,447 (GRCm39)	V843A	probably benign	Het
Trmt61a	T	A	12: 111,645,361 (GRCm39)	L99Q	probably damaging	Het
Trp53tg5	T	A	2: 164,313,401 (GRCm39)	K91N	probably damaging	Het
Ufsp2	T	C	8: 46,445,187 (GRCm39)	S339P	probably damaging	Het
Usp20	T	A	2: 30,894,462 (GRCm39)	V126E	probably damaging	Het
Vmn1r75	T	A	7: 11,614,797 (GRCm39)	N176K	probably damaging	Het
Vmn2r24	A	G	6: 123,793,012 (GRCm39)	S780G	probably benign	Het
Vmn2r89	A	G	14: 51,695,048 (GRCm39)		probably null	Het
Vps13d	A	T	4: 144,771,665 (GRCm39)	S4038T	probably damaging	Het
Vwa7	A	G	17: 35,241,627 (GRCm39)	T421A	probably damaging	Het
Wdr95	C	A	5: 149,504,271 (GRCm39)	L332I	probably damaging	Het
Wrn	T	A	8: 33,826,119 (GRCm39)	K181I	probably damaging	Het
Zc3h6	T	A	2: 128,859,143 (GRCm39)	I1058N	possibly damaging	Het
Zfp423	T	A	8: 88,508,713 (GRCm39)	I544F	probably damaging	Het
Zfp446	T	A	7: 12,713,516 (GRCm39)	S161T	possibly damaging	Het
Zmym6	T	A	4: 127,017,162 (GRCm39)	M889K	probably benign	Het

Other mutations in Smarca2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01368:Smarca2	APN	19	26,751,694 (GRCm39)	missense	possibly damaging	0.82
IGL01907:Smarca2	APN	19	26,675,865 (GRCm39)	missense	possibly damaging	0.59
IGL02039:Smarca2	APN	19	26,693,537 (GRCm39)	missense	probably damaging	1.00
IGL02110:Smarca2	APN	19	26,650,140 (GRCm39)	missense	possibly damaging	0.96
IGL02561:Smarca2	APN	19	26,693,582 (GRCm39)	missense	possibly damaging	0.92
IGL02649:Smarca2	APN	19	26,617,986 (GRCm39)	missense	possibly damaging	0.73
IGL02880:Smarca2	APN	19	26,654,024 (GRCm39)	splice site	probably benign
IGL03028:Smarca2	APN	19	26,655,712 (GRCm39)	splice site	probably benign
IGL03187:Smarca2	APN	19	26,650,224 (GRCm39)	missense	probably damaging	0.98
IGL03213:Smarca2	APN	19	26,601,375 (GRCm39)	missense	probably damaging	1.00
IGL03354:Smarca2	APN	19	26,597,303 (GRCm39)	missense	probably benign	0.01
Genghis	UTSW	19	26,597,284 (GRCm39)	missense	possibly damaging	0.53
kraft	UTSW	19	26,655,763 (GRCm39)	missense	probably damaging	0.99
Kublai	UTSW	19	26,618,013 (GRCm39)	missense	probably damaging	1.00
Samarkand	UTSW	19	26,631,864 (GRCm39)	nonsense	probably null
tashkent	UTSW	19	26,698,273 (GRCm39)	missense	probably benign	0.06
Xanadu	UTSW	19	26,659,452 (GRCm39)	missense	possibly damaging	0.52
FR4737:Smarca2	UTSW	19	26,608,399 (GRCm39)	unclassified	probably benign
PIT1430001:Smarca2	UTSW	19	26,626,493 (GRCm39)	missense	probably benign	0.35
R0184:Smarca2	UTSW	19	26,669,649 (GRCm39)	nonsense	probably null
R0306:Smarca2	UTSW	19	26,618,013 (GRCm39)	missense	probably damaging	1.00
R0565:Smarca2	UTSW	19	26,659,275 (GRCm39)	missense	possibly damaging	0.71
R0610:Smarca2	UTSW	19	26,668,791 (GRCm39)	missense	probably damaging	1.00
R0669:Smarca2	UTSW	19	26,683,600 (GRCm39)	missense	possibly damaging	0.51
R0726:Smarca2	UTSW	19	26,675,803 (GRCm39)	missense	probably damaging	1.00
R1184:Smarca2	UTSW	19	26,748,333 (GRCm39)	splice site	probably benign
R1256:Smarca2	UTSW	19	26,659,373 (GRCm39)	missense	probably benign	0.06
R1299:Smarca2	UTSW	19	26,749,011 (GRCm39)	critical splice donor site	probably null
