Incidental Mutation 'R0511:Chd6'
| ID |
46875 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Chd6
|
| Ensembl Gene |
ENSMUSG00000057133 |
| Gene Name |
chromodomain helicase DNA binding protein 6 |
| Synonyms |
5430439G14Rik, 6330406J24Rik |
| MMRRC Submission |
038705-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.745)
|
| Stock # |
R0511 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
160788898-160950995 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 160834111 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 917
(F917S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000042291
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000039782]
[ENSMUST00000134178]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000039782
AA Change: F917S
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000042291
Gene: ENSMUSG00000057133
AA Change: F917S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
106 |
N/A |
INTRINSIC |
|
low complexity region
|
113 |
143 |
N/A |
INTRINSIC |
|
low complexity region
|
214 |
229 |
N/A |
INTRINSIC |
|
CHROMO
|
289 |
355 |
1.35e-4 |
SMART |
|
CHROMO
|
372 |
430 |
3.48e-7 |
SMART |
|
DEXDc
|
456 |
658 |
1.73e-39 |
SMART |
|
HELICc
|
812 |
896 |
3.84e-23 |
SMART |
|
low complexity region
|
1080 |
1094 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
1108 |
1153 |
4e-23 |
BLAST |
|
SANT
|
1445 |
1504 |
1.51e0 |
SMART |
|
low complexity region
|
1866 |
1875 |
N/A |
INTRINSIC |
|
low complexity region
|
2048 |
2057 |
N/A |
INTRINSIC |
|
low complexity region
|
2130 |
2140 |
N/A |
INTRINSIC |
|
low complexity region
|
2277 |
2290 |
N/A |
INTRINSIC |
|
low complexity region
|
2333 |
2349 |
N/A |
INTRINSIC |
|
low complexity region
|
2437 |
2446 |
N/A |
INTRINSIC |
|
low complexity region
|
2539 |
2563 |
N/A |
INTRINSIC |
|
low complexity region
|
2652 |
2659 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000104607
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000134178
AA Change: F916S
PolyPhen 2
Score 0.698 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000123240
Gene: ENSMUSG00000057133
AA Change: F916S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
106 |
N/A |
INTRINSIC |
|
low complexity region
|
113 |
143 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
228 |
N/A |
INTRINSIC |
|
CHROMO
|
288 |
354 |
1.35e-4 |
SMART |
|
CHROMO
|
371 |
429 |
3.48e-7 |
SMART |
|
DEXDc
|
455 |
657 |
1.73e-39 |
SMART |
|
HELICc
|
811 |
895 |
3.84e-23 |
SMART |
|
low complexity region
|
1079 |
1093 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
1107 |
1152 |
4e-23 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149866
|
| Meta Mutation Damage Score |
0.8999 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.8%
|
| Validation Efficiency |
100% (116/116) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of the chromodomain/helicase/DNA-binding domain family of chromatin remodeling enzymes. This protein has been found to be specifically involved in transcription initiation and elongation. Homozygous knockout mice exhibit impaired motor coordination. A pseudogene has been identified on chromosome 8. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
PHENOTYPE: Homozygous null mice display impaired coordination that is not due to muscle weakness or bradykinesia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 118 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2fm1 |
A |
G |
3: 59,843,771 (GRCm39) |
H155R |
possibly damaging |
Het |
| Abca13 |
G |
T |
11: 9,244,559 (GRCm39) |
V2141L |
probably benign |
Het |
| Adam17 |
T |
C |
12: 21,390,459 (GRCm39) |
|
probably benign |
Het |
| Adam3 |
