Incidental Mutation 'R6155:Zzz3'
ID 489507
Institutional Source Beutler Lab
Gene Symbol Zzz3
Ensembl Gene ENSMUSG00000039068
Gene Name zinc finger, ZZ domain containing 3
Synonyms 6430567E01Rik, 3110065C23Rik
MMRRC Submission 044302-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6155 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 152101110-152168463 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 152133319 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 126 (I126V)
Ref Sequence ENSEMBL: ENSMUSP00000101707 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089982] [ENSMUST00000106100] [ENSMUST00000106101] [ENSMUST00000106103] [ENSMUST00000200570]
AlphaFold Q6KAQ7
Predicted Effect possibly damaging
Transcript: ENSMUST00000089982
AA Change: I126V

PolyPhen 2 Score 0.570 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000087428
Gene: ENSMUSG00000039068
AA Change: I126V

DomainStartEndE-ValueType
SANT 657 711 1.42e-9 SMART
low complexity region 776 787 N/A INTRINSIC
low complexity region 799 814 N/A INTRINSIC
ZnF_ZZ 823 871 6.46e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000106100
AA Change: I126V

PolyPhen 2 Score 0.570 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000101706
Gene: ENSMUSG00000039068
AA Change: I126V

DomainStartEndE-ValueType
SANT 658 712 1.42e-9 SMART
low complexity region 777 788 N/A INTRINSIC
low complexity region 800 815 N/A INTRINSIC
ZnF_ZZ 824 872 6.46e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000106101
AA Change: I126V

PolyPhen 2 Score 0.570 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000101707
Gene: ENSMUSG00000039068
AA Change: I126V

DomainStartEndE-ValueType
SANT 658 712 1.42e-9 SMART
low complexity region 777 788 N/A INTRINSIC
low complexity region 800 815 N/A INTRINSIC
ZnF_ZZ 824 872 6.46e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106103
SMART Domains Protein: ENSMUSP00000101709
Gene: ENSMUSG00000039068

DomainStartEndE-ValueType
SANT 157 211 1.42e-9 SMART
low complexity region 276 287 N/A INTRINSIC
low complexity region 299 314 N/A INTRINSIC
ZnF_ZZ 323 371 6.46e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138115
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150802
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197987
Predicted Effect probably benign
Transcript: ENSMUST00000200570
SMART Domains Protein: ENSMUSP00000143693
Gene: ENSMUSG00000039068

DomainStartEndE-ValueType
SANT 161 215 1.42e-9 SMART
low complexity region 280 291 N/A INTRINSIC
low complexity region 303 318 N/A INTRINSIC
ZnF_ZZ 327 375 6.46e-3 SMART
Meta Mutation Damage Score 0.0610 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 94.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 T C 5: 105,111,510 (GRCm39) Y319C probably benign Het
Actn4 A C 7: 28,595,566 (GRCm39) I763S probably damaging Het
Actr8 G A 14: 29,700,546 (GRCm39) probably null Het
Adrb1 T C 19: 56,711,336 (GRCm39) L178P probably damaging Het
Afap1 A G 5: 36,092,953 (GRCm39) Y19C unknown Het
Ankrd36 A G 11: 5,637,442 (GRCm39) E1337G probably benign Het
Arl4a A C 12: 40,086,519 (GRCm39) V76G probably damaging Het
Bmp1 A T 14: 70,745,447 (GRCm39) I246K probably damaging Het
Camk4 A T 18: 33,072,500 (GRCm39) T18S unknown Het
Cep152 T C 2: 125,423,620 (GRCm39) H927R probably benign Het
Clca3a2 A G 3: 144,525,118 (GRCm39) I38T probably damaging Het
Clec2g A C 6: 128,957,236 (GRCm39) T54P probably damaging Het
Cox20 A G 1: 178,149,362 (GRCm39) E31G possibly damaging Het
Crispld1 T A 1: 17,823,241 (GRCm39) H407Q probably benign Het
Csmd1 T C 8: 15,953,231 (GRCm39) I3417V probably benign Het
Dhtkd1 A C 2: 5,915,170 (GRCm39) H700Q probably null Het
Dnah10 G A 5: 124,847,663 (GRCm39) V1516M probably damaging Het
Dnah10 A G 5: 124,862,239 (GRCm39) T2165A probably damaging Het
Dock2 C G 11: 34,244,123 (GRCm39) M1072I probably benign Het
F11 T A 8: 45,705,119 (GRCm39) T141S probably damaging Het
Gabra6 T A 11: 42,207,350 (GRCm39) I245F probably damaging Het
H2-T5 G A 17: 36,478,399 (GRCm39) A211V possibly damaging Het
Herc1 T A 9: 66,340,705 (GRCm39) C1685S possibly damaging Het
Iftap A T 2: 101,406,355 (GRCm39) probably null Het
Il20 G T 1: 130,838,477 (GRCm39) D73E probably damaging Het
Ireb2 C A 9: 54,793,811 (GRCm39) P247Q probably damaging Het
Kcng3 T C 17: 83,895,807 (GRCm39) I220V probably benign Het
Lce1j T G 3: 92,696,379 (GRCm39) Q133P unknown Het
Lgals9 C T 11: 78,854,331 (GRCm39) A287T probably benign Het
Lrrc52 A G 1: 167,294,296 (GRCm39) probably benign Het
Map3k5 A T 10: 19,994,187 (GRCm39) H1027L probably benign Het
Morc3 A G 16: 93,659,313 (GRCm39) D407G possibly damaging Het
Myom1 T C 17: 71,415,690 (GRCm39) probably null Het
Ncapg2 T C 12: 116,401,631 (GRCm39) F673S possibly damaging Het
Ncoa6 T C 2: 155,249,368 (GRCm39) D1312G probably damaging Het
Nkx1-1 A T 5: 33,588,395 (GRCm39) F298I probably damaging Het
Npas2 G A 1: 39,326,557 (GRCm39) R14Q probably damaging Het
Npas4 C T 19: 5,036,898 (GRCm39) C422Y probably damaging Het
Or11h4 T C 14: 50,974,076 (GRCm39) D181G probably benign Het
Or2y11 T A 11: 49,443,411 (GRCm39) I279N possibly damaging Het
Or4c123 A G 2: 89,126,765 (GRCm39) L283S probably damaging Het
Or5p4 T C 7: 107,680,493 (GRCm39) V164A probably benign Het
Pcdhga4 T C 18: 37,819,546 (GRCm39) I365T probably damaging Het
Pear1 T A 3: 87,666,875 (GRCm39) T37S probably damaging Het
Pkn2 A T 3: 142,559,454 (GRCm39) F24I probably benign Het
Plcb3 G A 19: 6,943,533 (GRCm39) A122V probably damaging Het
Pnliprp1 T C 19: 58,718,565 (GRCm39) probably null Het
Pramel28 T A 4: 143,691,712 (GRCm39) H337L probably benign Het
Psmb3 T A 11: 97,603,278 (GRCm39) F164I probably damaging Het
Ptch2 T A 4: 116,954,105 (GRCm39) F45Y probably damaging Het
Ptpn23 C A 9: 110,216,849 (GRCm39) probably benign Het
Pusl1 A G 4: 155,975,005 (GRCm39) S199P probably damaging Het
Rasgrp2 C A 19: 6,452,531 (GRCm39) L35I probably damaging Het
Rictor T C 15: 6,823,458 (GRCm39) L1545P probably benign Het
Rtn4r A T 16: 17,969,258 (GRCm39) M229L probably benign Het
Ruvbl1 A T 6: 88,456,107 (GRCm39) probably null Het
Slc35b3 A T 13: 39,128,572 (GRCm39) S30T probably damaging Het
Sorcs3 T C 19: 48,387,136 (GRCm39) V207A possibly damaging Het
Sox13 A G 1: 133,321,005 (GRCm39) S2P probably damaging Het
Sptbn1 A C 11: 30,087,403 (GRCm39) L999R probably damaging Het
Taf4 A G 2: 179,555,317 (GRCm39) V1015A probably damaging Het
Top3b T C 16: 16,709,373 (GRCm39) L687P probably damaging Het
Tpp2 T A 1: 43,995,649 (GRCm39) V268E probably damaging Het
Ttc6 T C 12: 57,784,402 (GRCm39) Y1824H possibly damaging Het
Txk A G 5: 72,858,069 (GRCm39) Y360H probably damaging Het
Vmn2r57 T C 7: 41,078,114 (GRCm39) I115V probably benign Het
Vmn2r98 T C 17: 19,286,143 (GRCm39) S214P possibly damaging Het
Zbtb48 T C 4: 152,106,495 (GRCm39) probably null Het
Other mutations in Zzz3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00691:Zzz3 APN 3 152,134,151 (GRCm39) missense probably benign 0.16
IGL00707:Zzz3 APN 3 152,154,680 (GRCm39) nonsense probably null
IGL00983:Zzz3 APN 3 152,161,447 (GRCm39) splice site probably benign
IGL01586:Zzz3 APN 3 152,161,476 (GRCm39) missense possibly damaging 0.80
IGL01973:Zzz3 APN 3 152,134,007 (GRCm39) missense probably benign 0.00
IGL02002:Zzz3 APN 3 152,157,006 (GRCm39) missense probably damaging 0.98
IGL02009:Zzz3 APN 3 152,133,752 (GRCm39) missense possibly damaging 0.80
IGL02260:Zzz3 APN 3 152,157,720 (GRCm39) missense probably benign 0.04
IGL02336:Zzz3 APN 3 152,133,696 (GRCm39) missense possibly damaging 0.74
IGL02454:Zzz3 APN 3 152,134,211 (GRCm39) missense probably benign 0.03
IGL02519:Zzz3 APN 3 152,133,027 (GRCm39) missense probably damaging 1.00
R0067:Zzz3 UTSW 3 152,134,040 (GRCm39) missense possibly damaging 0.88
R0067:Zzz3 UTSW 3 152,134,040 (GRCm39) missense possibly damaging 0.88
R0314:Zzz3 UTSW 3 152,133,085 (GRCm39) missense probably benign 0.00
R0536:Zzz3 UTSW 3 152,154,465 (GRCm39) missense probably damaging 1.00
R1706:Zzz3 UTSW 3 152,154,735 (GRCm39) missense probably damaging 1.00
R2869:Zzz3 UTSW 3 152,152,481 (GRCm39) synonymous silent
R2870:Zzz3 UTSW 3 152,152,481 (GRCm39) synonymous silent
R2871:Zzz3 UTSW 3 152,152,481 (GRCm39) synonymous silent
R2872:Zzz3 UTSW 3 152,152,481 (GRCm39) synonymous silent
R3927:Zzz3 UTSW 3 152,161,499 (GRCm39) missense probably damaging 1.00
R4195:Zzz3 UTSW 3 152,134,102 (GRCm39) missense probably benign 0.02
R4768:Zzz3 UTSW 3 152,154,420 (GRCm39) missense probably damaging 1.00
R5248:Zzz3 UTSW 3 152,133,182 (GRCm39) missense probably damaging 0.99
R5566:Zzz3 UTSW 3 152,161,461 (GRCm39) missense probably damaging 1.00
R5752:Zzz3 UTSW 3 152,157,759 (GRCm39) missense possibly damaging 0.48
R5782:Zzz3 UTSW 3 152,133,737 (GRCm39) missense possibly damaging 0.69
R5884:Zzz3 UTSW 3 152,156,295 (GRCm39) missense probably damaging 1.00
R6008:Zzz3 UTSW 3 152,133,788 (GRCm39) missense probably benign 0.01
R6557:Zzz3 UTSW 3 152,134,097 (GRCm39) missense probably damaging 1.00
R6865:Zzz3 UTSW 3 152,133,690 (GRCm39) missense probably benign 0.01
R7344:Zzz3 UTSW 3 152,157,736 (GRCm39) missense probably damaging 0.98
R7588:Zzz3 UTSW 3 152,128,405 (GRCm39) missense possibly damaging 0.85
R7636:Zzz3 UTSW 3 152,133,289 (GRCm39) missense probably benign
R7732:Zzz3 UTSW 3 152,154,479 (GRCm39) missense probably damaging 1.00
R8157:Zzz3 UTSW 3 152,155,285 (GRCm39) missense probably null 0.71
R8490:Zzz3 UTSW 3 152,134,290 (GRCm39) nonsense probably null
R8926:Zzz3 UTSW 3 152,133,529 (GRCm39) missense possibly damaging 0.76
R9143:Zzz3 UTSW 3 152,163,908 (GRCm39) missense probably benign 0.04
R9243:Zzz3 UTSW 3 152,133,920 (GRCm39) missense probably damaging 1.00
R9494:Zzz3 UTSW 3 152,133,468 (GRCm39) missense possibly damaging 0.88
R9540:Zzz3 UTSW 3 152,156,306 (GRCm39) nonsense probably null
X0018:Zzz3 UTSW 3 152,134,370 (GRCm39) missense possibly damaging 0.88
Z1176:Zzz3 UTSW 3 152,154,734 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- CCTGTGCCAACTCAGAAAGG -3'
(R):5'- TAAGTGGCCCTTCCTCACTGAC -3'

Sequencing Primer
(F):5'- GCCAACTCAGAAAGGAACCAATAATG -3'
(R):5'- CCTCACTGACATTCACCTTTTTAAC -3'
Posted On 2017-10-10