Incidental Mutation 'R6007:Vmn2r86'
| ID |
479540 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r86
|
| Ensembl Gene |
ENSMUSG00000092162 |
| Gene Name |
vomeronasal 2, receptor 86 |
| Synonyms |
EG625109 |
| MMRRC Submission |
044184-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.068)
|
| Stock # |
R6007 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
130282068-130291763 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 130289535 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 120
(Y120C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126596
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170257]
|
| AlphaFold |
G5E8Y4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170257
AA Change: Y120C
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000126596
Gene: ENSMUSG00000092162
AA Change: Y120C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
425 |
1.1e-25 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
2.4e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
6.4e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.4%
- 10x: 97.1%
- 20x: 90.6%
|
| Validation Efficiency |
100% (54/54) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700003E16Rik |
G |
T |
6: 83,137,900 (GRCm39) |
A9S |
possibly damaging |
Het |
| 4930407I10Rik |
C |
G |
15: 81,946,940 (GRCm39) |
T279S |
probably benign |
Het |
| A830018L16Rik |
A |
G |
1: 11,582,140 (GRCm39) |
|
probably null |
Het |
| Abcg5 |
T |
G |
17: 84,976,392 (GRCm39) |
I482L |
probably benign |
Het |
| Adgrf5 |
T |
A |
17: 43,748,462 (GRCm39) |
D44E |
probably damaging |
Het |
| Amh |
A |
G |
10: 80,641,305 (GRCm39) |
N75S |
probably benign |
Het |
| Arl8a |
T |
C |
1: 135,080,606 (GRCm39) |
|
probably null |
Het |
| Bpifb4 |
T |
C |
2: 153,784,480 (GRCm39) |
Y63H |
possibly damaging |
Het |
| Chd5 |
A |
T |
4: 152,463,878 (GRCm39) |
E1449V |
probably null |
Het |
| Chml |
A |
G |
1: 175,515,594 (GRCm39) |
V109A |
probably benign |
Het |
| Crybg3 |
G |
T |
16: 59,374,837 (GRCm39) |
S2139* |
probably null |
Het |
| Cyp2c68 |
T |
C |
19: 39,722,780 (GRCm39) |
D256G |
probably damaging |
Het |
| Dchs2 |
G |
T |
3: 83,253,534 (GRCm39) |
V2315L |
probably damaging |
Het |
| Ddx20 |
T |
C |
3: 105,590,736 (GRCm39) |
I227V |
possibly damaging |
Het |
| Drg2 |
T |
C |
11: 60,353,451 (GRCm39) |
V266A |
possibly damaging |
Het |
| Flcn |
C |
A |
11: 59,683,448 (GRCm39) |
E576D |
probably benign |
Het |
| Fstl5 |
T |
A |
3: 76,317,899 (GRCm39) |
D188E |
probably damaging |
Het |
| Gm14496 |
A |
G |
2: 181,639,323 (GRCm39) |
Q471R |
probably benign |
Het |
| Gm43772 |
T |
C |
5: 66,332,334 (GRCm39) |
|
probably benign |
Het |
| Gpc6 |
C |
T |
14: 118,188,673 (GRCm39) |
H436Y |
probably damaging |
Het |
| Gpr179 |
A |
T |
11: 97,226,628 (GRCm39) |
C1842* |
probably null |
Het |
| Ints8 |
G |
A |
4: 11,208,845 (GRCm39) |
T934I |
possibly damaging |
Het |
| Iqsec1 |
G |
T |
6: 90,637,969 (GRCm39) |
C1050* |
probably null |
Het |
| Larp4b |
T |
C |
13: 9,218,793 (GRCm39) |
V510A |
probably benign |
Het |
| Map3k13 |
A |
T |
16: 21,723,933 (GRCm39) |
D305V |
possibly damaging |
Het |
| Mc5r |
A |
T |
18: 68,472,318 (GRCm39) |
I226F |
possibly damaging |
Het |
| Mme |
G |
A |
3: 63,250,929 (GRCm39) |
W323* |
probably null |
Het |
| Mrpl24 |
A |
G |
3: 87,829,705 (GRCm39) |
Y97C |
probably benign |
Het |
| Mslnl |
G |
A |
17: 25,965,749 (GRCm39) |
S541N |
probably benign |
Het |
| Npepl1 |
T |
C |
2: 173,962,850 (GRCm39) |
V412A |
probably benign |
Het |
| Nrg3 |
T |
A |
14: 39,194,409 (GRCm39) |
K117* |
probably null |
Het |
| Or11j4 |
G |
T |
14: 50,630,948 (GRCm39) |