A |
T |
8: 25,185,331 (GRCm39) |
C456S |
probably damaging |
Het |
| Aldh4a1 |
G |
T |
4: 139,369,882 (GRCm39) |
|
probably benign |
Het |
| Anapc4 |
A |
G |
5: 52,999,359 (GRCm39) |
|
probably benign |
Het |
| Ank3 |
A |
T |
10: 69,718,198 (GRCm39) |
Q483L |
probably damaging |
Het |
| Ankle2 |
A |
G |
5: 110,389,925 (GRCm39) |
|
probably benign |
Het |
| Ankrd13b |
T |
A |
11: 77,364,114 (GRCm39) |
T150S |
possibly damaging |
Het |
| Apeh |
A |
G |
9: 107,964,254 (GRCm39) |
M524T |
probably benign |
Het |
| Arl14epl |
T |
A |
18: 47,059,484 (GRCm39) |
|
probably null |
Het |
| Atg2a |
T |
C |
19: 6,302,569 (GRCm39) |
F964S |
possibly damaging |
Het |
| Atg2b |
C |
T |
12: 105,583,412 (GRCm39) |
V2050M |
probably damaging |
Het |
| Atp2b4 |
A |
T |
1: 133,659,956 (GRCm39) |
|
probably benign |
Het |
| Bbof1 |
T |
A |
12: 84,477,045 (GRCm39) |
S512T |
probably benign |
Het |
| Camta1 |
C |
A |
4: 151,159,597 (GRCm39) |
R1614L |
probably damaging |
Het |
| Car10 |
T |
C |
11: 93,381,408 (GRCm39) |
Y100H |
probably damaging |
Het |
| Ccdc81 |
T |
A |
7: 89,542,504 (GRCm39) |
E124V |
probably damaging |
Het |
| Cd84 |
A |
G |
1: 171,700,494 (GRCm39) |
T204A |
probably benign |
Het |
| Celf2 |
A |
G |
2: 6,608,987 (GRCm39) |
S178P |
probably damaging |
Het |
| Chat |
G |
A |
14: 32,130,976 (GRCm39) |
T555M |
probably damaging |
Het |
| Chrna2 |
C |
A |
14: 66,386,553 (GRCm39) |
T233N |
probably damaging |
Het |
| Cnpy2 |
T |
C |
10: 128,162,054 (GRCm39) |
V109A |
probably benign |
Het |
| Col4a1 |
T |
C |
8: 11,258,333 (GRCm39) |
|
probably null |
Het |
| Csmd1 |
C |
T |
8: 15,982,529 (GRCm39) |
V2713M |
possibly damaging |
Het |
| Cuedc1 |
G |
A |
11: 88,074,231 (GRCm39) |
R255Q |
probably damaging |
Het |
| Cxcl15 |
A |
T |
5: 90,945,897 (GRCm39) |
|
probably benign |
Het |
| Dach1 |
A |
T |
14: 98,138,765 (GRCm39) |
H559Q |
possibly damaging |
Het |
| Dele1 |
T |
C |
18: 38,387,124 (GRCm39) |
|
probably null |
Het |
| Dennd4c |
C |
T |
4: 86,744,259 (GRCm39) |
T1367M |
probably damaging |
Het |
| Depdc5 |
T |
A |
5: 33,102,372 (GRCm39) |
Y365* |
probably null |
Het |
| Dicer1 |
T |
C |
12: 104,669,100 (GRCm39) |
Y1194C |
possibly damaging |
Het |
| Dmxl1 |
C |
G |
18: 50,024,534 (GRCm39) |
S1736* |
probably null |
Het |
| Dnah7a |
C |
T |
1: 53,536,285 (GRCm39) |
R2586K |
probably benign |
Het |
| Dnajb8 |
T |
C |
6: 88,199,467 (GRCm39) |
M1T |
probably null |
Het |
| Dync2h1 |
G |
A |
9: 7,122,692 (GRCm39) |
P2088L |
probably benign |
Het |
| Eftud2 |
T |
G |
11: 102,735,048 (GRCm39) |
H617P |
probably damaging |
Het |
| Ephb1 |
A |
G |
9: 101,873,179 (GRCm39) |
|
probably benign |
Het |
| Fam184a |
G |
T |
10: 53,574,975 (GRCm39) |
H155Q |
probably benign |
Het |
| Firrm |
T |
C |
1: 163,799,412 (GRCm39) |
|
probably null |
Het |
| Ganc |
G |
T |
2: 120,278,882 (GRCm39) |
E700* |
probably null |
Het |
| Gm10912 |
A |
G |
2: 103,897,290 (GRCm39) |
|
probably benign |
Het |
| Haus5 |
A |
T |
7: 30,358,492 (GRCm39) |
I294N |
probably damaging |
Het |
| Hmgcr |
G |
T |
13: 96,796,651 (GRCm39) |
|
probably null |
Het |
| Hr |
T |
A |
14: 70,799,352 (GRCm39) |
C641* |
probably null |
Het |
| Itga10 |
A |
G |
3: 96,565,490 (GRCm39) |
N1038S |
probably damaging |
Het |
| Itgb1bp1 |
T |
G |
12: 21,321,436 (GRCm39) |
Y172S |
probably damaging |
Het |
| Kprp |
T |
C |
3: 92,732,030 (GRCm39) |
N340S |
probably damaging |
Het |
| Kremen1 |
A |
G |
11: 5,165,447 (GRCm39) |
I41T |
probably damaging |
Het |
| Krt6b |
A |
G |
15: 101,586,042 (GRCm39) |
|
probably benign |
Het |
| Krt81 |
C |
A |
15: 101,361,508 (GRCm39) |
R24L |
possibly damaging |
Het |
| Ldhd |
A |
G |
8: 112,356,309 (GRCm39) |
