Incidental Mutation 'R6159:Zswim5'
ID 489740
Institutional Source Beutler Lab
Gene Symbol Zswim5
Ensembl Gene ENSMUSG00000033948
Gene Name zinc finger SWIM-type containing 5
Synonyms 4933426E21Rik
MMRRC Submission 044306-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6159 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 116734573-116846461 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 116836876 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 720 (L720P)
Ref Sequence ENSEMBL: ENSMUSP00000049474 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044823]
AlphaFold Q80TC6
Predicted Effect probably damaging
Transcript: ENSMUST00000044823
AA Change: L720P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000049474
Gene: ENSMUSG00000033948
AA Change: L720P

DomainStartEndE-ValueType
low complexity region 35 56 N/A INTRINSIC
low complexity region 119 182 N/A INTRINSIC
low complexity region 692 708 N/A INTRINSIC
low complexity region 982 995 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 98.0%
  • 20x: 94.2%
Validation Efficiency 96% (54/56)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahcyl2 A C 6: 29,908,457 (GRCm39) N609T possibly damaging Het
Ankzf1 G A 1: 75,170,888 (GRCm39) C98Y probably damaging Het
Atg101 T A 15: 101,188,519 (GRCm39) M208K possibly damaging Het
Baiap2l2 A G 15: 79,143,930 (GRCm39) I388T probably benign Het
Cabs1 C T 5: 88,127,613 (GRCm39) T88I possibly damaging Het
Chrnd T A 1: 87,118,812 (GRCm39) D56E probably benign Het
Col28a1 A T 6: 8,162,247 (GRCm39) probably null Het
Col4a1 G T 8: 11,270,007 (GRCm39) P899Q probably damaging Het
Cts3 C A 13: 61,714,655 (GRCm39) A217S probably damaging Het
Dab2 A G 15: 6,465,941 (GRCm39) N495S possibly damaging Het
Dnah2 T A 11: 69,349,368 (GRCm39) I2423F probably damaging Het
Dnah2 C T 11: 69,349,746 (GRCm39) R2399Q probably benign Het
Dock6 T C 9: 21,733,041 (GRCm39) H1053R probably benign Het
Eif1ad14 G A 12: 87,886,521 (GRCm39) A36V probably damaging Het
Fam184a G A 10: 53,574,869 (GRCm39) L191F probably damaging Het
Fbxl9 T C 8: 106,049,925 (GRCm39) Y33C probably damaging Het
Fip1l1 C T 5: 74,752,608 (GRCm39) R472W probably damaging Het
Gbp2 T C 3: 142,338,018 (GRCm39) F378S probably damaging Het
Ggt1 A T 10: 75,420,799 (GRCm39) E388V probably damaging Het
Gm14496 A G 2: 181,638,050 (GRCm39) T375A probably benign Het
Gm43302 A G 5: 105,436,894 (GRCm39) S71P probably benign Het
Gnrhr G T 5: 86,330,216 (GRCm39) T268K probably damaging Het
Htt T C 5: 34,962,020 (GRCm39) V335A probably benign Het
Klhl20 A T 1: 160,933,037 (GRCm39) L257H probably damaging Het
Med27 C A 2: 29,414,376 (GRCm39) probably null Het
Muc5ac T A 7: 141,369,323 (GRCm39) C2433S possibly damaging Het
Nasp A G 4: 116,461,086 (GRCm39) probably null Het
Nipal2 A C 15: 34,600,172 (GRCm39) V215G probably damaging Het
Or10al5 A T 17: 38,063,038 (GRCm39) I98F probably damaging Het
Or9i1b C T 19: 13,897,104 (GRCm39) T240I probably damaging Het
Oxct2b G A 4: 123,011,244 (GRCm39) R388H probably damaging Het
Pbrm1 A G 14: 30,774,240 (GRCm39) I469V possibly damaging Het
Phyhip A G 14: 70,704,294 (GRCm39) H171R possibly damaging Het
Pigs C T 11: 78,219,326 (GRCm39) T9M probably benign Het
Plek T C 11: 16,935,539 (GRCm39) D256G probably damaging Het
Prss50 T C 9: 110,693,371 (GRCm39) V369A probably benign Het
Psmc5 A G 11: 106,152,088 (GRCm39) K82E possibly damaging Het
Qrsl1 A T 10: 43,758,189 (GRCm39) F301L probably benign Het
Rasal1 T C 5: 120,797,673 (GRCm39) L135P probably damaging Het
Rbm47 A G 5: 66,184,159 (GRCm39) V148A probably damaging Het
Scyl1 T A 19: 5,814,785 (GRCm39) D381V probably benign Het
Selplg G T 5: 113,957,162 (GRCm39) D381E probably benign Het
Sh3rf2 C A 18: 42,289,200 (GRCm39) Q674K probably damaging Het
Sned1 A G 1: 93,210,659 (GRCm39) T987A probably benign Het
Sntb1 A G 15: 55,539,698 (GRCm39) probably null Het
Synj2 A T 17: 6,036,327 (GRCm39) I14F probably damaging Het
Taf2 A T 15: 54,926,440 (GRCm39) M170K possibly damaging Het
Tg A G 15: 66,607,096 (GRCm39) E211G possibly damaging Het
Thnsl1 G T 2: 21,217,016 (GRCm39) E257* probably null Het
Tlr4 A G 4: 66,758,070 (GRCm39) R288G possibly damaging Het
Trbc1 T C 6: 41,515,385 (GRCm39) probably benign Het
Trim37 G A 11: 87,107,374 (GRCm39) probably null Het
Txnrd3 T C 6: 89,640,176 (GRCm39) probably null Het
Tyk2 C A 9: 21,021,800 (GRCm39) Q875H probably damaging Het
Vmn2r55 A G 7: 12,385,698 (GRCm39) Y761H probably damaging Het
Other mutations in Zswim5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00753:Zswim5 APN 4 116,842,933 (GRCm39) missense possibly damaging 0.93
IGL01700:Zswim5 APN 4 116,843,658 (GRCm39) unclassified probably benign
IGL01975:Zswim5 APN 4 116,822,889 (GRCm39) missense probably benign 0.03
IGL02334:Zswim5 APN 4 116,843,841 (GRCm39) missense probably damaging 1.00
IGL02505:Zswim5 APN 4 116,819,749 (GRCm39) missense probably benign 0.43
IGL02712:Zswim5 APN 4 116,842,892 (GRCm39) missense probably damaging 0.99
PIT4243001:Zswim5 UTSW 4 116,841,975 (GRCm39) missense probably benign 0.10
R0324:Zswim5 UTSW 4 116,844,103 (GRCm39) missense probably damaging 1.00
R0611:Zswim5 UTSW 4 116,843,874 (GRCm39) splice site probably null
R0730:Zswim5 UTSW 4 116,842,943 (GRCm39) missense possibly damaging 0.75
R1663:Zswim5 UTSW 4 116,844,092 (GRCm39) missense probably damaging 1.00
R1843:Zswim5 UTSW 4 116,734,896 (GRCm39) missense unknown
R2070:Zswim5 UTSW 4 116,837,109 (GRCm39) missense probably benign 0.14
R2176:Zswim5 UTSW 4 116,830,238 (GRCm39) missense probably damaging 0.99
R3715:Zswim5 UTSW 4 116,819,755 (GRCm39) missense probably benign 0.21
R4044:Zswim5 UTSW 4 116,843,899 (GRCm39) missense probably damaging 1.00
