Incidental Mutation 'R0538:Mga'
| ID |
49545 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mga
|
| Ensembl Gene |
ENSMUSG00000033943 |
| Gene Name |
MAX gene associated |
| Synonyms |
Mga, C130042M01Rik, Mad5, D030062C11Rik |
| MMRRC Submission |
038730-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.953)
|
| Stock # |
R0538 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
119727709-119800062 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
T to C
at 119750187 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000119044
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000046717]
[ENSMUST00000046717]
[ENSMUST00000079934]
[ENSMUST00000079934]
[ENSMUST00000110773]
[ENSMUST00000110773]
[ENSMUST00000110774]
[ENSMUST00000110774]
[ENSMUST00000156510]
[ENSMUST00000156510]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000046717
|
| SMART Domains |
Protein: ENSMUSP00000043795
Gene: ENSMUSG00000033943
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TBOX
|
6 |
73 |
6e-27 |
BLAST |
|
TBOX
|
74 |
265 |
2.34e-100 |
SMART |
|
low complexity region
|
969 |
978 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1031 |
N/A |
INTRINSIC |
|
low complexity region
|
1112 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1248 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1301 |
1315 |
N/A |
INTRINSIC |
|
low complexity region
|
1564 |
1581 |
N/A |
INTRINSIC |
|
low complexity region
|
1634 |
1649 |
N/A |
INTRINSIC |
|
low complexity region
|
1681 |
1716 |
N/A |
INTRINSIC |
|
low complexity region
|
1796 |
1818 |
N/A |
INTRINSIC |
|
low complexity region
|
1833 |
1850 |
N/A |
INTRINSIC |
|
low complexity region
|
1977 |
1992 |
N/A |
INTRINSIC |
|
low complexity region
|
2183 |
2197 |
N/A |
INTRINSIC |
|
low complexity region
|
2241 |
2259 |
N/A |
INTRINSIC |
|
HLH
|
2368 |
2419 |
8.27e-7 |
SMART |
|
low complexity region
|
2748 |
2769 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000046717
|
| SMART Domains |
Protein: ENSMUSP00000043795
Gene: ENSMUSG00000033943
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TBOX
|
6 |
73 |
6e-27 |
BLAST |
|
TBOX
|
74 |
265 |
2.34e-100 |
SMART |
|
low complexity region
|
969 |
978 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1031 |
N/A |
INTRINSIC |
|
low complexity region
|
1112 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1248 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1301 |
1315 |
N/A |
INTRINSIC |
|
low complexity region
|
1564 |
1581 |
N/A |
INTRINSIC |
|
low complexity region
|
1634 |
1649 |
N/A |
INTRINSIC |
|
low complexity region
|
1681 |
1716 |
N/A |
INTRINSIC |
|
low complexity region
|
1796 |
1818 |
N/A |
INTRINSIC |
|
low complexity region
|
1833 |
1850 |
N/A |
INTRINSIC |
|
low complexity region
|
1977 |
1992 |
N/A |
INTRINSIC |
|
low complexity region
|
2183 |
2197 |
N/A |
INTRINSIC |
|
low complexity region
|
2241 |
2259 |
N/A |
INTRINSIC |
|
HLH
|
2368 |
2419 |
8.27e-7 |
SMART |
|
low complexity region
|
2748 |
2769 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000079934
|
| SMART Domains |
Protein: ENSMUSP00000078853
Gene: ENSMUSG00000033943
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TBOX
|
6 |
73 |
5e-27 |
BLAST |
|
TBOX
|
74 |
265 |
2.34e-100 |
SMART |
|
low complexity region
|
969 |
978 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1031 |
N/A |
INTRINSIC |
|
low complexity region
|
1112 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1247 |
1268 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1314 |
N/A |
INTRINSIC |
|
low complexity region
|
1626 |
1648 |
N/A |
INTRINSIC |
|
low complexity region
|
1663 |
1680 |
N/A |
INTRINSIC |
|
low complexity region
|
1807 |
1822 |
N/A |
INTRINSIC |
|
low complexity region
|
2013 |
2027 |
N/A |
INTRINSIC |
|
low complexity region
|
2071 |
2089 |
N/A |
INTRINSIC |
|
HLH
|
2198 |
2249 |
8.27e-7 |
SMART |
|
low complexity region
|
2578 |
2599 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000079934
