Incidental Mutation 'R0511:Recql5'
ID 46946
Institutional Source Beutler Lab
Gene Symbol Recql5
Ensembl Gene ENSMUSG00000020752
Gene Name RecQ protein-like 5
Synonyms Recql5b, Recq5b
MMRRC Submission 038705-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.383) question?
Stock # R0511 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 115783421-115824303 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 115819209 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 119 (D119G)
Ref Sequence ENSEMBL: ENSMUSP00000136506 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021097] [ENSMUST00000131578] [ENSMUST00000134208] [ENSMUST00000140174] [ENSMUST00000140991]
AlphaFold Q8VID5
Predicted Effect probably benign
Transcript: ENSMUST00000021097
AA Change: D119G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000021097
Gene: ENSMUSG00000020752
AA Change: D119G

DomainStartEndE-ValueType
DEXDc 25 230 1.13e-29 SMART
HELICc 274 355 8.68e-22 SMART
Pfam:RecQ_Zn_bind 366 436 1.8e-12 PFAM
low complexity region 472 499 N/A INTRINSIC
PDB:4BK0|B 516 621 2e-51 PDB
Pfam:RecQ5 626 818 3.1e-97 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131578
SMART Domains Protein: ENSMUSP00000136178
Gene: ENSMUSG00000020752

DomainStartEndE-ValueType
HELICc 1 82 8.68e-22 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000134208
SMART Domains Protein: ENSMUSP00000137157
Gene: ENSMUSG00000020752

DomainStartEndE-ValueType
Blast:DEXDc 25 96 4e-34 BLAST
HELICc 160 241 8.68e-22 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134391
Predicted Effect probably benign
Transcript: ENSMUST00000140174
AA Change: D119G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000136506
Gene: ENSMUSG00000020752
AA Change: D119G

DomainStartEndE-ValueType
DEXDc 25 230 1.13e-29 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000140991
SMART Domains Protein: ENSMUSP00000114844
Gene: ENSMUSG00000020755

DomainStartEndE-ValueType
SCOP:d1qbkb_ 4 81 2e-3 SMART
Pfam:HCNGP 119 213 6.5e-38 PFAM
low complexity region 224 248 N/A INTRINSIC
low complexity region 263 289 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156776
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144824
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.8%
Validation Efficiency 100% (116/116)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
PHENOTYPE: Mice homozygous for disruptions in this gene express elevated levels of sister chromatid exchange due to a failure to suppress crossovers. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 118 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm1 A G 3: 59,843,771 (GRCm39) H155R possibly damaging Het
Abca13 G T 11: 9,244,559 (GRCm39) V2141L probably benign Het
Adam17 T C 12: 21,390,459 (GRCm39) probably benign Het
Adam3 A T 8: 25,185,331 (GRCm39) C456S probably damaging Het
Aldh4a1 G T 4: 139,369,882 (GRCm39) probably benign Het
Anapc4 A G 5: 52,999,359 (GRCm39) probably benign Het
Ank3 A T 10: 69,718,198 (GRCm39) Q483L probably damaging Het
Ankle2 A G 5: 110,389,925 (GRCm39) probably benign Het
Ankrd13b T A 11: 77,364,114 (GRCm39) T150S possibly damaging Het
Apeh A G 9: 107,964,254 (GRCm39) M524T probably benign Het
Arl14epl T A 18: 47,059,484 (GRCm39) probably null Het
Atg2a T C 19: 6,302,569 (GRCm39) F964S possibly damaging Het
Atg2b C T 12: 105,583,412 (GRCm39) V2050M probably damaging Het
Atp2b4 A T 1: 133,659,956 (GRCm39) probably benign Het
Bbof1 T A 12: 84,477,045 (GRCm39) S512T probably benign Het
Camta1 C A 4: 151,159,597 (GRCm39) R1614L probably damaging Het
Car10 T C 11: 93,381,408 (GRCm39) Y100H probably damaging Het
Ccdc81 T A 7: 89,542,504 (GRCm39) E124V probably damaging Het
Cd84 A G 1: 171,700,494 (GRCm39) T204A probably benign Het
Celf2 A G 2: 6,608,987 (GRCm39) S178P probably damaging Het
Chat G A 14: 32,130,976 (GRCm39) T555M probably damaging Het
Chd6 A G 2: 160,834,111 (GRCm39) F917S probably damaging Het
Chrna2 C A 14: 66,386,553 (GRCm39) T233N probably damaging Het
Cnpy2 T C 10: 128,162,054 (GRCm39) V109A probably benign Het
Col4a1 T C 8: 11,258,333 (GRCm39) probably null Het
Csmd1 C T 8: 15,982,529 (GRCm39) V2713M possibly damaging Het
Cuedc1 G A 11: 88,074,231 (GRCm39) R255Q probably damaging Het
Cxcl15 A T 5: 90,945,897 (GRCm39) probably benign Het
Dach1 A T 14: 98,138,765 (GRCm39) H559Q possibly damaging Het
Dele1 T C 18: 38,387,124 (GRCm39) probably null Het
Dennd4c C T 4: 86,744,259 (GRCm39) T1367M probably damaging Het
Depdc5 T A 5: 33,102,372 (GRCm39) Y365* probably null Het
Dicer1 T C 12: 104,669,100 (GRCm39) Y1194C possibly damaging Het
Dmxl1 C G 18: 50,024,534 (GRCm39) S1736* probably null Het
Dnah7a C T 1: 53,536,285 (GRCm39) R2586K probably benign Het
Dnajb8 T C 6: 88,199,467 (GRCm39) M1T probably null Het
Dync2h1 G A 9: 7,122,692 (GRCm39) P2088L probably benign Het
Eftud2 T G 11: 102,735,048 (GRCm39) H617P probably damaging Het
Ephb1 A G 9: 101,873,179 (GRCm39) probably benign Het
Fam184a G T 10: 53,574,975 (GRCm39) H155Q probably benign Het
Firrm T C 1: 163,799,412 (GRCm39) probably null Het
Ganc G T 2: 120,278,882 (GRCm39) E700* probably null Het
Gm10912 A G 2: 103,897,290 (GRCm39) probably benign Het
Haus5 A T 7: 30,358,492 (GRCm39) I294N probably damaging Het
Hmgcr G T 13: 96,796,651 (GRCm39) probably null Het
Hr T A 14: 70,799,352 (GRCm39) C641* probably null Het
Itga10 A G 3: 96,565,490 (GRCm39) N1038S probably damaging Het
Itgb1bp1 T G 12: 21,321,436 (GRCm39) Y172S probably damaging Het
Kprp T C 3: 92,732,030 (GRCm39) N340S probably damaging Het
Kremen1 A G 11: 5,165,447 (GRCm39) I41T probably damaging Het
Krt6b A G 15: 101,586,042 (GRCm39) probably benign Het
Krt81 C A 15: 101,361,508 (GRCm39) R24L possibly damaging Het
Ldhd A G 8: 112,356,309 (GRCm39) Y86H probably benign Het
Lilra6 A T 7: 3,915,784 (GRCm39) I76N possibly damaging Het
Mak T C 13: 41,199,743 (GRCm39) T299A probably benign Het
Med25 A G 7: 44,534,502 (GRCm39) probably null Het
Mpg A T 11: 32,180,039 (GRCm39) N189I probably damaging Het
Mroh8 A G 2: 157,071,838 (GRCm39) Y556H probably damaging Het
Myh8 T A 11: 67,175,333 (GRCm39) S294T probably benign Het
Myom1 T A 17: 71,391,312 (GRCm39) D842E probably benign Het
Myorg A G 4: 41,498,538 (GRCm39) F364S probably damaging Het
Nat2 C T 8: 67,953,982 (GRCm39) Q31* probably null Het
Nf1 T A 11: 79,329,595 (GRCm39) M653K probably benign Het
Nhs C A X: 160,620,355 (GRCm39) R1467I probably damaging Het
Npr2 A G 4: 43,632,801 (GRCm39) E206G probably benign Het
Nsd3 G A 8: 26,168,732 (GRCm39) G629D possibly damaging Het
Nwd1 G A 8: 73,408,633 (GRCm39) C831Y probably damaging Het
Or52r1c T C 7: 102,735,058 (GRCm39) I111T probably damaging Het
Or5t9 A G 2: 86,659,950 (GRCm39) I285V probably benign Het
P2ry14 A G 3: 59,023,449 (GRCm39) S4P possibly damaging Het
Parp4 A G 14: 56,873,172 (GRCm39) probably benign Het
Pate14 A T 9: 36,549,873 (GRCm39) probably null Het
Pclo A G 5: 14,728,299 (GRCm39) probably benign Het
Pclo T C 5: 14,729,412 (GRCm39) probably benign Het
Pcnt A T 10: 76,240,429 (GRCm39) S1202T possibly damaging Het
