Incidental Mutation 'R6156:Dis3'
ID 489612
Institutional Source Beutler Lab
Gene Symbol Dis3
Ensembl Gene ENSMUSG00000033166
Gene Name DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Synonyms 2810028N01Rik
MMRRC Submission 044303-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6156 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 99314070-99337217 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 99336215 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 97 (E97G)
Ref Sequence ENSEMBL: ENSMUSP00000154479 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022650] [ENSMUST00000042471] [ENSMUST00000227022] [ENSMUST00000228643]
AlphaFold Q9CSH3
Predicted Effect probably benign
Transcript: ENSMUST00000022650
SMART Domains Protein: ENSMUSP00000022650
Gene: ENSMUSG00000022064

DomainStartEndE-ValueType
low complexity region 14 26 N/A INTRINSIC
coiled coil region 58 165 N/A INTRINSIC
coiled coil region 200 364 N/A INTRINSIC
coiled coil region 396 444 N/A INTRINSIC
coiled coil region 474 553 N/A INTRINSIC
coiled coil region 586 679 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000042471
AA Change: E97G

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000041906
Gene: ENSMUSG00000033166
AA Change: E97G

DomainStartEndE-ValueType
low complexity region 30 47 N/A INTRINSIC
PINc 64 182 2.8e-24 SMART
low complexity region 425 436 N/A INTRINSIC
RNB 467 797 5.56e-141 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227001
Predicted Effect probably benign
Transcript: ENSMUST00000227022
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228246
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228279
Predicted Effect probably benign
Transcript: ENSMUST00000228643
AA Change: E97G