|
| SMART Domains |
Protein: ENSMUSP00000078853
Gene: ENSMUSG00000033943
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TBOX
|
6 |
73 |
5e-27 |
BLAST |
|
TBOX
|
74 |
265 |
2.34e-100 |
SMART |
|
low complexity region
|
969 |
978 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1031 |
N/A |
INTRINSIC |
|
low complexity region
|
1112 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1247 |
1268 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1314 |
N/A |
INTRINSIC |
|
low complexity region
|
1626 |
1648 |
N/A |
INTRINSIC |
|
low complexity region
|
1663 |
1680 |
N/A |
INTRINSIC |
|
low complexity region
|
1807 |
1822 |
N/A |
INTRINSIC |
|
low complexity region
|
2013 |
2027 |
N/A |
INTRINSIC |
|
low complexity region
|
2071 |
2089 |
N/A |
INTRINSIC |
|
HLH
|
2198 |
2249 |
8.27e-7 |
SMART |
|
low complexity region
|
2578 |
2599 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000110773
|
| SMART Domains |
Protein: ENSMUSP00000106400
Gene: ENSMUSG00000033943
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TBOX
|
6 |
73 |
5e-27 |
BLAST |
|
TBOX
|
74 |
265 |
2.34e-100 |
SMART |
|
low complexity region
|
890 |
899 |
N/A |
INTRINSIC |
|
low complexity region
|
938 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1059 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1190 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1485 |
1502 |
N/A |
INTRINSIC |
|
low complexity region
|
1555 |
1570 |
N/A |
INTRINSIC |
|
low complexity region
|
1602 |
1637 |
N/A |
INTRINSIC |
|
low complexity region
|
1717 |
1739 |
N/A |
INTRINSIC |
|
low complexity region
|
1754 |
1771 |
N/A |
INTRINSIC |
|
low complexity region
|
1898 |
1913 |
N/A |
INTRINSIC |
|
low complexity region
|
2104 |
2118 |
N/A |
INTRINSIC |
|
low complexity region
|
2162 |
2180 |
N/A |
INTRINSIC |
|
HLH
|
2289 |
2340 |
8.27e-7 |
SMART |
|
low complexity region
|
2669 |
2690 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000110773
|
| SMART Domains |
Protein: ENSMUSP00000106400
Gene: ENSMUSG00000033943
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TBOX
|
6 |
73 |
5e-27 |
BLAST |
|
TBOX
|
74 |
265 |
2.34e-100 |
SMART |
|
low complexity region
|
890 |
899 |
N/A |
INTRINSIC |
|
low complexity region
|
938 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1059 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1190 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1485 |
1502 |
N/A |
INTRINSIC |
|
low complexity region
|
1555 |
1570 |
N/A |
INTRINSIC |
|
low complexity region
|
1602 |
1637 |
N/A |
INTRINSIC |
|
low complexity region
|
1717 |
1739 |
N/A |
INTRINSIC |
|
low complexity region
|
1754 |
1771 |
N/A |
INTRINSIC |
|
low complexity region
|
1898 |
1913 |
N/A |
INTRINSIC |
|
low complexity region
|
2104 |
2118 |
N/A |
INTRINSIC |
|
low complexity region
|
2162 |
2180 |
N/A |
INTRINSIC |
|
HLH
|
2289 |
2340 |
8.27e-7 |
SMART |
|
low complexity region
|
2669 |
2690 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000110774
|
| SMART Domains |
Protein: ENSMUSP00000106401
Gene: ENSMUSG00000033943
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TBOX
|
6 |
73 |
7e-27 |
BLAST |
|
TBOX
|
74 |
265 |
2.34e-100 |
SMART |
|
low complexity region
|
969 |
978 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1031 |
N/A |
INTRINSIC |
|
Pfam:DUF4801
|
1037 |
1085 |
1e-19 |
PFAM |
|
low complexity region
|
1112 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1248 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1301 |
1315 |
N/A |
INTRINSIC |
|
low complexity region
|
1564 |
1581 |
N/A |
INTRINSIC |
|
low complexity region
|
1634 |
1649 |
N/A |
INTRINSIC |
|
low complexity region
|
1681 |
1716 |
N/A |
INTRINSIC |
|
low complexity region
|
1835 |
1857 |
N/A |
INTRINSIC |
|
low complexity region
|
1872 |
1889 |
N/A |
INTRINSIC |
|
low complexity region
|
2016 |
2031 |
N/A |
INTRINSIC |
|
low complexity region
|
2222 |
2236 |