C245F |
probably damaging |
Het |
| Or4f52 |
T |
C |
2: 111,061,275 (GRCm39) |
T288A |
probably benign |
Het |
| Orc2 |
A |
T |
1: 58,506,851 (GRCm39) |
M447K |
probably benign |
Het |
| Phf3 |
A |
T |
1: 30,843,426 (GRCm39) |
H1844Q |
probably damaging |
Het |
| Plxnc1 |
T |
C |
10: 94,629,152 (GRCm39) |
I1541V |
possibly damaging |
Het |
| Rapgef4 |
T |
C |
2: 72,010,293 (GRCm39) |
Y284H |
possibly damaging |
Het |
| Rnf180 |
C |
A |
13: 105,317,957 (GRCm39) |
|
probably null |
Het |
| Secisbp2 |
T |
C |
13: 51,819,395 (GRCm39) |
I325T |
probably damaging |
Het |
| Sertad2 |
G |
A |
11: 20,597,884 (GRCm39) |
G27S |
probably benign |
Het |
| Slc4a10 |
A |
G |
2: 62,099,216 (GRCm39) |
M625V |
probably benign |
Het |
| Synpo |
T |
A |
18: 60,736,687 (GRCm39) |
M420L |
probably benign |
Het |
| Tmem116 |
A |
C |
5: 121,655,955 (GRCm39) |
*147C |
probably null |
Het |
| Top2b |
G |
A |
14: 16,423,779 (GRCm38) |
|
probably null |
Het |
| Trp53bp2 |
T |
A |
1: 182,283,305 (GRCm39) |
C1014S |
probably damaging |
Het |
| Unc5b |
A |
G |
10: 60,601,139 (GRCm39) |
F896L |
probably damaging |
Het |
| Vil1 |
T |
C |
1: 74,459,026 (GRCm39) |
W177R |
probably damaging |
Het |
| Vmn2r107 |
A |
T |
17: 20,595,316 (GRCm39) |
Y623F |
probably benign |
Het |
| Wdr18 |
A |
G |
10: 79,801,177 (GRCm39) |
T197A |
possibly damaging |
Het |
| Ylpm1 |
A |
G |
12: 85,076,064 (GRCm39) |
M472V |
probably benign |
Het |
| Zfp647 |
G |
A |
15: 76,796,285 (GRCm39) |
P125L |
probably damaging |
Het |
| Zfp677 |
A |
G |
17: 21,617,918 (GRCm39) |
Y325C |
probably damaging |
Het |
| Zfyve1 |
A |
G |
12: 83,605,478 (GRCm39) |
F407S |
probably damaging |
Het |
|
| Other mutations in Vmn2r86 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01295:Vmn2r86
|
APN |
10 |
130,288,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01328:Vmn2r86
|
APN |
10 |
130,288,365 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL01377:Vmn2r86
|
APN |
10 |
130,288,855 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01548:Vmn2r86
|
APN |
10 |
130,282,151 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01804:Vmn2r86
|
APN |
10 |
130,288,858 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01921:Vmn2r86
|
APN |
10 |
130,291,610 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02406:Vmn2r86
|
APN |
10 |
130,284,508 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02625:Vmn2r86
|
APN |
10 |
130,288,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02960:Vmn2r86
|
APN |
10 |
130,289,636 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL03104:Vmn2r86
|
APN |
10 |
130,282,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0408:Vmn2r86
|
UTSW |
10 |
130,282,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0437:Vmn2r86
|
UTSW |
10 |
130,282,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0577:Vmn2r86
|
UTSW |
10 |
130,288,444 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0726:Vmn2r86
|
UTSW |
10 |
130,282,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0811:Vmn2r86
|
UTSW |
10 |
130,289,497 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0812:Vmn2r86
|
UTSW |
10 |
130,289,497 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1055:Vmn2r86
|
UTSW |
10 |
130,282,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1066:Vmn2r86
|
UTSW |
10 |
130,282,145 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1199:Vmn2r86
|
UTSW |
10 |
130,284,443 (GRCm39) |
splice site |
probably benign |
|
|
R1332:Vmn2r86
|
UTSW |
10 |
130,282,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Vmn2r86
|
UTSW |
10 |
130,289,010 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1866:Vmn2r86