PolyPhen 2 Score 0.100 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228449
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228598
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228354
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.9%
Validation Efficiency 97% (68/70)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy8 T G 15: 64,689,488 (GRCm39) probably null Het
Ank2 T C 3: 126,737,886 (GRCm39) D2579G probably damaging Het
Atp6v1b1 G C 6: 83,735,115 (GRCm39) G423R probably damaging Het
B4galnt3 T C 6: 120,191,801 (GRCm39) N644S probably benign Het
Bhmt1b C A 18: 87,775,231 (GRCm39) Y251* probably null Het
Capsl T G 15: 9,465,920 (GRCm39) M132R probably damaging Het
Cep120 A G 18: 53,836,295 (GRCm39) Y797H probably benign Het
Cimip4 T C 15: 78,263,013 (GRCm39) T214A probably damaging Het
Clec2e T A 6: 129,072,061 (GRCm39) D106V possibly damaging Het
Col6a2 C T 10: 76,440,004 (GRCm39) V634I possibly damaging Het
Dlec1 T C 9: 118,939,281 (GRCm39) probably null Het
Dock2 C A 11: 34,197,789 (GRCm39) V1484F possibly damaging Het
Ephb2 T A 4: 136,388,816 (GRCm39) M593L probably benign Het
Fcgrt T C 7: 44,751,484 (GRCm39) T125A probably benign Het
Gabbr1 T C 17: 37,359,319 (GRCm39) I98T probably benign Het
Gbp10 G A 5: 105,384,015 (GRCm39) probably benign Het
Gfod1 T C 13: 43,354,514 (GRCm39) S154G possibly damaging Het
Ggt5 C T 10: 75,445,160 (GRCm39) T389I probably damaging Het
Got2 A G 8: 96,598,896 (GRCm39) F169L probably benign Het
Gse1 A G 8: 121,215,866 (GRCm39) K5E possibly damaging Het
Hyal5 T C 6: 24,891,437 (GRCm39) I417T possibly damaging Het
Igkv4-91 G T 6: 68,745,607 (GRCm39) T97K probably damaging Het
Il4i1 T C 7: 44,489,608 (GRCm39) Y458H possibly damaging Het
Impg1 A T 9: 80,230,106 (GRCm39) C740S probably damaging Het
Itgb1 C G 8: 129,458,535 (GRCm39) T788R possibly damaging Het
Lman2l A G 1: 36,477,907 (GRCm39) V143A probably damaging Het
Ltbp4 G T 7: 27,029,587 (GRCm39) T136K unknown Het
Macf1 A G 4: 123,366,073 (GRCm39) I1331T probably benign Het
Mmp11 G A 10: 75,762,325 (GRCm39) A336V probably damaging Het
Myh2 A T 11: 67,071,879 (GRCm39) I536F probably damaging Het
Myh4 A G 11: 67,141,618 (GRCm39) M826V probably benign Het
Naca T C 10: 127,875,160 (GRCm39) probably benign Het
Nr4a2 A G 2: 57,002,364 (GRCm39) Y30H probably damaging Het
Or12j4 A G 7: 140,046,758 (GRCm39) T215A probably benign Het
Or1e35 A T 11: 73,797,447 (GRCm39) Y290* probably null Het
Or2n1d T A 17: 38,646,064 (GRCm39) N5K probably damaging Het
Or4a67 T A 2: 88,597,934 (GRCm39) I242L probably benign Het
Or4f14d A T 2: 111,960,445 (GRCm39) L237Q probably damaging Het
Or4k42 A T 2: 111,320,095 (GRCm39) M136K probably damaging Het
Or4z4 A G 19: 12,076,484 (GRCm39) V173A possibly damaging Het
Or8g22 T A 9: 38,958,671 (GRCm39) M15L possibly damaging Het
Paqr3 A C 5: 97,256,128 (GRCm39) L82R probably damaging Het
Pex6 C T 17: 47,031,567 (GRCm39) P456S probably benign Het
Pih1d2 A T 9: 50,532,452 (GRCm39) K186I possibly damaging Het
Plekhh3 A G 11: 101,061,013 (GRCm39) probably benign Het
Ptpn23 C A 9: 110,216,849 (GRCm39) probably benign Het
Rcor3 T A 1: 191,812,142 (GRCm39) probably benign Het
Rgs11 T A 17: 26,429,439 (GRCm39) Y403* probably null Het
Scn10a T C 9: 119,464,649 (GRCm39) N984D probably benign Het
Snx14 C T 9: 88,289,392 (GRCm39) A287T possibly damaging Het
Stx3 T C 19: 11,780,874 (GRCm39) D33G probably damaging Het
Tacc2 A G 7: 130,227,494 (GRCm39) K1393R probably damaging Het
Tas2r129 T C 6: 132,928,455 (GRCm39) S131P probably benign Het
Tbx15 G T 3: 99,220,431 (GRCm39) probably null Het
Thada A G 17: 84,700,795 (GRCm39) V1237A probably damaging Het
Tnc A G 4: 63,888,589 (GRCm39) Y1735H probably damaging Het
Ttc22 A G 4: 106,495,780 (GRCm39) K378R probably benign Het
Tubg2 A G 11: 101,051,635 (GRCm39) K287E possibly damaging Het
Ugt3a1 T C 15: 9,310,762 (GRCm39) I348T possibly damaging Het
Unc79 A G 12: 103,027,717 (GRCm39) N436S probably damaging Het
Unc80 A T 1: 66,651,409 (GRCm39) I1585F probably benign Het
Vmn2r104 T C 17: 20,261,909 (GRCm39) Y407C probably damaging Het
Vmn2r108 T A 17: 20,692,447 (GRCm39) L136F probably benign Het