N/A |
INTRINSIC |
|
low complexity region
|
2280 |
2298 |
N/A |
INTRINSIC |
|
HLH
|
2407 |
2458 |
8.27e-7 |
SMART |
|
low complexity region
|
2787 |
2808 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000110774
|
| SMART Domains |
Protein: ENSMUSP00000106401
Gene: ENSMUSG00000033943
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TBOX
|
6 |
73 |
7e-27 |
BLAST |
|
TBOX
|
74 |
265 |
2.34e-100 |
SMART |
|
low complexity region
|
969 |
978 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1031 |
N/A |
INTRINSIC |
|
Pfam:DUF4801
|
1037 |
1085 |
1e-19 |
PFAM |
|
low complexity region
|
1112 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1248 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1301 |
1315 |
N/A |
INTRINSIC |
|
low complexity region
|
1564 |
1581 |
N/A |
INTRINSIC |
|
low complexity region
|
1634 |
1649 |
N/A |
INTRINSIC |
|
low complexity region
|
1681 |
1716 |
N/A |
INTRINSIC |
|
low complexity region
|
1835 |
1857 |
N/A |
INTRINSIC |
|
low complexity region
|
1872 |
1889 |
N/A |
INTRINSIC |
|
low complexity region
|
2016 |
2031 |
N/A |
INTRINSIC |
|
low complexity region
|
2222 |
2236 |
N/A |
INTRINSIC |
|
low complexity region
|
2280 |
2298 |
N/A |
INTRINSIC |
|
HLH
|
2407 |
2458 |
8.27e-7 |
SMART |
|
low complexity region
|
2787 |
2808 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129405
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141776
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150742
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000156510
|
| SMART Domains |
Protein: ENSMUSP00000119044
Gene: ENSMUSG00000033943
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TBOX
|
6 |
73 |
4e-27 |
BLAST |
|
TBOX
|
74 |
265 |
2.34e-100 |
SMART |
|
low complexity region
|
969 |
978 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1031 |
N/A |
INTRINSIC |
|
low complexity region
|
1112 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1247 |
1268 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1314 |
N/A |
INTRINSIC |
|
low complexity region
|
1626 |
1648 |
N/A |
INTRINSIC |
|
low complexity region
|
1663 |
1680 |
N/A |
INTRINSIC |
|
low complexity region
|
1807 |
1822 |
N/A |
INTRINSIC |
|
low complexity region
|
2013 |
2027 |
N/A |
INTRINSIC |
|
low complexity region
|
2071 |
2089 |
N/A |
INTRINSIC |
|
HLH
|
2198 |
2249 |
8.27e-7 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000156510
|
| SMART Domains |
Protein: ENSMUSP00000119044
Gene: ENSMUSG00000033943
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TBOX
|
6 |
73 |
4e-27 |
BLAST |
|
TBOX
|
74 |
265 |
2.34e-100 |
SMART |
|
low complexity region
|
969 |
978 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1031 |
N/A |
INTRINSIC |
|
low complexity region
|
1112 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1247 |
1268 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1314 |
N/A |
INTRINSIC |
|
low complexity region
|
1626 |
1648 |
N/A |
INTRINSIC |
|
low complexity region
|
1663 |
1680 |
N/A |
INTRINSIC |
|
low complexity region
|
1807 |
1822 |
N/A |
INTRINSIC |
|
low complexity region
|
2013 |
2027 |
N/A |
INTRINSIC |
|
low complexity region
|
2071 |
2089 |
N/A |
INTRINSIC |
|
HLH
|
2198 |
2249 |
8.27e-7 |
SMART |
|
| Meta Mutation Damage Score |
0.9501 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.7%
|
| Validation Efficiency |
98% (126/129) |
| MGI Phenotype |
PHENOTYPE: Embryos homozygous for a gene trap allele die shortly after implantation due to defective development of the inner cell mass (ICM) and the epiblast. ICM derivatives fail to develop past E4.5 and show increased apoptosis but no change in cell proliferation. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(135) : Gene trapped(135)
|
| Other mutations in this stock |
Total: 129 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930578I07Rik |
A |
T |
14: 67,175,823 (GRCm39) |
H6L |
unknown |
Het |
| Abca13 |
G |
A |
11: 9,217,622 (GRCm39) |