Pfkfb4 A G 9: 108,856,825 (GRCm39) Y412C probably damaging Het
Pgm2 T A 5: 64,267,898 (GRCm39) V449D probably damaging Het
Poldip3 T A 15: 83,022,436 (GRCm39) D116V probably damaging Het
Pom121 G T 5: 135,410,686 (GRCm39) Q824K unknown Het
Prkdc G T 16: 15,649,146 (GRCm39) G3707* probably null Het
Prr14l T C 5: 33,001,560 (GRCm39) probably benign Het
Ptbp2 T G 3: 119,514,613 (GRCm39) I405L probably benign Het
Rad21l A T 2: 151,490,989 (GRCm39) probably benign Het
Rbm6 G A 9: 107,724,488 (GRCm39) Q488* probably null Het
Rdh1 T A 10: 127,600,652 (GRCm39) M225K probably benign Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Robo1 T C 16: 72,810,013 (GRCm39) probably null Het
Samd12 G A 15: 53,723,567 (GRCm39) T42I probably benign Het
Scn10a A T 9: 119,442,766 (GRCm39) M1494K probably damaging Het
Sec31a G A 5: 100,523,099 (GRCm39) P864L probably benign Het
Senp2 T C 16: 21,855,320 (GRCm39) V344A probably benign Het
Serpina5 G A 12: 104,069,621 (GRCm39) D278N probably benign Het
Sh3tc1 A T 5: 35,860,806 (GRCm39) V1017D probably damaging Het
Sin3a T A 9: 57,004,179 (GRCm39) Y310* probably null Het
Slc25a32 T C 15: 38,960,940 (GRCm39) T248A probably benign Het
Slc35e1 T C 8: 73,246,415 (GRCm39) probably benign Het
Slc4a10 G A 2: 62,117,206 (GRCm39) V722M probably damaging Het
Slco1a4 A G 6: 141,776,586 (GRCm39) probably benign Het
Smg6 T A 11: 74,819,884 (GRCm39) Y52N probably damaging Het
Sncb T G 13: 54,913,400 (GRCm39) T33P probably damaging Het
Spef2 A G 15: 9,584,070 (GRCm39) probably null Het
Spmip1 G T 6: 29,478,169 (GRCm39) probably benign Het
Sugp1 A G 8: 70,512,013 (GRCm39) E203G probably damaging Het
Suv39h2 A T 2: 3,473,616 (GRCm39) C105S probably damaging Het
Tlr1 A T 5: 65,083,963 (GRCm39) F205I probably damaging Het
Tnip1 A T 11: 54,808,699 (GRCm39) M496K probably damaging Het
Tnxb G A 17: 34,937,219 (GRCm39) E2889K probably damaging Het
Trim30b T A 7: 104,015,010 (GRCm39) H126L possibly damaging Het
Trpm7 A T 2: 126,668,638 (GRCm39) Y759* probably null Het
Ttc17 A G 2: 94,153,465 (GRCm39) I1000T possibly damaging Het
Ttc27 A T 17: 75,025,710 (GRCm39) N61I probably benign Het
Uba6 T C 5: 86,260,609 (GRCm39) Y990C probably damaging Het
Vav3 A G 3: 109,571,756 (GRCm39) probably benign Het
Vmn2r55 C T 7: 12,404,945 (GRCm39) A153T possibly damaging Het
Wars2 A G 3: 99,123,865 (GRCm39) D242G probably damaging Het
Xylt2 G A 11: 94,560,762 (GRCm39) Q259* probably null Het
Zfp27 G A 7: 29,593,947 (GRCm39) P673S probably damaging Het
Zgrf1 T C 3: 127,378,309 (GRCm39) I1023T possibly damaging Het
Other mutations in Recql5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01108:Recql5 APN 11 115,788,007 (GRCm39) missense probably benign 0.04
IGL01589:Recql5 APN 11 115,785,495 (GRCm39) missense probably damaging 1.00
IGL02040:Recql5 APN 11 115,823,623 (GRCm39) missense possibly damaging 0.89
IGL02131:Recql5 APN 11 115,814,068 (GRCm39) missense probably benign 0.01
IGL02198:Recql5 APN 11 115,785,499 (GRCm39) missense probably benign 0.00
IGL02236:Recql5 APN 11 115,784,856 (GRCm39) missense probably benign 0.01
IGL02501:Recql5 APN 11 115,785,917 (GRCm39) missense probably benign 0.26
IGL02980:Recql5 APN 11 115,784,770 (GRCm39) splice site probably null
IGL03028:Recql5 APN 11 115,785,257 (GRCm39) missense possibly damaging 0.94
PIT4581001:Recql5 UTSW 11 115,823,682 (GRCm39) missense possibly damaging 0.53
R0152:Recql5 UTSW 11 115,785,499 (GRCm39) missense probably benign
R0269:Recql5 UTSW 11 115,819,050 (GRCm39) missense possibly damaging 0.91
R0317:Recql5 UTSW 11 115,785,499 (GRCm39) missense probably benign
R0786:Recql5 UTSW 11 115,786,628 (GRCm39) missense probably benign
R0975:Recql5 UTSW 11 115,814,082 (GRCm39) missense probably damaging 1.00
R1170:Recql5 UTSW 11 115,788,060 (GRCm39) missense probably damaging 0.98
R1208:Recql5 UTSW 11 115,783,982 (GRCm39) missense probably damaging 0.98
R1208:Recql5 UTSW 11 115,783,982 (GRCm39) missense probably damaging 0.98
R1807:Recql5 UTSW 11 115,785,941 (GRCm39) missense possibly damaging 0.63
R1872:Recql5 UTSW 11 115,814,135 (GRCm39) missense probably benign 0.15
R1878:Recql5 UTSW 11 115,785,927 (GRCm39) missense probably benign 0.00
R1935:Recql5 UTSW 11 115,788,017 (GRCm39) missense probably benign 0.00
R1936:Recql5 UTSW 11 115,788,017 (GRCm39) missense probably benign 0.00
R1945:Recql5 UTSW 11 115,819,123 (GRCm39) nonsense probably null
R2011:Recql5 UTSW 11 115,787,923 (GRCm39) missense probably benign 0.20
R2012:Recql5 UTSW 11 115,787,923 (GRCm39) missense probably benign 0.20
R2023:Recql5 UTSW 11 115,784,466 (GRCm39) missense probably benign
R2183:Recql5 UTSW 11 115,787,613 (GRCm39) missense probably benign 0.00
R3881:Recql5 UTSW 11 115,784,781 (GRCm39) missense probably benign 0.00
R3881:Recql5 UTSW 11 115,784,780 (GRCm39) missense probably benign
R4093:Recql5 UTSW 11 115,795,714 (GRCm39) missense probably benign 0.05
R4857:Recql5 UTSW 11 115,819,038 (GRCm39) missense probably damaging 1.00
R5245:Recql5 UTSW 11 115,784,385 (GRCm39) missense probably damaging 1.00
R5323:Recql5 UTSW 11 115,818,215 (GRCm39) missense probably damaging 1.00
R5796:Recql5 UTSW 11 115,818,691 (GRCm39) intron probably benign
R6160:Recql5 UTSW 11 115,823,613 (GRCm39) critical splice donor site probably null
R6229:Recql5 UTSW 11 115,821,540 (GRCm39) missense probably damaging 0.96
R6824:Recql5 UTSW 11 115,814,038 (GRCm39) missense possibly damaging 0.83
R7013:Recql5 UTSW 11 115,785,402 (GRCm39) missense probably benign 0.02
R7043:Recql5 UTSW 11 115,821,502 (GRCm39) critical splice donor site probably null
R7135:Recql5 UTSW 11 115,821,498 (GRCm39) splice site probably null
R7354:Recql5 UTSW 11 115,819,027 (GRCm39) missense probably damaging 1.00
R7373:Recql5 UTSW 11 115,819,198 (GRCm39) missense possibly damaging 0.92
R7503:Recql5 UTSW 11 115,785,881 (GRCm39) missense probably benign 0.00
R7574:Recql5 UTSW 11 115,819,248 (GRCm39) missense probably benign
R7597:Recql5 UTSW 11 115,819,207 (GRCm39) missense probably benign 0.03
R7658:Recql5 UTSW 11 115,814,102 (GRCm39) missense probably damaging 1.00
R8025:Recql5 UTSW 11 115,818,938 (GRCm39) missense probably damaging 1.00
R8038:Recql5 UTSW 11 115,818,178 (GRCm39) missense possibly damaging 0.90
R8316:Recql5 UTSW 11 115,784,861 (GRCm39) missense possibly damaging 0.46
R8463:Recql5 UTSW 11 115,787,619 (GRCm39) nonsense probably null
R8770:Recql5 UTSW 11 115,787,943 (GRCm39) missense probably benign 0.00
R8788:Recql5 UTSW 11 115,786,628 (GRCm39) missense probably benign
R9083:Recql5 UTSW 11 115,785,475 (GRCm39) missense possibly damaging 0.46
R9653:Recql5 UTSW 11 115,788,032 (GRCm39) missense probably benign 0.01
R9711:Recql5 UTSW 11 115,784,367 (GRCm39) missense probably damaging 1.00
X0026:Recql5 UTSW 11 115,814,087 (GRCm39) missense probably damaging 1.00
X0028:Recql5 UTSW 11 115,785,432 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GGGCAGCAAACACATCCTCTTGAAC -3'
(R):5'- TCCTGAGGACTCATGATGCTCCAC -3'

Sequencing Primer
(F):5'- TGTAGCCGTCAGAGCCAC -3'
(R):5'- ATGATGCTCCACTCCGTATTC -3'
Posted On 2013-06-11