Vmn2r38 A G 7: 9,097,611 (GRCm39) S161P probably damaging Het
Vmn2r90 T C 17: 17,953,606 (GRCm39) I590T probably benign Het
Washc5 T C 15: 59,217,248 (GRCm39) E323G probably damaging Het
Wdhd1 C T 14: 47,505,653 (GRCm39) G273D probably damaging Het
Xpo6 G T 7: 125,708,016 (GRCm39) Q851K probably damaging Het
Zfp386 T C 12: 116,023,526 (GRCm39) S380P probably damaging Het
Zfp536 A G 7: 37,173,281 (GRCm39) C274R unknown Het
Zfp64 A G 2: 168,768,088 (GRCm39) I508T probably benign Het
Other mutations in Dis3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00492:Dis3 APN 14 99,320,110 (GRCm39) missense probably damaging 1.00
IGL00821:Dis3 APN 14 99,328,922 (GRCm39) missense probably benign 0.00
IGL00975:Dis3 APN 14 99,316,670 (GRCm39) missense probably damaging 1.00
IGL01536:Dis3 APN 14 99,316,859 (GRCm39) missense probably damaging 1.00
IGL01538:Dis3 APN 14 99,335,181 (GRCm39) missense probably benign 0.00
IGL02143:Dis3 APN 14 99,328,754 (GRCm39) splice site probably benign
IGL02270:Dis3 APN 14 99,315,790 (GRCm39) missense probably benign 0.01
IGL02354:Dis3 APN 14 99,317,148 (GRCm39) nonsense probably null
IGL02361:Dis3 APN 14 99,317,148 (GRCm39) nonsense probably null
IGL02650:Dis3 APN 14 99,336,221 (GRCm39) missense probably benign 0.00
IGL03053:Dis3 APN 14 99,336,170 (GRCm39) missense probably benign 0.00
IGL03057:Dis3 APN 14 99,327,426 (GRCm39) missense possibly damaging 0.95
IGL03389:Dis3 APN 14 99,332,783 (GRCm39) splice site probably benign
R0415:Dis3 UTSW 14 99,324,892 (GRCm39) missense probably damaging 1.00
R0504:Dis3 UTSW 14 99,318,826 (GRCm39) splice site probably benign
R1535:Dis3 UTSW 14 99,316,862 (GRCm39) missense probably damaging 1.00
R1756:Dis3 UTSW 14 99,323,539 (GRCm39) missense probably damaging 1.00
R1767:Dis3 UTSW 14 99,321,578 (GRCm39) missense probably damaging 1.00
R1883:Dis3 UTSW 14 99,328,905 (GRCm39) missense probably benign 0.21
R1938:Dis3 UTSW 14 99,335,026 (GRCm39) missense probably benign 0.09
R2056:Dis3 UTSW 14 99,336,251 (GRCm39) missense possibly damaging 0.90
R2133:Dis3 UTSW 14 99,317,313 (GRCm39) missense probably benign 0.18
R2448:Dis3 UTSW 14 99,324,848 (GRCm39) missense probably damaging 0.99
R3407:Dis3 UTSW 14 99,336,212 (GRCm39) missense probably benign 0.15
R4052:Dis3 UTSW 14 99,332,752 (GRCm39) missense probably benign 0.00
R4207:Dis3 UTSW 14 99,332,752 (GRCm39) missense probably benign 0.00
R4208:Dis3 UTSW 14 99,332,752 (GRCm39) missense probably benign 0.00
R4465:Dis3 UTSW 14 99,321,550 (GRCm39) missense possibly damaging 0.88
R4612:Dis3 UTSW 14 99,328,871 (GRCm39) missense probably benign 0.07
R4859:Dis3 UTSW 14 99,325,226 (GRCm39) missense probably damaging 1.00
R4932:Dis3 UTSW 14 99,326,340 (GRCm39) missense probably damaging 1.00
R5273:Dis3 UTSW 14 99,336,242 (GRCm39) missense probably benign 0.32
R5335:Dis3 UTSW 14 99,335,089 (GRCm39) missense possibly damaging 0.72
R5409:Dis3 UTSW 14 99,323,368 (GRCm39) missense possibly damaging 0.95
R5802:Dis3 UTSW 14 99,337,100 (GRCm39) missense probably damaging 1.00
R6309:Dis3 UTSW 14 99,323,358 (GRCm39) missense probably benign 0.00
R7275:Dis3 UTSW 14 99,324,925 (GRCm39) missense probably damaging 1.00
R7511:Dis3 UTSW 14 99,337,042 (GRCm39) missense possibly damaging 0.94
R7535:Dis3 UTSW 14 99,327,415 (GRCm39) missense probably benign 0.15
R7794:Dis3 UTSW 14 99,336,233 (GRCm39) missense probably benign 0.04
R8013:Dis3 UTSW 14 99,314,835 (GRCm39) missense possibly damaging 0.50
R8014:Dis3 UTSW 14 99,314,835 (GRCm39) missense possibly damaging 0.50
R8077:Dis3 UTSW 14 99,327,471 (GRCm39) missense probably benign 0.03
R8957:Dis3 UTSW 14 99,337,027 (GRCm39) missense probably damaging 1.00
R9072:Dis3 UTSW 14 99,332,647 (GRCm39) missense probably benign 0.44
R9073:Dis3 UTSW 14 99,332,647 (GRCm39) missense probably benign 0.44
R9345:Dis3 UTSW 14 99,318,814 (GRCm39) missense probably damaging 1.00
R9542:Dis3 UTSW 14 99,316,975 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGTAGGTAGCACTGTCTTCCAC -3'
(R):5'- TTTGGCCTAACGGAGAGTCAG -3'

Sequencing Primer
(F):5'- CACAGGAAGCTACAGCCTGTG -3'
(R):5'- CCTAACGGAGAGTCAGTGTTTTAAAC -3'
Posted On 2017-10-10