|
probably null |
Het |
| Acad12 |
C |
T |
5: 121,745,511 (GRCm39) |
R260Q |
possibly damaging |
Het |
| Actn1 |
G |
A |
12: 80,306,874 (GRCm39) |
|
probably benign |
Het |
| Acvrl1 |
A |
G |
15: 101,034,030 (GRCm39) |
T182A |
probably damaging |
Het |
| Adam23 |
T |
C |
1: 63,607,003 (GRCm39) |
|
probably benign |
Het |
| Adamtsl1 |
A |
T |
4: 86,261,358 (GRCm39) |
T1190S |
probably benign |
Het |
| Adh6b |
A |
T |
3: 138,063,411 (GRCm39) |
Y330F |
probably benign |
Het |
| Ak7 |
A |
G |
12: 105,732,876 (GRCm39) |
E540G |
probably damaging |
Het |
| Akr1c19 |
T |
A |
13: 4,287,099 (GRCm39) |
L106Q |
probably damaging |
Het |
| Ankrd12 |
A |
T |
17: 66,356,847 (GRCm39) |
S57T |
probably damaging |
Het |
| Aoc3 |
G |
A |
11: 101,222,964 (GRCm39) |
R400Q |
possibly damaging |
Het |
| Arel1 |
A |
T |
12: 84,988,611 (GRCm39) |
I46N |
probably damaging |
Het |
| Armc5 |
A |
G |
7: 127,843,463 (GRCm39) |
D752G |
probably damaging |
Het |
| Atp11b |
T |
C |
3: 35,891,163 (GRCm39) |
V812A |
probably damaging |
Het |
| Axin1 |
A |
G |
17: 26,403,215 (GRCm39) |
H131R |
possibly damaging |
Het |
| Bpifb3 |
A |
G |
2: 153,765,789 (GRCm39) |
E184G |
probably benign |
Het |
| Cacna2d2 |
T |
C |
9: 107,401,582 (GRCm39) |
|
probably benign |
Het |
| Catsperd |
T |
C |
17: 56,969,828 (GRCm39) |
F641L |
probably benign |
Het |
| Ccdc83 |
A |
C |
7: 89,877,591 (GRCm39) |
L284V |
probably damaging |
Het |
| Ccn2 |
T |
A |
10: 24,472,364 (GRCm39) |
C136S |
probably damaging |
Het |
| Ccnt2 |
T |
A |
1: 127,730,902 (GRCm39) |
V593E |
probably damaging |
Het |
| Cd53 |
T |
A |
3: 106,669,444 (GRCm39) |
I185F |
probably benign |
Het |
| Cep350 |
A |
T |
1: 155,724,366 (GRCm39) |
D3077E |
possibly damaging |
Het |
| Ces1h |
C |
A |
8: 94,083,628 (GRCm39) |
|
probably null |
Het |
| Chrna3 |
T |
A |
9: 54,923,290 (GRCm39) |
T173S |
probably benign |
Het |
| Clca4b |
T |
C |
3: 144,627,717 (GRCm39) |
D418G |
probably benign |
Het |
| Col11a2 |
T |
C |
17: 34,270,302 (GRCm39) |
|
probably benign |
Het |
| Coq2 |
T |
A |
5: 100,815,889 (GRCm39) |
I97F |
possibly damaging |
Het |
| Cr2 |
A |
G |
1: 194,842,667 (GRCm39) |
|
probably benign |
Het |
| D2hgdh |
A |
G |
1: 93,754,099 (GRCm39) |
Y24C |
probably damaging |
Het |
| D630045J12Rik |
G |
A |
6: 38,168,628 (GRCm39) |
R974C |
probably damaging |
Het |
| Dach1 |
A |
G |
14: 98,140,715 (GRCm39) |
V429A |
possibly damaging |
Het |
| Ddr1 |
G |
A |
17: 35,995,899 (GRCm39) |
T660I |
probably damaging |
Het |
| Dlg1 |
A |
C |
16: 31,615,682 (GRCm39) |
|
probably null |
Het |
| Dmbt1 |
T |
C |
7: 130,651,631 (GRCm39) |
|
probably benign |
Het |
| Dmxl2 |
A |
T |
9: 54,301,120 (GRCm39) |
D2330E |
probably benign |
Het |
| Dnai4 |
T |
C |
4: 102,953,815 (GRCm39) |
N128S |
possibly damaging |
Het |
| Doc2a |
A |
G |
7: 126,447,983 (GRCm39) |
T5A |
probably benign |
Het |
| Dock2 |
G |
A |
11: 34,595,545 (GRCm39) |
|
probably benign |
Het |
| Dok4 |
T |
A |
8: 95,591,866 (GRCm39) |
Y290F |
probably damaging |
Het |
| Dop1a |
A |
G |
9: 86,367,550 (GRCm39) |
D11G |
probably damaging |
Het |
| E230025N22Rik |
T |
C |
18: 36,821,987 (GRCm39) |
H235R |
probably benign |
Het |
| Ear6 |
A |
G |
14: 52,091,909 (GRCm39) |
D152G |
probably damaging |
Het |
| Ecscr |
T |
A |
18: 35,846,689 (GRCm39) |
|
probably benign |
Het |
| Eml6 |
A |
T |
11: 29,710,010 (GRCm39) |
|
probably benign |
Het |
| Epha4 |
T |
A |
1: 77,365,178 (GRCm39) |
Q607L |
probably damaging |
Het |
| Exoc4 |
A |
G |
6: 33,948,998 (GRCm39) |
N947S |
probably benign |
Het |
| Flg |
A |
G |
3: 93,186,767 (GRCm39) |
E73G |
probably damaging |
Het |
| Fndc1 |
C |
T |
17: 8,003,173 (GRCm39) |
|
probably benign |
Het |
| Gad1-ps |
T |
C |
10: 99,280,854 (GRCm39) |
|
noncoding transcript |
Het |
| Gata6 |
A |
G |
18: 11,064,771 (GRCm39) |
T528A |
probably benign |
Het |
| Gjd4 |
T |
C |
18: 9,280,244 (GRCm39) |
E278G |
probably benign |
Het |
| Gm20091 |
T |
A |
10: 96,244,864 (GRCm39) |
|
