Mutagenetix > Incidental Mutation

Incidental Mutation 'R0538:Col11a2'

49645

Institutional Source

Beutler Lab

Gene Symbol

Col11a2

Ensembl Gene

ENSMUSG00000024330

Gene Name

collagen, type XI, alpha 2

Synonyms

MMRRC Submission

038730-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.936) question?

Stock #

R0538 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

34258411-34285659 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 34270302 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000115026 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087497] [ENSMUST00000114252] [ENSMUST00000114255] [ENSMUST00000131134] [ENSMUST00000143354]

AlphaFold

Q64739

Predicted Effect

probably benign
Transcript: ENSMUST00000087497

SMART Domains

Protein: ENSMUSP00000084772
Gene: ENSMUSG00000024330

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
TSPN	31	214	4.25e-72	SMART
LamG	82	213	1.08e-9	SMART
Pfam:Collagen	306	364	2.2e-9	PFAM
Pfam:Collagen	399	460	1e-10	PFAM
Pfam:Collagen	437	520	1.2e-7	PFAM
Pfam:Collagen	479	553	5.7e-9	PFAM
Pfam:Collagen	506	579	1.6e-8	PFAM
internal_repeat_4	584	614	3.98e-5	PROSPERO
internal_repeat_2	584	669	5.49e-20	PROSPERO
internal_repeat_1	587	740	2.58e-22	PROSPERO
Pfam:Collagen	743	814	1.5e-8	PFAM
Pfam:Collagen	767	839	4.8e-7	PFAM
low complexity region	854	872	N/A	INTRINSIC
Pfam:Collagen	881	946	4.5e-8	PFAM
Pfam:Collagen	905	976	2e-7	PFAM
Pfam:Collagen	933	1002	2.7e-8	PFAM
low complexity region	1013	1047	N/A	INTRINSIC
low complexity region	1064	1112	N/A	INTRINSIC
low complexity region	1121	1199	N/A	INTRINSIC
low complexity region	1216	1232	N/A	INTRINSIC
low complexity region	1289	1320	N/A	INTRINSIC
Pfam:Collagen	1358	1417	1.7e-8	PFAM
COLFI	1454	1649	4.42e-117	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000114252

SMART Domains

Protein: ENSMUSP00000109890
Gene: ENSMUSG00000024330

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
TSPN	31	214	4.25e-72	SMART
LamG	82	213	1.08e-9	SMART
Pfam:Collagen	311	369	2.3e-9	PFAM
Pfam:Collagen	404	465	1.1e-10	PFAM
Pfam:Collagen	442	525	1.3e-7	PFAM
Pfam:Collagen	484	558	6.4e-9	PFAM
Pfam:Collagen	511	584	1.7e-8	PFAM
internal_repeat_4	589	619	3.69e-5	PROSPERO
internal_repeat_2	589	674	4.46e-20	PROSPERO
internal_repeat_1	592	745	2.05e-22	PROSPERO
internal_repeat_3	636	752	7.84e-10	PROSPERO
Pfam:Collagen	772	844	5.5e-7	PFAM
Pfam:Collagen	800	869	1.9e-8	PFAM
Pfam:Collagen	886	951	5e-8	PFAM
Pfam:Collagen	910	981	2.2e-7	PFAM
Pfam:Collagen	934	1007	6.9e-7	PFAM
low complexity region	1018	1052	N/A	INTRINSIC
low complexity region	1069	1117	N/A	INTRINSIC
low complexity region	1126	1204	N/A	INTRINSIC
low complexity region	1221	1237	N/A	INTRINSIC
low complexity region	1294	1325	N/A	INTRINSIC
Pfam:Collagen	1363	1422	1.9e-8	PFAM
COLFI	1459	1654	4.42e-117	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000114255