Y86H |
probably benign |
Het |
| Lilra6 |
A |
T |
7: 3,915,784 (GRCm39) |
I76N |
possibly damaging |
Het |
| Mak |
T |
C |
13: 41,199,743 (GRCm39) |
T299A |
probably benign |
Het |
| Med25 |
A |
G |
7: 44,534,502 (GRCm39) |
|
probably null |
Het |
| Mpg |
A |
T |
11: 32,180,039 (GRCm39) |
N189I |
probably damaging |
Het |
| Mroh8 |
A |
G |
2: 157,071,838 (GRCm39) |
Y556H |
probably damaging |
Het |
| Myh8 |
T |
A |
11: 67,175,333 (GRCm39) |
S294T |
probably benign |
Het |
| Myom1 |
T |
A |
17: 71,391,312 (GRCm39) |
D842E |
probably benign |
Het |
| Myorg |
A |
G |
4: 41,498,538 (GRCm39) |
F364S |
probably damaging |
Het |
| Nat2 |
C |
T |
8: 67,953,982 (GRCm39) |
Q31* |
probably null |
Het |
| Nf1 |
T |
A |
11: 79,329,595 (GRCm39) |
M653K |
probably benign |
Het |
| Nhs |
C |
A |
X: 160,620,355 (GRCm39) |
R1467I |
probably damaging |
Het |
| Npr2 |
A |
G |
4: 43,632,801 (GRCm39) |
E206G |
probably benign |
Het |
| Nsd3 |
G |
A |
8: 26,168,732 (GRCm39) |
G629D |
possibly damaging |
Het |
| Nwd1 |
G |
A |
8: 73,408,633 (GRCm39) |
C831Y |
probably damaging |
Het |
| Or52r1c |
T |
C |
7: 102,735,058 (GRCm39) |
I111T |
probably damaging |
Het |
| Or5t9 |
A |
G |
2: 86,659,950 (GRCm39) |
I285V |
probably benign |
Het |
| P2ry14 |
A |
G |
3: 59,023,449 (GRCm39) |
S4P |
possibly damaging |
Het |
| Parp4 |
A |
G |
14: 56,873,172 (GRCm39) |
|
probably benign |
Het |
| Pate14 |
A |
T |
9: 36,549,873 (GRCm39) |
|
probably null |
Het |
| Pclo |
A |
G |
5: 14,728,299 (GRCm39) |
|
probably benign |
Het |
| Pclo |
T |
C |
5: 14,729,412 (GRCm39) |
|
probably benign |
Het |
| Pcnt |
A |
T |
10: 76,240,429 (GRCm39) |
S1202T |
possibly damaging |
Het |
| Pfkfb4 |
A |
G |
9: 108,856,825 (GRCm39) |
Y412C |
probably damaging |
Het |
| Pgm2 |
T |
A |
5: 64,267,898 (GRCm39) |
V449D |
probably damaging |
Het |
| Poldip3 |
T |
A |
15: 83,022,436 (GRCm39) |
D116V |
probably damaging |
Het |
| Pom121 |
G |
T |
5: 135,410,686 (GRCm39) |
Q824K |
unknown |
Het |
| Prkdc |
G |
T |
16: 15,649,146 (GRCm39) |
G3707* |
probably null |
Het |
| Prr14l |
T |
C |
5: 33,001,560 (GRCm39) |
|
probably benign |
Het |
| Ptbp2 |
T |
G |
3: 119,514,613 (GRCm39) |
I405L |
probably benign |
Het |
| Rad21l |
A |
T |
2: 151,490,989 (GRCm39) |
|
probably benign |
Het |
| Rbm6 |
G |
A |
9: 107,724,488 (GRCm39) |
Q488* |
probably null |
Het |
| Rdh1 |
T |
A |
10: 127,600,652 (GRCm39) |
M225K |
probably benign |
Het |
| Recql5 |
T |
C |
11: 115,819,209 (GRCm39) |
D119G |
probably benign |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,000,336 (GRCm39) |
|
probably benign |
Het |
| Robo1 |
T |
C |
16: 72,810,013 (GRCm39) |
|
probably null |
Het |
| Samd12 |
G |
A |
15: 53,723,567 (GRCm39) |
T42I |
probably benign |
Het |
| Scn10a |
A |
T |
9: 119,442,766 (GRCm39) |
M1494K |
probably damaging |
Het |
| Sec31a |
G |
A |
5: 100,523,099 (GRCm39) |
P864L |
probably benign |
Het |
| Senp2 |
T |
C |
16: 21,855,320 (GRCm39) |
V344A |
probably benign |
Het |
| Serpina5 |
G |
A |
12: 104,069,621 (GRCm39) |
D278N |
probably benign |
Het |
| Sh3tc1 |
A |
T |
5: 35,860,806 (GRCm39) |
V1017D |
probably damaging |
Het |
| Sin3a |
T |
A |
9: 57,004,179 (GRCm39) |
Y310* |
probably null |
Het |
| Slc25a32 |
T |
C |
15: 38,960,940 (GRCm39) |
T248A |
probably benign |
Het |
| Slc35e1 |
T |
C |
8: 73,246,415 (GRCm39) |
|
probably benign |
Het |
| Slc4a10 |
G |
A |
2: 62,117,206 (GRCm39) |
V722M |
probably damaging |
Het |
| Slco1a4 |
A |
G |
6: 141,776,586 (GRCm39) |
|
probably benign |
Het |
| Smg6 |
T |
A |
11: 74,819,884 (GRCm39) |
Y52N |
probably damaging |
Het |
| Sncb |
T |
G |
13: 54,913,400 (GRCm39) |
T33P |
probably damaging |
Het |
| Spef2 |
A |
G |
15: 9,584,070 (GRCm39) |
|
probably null |
Het |
| Spmip1 |
G |
T |
6: 29,478,169 (GRCm39) |
|
probably benign |
Het |
| Sugp1 |
A |
G |
8: 70,512,013 (GRCm39) |
E203G |
probably damaging |
Het |
| Suv39h2 |
A |
T |
2: 3,473,616 (GRCm39) |
C105S |
probably damaging |
Het |
| Tlr1 |
A |
T |
5: 65,083,963 (GRCm39) |
F205I |
probably damaging |
Het |
| Tnip1 |
A |
T |
11: 54,808,699 (GRCm39) |
M496K |
probably damaging |
Het |
| Tnxb |
G |
A |
17: 34,937,219 (GRCm39) |
E2889K |
probably damaging |
Het |
| Trim30b |
T |
A |
7: 104,015,010 (GRCm39) |
H126L |
possibly damaging |
Het |
| Trpm7 |
A |
T |
2: 126,668,638 (GRCm39) |
Y759* |
probably null |
Het |
| Ttc17 |
A |
G |
2: 94,153,465 (GRCm39) |
I1000T |
possibly damaging |
Het |
| Ttc27 |
A |
T |
17: 75,025,710 (GRCm39) |
N61I |
probably benign |
Het |
| Uba6 |
T |
C |
5: 86,260,609 (GRCm39) |
Y990C |
probably damaging |
Het |
| Vav3 |
A |
G |
3: 109,571,756 (GRCm39) |
|
probably benign |
Het |
| Vmn2r55 |
C |
T |
7: 12,404,945 (GRCm39) |
A153T |
possibly damaging |
Het |
| Wars2 |
A |
G |
3: 99,123,865 (GRCm39) |
D242G |
probably damaging |
Het |
| Xylt2 |
G |
A |
11: 94,560,762 (GRCm39) |
Q259* |
probably null |
Het |
| Zfp27 |
G |
A |
7: 29,593,947 (GRCm39) |
P673S |
probably damaging |
Het |
| Zgrf1 |
T |
C |
3: 127,378,309 (GRCm39) |
I1023T |
possibly damaging |
Het |
|
| Other mutations in Chd6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00837:Chd6
|
APN |
2 |
160,883,999 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00899:Chd6
|
APN |
2 |
160,871,218 (GRCm39) |
splice site |
probably benign |
|
|
IGL01104:Chd6
|
APN |
2 |
160,803,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01295:Chd6
|
APN |
2 |
160,830,290 (GRCm39) |
splice site |
probably benign |
|
|
IGL01717:Chd6
|
APN |
2 |
160,807,179 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL01795:Chd6
|
APN |
2 |
160,803,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01814:Chd6
|
APN |
2 |
160,901,849 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02016:Chd6
|
APN |
2 |
160,825,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02104:Chd6
|
APN |
2 |
160,819,432 (GRCm39) |
missense |
probably benign |
|
|
IGL02158:Chd6
|
APN |
2 |
160,868,212 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL02313:Chd6
|
APN |
2 |
160,807,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02472:Chd6
|
APN |
2 |
160,826,372 (GRCm39) |
splice site |
probably benign |
|
|
IGL02522:Chd6
|
APN |
2 |
160,807,716 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL02626:Chd6
|
APN |
2 |
160,881,270 (GRCm39) |
splice site |
probably benign |
|
|
IGL02727:Chd6
|
APN |
2 |
160,811,383 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02738:Chd6
|
APN |
2 |
160,807,618 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02743:Chd6
|
APN |
2 |
160,802,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02800:Chd6
|
APN |
2 |
160,826,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02811:Chd6
|
APN |
2 |
160,832,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02850:Chd6
|
APN |
2 |
160,861,536 (GRCm39) |
nonsense |
probably null |
|
|
IGL02979:Chd6
|
APN |
2 |
160,808,090 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02993:Chd6
|
APN |
2 |
160,894,304 (GRCm39) |
splice site |
probably benign |
|
|
IGL03277:Chd6
|
APN |
2 |
160,824,981 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL03346:Chd6
|
APN |
2 |
160,802,282 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03357:Chd6
|
APN |
2 |
160,859,936 (GRCm39) |
splice site |
probably benign |
|
|
IGL03134:Chd6
|
UTSW |
2 |
160,807,403 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0106:Chd6