noncoding transcript |
Het |
| Gnb3 |
G |
A |
6: 124,812,659 (GRCm39) |
Q266* |
probably null |
Het |
| Grm3 |
A |
G |
5: 9,562,446 (GRCm39) |
V468A |
possibly damaging |
Het |
| Igf1r |
C |
T |
7: 67,857,574 (GRCm39) |
R1085C |
probably damaging |
Het |
| Igsf10 |
T |
C |
3: 59,227,527 (GRCm39) |
T2049A |
probably damaging |
Het |
| Jak3 |
A |
T |
8: 72,138,126 (GRCm39) |
D859V |
probably benign |
Het |
| Kcnb2 |
G |
T |
1: 15,783,108 (GRCm39) |
|
probably benign |
Het |
| Kcnh3 |
G |
A |
15: 99,138,839 (GRCm39) |
G858D |
probably benign |
Het |
| Kif1a |
C |
A |
1: 92,971,360 (GRCm39) |
R1006L |
probably damaging |
Het |
| Klhl23 |
C |
T |
2: 69,654,757 (GRCm39) |
A209V |
probably benign |
Het |
| Mapk13 |
T |
C |
17: 28,994,229 (GRCm39) |
Y104H |
probably damaging |
Het |
| Mbd4 |
A |
G |
6: 115,826,443 (GRCm39) |
S183P |
probably damaging |
Het |
| Mipol1 |
G |
A |
12: 57,461,197 (GRCm39) |
|
probably null |
Het |
| Mmp14 |
A |
G |
14: 54,676,166 (GRCm39) |
T299A |
possibly damaging |
Het |
| Mmrn1 |
A |
G |
6: 60,953,453 (GRCm39) |
E578G |
probably benign |
Het |
| Mov10l1 |
G |
A |
15: 88,879,063 (GRCm39) |
C193Y |
possibly damaging |
Het |
| Mppe1 |
A |
G |
18: 67,370,548 (GRCm39) |
C50R |
probably damaging |
Het |
| Msantd1 |
C |
A |
5: 35,075,069 (GRCm39) |
R44S |
probably damaging |
Het |
| Myt1l |
T |
C |
12: 29,892,570 (GRCm39) |
V69A |
possibly damaging |
Het |
| Nav1 |
A |
T |
1: 135,392,430 (GRCm39) |
|
probably benign |
Het |
| Ncan |
A |
G |
8: 70,561,252 (GRCm39) |
S572P |
possibly damaging |
Het |
| Nck2 |
T |
C |
1: 43,608,304 (GRCm39) |
|
probably benign |
Het |
| Nemf |
A |
T |
12: 69,403,088 (GRCm39) |
D31E |
probably damaging |
Het |
| Nlrp12 |
T |
C |
7: 3,297,892 (GRCm39) |
D93G |
possibly damaging |
Het |
| Nsmaf |
A |
T |
4: 6,419,930 (GRCm39) |
|
probably null |
Het |
| Nup98 |
T |
C |
7: 101,835,892 (GRCm39) |
T184A |
probably damaging |
Het |
| Oog2 |
C |
A |
4: 143,922,654 (GRCm39) |
Y306* |
probably null |
Het |
| Or13a18 |
A |
T |
7: 140,190,297 (GRCm39) |
N73Y |
probably damaging |
Het |
| Or6ae1 |
A |
T |
7: 139,742,144 (GRCm39) |
S240T |
probably damaging |
Het |
| Or6b2b |
A |
T |
1: 92,419,055 (GRCm39) |
C141S |
possibly damaging |
Het |
| Osmr |
A |
G |
15: 6,871,419 (GRCm39) |
|
probably benign |
Het |
| P2rx6 |
A |
G |
16: 17,386,162 (GRCm39) |
N275S |
probably benign |
Het |
| Pbxip1 |
G |
T |
3: 89,354,926 (GRCm39) |
G482W |
possibly damaging |
Het |
| Pcsk4 |
T |
G |
10: 80,161,168 (GRCm39) |
I249L |
probably damaging |
Het |
| Pou4f2 |
C |
T |
8: 79,162,291 (GRCm39) |
G104E |
probably damaging |
Het |
| Pramel28 |
T |
A |
4: 143,691,653 (GRCm39) |
T357S |
possibly damaging |
Het |
| Prkdc |
G |
T |
16: 15,651,652 (GRCm39) |
R3763L |
probably damaging |
Het |
| Ptpre |
A |
T |
7: 135,265,044 (GRCm39) |
I207F |
probably damaging |
Het |
| Rapgef3 |
A |
T |
15: 97,655,698 (GRCm39) |
|
probably benign |
Het |
| Rasgrp1 |
T |
G |
2: 117,115,428 (GRCm39) |
K685T |
probably benign |
Het |
| Rnf148 |
C |
T |
6: 23,654,237 (GRCm39) |
R253Q |
probably damaging |
Het |
| Rock1 |
T |
C |
18: 10,132,227 (GRCm39) |
I241V |
possibly damaging |
Het |
| Rp1l1 |
T |
G |
14: 64,259,541 (GRCm39) |
V61G |
probably damaging |
Het |
| Scin |
A |
C |
12: 40,131,770 (GRCm39) |
S255A |
probably damaging |
Het |
| Scn8a |
A |
T |
15: 100,933,505 (GRCm39) |
K1570* |
probably null |
Het |
| Sec14l4 |
A |
C |
11: 3,990,018 (GRCm39) |
M106L |
probably benign |
Het |
| Sec63 |
G |
A |
10: 42,674,795 (GRCm39) |
R226H |
probably benign |
Het |
| Septin2 |
T |
A |
1: 93,429,345 (GRCm39) |
N271K |
probably damaging |
Het |
| Serac1 |
G |
T |
17: 6,099,101 (GRCm39) |
|
probably benign |
Het |
| Shc2 |
T |
A |
10: 79,465,974 (GRCm39) |
|
probably benign |
Het |
| Sipa1l1 |
T |
A |
12: 82,471,873 (GRCm39) |
D1284E |
probably benign |
Het |
| Slc11a2 |
A |
G |
15: 100,306,097 (GRCm39) |
L105P |
probably damaging |
Het |
| Slc1a3 |
T |
A |
15: 8,680,406 (GRCm39) |
T151S |
probably benign |
Het |
| Smarca2 |
G |
T |
19: 26,668,762 (GRCm39) |
K920N |
probably damaging |
Het |
| Sugp2 |
G |
A |
8: 70,711,598 (GRCm39) |
E964K |
probably damaging |
Het |
| Tas2r122 |
A |
C |
6: 132,688,778 (GRCm39) |
N38K |
probably benign |
Het |
| Tecpr1 |
G |
A |
5: 144,143,092 (GRCm39) |
R730C |
probably damaging |
Het |
| Tent2 |
A |
T |
13: 93,312,123 (GRCm39) |
|
probably benign |
Het |
| Themis3 |
G |
T |
17: 66,900,265 (GRCm39) |
N34K |
possibly damaging |
Het |
| Traf3ip1 |
A |
G |
1: 91,427,341 (GRCm39) |
T104A |
unknown |
Het |
| Trappc11 |
A |
G |
8: 47,956,447 (GRCm39) |
V843A |
probably benign |
Het |
| Trmt61a |
T |
A |
12: 111,645,361 (GRCm39) |
L99Q |
probably damaging |
Het |
| Trp53tg5 |
T |
A |
2: 164,313,401 (GRCm39) |
K91N |
probably damaging |
Het |
| Ufsp2 |
T |
C |
8: 46,445,187 (GRCm39) |
S339P |
probably damaging |
Het |
| Usp20 |
T |
A |
2: 30,894,462 (GRCm39) |
V126E |
probably damaging |
Het |
| Vmn1r75 |
T |
A |
7: 11,614,797 (GRCm39) |
N176K |
probably damaging |
Het |
| Vmn2r24 |
A |
G |
6: 123,793,012 (GRCm39) |
S780G |
probably benign |
Het |
| Vmn2r89 |
A |
G |
14: 51,695,048 (GRCm39) |
|
probably null |
Het |
| Vps13d |
A |
T |
4: 144,771,665 (GRCm39) |
S4038T |
probably damaging |
Het |
| Vwa7 |
A |
G |
17: 35,241,627 (GRCm39) |
T421A |
probably damaging |
Het |
| Wdr95 |
C |
A |
5: 149,504,271 (GRCm39) |
L332I |
probably damaging |
Het |
| Wrn |
T |
A |
8: 33,826,119 (GRCm39) |
K181I |
probably damaging |
Het |
| Zc3h6 |
T |
A |
2: 128,859,143 (GRCm39) |
I1058N |
possibly damaging |
Het |
| Zfp423 |
T |
A |
8: 88,508,713 (GRCm39) |
I544F |
probably damaging |
Het |
| Zfp446 |
T |
A |
7: 12,713,516 (GRCm39) |
S161T |
possibly damaging |
Het |
| Zmym6 |
T |
A |
4: 127,017,162 (GRCm39) |
M889K |
probably benign |
Het |
|
| Other mutations in Mga |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00551:Mga
|
APN |
2 |
119,750,295 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL00719:Mga
|
APN |
2 |
119,777,934 (GRCm39) |
nonsense |
probably null |
|
|
IGL01619:Mga
|
APN |
2 |
119,762,309 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL01721:Mga
|
APN |
2 |
119,765,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01759:Mga
|
APN |
2 |
119,781,676 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL01785:Mga
|
APN |
2 |
119,733,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01786:Mga
|
APN |
2 |
119,733,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01950:Mga
|
APN |
2 |
119,772,135 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
IGL01960:Mga
|
APN |
2 |
119,769,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02086:Mga
|
APN |
2 |
119,754,517 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02364:Mga
|
APN |
2 |
119,794,535 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL02602:Mga
|
APN |
2 |
119,762,365 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL02751:Mga
|
APN |
2 |
119,778,251 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02794:Mga
|
APN |
2 |
119,776,770 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL03247:Mga
|
APN |
2 |
119,765,994 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03303:Mga
|
APN |
2 |
119,733,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4515001:Mga
|
UTSW |
2 |
119,746,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0060:Mga
|
UTSW |
2 |
119,791,442 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0060:Mga
|
UTSW |
2 |
119,791,442 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0417:Mga
|
UTSW |
2 |
119,733,271 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0449:Mga
|
UTSW |
2 |
119,771,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0457:Mga
|
UTSW |
2 |
119,746,969 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0568:Mga
|
UTSW |
2 |
119,765,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Mga
|
UTSW |
2 |
119,794,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0671:Mga