SMART Domains

Protein: ENSMUSP00000109893
Gene: ENSMUSG00000024330

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
TSPN	31	214	4.25e-72	SMART
LamG	82	213	1.08e-9	SMART
low complexity region	257	268	N/A	INTRINSIC
low complexity region	295	307	N/A	INTRINSIC
Pfam:Collagen	345	403	2.1e-9	PFAM
Pfam:Collagen	438	499	1.1e-10	PFAM
Pfam:Collagen	521	593	2.2e-8	PFAM
Pfam:Collagen	545	613	9.1e-10	PFAM
internal_repeat_4	623	653	2.83e-5	PROSPERO
internal_repeat_2	623	708	2.11e-20	PROSPERO
internal_repeat_1	626	779	9e-23	PROSPERO
internal_repeat_3	670	786	5.16e-10	PROSPERO
low complexity region	788	819	N/A	INTRINSIC
low complexity region	830	857	N/A	INTRINSIC
low complexity region	866	887	N/A	INTRINSIC
low complexity region	893	911	N/A	INTRINSIC
low complexity region	919	935	N/A	INTRINSIC
Pfam:Collagen	973	1041	2.9e-8	PFAM
low complexity region	1052	1086	N/A	INTRINSIC
low complexity region	1103	1151	N/A	INTRINSIC
low complexity region	1160	1238	N/A	INTRINSIC
low complexity region	1255	1271	N/A	INTRINSIC
low complexity region	1328	1359	N/A	INTRINSIC
Pfam:Collagen	1394	1456	1.5e-8	PFAM
COLFI	1493	1688	4.42e-117	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000131134

SMART Domains

Protein: ENSMUSP00000122082
Gene: ENSMUSG00000024330

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
TSPN	31	214	4.25e-72	SMART
LamG	82	213	1.08e-9	SMART
low complexity region	303	314	N/A	INTRINSIC
low complexity region	342	354	N/A	INTRINSIC
Pfam:Collagen	392	450	7.8e-10	PFAM
Pfam:Collagen	484	543	1.4e-10	PFAM
Pfam:Collagen	514	581	9.5e-11	PFAM
Pfam:Collagen	565	624	2.1e-11	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137374

Predicted Effect

probably benign
Transcript: ENSMUST00000143354

SMART Domains

Protein: ENSMUSP00000115026
Gene: ENSMUSG00000024330

Domain	Start	End	E-Value	Type
Pfam:Collagen	3	56	4.7e-9	PFAM
Pfam:Collagen	91	152	1.7e-9	PFAM
internal_repeat_1	158	301	3.7e-11	PROSPERO
internal_repeat_2	276	321	1.18e-9	PROSPERO
internal_repeat_4	291	306	1.06e-5	PROSPERO
internal_repeat_3	303	353	1.87e-6	PROSPERO
internal_repeat_2	315	360	1.18e-9	PROSPERO
internal_repeat_1	323	439	3.7e-11	PROSPERO
low complexity region	441	472	N/A	INTRINSIC
low complexity region	483	510	N/A	INTRINSIC
low complexity region	519	540	N/A	INTRINSIC
low complexity region	546	564	N/A	INTRINSIC
low complexity region	572	588	N/A	INTRINSIC
Pfam:Collagen	603	673	6.6e-6	PFAM
Pfam:Collagen	627	694	5.4e-7	PFAM
Pfam:Collagen	660	734	3.2e-7	PFAM
Pfam:Collagen	711	770	1.1e-8	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173749

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.3%
20x: 92.7%

Validation Efficiency

98% (126/129)

MGI Phenotype

FUNCTION: This gene encodes the alpha-2 subunit of type XI collagen, one of the low abundance fibrillar collagens found in cartilage. The encoded protein, in association with other collagen subunits, forms a heterotrimeric type XI procollagen that may undergo proteolytic processing similar to the alpha-1 subunit. Mice lacking the encoded protein exhibit a mild phenotype similar to nonocular Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED) as well as a nonsyndromic form of deafness called DFNA13. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
PHENOTYPE: Homozygous mutant animals exhibit reduced body size, short snout, a slightly bulged forehead, deafness, and disorganization of chondrocytes in the growth plate of long bones. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 129 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930578I07Rik	A	T	14: 67,175,823 (GRCm39)	H6L	unknown	Het
Abca13	G	A	11: 9,217,622 (GRCm39)		probably null	Het
Acad12	C	T	5: 121,745,511 (GRCm39)	R260Q	possibly damaging	Het
Actn1	G	A	12: 80,306,874 (GRCm39)		probably benign	Het
Acvrl1	A	G	15: 101,034,030 (GRCm39)	T182A	probably damaging	Het
Adam23	T	C	1: 63,607,003 (GRCm39)		probably benign	Het
Adamtsl1	A	T	4: 86,261,358 (GRCm39)	T1190S	probably benign	Het
Adh6b	A	T	3: 138,063,411 (GRCm39)	Y330F	probably benign	Het
Ak7	A	G	12: 105,732,876 (GRCm39)	E540G	probably damaging	Het
Akr1c19	T	A	13: 4,287,099 (GRCm39)	L106Q	probably damaging	Het
Ankrd12	A	T	17: 66,356,847 (GRCm39)	S57T	probably damaging	Het
Aoc3	G	A	11: 101,222,964 (GRCm39)	R400Q	possibly damaging	Het
Arel1	A	T	12: 84,988,611 (GRCm39)	I46N	probably damaging	Het
Armc5	A	G	7: 127,843,463 (GRCm39)	D752G	probably damaging	Het
Atp11b	T	C	3: 35,891,163 (GRCm39)	V812A	probably damaging	Het
Axin1	A	G	17: 26,403,215 (GRCm39)	H131R	possibly damaging	Het
Bpifb3	A	G	2: 153,765,789 (GRCm39)	E184G	probably benign	Het
Cacna2d2	T	C	9: 107,401,582 (GRCm39)		probably benign	Het
Catsperd	T	C	17: 56,969,828 (GRCm39)	F641L	probably benign	Het
Ccdc83	A	C	7: 89,877,591 (GRCm39)	L284V	probably damaging	Het
Ccn2	T	A	10: 24,472,364 (GRCm39)	C136S	probably damaging	Het
Ccnt2	T	A	1: 127,730,902 (GRCm39)	V593E	probably damaging	Het
Cd53	T	A	3: 106,669,444 (GRCm39)	I185F	probably benign	Het
Cep350	A	T	1: 155,724,366 (GRCm39)	D3077E	possibly damaging	Het
Ces1h	C	A	8: 94,083,628 (GRCm39)		probably null	Het
Chrna3	T	A	9: 54,923,290 (GRCm39)	T173S	probably benign	Het
Clca4b	T	C	3: 144,627,717 (GRCm39)	D418G	probably benign	Het
Coq2	T	A	5: 100,815,889 (GRCm39)	I97F	possibly damaging	Het
Cr2	A	G	1: 194,842,667 (GRCm39)		probably benign	Het
D2hgdh	A	G	1: 93,754,099 (GRCm39)	Y24C	probably damaging	Het
D630045J12Rik	G	A	6: 38,168,628 (GRCm39)	R974C	probably damaging	Het
Dach1	A	G	14: 98,140,715 (GRCm39)	V429A	possibly damaging	Het
Ddr1	G	A	17: 35,995,899 (GRCm39)	T660I	probably damaging	Het
Dlg1	A	C	16: 31,615,682 (GRCm39)		probably null	Het
Dmbt1	T	C	7: 130,651,631 (GRCm39)		probably benign	Het
Dmxl2	A	T	9: 54,301,120 (GRCm39)	D2330E	probably benign	Het
Dnai4	T	C	4: 102,953,815 (GRCm39)	N128S	possibly damaging	Het
Doc2a	A	G	7: 126,447,983 (GRCm39)	T5A	probably benign	Het
Dock2	G	A	11: 34,595,545 (GRCm39)		probably benign	Het
Dok4	T	A	8: 95,591,866 (GRCm39)	Y290F	probably damaging	Het
Dop1a	A	G	9: 86,367,550 (GRCm39)	D11G	probably damaging	Het
E230025N22Rik	T	C	18: 36,821,987 (GRCm39)	H235R	probably benign	Het
Ear6	A	G	14: 52,091,909 (GRCm39)	D152G	probably damaging	Het
Ecscr	T	A	18: 35,846,689 (GRCm39)		probably benign	Het
Eml6	A	T	11: 29,710,010 (GRCm39)		probably benign	Het
Epha4	T	A	1: 77,365,178 (GRCm39)	Q607L	probably damaging	Het
Exoc4	A	G	6: 33,948,998 (GRCm39)	N947S	probably benign	Het
Flg	A	G	3: 93,186,767 (GRCm39)	E73G	probably damaging	Het
Fndc1	C	T	17: 8,003,173 (GRCm39)		probably benign	Het
Gad1-ps	T	C	10: 99,280,854 (GRCm39)		noncoding transcript	Het
Gata6	A	G	18: 11,064,771 (GRCm39)	T528A	probably benign	Het
Gjd4	T	C	18: 9,280,244 (GRCm39)	E278G	probably benign	Het
Gm20091	T	A	10: 96,244,864 (GRCm39)		noncoding transcript	Het
Gnb3	G	A	6: 124,812,659 (GRCm39)	Q266*	probably null	Het
Grm3	A	G	5: 9,562,446 (GRCm39)	V468A	possibly damaging	Het
Igf1r	C	T	7: 67,857,574 (GRCm39)	R1085C	probably damaging	Het
Igsf10	T	C	3: 59,227,527 (GRCm39)	T2049A	probably damaging	Het
Jak3	A	T	8: 72,138,126 (GRCm39)	D859V	probably benign	Het
Kcnb2	G	T	1: 15,783,108 (GRCm39)		probably benign	Het
Kcnh3	G	A	15: 99,138,839 (GRCm39)	G858D	probably benign	Het
Kif1a	C	A	1: 92,971,360 (GRCm39)	R1006L	probably damaging	Het
Klhl23	C	T	2: 69,654,757 (GRCm39)	A209V	probably benign	Het
Mapk13	T	C	17: 28,994,229 (GRCm39)	Y104H	probably damaging	Het
Mbd4	A	G	6: 115,826,443 (GRCm39)	S183P	probably damaging	Het
Mga	T	C	2: 119,750,187 (GRCm39)		probably null	Het
Mipol1	G	A	12: 57,461,197 (GRCm39)		probably null	Het
Mmp14	A	G	14: 54,676,166 (GRCm39)	T299A	possibly damaging	Het
Mmrn1	A	G	6: 60,953,453 (GRCm39)	E578G	probably benign	Het
Mov10l1	G	A	15: 88,879,063 (GRCm39)	C193Y	possibly damaging	Het
Mppe1	A	G	18: 67,370,548 (GRCm39)	C50R	probably damaging	Het
Msantd1	C	A	5: 35,075,069 (GRCm39)	R44S	probably damaging	Het
Myt1l	T	C	12: 29,892,570 (GRCm39)	V69A	possibly damaging	Het
Nav1	A	T	1: 135,392,430 (GRCm39)		probably benign	Het
Ncan	A	G	8: 70,561,252 (GRCm39)	S572P	possibly damaging	Het
Nck2	T	C	1: 43,608,304 (GRCm39)		probably benign	Het
Nemf	A	T	12: 69,403,088 (GRCm39)	D31E	probably damaging	Het
Nlrp12	T	C	7: 3,297,892 (GRCm39)	D93G	possibly damaging	Het
Nsmaf	A	T	4: 6,419,930 (GRCm39)		probably null	Het
Nup98	T	C	7: 101,835,892 (GRCm39)	T184A	probably damaging	Het
Oog2	C	A	4: 143,922,654 (GRCm39)	Y306*	probably null	Het
Or13a18	A	T	7: 140,190,297 (GRCm39)	N73Y	probably damaging	Het
Or6ae1	A	T	7: 139,742,144 (GRCm39)	S240T	probably damaging	Het
Or6b2b	A	T	1: 92,419,055 (GRCm39)	C141S	possibly damaging	Het
Osmr	A	G	15: 6,871,419 (GRCm39)		probably benign	Het
P2rx6	A	G	16: 17,386,162 (GRCm39)	N275S	probably benign	Het
Pbxip1	G	T	3: 89,354,926 (GRCm39)	G482W	possibly damaging	Het
Pcsk4	T	G	10: 80,161,168 (GRCm39)	I249L	probably damaging	Het
Pou4f2	C	T	8: 79,162,291 (GRCm39)	G104E	probably damaging	Het
Pramel28	T	A	4: 143,691,653 (GRCm39)	T357S	possibly damaging	Het
Prkdc	G	T	16: 15,651,652 (GRCm39)	R3763L	probably damaging	Het
Ptpre	A	T	7: 135,265,044 (GRCm39)	I207F	probably damaging	Het
Rapgef3	A	T	15: 97,655,698 (GRCm39)		probably benign	Het
Rasgrp1	T	G	2: 117,115,428 (GRCm39)	K685T	probably benign	Het
Rnf148	C	T	6: 23,654,237 (GRCm39)	R253Q	probably damaging	Het
Rock1	T	C	18: 10,132,227 (GRCm39)	I241V	possibly damaging	Het
Rp1l1	T	G	14: 64,259,541 (GRCm39)	V61G	probably damaging	Het
Scin	A	C	12: 40,131,770 (GRCm39)	S255A	probably damaging	Het
Scn8a	A	T	15: 100,933,505 (GRCm39)	K1570*	probably null	Het
Sec14l4	A	C	11: 3,990,018 (GRCm39)	M106L	probably benign	Het
Sec63	G	A	10: 42,674,795 (GRCm39)	R226H	probably benign	Het
Septin2	T	A	1: 93,429,345 (GRCm39)	N271K	probably damaging	Het
Serac1	G	T	17: 6,099,101 (GRCm39)		probably benign	Het
Shc2	T	A	10: 79,465,974 (GRCm39)		probably benign	Het
Sipa1l1	T	A	12: 82,471,873 (GRCm39)	D1284E	probably benign	Het
Slc11a2	A	G	15: 100,306,097 (GRCm39)	L105P	probably damaging	Het
Slc1a3	T	A	15: 8,680,406 (GRCm39)	T151S	probably benign	Het
Smarca2	G	T	19: 26,668,762 (GRCm39)	K920N	probably damaging	Het
Sugp2	G	A	8: 70,711,598 (GRCm39)	E964K	probably damaging	Het
Tas2r122	A	C	6: 132,688,778 (GRCm39)	N38K	probably benign	Het
Tecpr1	G	A	5: 144,143,092 (GRCm39)	R730C	probably damaging	Het
Tent2	A	T	13: 93,312,123 (GRCm39)		probably benign	Het
Themis3	G	T	17: 66,900,265 (GRCm39)	N34K	possibly damaging	Het
Traf3ip1	A	G	1: 91,427,341 (GRCm39)	T104A	unknown	Het
Trappc11	A	G	8: 47,956,447 (GRCm39)	V843A	probably benign	Het
Trmt61a	T	A	12: 111,645,361 (GRCm39)	L99Q	probably damaging	Het
Trp53tg5	T	A	2: 164,313,401 (GRCm39)	K91N	probably damaging	Het
Ufsp2	T	C	8: 46,445,187 (GRCm39)	S339P	probably damaging	Het
Usp20	T	A	2: 30,894,462 (GRCm39)	V126E	probably damaging	Het
Vmn1r75	T	A	7: 11,614,797 (GRCm39)	N176K	probably damaging	Het
Vmn2r24	A	G	6: 123,793,012 (GRCm39)	S780G	probably benign	Het
Vmn2r89	A	G	14: 51,695,048 (GRCm39)		probably null	Het
Vps13d	A	T	4: 144,771,665 (GRCm39)	S4038T	probably damaging	Het
Vwa7	A	G	17: 35,241,627 (GRCm39)	T421A	probably damaging	Het
Wdr95	C	A	5: 149,504,271 (GRCm39)	L332I	probably damaging	Het
Wrn	T	A	8: 33,826,119 (GRCm39)	K181I	probably damaging	Het
Zc3h6	T	A	2: 128,859,143 (GRCm39)	I1058N	possibly damaging	Het
Zfp423	T	A	8: 88,508,713 (GRCm39)	I544F	probably damaging	Het
Zfp446	T	A	7: 12,713,516 (GRCm39)	S161T	possibly damaging	Het
Zmym6	T	A	4: 127,017,162 (GRCm39)	M889K	probably benign	Het