|
UTSW |
2 |
160,809,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Chd6
|
UTSW |
2 |
160,809,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0212:Chd6
|
UTSW |
2 |
160,894,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0363:Chd6
|
UTSW |
2 |
160,856,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0399:Chd6
|
UTSW |
2 |
160,894,608 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0771:Chd6
|
UTSW |
2 |
160,861,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1147:Chd6
|
UTSW |
2 |
160,832,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1147:Chd6
|
UTSW |
2 |
160,832,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Chd6
|
UTSW |
2 |
160,872,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1277:Chd6
|
UTSW |
2 |
160,809,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1396:Chd6
|
UTSW |
2 |
160,825,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1647:Chd6
|
UTSW |
2 |
160,883,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Chd6
|
UTSW |
2 |
160,883,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1745:Chd6
|
UTSW |
2 |
160,823,587 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1766:Chd6
|
UTSW |
2 |
160,808,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1871:Chd6
|
UTSW |
2 |
160,832,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1928:Chd6
|
UTSW |
2 |
160,809,920 (GRCm39) |
splice site |
probably benign |
|
|
R1973:Chd6
|
UTSW |
2 |
160,808,307 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2200:Chd6
|
UTSW |
2 |
160,825,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2340:Chd6
|
UTSW |
2 |
160,807,679 (GRCm39) |
frame shift |
probably null |
|
|
R2341:Chd6
|
UTSW |
2 |
160,807,679 (GRCm39) |
frame shift |
probably null |
|
|
R2519:Chd6
|
UTSW |
2 |
160,871,796 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2919:Chd6
|
UTSW |
2 |
160,809,800 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3025:Chd6
|
UTSW |
2 |
160,808,472 (GRCm39) |
small deletion |
probably benign |
|
|
R3426:Chd6
|
UTSW |
2 |
160,832,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3427:Chd6
|
UTSW |
2 |
160,832,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4042:Chd6
|
UTSW |
2 |
160,830,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4273:Chd6
|
UTSW |
2 |
160,803,211 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4360:Chd6
|
UTSW |
2 |
160,791,776 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R4399:Chd6
|
UTSW |
2 |
160,807,238 (GRCm39) |
missense |
probably benign |
|
|
R4458:Chd6
|
UTSW |
2 |
160,871,796 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4583:Chd6
|
UTSW |
2 |
160,856,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4625:Chd6
|
UTSW |
2 |
160,811,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4740:Chd6
|
UTSW |
2 |
160,812,103 (GRCm39) |
missense |
probably benign |
|
|
R4765:Chd6
|
UTSW |
2 |
160,808,164 (GRCm39) |
nonsense |
probably null |
|
|
R4779:Chd6
|
UTSW |
2 |
160,791,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4877:Chd6
|
UTSW |
2 |
160,871,219 (GRCm39) |
splice site |
probably benign |
|
|
R5068:Chd6
|
UTSW |
2 |
160,808,289 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R5215:Chd6
|
UTSW |
2 |
160,791,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5275:Chd6
|
UTSW |
2 |
160,811,283 (GRCm39) |
missense |
probably benign |
|
|
R5405:Chd6
|
UTSW |
2 |
160,807,310 (GRCm39) |
missense |
probably benign |
|
|
R5598:Chd6
|
UTSW |
2 |
160,856,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5693:Chd6
|
UTSW |
2 |
160,807,185 (GRCm39) |
missense |
probably benign |
|
|
R5697:Chd6
|
UTSW |
2 |