|
UTSW |
2 |
119,750,391 (GRCm39) |
splice site |
probably null |
|
|
R0811:Mga
|
UTSW |
2 |
119,778,442 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0812:Mga
|
UTSW |
2 |
119,778,442 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0948:Mga
|
UTSW |
2 |
119,772,140 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1177:Mga
|
UTSW |
2 |
119,756,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1445:Mga
|
UTSW |
2 |
119,733,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1476:Mga
|
UTSW |
2 |
119,772,156 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1527:Mga
|
UTSW |
2 |
119,747,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1583:Mga
|
UTSW |
2 |
119,794,441 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1592:Mga
|
UTSW |
2 |
119,795,147 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1627:Mga
|
UTSW |
2 |
119,795,043 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1658:Mga
|
UTSW |
2 |
119,772,170 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1677:Mga
|
UTSW |
2 |
119,791,333 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1887:Mga
|
UTSW |
2 |
119,754,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Mga
|
UTSW |
2 |
119,757,075 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1909:Mga
|
UTSW |
2 |
119,757,075 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2061:Mga
|
UTSW |
2 |
119,795,461 (GRCm39) |
unclassified |
probably benign |
|
|
R2145:Mga
|
UTSW |
2 |
119,794,638 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R2159:Mga
|
UTSW |
2 |
119,750,124 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2179:Mga
|
UTSW |
2 |
119,790,923 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2281:Mga
|
UTSW |
2 |
119,734,204 (GRCm39) |
missense |
probably benign |
|
|
R2423:Mga
|
UTSW |
2 |
119,795,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3620:Mga
|
UTSW |
2 |
119,747,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3622:Mga
|
UTSW |
2 |
119,772,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Mga
|
UTSW |
2 |
119,772,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3802:Mga
|
UTSW |
2 |
119,777,820 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4011:Mga
|
UTSW |
2 |
119,762,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4065:Mga
|
UTSW |
2 |
119,777,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4520:Mga
|
UTSW |
2 |
119,778,579 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4649:Mga
|
UTSW |
2 |
119,771,974 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4660:Mga
|
UTSW |
2 |
119,769,104 (GRCm39) |
intron |
probably benign |
|
|
R4757:Mga
|
UTSW |
2 |
119,734,120 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4771:Mga
|
UTSW |
2 |
119,794,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4784:Mga
|
UTSW |
2 |
119,733,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4866:Mga
|
UTSW |
2 |
119,794,535 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4900:Mga
|
UTSW |
2 |
119,794,535 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4952:Mga
|
UTSW |
2 |
119,733,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4995:Mga
|
UTSW |
2 |
119,763,063 (GRCm39) |
nonsense |
probably null |
|
|
R5020:Mga
|
UTSW |
2 |
119,781,654 (GRCm39) |
nonsense |
probably null |
|
|
R5082:Mga
|
UTSW |
2 |
119,733,825 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5208:Mga
|
UTSW |
2 |
119,778,462 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5454:Mga
|
UTSW |
2 |
119,733,810 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5466:Mga
|
UTSW |
2 |
119,733,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Mga
|
UTSW |
2 |
119,747,107 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5669:Mga
|
UTSW |
2 |
119,733,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5819:Mga
|
UTSW |
2 |
119,771,744 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5916:Mga
|
UTSW |
2 |