|
UTSW |
10 |
130,282,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1897:Vmn2r86
|
UTSW |
10 |
130,288,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Vmn2r86
|
UTSW |
10 |
130,282,582 (GRCm39) |
missense |
probably benign |
0.39 |
|
R3162:Vmn2r86
|
UTSW |
10 |
130,291,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3162:Vmn2r86
|
UTSW |
10 |
130,291,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3858:Vmn2r86
|
UTSW |
10 |
130,291,594 (GRCm39) |
missense |
probably benign |
|
|
R4049:Vmn2r86
|
UTSW |
10 |
130,282,966 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4378:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4411:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4413:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4422:Vmn2r86
|
UTSW |
10 |
130,288,845 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4738:Vmn2r86
|
UTSW |
10 |
130,282,939 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4767:Vmn2r86
|
UTSW |
10 |
130,291,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4872:Vmn2r86
|
UTSW |
10 |
130,289,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4880:Vmn2r86
|
UTSW |
10 |
130,289,484 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5092:Vmn2r86
|
UTSW |
10 |
130,282,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5421:Vmn2r86
|
UTSW |
10 |
130,282,805 (GRCm39) |
missense |
probably benign |
0.41 |
|
R6330:Vmn2r86
|
UTSW |
10 |
130,282,396 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6355:Vmn2r86
|
UTSW |
10 |
130,291,763 (GRCm39) |
start codon destroyed |
probably damaging |
0.98 |
|
R6397:Vmn2r86
|
UTSW |
10 |
130,282,131 (GRCm39) |
nonsense |
probably null |
|
|
R6419:Vmn2r86
|
UTSW |
10 |
130,282,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6933:Vmn2r86
|
UTSW |
10 |
130,282,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6937:Vmn2r86
|
UTSW |
10 |
130,284,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6959:Vmn2r86
|
UTSW |
10 |
130,282,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7010:Vmn2r86
|
UTSW |
10 |
130,291,726 (GRCm39) |
missense |
probably benign |
|
|
R7549:Vmn2r86
|
UTSW |
10 |
130,282,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8179:Vmn2r86
|
UTSW |
10 |
130,288,953 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8257:Vmn2r86
|
UTSW |
10 |
130,288,279 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8286:Vmn2r86
|
UTSW |
10 |
130,285,855 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8479:Vmn2r86
|
UTSW |
10 |
130,282,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8805:Vmn2r86
|
UTSW |
10 |
130,282,396 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8960:Vmn2r86
|
UTSW |
10 |
130,289,672 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9021:Vmn2r86
|
UTSW |
10 |
130,282,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9120:Vmn2r86
|
UTSW |
10 |
130,289,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9137:Vmn2r86
|
UTSW |
10 |
130,282,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9311:Vmn2r86
|
UTSW |
10 |
130,288,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9312:Vmn2r86
|
UTSW |
10 |
130,288,406 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9433:Vmn2r86
|
UTSW |
10 |
130,282,567 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9696:Vmn2r86
|
UTSW |
10 |
130,285,702 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCACACTCATAAATTCATGCTGTC -3'
(R):5'- GCTCTAACGATCTCTAATATATGAGGC -3'
Sequencing Primer
(F):5'- TTACCGTTGGTGTCCAAG -3'
(R):5'- AGTTAGCATGTCTCATTCTACAAAC -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation