Incidental Mutation 'R5001:Megf6'
| ID |
478084 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Megf6
|
| Ensembl Gene |
ENSMUSG00000057751 |
| Gene Name |
multiple EGF-like-domains 6 |
| Synonyms |
2600001P17Rik, Egfl3 |
| MMRRC Submission |
042595-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5001 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
154255187-154360170 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 154352517 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Histidine
at position 1292
(L1292H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000030897
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030897]
[ENSMUST00000152159]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030897
AA Change: L1292H
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000030897
Gene: ENSMUSG00000057751
AA Change: L1292H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
EGF_CA
|
122 |
162 |
1.54e-6 |
SMART |
|
EGF_CA
|
163 |
203 |
2.08e-12 |
SMART |
|
EGF
|
207 |
245 |
5.4e-2 |
SMART |
|
EGF
|
249 |
286 |
2.39e-3 |
SMART |
|
EGF_CA
|
287 |
327 |
4.96e-10 |
SMART |
|
EGF
|
336 |
373 |
1.64e-1 |
SMART |
|
EGF
|
377 |
413 |
1.99e1 |
SMART |
|
EGF_CA
|
414 |
454 |
7.4e-9 |
SMART |
|
EGF
|
521 |
554 |
4.26e0 |
SMART |
|
EGF_Lam
|
570 |
609 |
1.19e-3 |
SMART |
|
EGF_like
|
613 |
652 |
5.29e-1 |
SMART |
|
EGF
|
642 |
685 |
2.2e1 |
SMART |
|
EGF_Lam
|
656 |
697 |
1.04e-3 |
SMART |
|
EGF
|
687 |
730 |
1.59e1 |
SMART |
|
EGF_like
|
701 |
742 |
2.27e0 |
SMART |
|
EGF_Lam
|
746 |
784 |
1.33e-1 |
SMART |
|
EGF
|
783 |
816 |
2.85e-1 |
SMART |
|
EGF_Lam
|
832 |
871 |
3.88e-3 |
SMART |
|
EGF_Lam
|
875 |
915 |
3.25e-5 |
SMART |
|
EGF
|
914 |
946 |
4.7e-2 |
SMART |
|
EGF_like
|
962 |
1001 |
1.69e-1 |
SMART |
|
EGF
|
1000 |
1032 |
7.02e-1 |
SMART |
|
EGF_Lam
|
1048 |
1087 |
3.1e-2 |
SMART |
|
EGF
|
1077 |
1118 |
7.53e-1 |
SMART |
|
EGF_like
|
1091 |
1130 |
5.59e-1 |
SMART |
|
EGF
|
1129 |
1161 |
5.04e-2 |
SMART |
|
EGF_Lam
|
1177 |
1216 |
2.94e-3 |
SMART |
|
EGF
|
1206 |
1248 |
1.87e1 |
SMART |
|
EGF_Lam
|
1220 |
1260 |
3.1e-2 |
SMART |
|
EGF
|
1259 |
1291 |
1.73e0 |
SMART |
|
EGF
|
1302 |
1334 |
6.55e-1 |
SMART |
|
EGF
|
1345 |
1377 |
4.39e-2 |
SMART |
|
EGF_Lam
|
1393 |
1432 |
7.64e-2 |
SMART |
|
EGF_Lam
|
1436 |
1475 |
2.64e-5 |
SMART |
|
EGF_like
|
1465 |
1506 |
4.2e1 |
SMART |
|
EGF_Lam
|
1479 |
1518 |
1.19e-3 |
SMART |
|
EGF
|
1517 |
1549 |
1.84e1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127088
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000128700
AA Change: L159H
|
| SMART Domains |
Protein: ENSMUSP00000117277
Gene: ENSMUSG00000057751
AA Change: L159H
| Domain | Start | End | E-Value | Type |
|---|
|
EGF_Lam
|
3 |
42 |
3.1e-2 |
SMART |
|
EGF
|
32 |
73 |
7.53e-1 |
SMART |
|
EGF_like
|
46 |
85 |
8.92e-1 |
SMART |
|
EGF
|
84 |
116 |
7.13e-2 |
SMART |
|
EGF
|
127 |
159 |
1.73e0 |
SMART |
|
EGF
|
170 |
202 |
6.55e-1 |
SMART |
|
EGF
|
213 |
245 |
4.39e-2 |
SMART |
|
EGF_Lam
|
261 |
300 |
7.64e-2 |
SMART |
|
EGF
|
299 |
331 |
1.51e0 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138945
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142110
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000152159
AA Change: L1011H