119,794,793 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5942:Mga
|
UTSW |
2 |
119,777,440 (GRCm39) |
missense |
probably benign |
0.41 |
|
R6305:Mga
|
UTSW |
2 |
119,778,179 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6434:Mga
|
UTSW |
2 |
119,754,419 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6467:Mga
|
UTSW |
2 |
119,776,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6488:Mga
|
UTSW |
2 |
119,791,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6630:Mga
|
UTSW |
2 |
119,754,140 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6790:Mga
|
UTSW |
2 |
119,754,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7029:Mga
|
UTSW |
2 |
119,754,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7039:Mga
|
UTSW |
2 |
119,763,159 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7088:Mga
|
UTSW |
2 |
119,792,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Mga
|
UTSW |
2 |
119,747,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7273:Mga
|
UTSW |
2 |
119,765,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7286:Mga
|
UTSW |
2 |
119,795,269 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7346:Mga
|
UTSW |
2 |
119,766,008 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7383:Mga
|
UTSW |
2 |
119,790,821 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7469:Mga
|
UTSW |
2 |
119,733,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7484:Mga
|
UTSW |
2 |
119,776,710 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7537:Mga
|
UTSW |
2 |
119,766,032 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7781:Mga
|
UTSW |
2 |
119,747,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7921:Mga
|
UTSW |
2 |
119,750,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8165:Mga
|
UTSW |
2 |
119,777,719 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8226:Mga
|
UTSW |
2 |
119,790,866 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8305:Mga
|
UTSW |
2 |
119,776,800 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8309:Mga
|
UTSW |
2 |
119,791,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8363:Mga
|
UTSW |
2 |
119,794,407 (GRCm39) |
missense |
probably benign |
0.43 |
|
R8388:Mga
|
UTSW |
2 |
119,794,562 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8524:Mga
|
UTSW |
2 |
119,771,997 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8693:Mga
|
UTSW |
2 |
119,794,407 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8837:Mga
|
UTSW |
2 |
119,769,272 (GRCm39) |
splice site |
probably benign |
|
|
R8916:Mga
|
UTSW |
2 |
119,788,819 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8936:Mga
|
UTSW |
2 |
119,794,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9028:Mga
|
UTSW |
2 |
119,778,070 (GRCm39) |
missense |
probably benign |
|
|
R9145:Mga
|
UTSW |
2 |
119,794,493 (GRCm39) |
missense |
probably benign |
|
|
R9155:Mga
|
UTSW |
2 |
119,757,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9308:Mga
|
UTSW |
2 |
119,754,369 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9342:Mga
|
UTSW |
2 |
119,778,656 (GRCm39) |
missense |
probably benign |
|
|
R9347:Mga
|
UTSW |
2 |
119,733,518 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9390:Mga
|
UTSW |
2 |
119,794,332 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9408:Mga
|
UTSW |
2 |
119,765,999 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9488:Mga
|
UTSW |
2 |
119,795,304 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9495:Mga
|
UTSW |
2 |
119,781,676 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9521:Mga
|
UTSW |
2 |
119,794,979 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9780:Mga
|
UTSW |
2 |
119,747,253 (GRCm39) |
missense |
probably benign |
0.26 |
|
| Predicted Primers |
PCR Primer
(F):5'- cagccACTCGTCATTGTCATCCTT -3'
(R):5'- TCGGCATGAGAGCATTGAACAAGT -3'
Sequencing Primer
(F):5'- TCGTCATTGTCATCCTTTTTTTTTC -3'
(R):5'- gtgggaggcagaggcag -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation