Incidental Mutation 'R5967:Grep1'
ID 470678
Institutional Source Beutler Lab
Gene Symbol Grep1
Ensembl Gene ENSMUSG00000043747
Gene Name glycine rich extracellular protein 1
Synonyms 1520401A03Rik
MMRRC Submission 043248-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R5967 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 23923462-23941757 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 23931332 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Tryptophan at position 192 (G192W)
Ref Sequence ENSEMBL: ENSMUSP00000144253 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178006] [ENSMUST00000201734]
AlphaFold A0A0J9YVH6
Predicted Effect noncoding transcript
Transcript: ENSMUST00000062827
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176095
Predicted Effect probably damaging
Transcript: ENSMUST00000178006
AA Change: G192W

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000144253
Gene: ENSMUSG00000043747
AA Change: G192W

DomainStartEndE-ValueType
low complexity region 3 16 N/A INTRINSIC
low complexity region 18 47 N/A INTRINSIC
internal_repeat_1 49 75 7.63e-5 PROSPERO
low complexity region 82 99 N/A INTRINSIC
internal_repeat_1 101 132 7.63e-5 PROSPERO
low complexity region 133 164 N/A INTRINSIC
low complexity region 174 196 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000201734
SMART Domains Protein: ENSMUSP00000144664
Gene: ENSMUSG00000043747

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 61 69 N/A INTRINSIC
low complexity region 72 85 N/A INTRINSIC
low complexity region 87 116 N/A INTRINSIC
internal_repeat_1 117 149 3.72e-8 PROSPERO
low complexity region 151 168 N/A INTRINSIC
low complexity region 202 233 N/A INTRINSIC
low complexity region 238 258 N/A INTRINSIC
internal_repeat_1 268 310 3.72e-8 PROSPERO
low complexity region 518 528 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.4%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agl T A 3: 116,587,357 (GRCm39) D66V probably benign Het
Agrn G A 4: 156,259,560 (GRCm39) P792S probably damaging Het
Angptl2 A G 2: 33,118,718 (GRCm39) N164S probably damaging Het
Birc6 T C 17: 74,967,434 (GRCm39) F4112L probably damaging Het
C8b A G 4: 104,650,530 (GRCm39) E446G possibly damaging Het
Ceacam1 C T 7: 25,174,167 (GRCm39) V163I probably damaging Het
Cngb1 T C 8: 95,978,534 (GRCm39) K1068R probably damaging Het
Gna11 A G 10: 81,366,643 (GRCm39) Y356H probably benign Het
Gnl2 A G 4: 124,934,823 (GRCm39) M160V probably benign Het
Gpsm1 A G 2: 26,230,546 (GRCm39) probably null Het
Gtf2h3 C T 5: 124,722,360 (GRCm39) T121I probably benign Het
Kif20a G T 18: 34,763,580 (GRCm39) R609L probably benign Het
Meis2 G A 2: 115,694,790 (GRCm39) T444I probably benign Het
Muc17 T A 5: 137,175,485 (GRCm39) I62L probably benign Het
Myorg G A 4: 41,497,830 (GRCm39) A600V probably benign Het
Ncor2 C T 5: 125,146,048 (GRCm39) D526N unknown Het
Nodal G T 10: 61,259,446 (GRCm39) E294D probably damaging Het
Nup214 T C 2: 31,869,790 (GRCm39) V161A possibly damaging Het
Or10a48 C T 7: 108,424,921 (GRCm39) G95D probably benign Het
Or5k1b G T 16: 58,580,725 (GRCm39) D271E probably damaging Het
Or5m11b G A 2: 85,806,535 (GRCm39) R316H probably benign Het
Pclo A T 5: 14,590,669 (GRCm39) T990S unknown Het
Piwil2 A T 14: 70,628,013 (GRCm39) M752K probably benign Het
Ppargc1b A G 18: 61,431,837 (GRCm39) S1004P probably damaging Het
Prkd1 A T 12: 50,411,333 (GRCm39) M805K probably damaging Het
Rad23a T C 8: 85,565,568 (GRCm39) E30G probably damaging Het
Ralbp1 A G 17: 66,171,274 (GRCm39) V233A probably benign Het
Scin C T 12: 40,127,537 (GRCm39) E418K probably benign Het
Scn7a T A 2: 66,506,057 (GRCm39) I1611F probably damaging Het
Slit2 A T 5: 48,142,506 (GRCm39) H42L probably damaging Het
Stard9 T A 2: 120,537,375 (GRCm39) V4259D probably damaging Het
Trhde T A 10: 114,403,039 (GRCm39) Y528F probably damaging Het
Txlnb A G 10: 17,675,168 (GRCm39) E107G probably damaging Het
Zfp715 T C 7: 42,948,572 (GRCm39) T463A probably benign Het
Other mutations in Grep1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0332:Grep1 UTSW 17 23,933,578 (GRCm39) splice site probably benign
R1165:Grep1 UTSW 17 23,929,489 (GRCm39) splice site probably benign
R1539:Grep1 UTSW 17 23,936,118 (GRCm39) splice site probably benign
R2968:Grep1 UTSW 17 23,934,785 (GRCm39) missense possibly damaging 0.90
R5459:Grep1 UTSW 17 23,930,817 (GRCm39) intron probably benign
R5800:Grep1 UTSW 17 23,936,966 (GRCm39) missense probably damaging 0.96
R6246:Grep1 UTSW 17 23,929,465 (GRCm39) nonsense probably null
R6306:Grep1 UTSW 17 23,925,124 (GRCm39) missense possibly damaging 0.66
R6892:Grep1 UTSW 17 23,931,328 (GRCm39) missense probably damaging 0.97
R7126:Grep1 UTSW 17 23,939,538 (GRCm39) missense probably benign 0.23
R7264:Grep1 UTSW 17 23,931,308 (GRCm39) missense not run
R7563:Grep1 UTSW 17 23,936,302 (GRCm39) missense probably benign 0.27
R9058:Grep1 UTSW 17 23,935,016 (GRCm39) missense probably benign 0.05
R9323:Grep1 UTSW 17 23,937,387 (GRCm39) missense unknown
R9451:Grep1 UTSW 17 23,936,187 (GRCm39) missense unknown
Z1176:Grep1 UTSW 17 23,934,737 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- TGACCATTCTGAGCTGGAGG -3'
(R):5'- ATGACTATGGACCAGGCAGG -3'

Sequencing Primer
(F):5'- ATTCTGAGCTGGAGGCCCTG -3'
(R):5'- TGTCTTTCCTCCAGGCTACGAAG -3'
Posted On 2017-03-31