R1306:Smarca2	UTSW	19	26,748,388 (GRCm39)	missense	possibly damaging	0.81
R1381:Smarca2	UTSW	19	26,608,228 (GRCm39)	missense	probably damaging	1.00
R1400:Smarca2	UTSW	19	26,654,140 (GRCm39)	missense	probably damaging	0.98
R1415:Smarca2	UTSW	19	26,688,084 (GRCm39)	missense	probably null	0.72
R1496:Smarca2	UTSW	19	26,608,501 (GRCm39)	missense	possibly damaging	0.85
R1582:Smarca2	UTSW	19	26,729,305 (GRCm39)	missense	probably damaging	0.99
R1666:Smarca2	UTSW	19	26,624,434 (GRCm39)	missense	possibly damaging	0.65
R1668:Smarca2	UTSW	19	26,624,434 (GRCm39)	missense	possibly damaging	0.65
R1751:Smarca2	UTSW	19	26,617,780 (GRCm39)	splice site	probably benign
R1861:Smarca2	UTSW	19	26,601,284 (GRCm39)	missense	probably benign	0.03
R1962:Smarca2	UTSW	19	26,650,124 (GRCm39)	nonsense	probably null
R1964:Smarca2	UTSW	19	26,650,124 (GRCm39)	nonsense	probably null
R1998:Smarca2	UTSW	19	26,608,493 (GRCm39)	missense	probably benign	0.33
R2014:Smarca2	UTSW	19	26,661,305 (GRCm39)	missense	possibly damaging	0.86
R2255:Smarca2	UTSW	19	26,748,438 (GRCm39)	missense	probably benign	0.01
R2392:Smarca2	UTSW	19	26,618,050 (GRCm39)	critical splice donor site	probably null
R2439:Smarca2	UTSW	19	26,668,854 (GRCm39)	critical splice donor site	probably null
R3030:Smarca2	UTSW	19	26,729,429 (GRCm39)	missense	possibly damaging	0.84
R3195:Smarca2	UTSW	19	26,661,222 (GRCm39)	missense	possibly damaging	0.85
R3430:Smarca2	UTSW	19	26,668,749 (GRCm39)	missense	probably damaging	1.00
R3710:Smarca2	UTSW	19	26,646,290 (GRCm39)	unclassified	probably benign
R3845:Smarca2	UTSW	19	26,698,273 (GRCm39)	missense	probably benign	0.06
R4013:Smarca2	UTSW	19	26,661,327 (GRCm39)	splice site	probably null
R4014:Smarca2	UTSW	19	26,661,327 (GRCm39)	splice site	probably null
R4016:Smarca2	UTSW	19	26,661,327 (GRCm39)	splice site	probably null
R4271:Smarca2	UTSW	19	26,698,349 (GRCm39)	critical splice donor site	probably null
R4471:Smarca2	UTSW	19	26,597,277 (GRCm39)	missense	possibly damaging	0.86
R4612:Smarca2	UTSW	19	26,753,625 (GRCm39)	missense	possibly damaging	0.70
R4730:Smarca2	UTSW	19	26,608,073 (GRCm39)	missense	probably damaging	1.00
R4755:Smarca2	UTSW	19	26,631,883 (GRCm39)	missense	possibly damaging	0.86
R4999:Smarca2	UTSW	19	26,698,255 (GRCm39)	nonsense	probably null
R5015:Smarca2	UTSW	19	26,668,788 (GRCm39)	missense	possibly damaging	0.86
R5320:Smarca2	UTSW	19	26,668,772 (GRCm39)	missense	probably damaging	1.00
R5393:Smarca2	UTSW	19	26,617,829 (GRCm39)	missense	probably benign	0.18
R5503:Smarca2	UTSW	19	26,659,446 (GRCm39)	missense	possibly damaging	0.93
R5503:Smarca2	UTSW	19	26,601,336 (GRCm39)	missense	probably damaging	0.96
R5715:Smarca2	UTSW	19	26,626,522 (GRCm39)	missense	probably benign	0.16
R5790:Smarca2	UTSW	19	26,654,124 (GRCm39)	missense	probably damaging	1.00
R5874:Smarca2	UTSW	19	26,753,469 (GRCm39)	intron	probably benign
R6209:Smarca2	UTSW	19	26,748,404 (GRCm39)	nonsense	probably null
R6236:Smarca2	UTSW	19	26,673,613 (GRCm39)	missense	probably benign	0.33
R6291:Smarca2	UTSW	19	26,608,292 (GRCm39)	missense	probably damaging	1.00
R6292:Smarca2	UTSW	19	26,608,292 (GRCm39)	missense	probably damaging	1.00
R6325:Smarca2	UTSW	19	26,655,763 (GRCm39)	missense	probably damaging	0.99
R6544:Smarca2	UTSW	19	26,608,331 (GRCm39)	missense	probably damaging	1.00
R6572:Smarca2	UTSW	19	26,656,573 (GRCm39)	missense	possibly damaging	0.71
R6589:Smarca2	UTSW	19	26,597,284 (GRCm39)	missense	possibly damaging	0.53
R6601:Smarca2	UTSW	19	26,631,777 (GRCm39)	missense	probably benign	0.30
R6804:Smarca2	UTSW	19	26,729,286 (GRCm39)	missense	possibly damaging	0.93
R6922:Smarca2	UTSW	19	26,668,749 (GRCm39)	missense	probably damaging	1.00
R7047:Smarca2	UTSW	19	26,646,555 (GRCm39)	missense	possibly damaging	0.83
R7213:Smarca2	UTSW	19	26,624,531 (GRCm39)	missense	possibly damaging	0.96
R7257:Smarca2	UTSW	19	26,631,864 (GRCm39)	nonsense	probably null
R7259:Smarca2	UTSW	19	26,631,864 (GRCm39)	nonsense	probably null
R7479:Smarca2	UTSW	19	26,617,887 (GRCm39)	missense	probably benign	0.00
R7512:Smarca2	UTSW	19	26,661,209 (GRCm39)	missense	possibly damaging	0.51
R8158:Smarca2	UTSW	19	26,659,448 (GRCm39)	missense	probably benign	0.16
R8182:Smarca2	UTSW	19	26,608,120 (GRCm39)	missense	probably benign	0.39
R8207:Smarca2	UTSW	19	26,654,080 (GRCm39)	missense	possibly damaging	0.71
R8467:Smarca2	UTSW	19	26,597,121 (GRCm39)	start codon destroyed	probably null	0.02
R8527:Smarca2	UTSW	19	26,654,187 (GRCm39)	missense	probably damaging	0.98
R8784:Smarca2	UTSW	19	26,753,558 (GRCm39)	missense	probably benign	0.17
R8898:Smarca2	UTSW	19	26,608,358 (GRCm39)	unclassified	probably benign
R9076:Smarca2	UTSW	19	26,659,452 (GRCm39)	missense	possibly damaging	0.52
R9123:Smarca2	UTSW	19	26,693,583 (GRCm39)	missense	possibly damaging	0.84
R9125:Smarca2	UTSW	19	26,693,583 (GRCm39)	missense	possibly damaging	0.84
R9317:Smarca2	UTSW	19	26,737,279 (GRCm39)	missense	possibly damaging	0.75
R9501:Smarca2	UTSW	19	26,617,977 (GRCm39)	missense	probably benign	0.04
R9514:Smarca2	UTSW	19	26,659,452 (GRCm39)	missense	possibly damaging	0.71
R9641:Smarca2	UTSW	19	26,656,498 (GRCm39)	missense	possibly damaging	0.93
RF001:Smarca2	UTSW	19	26,608,421 (GRCm39)	unclassified	probably benign
RF001:Smarca2	UTSW	19	26,608,386 (GRCm39)	unclassified	probably benign
RF004:Smarca2	UTSW	19	26,608,420 (GRCm39)	unclassified	probably benign
RF019:Smarca2	UTSW	19	26,608,401 (GRCm39)	unclassified	probably benign
RF021:Smarca2	UTSW	19	26,608,397 (GRCm39)	unclassified	probably benign
RF024:Smarca2	UTSW	19	26,608,420 (GRCm39)	unclassified	probably benign
RF034:Smarca2	UTSW	19	26,608,411 (GRCm39)	unclassified	probably benign
RF040:Smarca2	UTSW	19	26,608,422 (GRCm39)	unclassified	probably benign
RF041:Smarca2	UTSW	19	26,608,421 (GRCm39)	unclassified	probably benign
RF047:Smarca2	UTSW	19	26,608,405 (GRCm39)	unclassified	probably benign
RF051:Smarca2	UTSW	19	26,608,388 (GRCm39)	unclassified	probably benign
X0061:Smarca2	UTSW	19	26,698,240 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- GGCAGTCGCTGGTTTTCCTGATAC -3'
(R):5'- AGCTTGCATCCTCGGTCCACAG -3'

Sequencing Primer
(F):5'- AAGCTTACATCTTCCACATGTAGC -3'
(R):5'- CGGTCCACAGAGCTATCATGAG -3'

Posted On

2013-06-12