Other mutations in Col11a2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01723:Col11a2	APN	17	34,280,254 (GRCm39)	unclassified	probably benign
IGL01839:Col11a2	APN	17	34,283,056 (GRCm39)	unclassified	probably benign
IGL02429:Col11a2	APN	17	34,261,266 (GRCm39)	missense	probably damaging	1.00
IGL02491:Col11a2	APN	17	34,283,181 (GRCm39)	unclassified	probably benign
BB010:Col11a2	UTSW	17	34,275,029 (GRCm39)	nonsense	probably null
BB020:Col11a2	UTSW	17	34,275,029 (GRCm39)	nonsense	probably null
PIT4531001:Col11a2	UTSW	17	34,265,412 (GRCm39)	critical splice acceptor site	probably null
R0001:Col11a2	UTSW	17	34,280,586 (GRCm39)	missense	probably benign	0.00
R0005:Col11a2	UTSW	17	34,281,853 (GRCm39)	unclassified	probably benign
R0099:Col11a2	UTSW	17	34,268,648 (GRCm39)	missense	probably damaging	0.99
R0106:Col11a2	UTSW	17	34,276,249 (GRCm39)	missense	probably damaging	0.99
R0243:Col11a2	UTSW	17	34,281,520 (GRCm39)	unclassified	probably benign
R0254:Col11a2	UTSW	17	34,283,777 (GRCm39)	unclassified	probably benign
R0352:Col11a2	UTSW	17	34,261,501 (GRCm39)	missense	probably benign	0.43
R0362:Col11a2	UTSW	17	34,281,420 (GRCm39)	splice site	probably null
R0491:Col11a2	UTSW	17	34,261,186 (GRCm39)	missense	probably null	0.00
R0531:Col11a2	UTSW	17	34,277,351 (GRCm39)	splice site	probably benign
R0646:Col11a2	UTSW	17	34,278,322 (GRCm39)	critical splice donor site	probably null
R0676:Col11a2	UTSW	17	34,276,249 (GRCm39)	missense	probably damaging	0.99
R0919:Col11a2	UTSW	17	34,278,124 (GRCm39)	missense	possibly damaging	0.93
R1522:Col11a2	UTSW	17	34,274,228 (GRCm39)	missense	probably damaging	1.00
R1767:Col11a2	UTSW	17	34,282,869 (GRCm39)	unclassified	probably benign
R1872:Col11a2	UTSW	17	34,281,529 (GRCm39)	unclassified	probably benign
R1941:Col11a2	UTSW	17	34,263,925 (GRCm39)	missense	probably benign	0.01
R1945:Col11a2	UTSW	17	34,278,142 (GRCm39)	missense	probably damaging	1.00
R2101:Col11a2	UTSW	17	34,271,143 (GRCm39)	missense	probably damaging	1.00
R2161:Col11a2	UTSW	17	34,283,771 (GRCm39)	unclassified	probably benign
R2258:Col11a2	UTSW	17	34,258,651 (GRCm39)	missense	probably benign
R2259:Col11a2	UTSW	17	34,258,651 (GRCm39)	missense	probably benign
R2260:Col11a2	UTSW	17	34,258,651 (GRCm39)	missense	probably benign
R2761:Col11a2	UTSW	17	34,270,000 (GRCm39)	missense	probably damaging	1.00
R3114:Col11a2	UTSW	17	34,265,442 (GRCm39)	missense	possibly damaging	0.69
R3824:Col11a2	UTSW	17	34,273,154 (GRCm39)	missense	probably damaging	1.00
R3938:Col11a2	UTSW	17	34,258,599 (GRCm39)	unclassified	probably benign
R4039:Col11a2	UTSW	17	34,264,748 (GRCm39)	missense	probably benign	0.00
R4675:Col11a2	UTSW	17	34,283,267 (GRCm39)	critical splice donor site	probably null
R4810:Col11a2	UTSW	17	34,276,086 (GRCm39)	missense	probably damaging	0.99
R4824:Col11a2	UTSW	17	34,269,937 (GRCm39)	missense	probably damaging	1.00
R4944:Col11a2	UTSW	17	34,261,164 (GRCm39)	missense	possibly damaging	0.47
R5112:Col11a2	UTSW	17	34,283,062 (GRCm39)	unclassified	probably benign
R5355:Col11a2	UTSW	17	34,270,775 (GRCm39)	missense	probably benign	0.07
R5384:Col11a2	UTSW	17	34,278,148 (GRCm39)	critical splice donor site	probably null
R5534:Col11a2	UTSW	17	34,269,998 (GRCm39)	missense	probably damaging	0.99
R5860:Col11a2	UTSW	17	34,283,159 (GRCm39)	unclassified	probably benign
R6252:Col11a2	UTSW	17	34,261,186 (GRCm39)	missense	probably null	0.00
R6327:Col11a2	UTSW	17	34,262,291 (GRCm39)	missense	probably benign	0.32
R6828:Col11a2	UTSW	17	34,272,607 (GRCm39)	splice site	probably null
R6860:Col11a2	UTSW	17	34,272,572 (GRCm39)	missense	probably damaging	1.00
R6873:Col11a2	UTSW	17	34,283,993 (GRCm39)	missense	unknown
R6992:Col11a2	UTSW	17	34,266,118 (GRCm39)	missense	probably benign	0.01
R7292:Col11a2	UTSW	17	34,270,482 (GRCm39)	missense	unknown
R7543:Col11a2	UTSW	17	34,269,430 (GRCm39)	missense	unknown
R7933:Col11a2	UTSW	17	34,275,029 (GRCm39)	nonsense	probably null
R8157:Col11a2	UTSW	17	34,280,230 (GRCm39)	missense	unknown
R8161:Col11a2	UTSW	17	34,270,264 (GRCm39)	missense	unknown
R8209:Col11a2	UTSW	17	34,266,253 (GRCm39)	critical splice donor site	probably null
R8493:Col11a2	UTSW	17	34,278,936 (GRCm39)	missense	possibly damaging	0.82
R8705:Col11a2	UTSW	17	34,268,769 (GRCm39)	missense	unknown
R8901:Col11a2	UTSW	17	34,262,254 (GRCm39)	missense	probably damaging	1.00
R8946:Col11a2	UTSW	17	34,270,757 (GRCm39)	missense	probably benign	0.40
R9010:Col11a2	UTSW	17	34,283,760 (GRCm39)	missense	unknown
R9108:Col11a2	UTSW	17	34,276,634 (GRCm39)	missense	probably benign	0.21
R9138:Col11a2	UTSW	17	34,279,847 (GRCm39)	missense
R9147:Col11a2	UTSW	17	34,273,119 (GRCm39)	splice site	probably benign
R9148:Col11a2	UTSW	17	34,273,119 (GRCm39)	splice site	probably benign
R9338:Col11a2	UTSW	17	34,266,204 (GRCm39)	missense	unknown
R9485:Col11a2	UTSW	17	34,258,669 (GRCm39)	missense	unknown
X0017:Col11a2	UTSW	17	34,278,959 (GRCm39)	critical splice donor site	probably null
X0064:Col11a2	UTSW	17	34,261,221 (GRCm39)	missense	possibly damaging	0.88
Z1176:Col11a2	UTSW	17	34,275,376 (GRCm39)	missense	unknown
Z1177:Col11a2	UTSW	17	34,270,640 (GRCm39)	missense	probably benign	0.40

Predicted Primers

PCR Primer
(F):5'- TCTAGAAGCCTCTGAGTGCTGTGC -3'
(R):5'- AGAAACACTGGGCTGAACATCAGAC -3'

Sequencing Primer
(F):5'- GGGAACTTGAATTTTCCATTGCC -3'
(R):5'- AGATTCTCCCTTCAAGCCAGG -3'

Posted On

2013-06-12