PolyPhen 2
Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000121641
Gene: ENSMUSG00000057751
AA Change: L1011H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
EGF_CA
|
55 |
95 |
2.08e-12 |
SMART |
|
EGF
|
99 |
137 |
5.4e-2 |
SMART |
|
EGF
|
141 |
178 |
2.39e-3 |
SMART |
|
EGF_CA
|
179 |
219 |
4.96e-10 |
SMART |
|
EGF
|
228 |
265 |
1.64e-1 |
SMART |
|
EGF
|
269 |
305 |
1.99e1 |
SMART |
|
EGF_CA
|
306 |
346 |
7.4e-9 |
SMART |
|
EGF
|
413 |
446 |
4.26e0 |
SMART |
|
EGF_Lam
|
462 |
501 |
1.19e-3 |
SMART |
|
EGF_like
|
505 |
544 |
5.29e-1 |
SMART |
|
EGF
|
534 |
577 |
2.2e1 |
SMART |
|
EGF_Lam
|
548 |
589 |
1.04e-3 |
SMART |
|
EGF
|
579 |
622 |
1.59e1 |
SMART |
|
EGF_like
|
593 |
634 |
2.27e0 |
SMART |
|
EGF_Lam
|
638 |
676 |
1.33e-1 |
SMART |
|
EGF
|
675 |
708 |
2.85e-1 |
SMART |
|
EGF_Lam
|
724 |
763 |
3.88e-3 |
SMART |
|
EGF_Lam
|
767 |
807 |
3.25e-5 |
SMART |
|
EGF
|
806 |
838 |
4.7e-2 |
SMART |
|
EGF_Lam
|
854 |
893 |
2.56e-3 |
SMART |
|
EGF
|
892 |
924 |
2.02e-1 |
SMART |
|
EGF
|
935 |
967 |
7.13e-2 |
SMART |
|
EGF
|
978 |
1010 |
1.73e0 |
SMART |
|
EGF
|
1021 |
1053 |
6.55e-1 |
SMART |
|
EGF
|
1064 |
1096 |
4.39e-2 |
SMART |
|
EGF
|
1107 |
1139 |
4.97e-1 |
SMART |
|
EGF
|
1159 |
1191 |
1.84e1 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.4%
- 20x: 92.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy3 |
G |
A |
12: 4,248,434 (GRCm39) |
V499M |
possibly damaging |
Het |
| Aff4 |
T |
C |
11: 53,295,184 (GRCm39) |
S795P |
probably damaging |
Het |
| Ank |
G |
A |
15: 27,562,819 (GRCm39) |
V176I |
probably damaging |
Het |
| Ankfn1 |
A |
G |
11: 89,332,268 (GRCm39) |
I446T |
possibly damaging |
Het |
| Arhgap33 |
C |
A |
7: 30,232,441 (GRCm39) |
S32I |
possibly damaging |
Het |
| Ascc3 |
T |
A |
10: 50,699,744 (GRCm39) |
Y1856N |
probably damaging |
Het |
| Atf3 |
T |
C |
1: 190,909,472 (GRCm39) |
T66A |
probably benign |
Het |
| Atf7ip |
T |
C |
6: 136,538,386 (GRCm39) |
C548R |
probably damaging |
Het |
| Bag6 |
A |
G |
17: 35,364,152 (GRCm39) |
T841A |
probably damaging |
Het |
| Bbof1 |
A |
T |
12: 84,473,630 (GRCm39) |
Q320L |
possibly damaging |
Het |
| Bmp2k |
A |
T |
5: 97,201,001 (GRCm39) |
Q307L |
probably damaging |
Het |
| Btaf1 |
T |
A |
19: 36,964,052 (GRCm39) |
N874K |
possibly damaging |
Het |
| Calr4 |
G |
A |
4: 109,096,179 (GRCm39) |
|
probably null |
Het |
| Camk1d |
T |
C |
2: 5,317,912 (GRCm39) |
I248V |
possibly damaging |
Het |
| Ccdc177 |
G |
A |
12: 80,804,160 (GRCm39) |
R705C |
unknown |
Het |
| Cdk18 |
C |
T |
1: 132,046,587 (GRCm39) |
|
probably null |
Het |
| Cers4 |
A |
G |
8: 4,565,565 (GRCm39) |
S4G |
probably benign |
Het |
| Cfap54 |
A |
G |
10: 92,800,396 (GRCm39) |
V1604A |
probably benign |
Het |
| Chd8 |
C |
T |
14: 52,441,372 (GRCm39) |
G907S |
probably benign |
Het |
| Cilk1 |
T |
C |
9: 78,038,801 (GRCm39) |
S17P |
probably damaging |
Het |
| Cnksr3 |
G |
A |
10: 7,076,746 (GRCm39) |
Q149* |
probably null |
Het |
| Cntd1 |
T |
C |
11: 101,176,557 (GRCm39) |
V218A |
possibly damaging |
Het |
| Cog7 |
A |
T |
7: 121,549,109 (GRCm39) |
V384E |
probably damaging |
Het |
| Col5a2 |
A |
G |
1: 45,542,058 (GRCm39) |
V6A |
unknown |
Het |
| Col7a1 |
T |
C |
9: 108,794,146 (GRCm39) |
|
probably null |
Het |
| Cpsf6 |
T |
A |
10: 117,203,866 (GRCm39) |
I29L |
possibly damaging |
Het |
| Cyp3a13 |
T |
C |
5: 137,897,178 (GRCm39) |
T379A |
probably benign |
Het |
| Ddx46 |
T |
C |
13: 55,800,732 (GRCm39) |
S296P |
probably damaging |
Het |
| Dmbt1 |
A |
G |
7: 130,651,742 (GRCm39) |
D328G |
probably damaging |
Het |
| Dnah8 |
T |
G |
17: 31,006,159 (GRCm39) |
L3692W |
probably damaging |
Het |
| Dnmt3l |
A |
C |
10: 77,895,565 (GRCm39) |
S368R |
probably null |
Het |
| Egfr |
A |
G |
11: 16,854,434 (GRCm39) |
K869E |
probably damaging |
Het |
| Ehd1 |
G |
A |
19: 6,347,724 (GRCm39) |
M359I |
probably benign |
Het |
| F5 |
A |
T |
1: 164,023,139 (GRCm39) |
T1566S |
probably benign |
Het |
| Flrt2 |
T |
C |
12: 95,745,725 (GRCm39) |
I21T |
probably benign |
Het |
| Galnt1 |
T |
A |
18: 24,404,812 (GRCm39) |
I383K |
probably benign |
Het |
| Ghdc |
G |
T |
11: 100,657,660 (GRCm39) |
A523D |
probably damaging |
Het |
| Gm24022 |
A |
G |
12: 113,393,399 (GRCm39) |
|
probably benign |
Het |
| Golga3 |
T |
C |
5: 110,353,643 (GRCm39) |
S934P |
probably damaging |
Het |
| Gpr135 |
T |
A |
12: 72,117,282 (GRCm39) |
T162S |
probably benign |
Het |
| Gucd1 |
G |
A |
10: 75,353,036 (GRCm39) |
|
probably null |
Het |
| Hcrtr2 |
T |
A |
9: 76,137,886 (GRCm39) |
I410F |
probably benign |
Het |
| Igkv6-15 |
T |
C |
6: 70,383,633 (GRCm39) |
Y56C |
probably damaging |
Het |
| Il22ra1 |
A |
T |
4: 135,460,415 (GRCm39) |
Y57F |
probably damaging |
Het |
| Irak4 |
A |
G |
15: 94,456,154 (GRCm39) |
E247G |
possibly damaging |
Het |
| Kank3 |
T |
C |
17: 34,040,746 (GRCm39) |
V13A |
possibly damaging |
Het |
| Klhl1 |
A |
T |
14: 96,374,046 (GRCm39) |
S667T |
probably damaging |
Het |
| Klhl6 |
T |
G |
16: 19,765,741 (GRCm39) |
*620C |
probably null |
Het |
| Lct |
A |
G |
1: 128,235,978 (GRCm39) |
L343P |
probably damaging |
Het |
| Lgr6 |
G |
T |
1: 134,918,370 (GRCm39) |
P264T |
probably benign |
Het |
| Lilrb4a |
T |
A |
10: 51,367,516 (GRCm39) |
|
probably null |
Het |
| Lin7a |
G |
T |
10: 107,218,530 (GRCm39) |
G25* |
probably null |
Het |
| Lmnb2 |
G |
A |
10: 80,753,946 (GRCm39) |
T36M |
probably damaging |
Het |
| Manba |
T |
C |
3: 135,273,391 (GRCm39) |
F775S |
probably benign |
Het |
| Marchf6 |
A |
G |
15: 31,465,468 (GRCm39) |
V812A |
probably damaging |
Het |
| Myo18b |
T |
G |
5: 112,909,206 (GRCm39) |
Q1979P |
probably damaging |
Het |
| Myoz1 |
T |
C |
14: 20,703,769 (GRCm39) |
M59V |
probably damaging |
Het |
| Naa35 |
T |
C |
13: 59,773,345 (GRCm39) |
I100T |
possibly damaging |
Het |
| Nox4 |
A |
T |
7: 87,010,011 (GRCm39) |
Y404F |
probably damaging |
Het |
| Ntn1 |
T |
C |
11: 68,151,358 (GRCm39) |
Y441C |
probably damaging |
Het |
| Onecut3 |
A |
G |
10: 80,331,154 (GRCm39) |
T105A |
unknown |
Het |
| Or10ak8 |
C |
A |
4: 118,774,440 (GRCm39) |
V75F |
probably damaging |
Het |
| Or1n1 |
T |
C |
2: 36,750,082 (GRCm39) |
T93A |
probably benign |
Het |
| Or4d5 |
G |
A |
9: 40,012,523 (GRCm39) |
H88Y |
probably benign |
Het |
| Pabpc1l |
A |
G |
2: 163,884,438 (GRCm39) |
S392G |
probably benign |
Het |
| Pan3 |
T |
A |
5: 147,463,492 (GRCm39) |
|
probably null |
Het |
| Pcdha4 |
G |
A |
18: 37,088,001 (GRCm39) |
S728N |
probably benign |
Het |
| Pds5a |
T |
C |
5: 65,854,128 (GRCm39) |
D38G |
probably damaging |
Het |
| Pgm2l1 |
A |
G |
7: 99,921,583 (GRCm39) |
I605V |
probably benign |
Het |
| Phip |
T |
C |
9: 82,778,072 (GRCm39) |
|
probably null |
Het |
| Pilra |
T |
C |
5: 137,833,777 (GRCm39) |
I96M |
probably damaging |
Het |
| Ppig |
T |
A |
2: 69,571,830 (GRCm39) |
V183D |
unknown |
Het |
| Ppp2r2a |
A |
T |
14: 67,259,757 (GRCm39) |
L313* |
probably null |
Het |
| Ppp4c |
A |
G |
7: 126,386,709 (GRCm39) |
F126S |
probably damaging |
Het |
| Ptger2 |
C |
A |
14: 45,226,824 (GRCm39) |
R135S |
probably damaging |
Het |
| Rab11fip5 |
T |
A |
6: 85,324,788 (GRCm39) |
E506D |
probably damaging |
Het |
| Rdh12 |
G |
A |
12: 79,259,516 (GRCm39) |
G133R |
probably damaging |
Het |
| Rims2 |
A |
T |
15: 39,315,824 (GRCm39) |
D610V |
probably benign |
Het |
| Saa1 |
T |
A |
7: 46,390,132 (GRCm39) |
Y122F |
probably damaging |
Het |
| Septin10 |
A |
T |
10: 59,012,811 (GRCm39) |
V269E |
probably damaging |
Het |
| Serpina3n |
T |
A |
12: 104,374,998 (GRCm39) |
D23E |
probably benign |
Het |
| Serpinb11 |
A |
G |
1: 107,304,598 (GRCm39) |
K188E |
possibly damaging |
Het |
| Slc18a3 |
C |
T |
14: 32,185,736 (GRCm39) |
V216M |
possibly damaging |
Het |
| Slc19a3 |
G |
T |
1: 83,000,341 (GRCm39) |
N225K |
probably benign |
Het |
| Slc4a1 |
T |
A |
11: 102,242,329 (GRCm39) |
I797F |
probably benign |
Het |
| Slx9 |
A |
G |
10: 77,325,850 (GRCm39) |
V154A |
probably benign |
Het |
| Spic |
A |
G |
10: 88,511,761 (GRCm39) |
M165T |
possibly damaging |
Het |
| Timm44 |
A |
T |
8: 4,325,886 (GRCm39) |
M1K |
probably null |
Het |
| Tmc6 |
A |
G |
11: 117,661,610 (GRCm39) |
L572P |
probably benign |
Het |
| Tnc |
G |
A |
4: 63,918,299 (GRCm39) |
T1204M |
probably benign |
Het |
| Tnc |
G |
A |
4: 63,902,726 (GRCm39) |
T1517I |
probably damaging |
Het |
| Trip11 |
A |
T |
12: 101,851,169 (GRCm39) |
L680* |
probably null |
Het |
| Trps1 |
T |
A |
15: 50,524,703 (GRCm39) |
M887L |
possibly damaging |
Het |
| Tulp3 |
A |
C |
6: 128,302,031 (GRCm39) |
V330G |
probably damaging |
Het |
| Upf1 |
A |
G |
8: 70,787,350 (GRCm39) |
S835P |
probably damaging |
Het |
| Wdr64 |
A |
G |
1: 175,620,525 (GRCm39) |
|
probably null |
Het |
| Yju2b |
G |
A |
8: 84,985,304 (GRCm39) |
P322S |
probably benign |
Het |
| Zbtb40 |
A |
G |
4: 136,723,461 (GRCm39) |
L643P |
probably damaging |
Het |
| Zc3h18 |
A |
T |
8: 123,110,259 (GRCm39) |
D36V |
probably damaging |
Het |
|
| Other mutations in Megf6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01122:Megf6
|
APN |
4 |
154,338,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01410:Megf6
|
APN |
4 |
154,337,020 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01512:Megf6
|
APN |
4 |
154,347,040 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL01824:Megf6
|
APN |
4 |
154,336,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02172:Megf6
|
APN |
4 |
154,355,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02727:Megf6
|
APN |
4 |
154,337,606 (GRCm39) |
splice site |
probably null |
|
|
IGL02966:Megf6
|
APN |
4 |
154,338,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Didactic
|
UTSW |
4 |
154,339,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0118:Megf6
|
UTSW |
4 |
154,339,098 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0220:Megf6
|
UTSW |
4 |
154,342,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0347:Megf6
|
UTSW |
4 |
154,339,092 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0383:Megf6
|
UTSW |
4 |
154,349,783 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0417:Megf6
|
UTSW |
4 |
154,352,424 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0526:Megf6
|
UTSW |
4 |
154,343,398 (GRCm39) |
missense |
probably benign |
|
|
R0528:Megf6
|
UTSW |
4 |
154,343,630 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0928:Megf6
|
UTSW |
4 |
154,261,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1311:Megf6
|
UTSW |
4 |
154,348,239 (GRCm39) |
splice site |
probably null |
|
|
R1458:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1470:Megf6
|
UTSW |
4 |
154,336,876 (GRCm39) |
splice site |
probably benign |
|
|
R1476:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1479:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1624:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1626:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1638:Megf6
|
UTSW |
4 |
154,346,967 (GRCm39) |
splice site |
probably benign |
|
|
R1777:Megf6
|
UTSW |
4 |
154,355,147 (GRCm39) |
nonsense |
probably null |
|
|
R1831:Megf6
|
UTSW |
4 |
154,355,134 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1944:Megf6
|
UTSW |
4 |
154,340,523 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1984:Megf6
|
UTSW |
4 |
154,352,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2448:Megf6
|
UTSW |
4 |
154,351,102 (GRCm39) |
splice site |
probably null |
|
|
R2880:Megf6
|
UTSW |
4 |
154,337,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4032:Megf6
|
UTSW |
4 |
154,261,550 (GRCm39) |
nonsense |
probably null |
|
|
R4058:Megf6
|
UTSW |
4 |
154,326,989 (GRCm39) |
splice site |
probably benign |
|
|
R4672:Megf6
|
UTSW |
4 |
154,333,909 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4688:Megf6
|
UTSW |
4 |
154,338,271 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4752:Megf6
|
UTSW |
4 |
154,336,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4863:Megf6
|
UTSW |
4 |
154,338,738 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4909:Megf6
|
UTSW |
4 |
154,349,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4942:Megf6
|
UTSW |
4 |
154,338,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4981:Megf6
|
UTSW |
4 |
154,351,907 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4990:Megf6
|
UTSW |
4 |
154,351,683 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5189:Megf6
|
UTSW |
4 |
154,336,980 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5210:Megf6
|
UTSW |
4 |
154,354,273 (GRCm39) |
intron |
probably benign |
|
|
R5220:Megf6
|
UTSW |
4 |
154,338,295 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5250:Megf6
|
UTSW |
4 |
154,340,467 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5697:Megf6
|
UTSW |
4 |
154,342,686 (GRCm39) |
missense |
probably null |
0.15 |
|
R5808:Megf6
|
UTSW |
4 |
154,352,119 (GRCm39) |
missense |
probably benign |
|
|
R5916:Megf6
|
UTSW |
4 |
154,333,882 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6054:Megf6
|
UTSW |
4 |
154,347,636 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6075:Megf6
|
UTSW |
4 |
154,347,056 (GRCm39) |
nonsense |
probably null |
|
|
R6515:Megf6
|
UTSW |
4 |
154,343,376 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6599:Megf6
|
UTSW |
4 |
154,342,544 (GRCm39) |
splice site |
probably null |
|
|
R6811:Megf6
|
UTSW |
4 |
154,336,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6925:Megf6
|
UTSW |
4 |
154,339,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Megf6
|
UTSW |
4 |
154,338,602 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7117:Megf6
|
UTSW |
4 |
154,343,379 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7163:Megf6
|
UTSW |
4 |
154,351,898 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7345:Megf6
|
UTSW |
4 |
154,351,772 (GRCm39) |
missense |
probably benign |
|
|
R7580:Megf6
|
UTSW |
4 |
154,355,201 (GRCm39) |
nonsense |
probably null |
|
|
R7649:Megf6
|
UTSW |
4 |
154,349,542 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7702:Megf6
|
UTSW |
4 |
154,354,927 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8010:Megf6
|
UTSW |
4 |
154,354,964 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8175:Megf6
|
UTSW |
4 |
154,353,076 (GRCm39) |
nonsense |
probably null |
|
|
R8231:Megf6
|
UTSW |
4 |
154,336,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8436:Megf6
|
UTSW |
4 |
154,349,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8460:Megf6
|
UTSW |
4 |
154,350,634 (GRCm39) |
nonsense |
probably null |
|
|
R8738:Megf6
|
UTSW |
4 |
154,352,436 (GRCm39) |
missense |
probably benign |
|
|
R8854:Megf6
|
UTSW |
4 |
154,352,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Megf6
|
UTSW |
4 |
154,326,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9098:Megf6
|
UTSW |
4 |
154,354,160 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9147:Megf6
|
UTSW |
4 |
154,339,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9148:Megf6
|
UTSW |
4 |
154,339,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9161:Megf6
|
UTSW |
4 |
154,352,172 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9355:Megf6
|
UTSW |
4 |
154,338,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9386:Megf6
|
UTSW |
4 |
154,340,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9404:Megf6
|
UTSW |
4 |
154,348,225 (GRCm39) |
missense |
|
|
|
R9469:Megf6
|
UTSW |
4 |
154,335,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9472:Megf6
|
UTSW |
4 |
154,333,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9777:Megf6
|
UTSW |
4 |
154,343,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Megf6
|
UTSW |
4 |
154,322,283 (GRCm39) |
missense |
probably benign |
0.12 |
|
Z1177:Megf6
|
UTSW |
4 |
154,354,198 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Megf6
|
UTSW |
4 |
154,352,204 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Megf6
|
UTSW |
4 |
154,352,139 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Megf6
|
UTSW |
4 |
154,352,138 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
Z1177:Megf6
|
UTSW |
4 |
154,335,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTTCACCTCCAGCTTGTG -3'
(R):5'- ACAGGGTTGTGCTCAGTTATC -3'
Sequencing Primer
(F):5'- TGTGTAGCAGACCTCCACC -3'
(R):5'- TCCTCTGGGGTCACACTGATG -3'
|
| Posted On |
2017-05-23 |
Incidental Mutation