R4063:Zswim5 UTSW 4 116,735,177 (GRCm39) missense unknown
R4118:Zswim5 UTSW 4 116,844,016 (GRCm39) missense possibly damaging 0.93
R4612:Zswim5 UTSW 4 116,843,901 (GRCm39) missense probably damaging 1.00
R4782:Zswim5 UTSW 4 116,830,169 (GRCm39) missense probably benign 0.00
R4799:Zswim5 UTSW 4 116,830,169 (GRCm39) missense probably benign 0.00
R4983:Zswim5 UTSW 4 116,842,883 (GRCm39) missense possibly damaging 0.60
R5294:Zswim5 UTSW 4 116,836,774 (GRCm39) missense possibly damaging 0.93
R5836:Zswim5 UTSW 4 116,842,000 (GRCm39) missense probably benign 0.27
R6025:Zswim5 UTSW 4 116,808,106 (GRCm39) missense probably damaging 1.00
R6041:Zswim5 UTSW 4 116,819,818 (GRCm39) missense probably benign 0.01
R6042:Zswim5 UTSW 4 116,819,818 (GRCm39) missense probably benign 0.01
R6043:Zswim5 UTSW 4 116,819,818 (GRCm39) missense probably benign 0.01
R6198:Zswim5 UTSW 4 116,735,204 (GRCm39) missense probably benign 0.13
R6415:Zswim5 UTSW 4 116,838,063 (GRCm39) missense possibly damaging 0.89
R6442:Zswim5 UTSW 4 116,808,202 (GRCm39) missense probably damaging 1.00
R6547:Zswim5 UTSW 4 116,844,100 (GRCm39) missense probably damaging 1.00
R6616:Zswim5 UTSW 4 116,843,938 (GRCm39) missense possibly damaging 0.93
R6745:Zswim5 UTSW 4 116,832,401 (GRCm39) missense probably damaging 1.00
R7144:Zswim5 UTSW 4 116,833,173 (GRCm39) critical splice donor site probably null
R7260:Zswim5 UTSW 4 116,819,843 (GRCm39) missense probably damaging 1.00
R7300:Zswim5 UTSW 4 116,833,102 (GRCm39) missense probably damaging 1.00
R7310:Zswim5 UTSW 4 116,841,885 (GRCm39) missense probably benign 0.01
R7326:Zswim5 UTSW 4 116,838,031 (GRCm39) missense possibly damaging 0.75
R7429:Zswim5 UTSW 4 116,833,054 (GRCm39) missense possibly damaging 0.87
R7430:Zswim5 UTSW 4 116,833,054 (GRCm39) missense possibly damaging 0.87
R7607:Zswim5 UTSW 4 116,843,939 (GRCm39) missense possibly damaging 0.93
R7811:Zswim5 UTSW 4 116,734,673 (GRCm39) missense unknown
R7993:Zswim5 UTSW 4 116,808,291 (GRCm39) missense probably benign 0.10
R8221:Zswim5 UTSW 4 116,735,219 (GRCm39) missense probably benign 0.09
R8341:Zswim5 UTSW 4 116,843,989 (GRCm39) missense probably damaging 1.00
R8433:Zswim5 UTSW 4 116,844,007 (GRCm39) missense possibly damaging 0.90
R8690:Zswim5 UTSW 4 116,842,002 (GRCm39) missense probably damaging 1.00
R8766:Zswim5 UTSW 4 116,816,004 (GRCm39) missense probably damaging 1.00
R8808:Zswim5 UTSW 4 116,822,887 (GRCm39) missense probably benign 0.34
R9175:Zswim5 UTSW 4 116,822,941 (GRCm39) missense probably benign 0.38
R9354:Zswim5 UTSW 4 116,844,232 (GRCm39) missense probably damaging 1.00
R9639:Zswim5 UTSW 4 116,836,714 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCCAAACAGCAATGAGTCG -3'
(R):5'- ACAGATACTTTGCAAAGGTGTGC -3'

Sequencing Primer
(F):5'- AGCAATGAGTCGTACCTGTC -3'
(R):5'- AACACTCTCCCGGTGGATGAC -3'
Posted On 2017-10-10