160,859,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5715:Chd6
|
UTSW |
2 |
160,791,798 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5759:Chd6
|
UTSW |
2 |
160,825,682 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5761:Chd6
|
UTSW |
2 |
160,798,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5761:Chd6
|
UTSW |
2 |
160,798,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5954:Chd6
|
UTSW |
2 |
160,807,747 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6025:Chd6
|
UTSW |
2 |
160,807,502 (GRCm39) |
missense |
probably benign |
|
|
R6104:Chd6
|
UTSW |
2 |
160,856,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6247:Chd6
|
UTSW |
2 |
160,791,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6393:Chd6
|
UTSW |
2 |
160,821,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6452:Chd6
|
UTSW |
2 |
160,807,418 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R6468:Chd6
|
UTSW |
2 |
160,854,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6784:Chd6
|
UTSW |
2 |
160,808,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6803:Chd6
|
UTSW |
2 |
160,802,279 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6869:Chd6
|
UTSW |
2 |
160,807,650 (GRCm39) |
missense |
probably benign |
|
|
R6895:Chd6
|
UTSW |
2 |
160,830,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6925:Chd6
|
UTSW |
2 |
160,855,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7061:Chd6
|
UTSW |
2 |
160,867,885 (GRCm39) |
nonsense |
probably null |
|
|
R7064:Chd6
|
UTSW |
2 |
160,791,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7248:Chd6
|
UTSW |
2 |
160,803,199 (GRCm39) |
nonsense |
probably null |
|
|
R7287:Chd6
|
UTSW |
2 |
160,850,312 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7431:Chd6
|
UTSW |
2 |
160,868,248 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7486:Chd6
|
UTSW |
2 |
160,791,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7509:Chd6
|
UTSW |
2 |
160,855,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7699:Chd6
|
UTSW |
2 |
160,867,863 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7748:Chd6
|
UTSW |
2 |
160,808,539 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7785:Chd6
|
UTSW |
2 |
160,812,095 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R8002:Chd6
|
UTSW |
2 |
160,832,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8261:Chd6
|
UTSW |
2 |
160,799,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8317:Chd6
|
UTSW |
2 |
160,832,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8388:Chd6
|
UTSW |
2 |
160,861,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8865:Chd6
|
UTSW |
2 |
160,862,989 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8867:Chd6
|
UTSW |
2 |
160,862,989 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8996:Chd6
|
UTSW |
2 |
160,823,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9091:Chd6
|
UTSW |
2 |
160,871,793 (GRCm39) |
nonsense |
probably null |
|
|
R9270:Chd6
|
UTSW |
2 |
160,871,793 (GRCm39) |
nonsense |
probably null |
|
|
R9310:Chd6
|
UTSW |
2 |
160,881,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Chd6
|
UTSW |
2 |
160,871,784 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9438:Chd6
|
UTSW |
2 |
160,799,078 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9756:Chd6
|
UTSW |
2 |
160,802,259 (GRCm39) |
missense |
probably benign |
|
|
Z1088:Chd6
|
UTSW |
2 |
160,808,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCAGTCTGACTCAGAGAGCCATC -3'
(R):5'- CATTCACAGAGGTAGAGCAGCATCC -3'
Sequencing Primer
(F):5'- CTGTCTGGTGCTGCAATCAAAG -3'
(R):5'- TACCCAAGAGTCTGTGAACCTG -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation