Mutagenetix > Incidental Mutation

Incidental Mutation 'R0511:Celf2'

46866

Institutional Source

Beutler Lab

Gene Symbol

Celf2

Ensembl Gene

ENSMUSG00000002107

Gene Name

CUGBP, Elav-like family member 2

Synonyms

Cugbp2, B230345P09Rik, Napor-2, ETR-3

MMRRC Submission

038705-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.449) question?

Stock #

R0511 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

6544505-7401345 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 6608987 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 178 (S178P)

Ref Sequence

ENSEMBL: ENSMUSP00000138359 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000002176] [ENSMUST00000100429] [ENSMUST00000114924] [ENSMUST00000114927] [ENSMUST00000114934] [ENSMUST00000142941] [ENSMUST00000182879] [ENSMUST00000183091] [ENSMUST00000183984] [ENSMUST00000182851] [ENSMUST00000182404] [ENSMUST00000183209] [ENSMUST00000170438] [ENSMUST00000182706] [ENSMUST00000150624]

AlphaFold

Q9Z0H4

Predicted Effect

probably damaging
Transcript: ENSMUST00000002176
AA Change: S178P

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000002176
Gene: ENSMUSG00000002107
AA Change: S178P

Domain	Start	End	E-Value	Type
RRM	17	95	1.29e-17	SMART
RRM	109	184	4.22e-22	SMART
low complexity region	194	223	N/A	INTRINSIC
low complexity region	252	279	N/A	INTRINSIC
low complexity region	281	293	N/A	INTRINSIC
low complexity region	326	355	N/A	INTRINSIC
low complexity region	379	392	N/A	INTRINSIC
RRM	400	473	3.2e-22	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000100429
AA Change: S178P

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000097996
Gene: ENSMUSG00000002107
AA Change: S178P

Domain	Start	End	E-Value	Type
RRM	17	95	1.29e-17	SMART
RRM	109	184	4.22e-22	SMART
low complexity region	194	223	N/A	INTRINSIC
low complexity region	252	279	N/A	INTRINSIC
low complexity region	281	293	N/A	INTRINSIC
low complexity region	341	362	N/A	INTRINSIC
low complexity region	385	398	N/A	INTRINSIC
RRM	406	479	3.2e-22	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000114924
AA Change: S220P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000110574
Gene: ENSMUSG00000002107
AA Change: S220P

Domain	Start	End	E-Value	Type
RRM	59	137	1.29e-17	SMART
RRM	151	226	4.22e-22	SMART
low complexity region	236	265	N/A	INTRINSIC
low complexity region	294	321	N/A	INTRINSIC
low complexity region	323	335	N/A	INTRINSIC
low complexity region	368	397	N/A	INTRINSIC
low complexity region	421	434	N/A	INTRINSIC
RRM	442	515	3.2e-22	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000114927
AA Change: S178P

PolyPhen 2 Score 0.826 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000110577
Gene: ENSMUSG00000002107
AA Change: S178P

Domain	Start	End	E-Value	Type
RRM	17	95	1.29e-17	SMART
RRM	109	184	4.22e-22	SMART
low complexity region	194	223	N/A	INTRINSIC
low complexity region	252	279	N/A	INTRINSIC
low complexity region	281	293	N/A	INTRINSIC
low complexity region	341	359	N/A	INTRINSIC
low complexity region	383	396	N/A	INTRINSIC
RRM	404	477	3.2e-22	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000114934
AA Change: S220P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000110584
Gene: ENSMUSG00000002107
AA Change: S220P

Domain	Start	End	E-Value	Type
RRM	59	137	1.29e-17	SMART
RRM	151	226	4.22e-22	SMART
low complexity region	236	265	N/A	INTRINSIC
low complexity region	294	321	N/A	INTRINSIC
low complexity region	323	335	N/A	INTRINSIC
low complexity region	368	397	N/A	INTRINSIC
low complexity region	421	434	N/A	INTRINSIC
RRM	442	515	3.2e-22	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138347

SMART Domains

Protein: ENSMUSP00000114914
Gene: ENSMUSG00000002107

Domain	Start	End	E-Value	Type
RRM	24	102	1.29e-17	SMART
RRM	116	184	1.64e-19	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000142941
AA Change: S178P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000120459
Gene: ENSMUSG00000002107
AA Change: S178P

Domain	Start	End	E-Value	Type
RRM	17	95	1.29e-17	SMART
RRM	109	184	4.22e-22	SMART
low complexity region	194	223	N/A	INTRINSIC
low complexity region	252	279	N/A	INTRINSIC
low complexity region	281	293	N/A	INTRINSIC
low complexity region	341	362	N/A	INTRINSIC
low complexity region	385	398	N/A	INTRINSIC
RRM	406	479	3.2e-22	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000182879
AA Change: S178P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000138359
Gene: ENSMUSG00000002107
AA Change: S178P

Domain	Start	End	E-Value	Type
RRM	17	95	1.29e-17	SMART
RRM	109	184	4.22e-22	SMART
low complexity region	194	223	N/A	INTRINSIC
low complexity region	252	279	N/A	INTRINSIC
low complexity region	281	293	N/A	INTRINSIC
RRM	346	429	4.92e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000183091
AA Change: S202P

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000138795
Gene: ENSMUSG00000002107
AA Change: S202P

Domain	Start	End	E-Value	Type
RRM	41	119	1.29e-17	SMART
RRM	133	208	4.22e-22	SMART
low complexity region	218	247	N/A	INTRINSIC
low complexity region	276	303	N/A	INTRINSIC
low complexity region	305	317	N/A	INTRINSIC
RRM	366	449	4.92e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000183984
AA Change: S265P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000138974
Gene: ENSMUSG00000002107
AA Change: S265P

Domain	Start	End	E-Value	Type
low complexity region	2	54	N/A	INTRINSIC
RRM	104	182	1.29e-17	SMART
RRM	196	271	4.22e-22	SMART
low complexity region	281	310	N/A	INTRINSIC
low complexity region	339	366	N/A	INTRINSIC
low complexity region	368	380	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000182851
AA Change: S202P

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000138363
Gene: ENSMUSG00000002107
AA Change: S202P

Domain	Start	End	E-Value	Type
RRM	41	119	1.29e-17	SMART
RRM	133	208	4.22e-22	SMART
low complexity region	218	247	N/A	INTRINSIC
low complexity region	276	303	N/A	INTRINSIC
low complexity region	305	317	N/A	INTRINSIC
low complexity region	350	379	N/A	INTRINSIC
low complexity region	403	416	N/A	INTRINSIC
RRM	424	497	3.2e-22	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000182404
AA Change: S91P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000138769
Gene: ENSMUSG00000002107
AA Change: S91P

Domain	Start	End	E-Value	Type
RRM	22	97	4.22e-22	SMART
low complexity region	107	136	N/A	INTRINSIC
low complexity region	165	192	N/A	INTRINSIC
low complexity region	194	206	N/A	INTRINSIC
low complexity region	254	272	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000183209
AA Change: S214P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000138355
Gene: ENSMUSG00000002107
AA Change: S214P

Domain	Start	End	E-Value	Type
RRM	53	131	1.29e-17	SMART
RRM	145	220	4.22e-22	SMART
low complexity region	230	259	N/A	INTRINSIC
low complexity region	288	315	N/A	INTRINSIC
low complexity region	317	329	N/A	INTRINSIC
RRM	378	461	4.92e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000170438
AA Change: S220P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000130829
Gene: ENSMUSG00000002107
AA Change: S220P

Domain	Start	End	E-Value	Type
RRM	59	137	1.29e-17	SMART
RRM	151	226	4.22e-22	SMART
low complexity region	236	265	N/A	INTRINSIC
low complexity region	294	321	N/A	INTRINSIC
low complexity region	323	335	N/A	INTRINSIC
RRM	384	467	4.92e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000182706
AA Change: S214P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000138764
Gene: ENSMUSG00000002107
AA Change: S214P

Domain	Start	End	E-Value	Type
RRM	53	131	1.29e-17	SMART
RRM	145	220	4.22e-22	SMART
low complexity region	230	259	N/A	INTRINSIC
low complexity region	288	315	N/A	INTRINSIC
low complexity region	317	329	N/A	INTRINSIC
low complexity region	362	391	N/A	INTRINSIC
low complexity region	415	428	N/A	INTRINSIC
RRM	436	509	3.2e-22	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000150624
AA Change: S178P

PolyPhen 2 Score 0.826 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000138297
Gene: ENSMUSG00000002107
AA Change: S178P

Domain	Start	End	E-Value	Type
RRM	17	95	1.29e-17	SMART
RRM	109	184	4.22e-22	SMART
low complexity region	194	223	N/A	INTRINSIC
low complexity region	252	279	N/A	INTRINSIC
low complexity region	281	293	N/A	INTRINSIC
low complexity region	341	359	N/A	INTRINSIC
low complexity region	383	396	N/A	INTRINSIC
RRM	404	477	3.2e-22	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148321

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183269

Meta Mutation Damage Score

0.6224

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.7%
20x: 93.8%

Validation Efficiency

100% (116/116)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 118 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl2fm1	A	G	3: 59,843,771 (GRCm39)	H155R	possibly damaging	Het
Abca13	G	T	11: 9,244,559 (GRCm39)	V2141L	probably benign	Het
Adam17	T	C	12: 21,390,459 (GRCm39)		probably benign	Het
Adam3	A	T	8: 25,185,331 (GRCm39)	C456S	probably damaging	Het
Aldh4a1	G	T	4: 139,369,882 (GRCm39)		probably benign	Het
Anapc4	A	G	5: 52,999,359 (GRCm39)		probably benign	Het
Ank3	A	T	10: 69,718,198 (GRCm39)	Q483L	probably damaging	Het
Ankle2	A	G	5: 110,389,925 (GRCm39)		probably benign	Het
Ankrd13b	T	A	11: 77,364,114 (GRCm39)	T150S	possibly damaging	Het
Apeh	A	G	9: 107,964,254 (GRCm39)	M524T	probably benign	Het
Arl14epl	T	A	18: 47,059,484 (GRCm39)		probably null	Het
Atg2a	T	C	19: 6,302,569 (GRCm39)	F964S	possibly damaging	Het
Atg2b	C	T	12: 105,583,412 (GRCm39)	V2050M	probably damaging	Het
Atp2b4	A	T	1: 133,659,956 (GRCm39)		probably benign	Het
Bbof1	T	A	12: 84,477,045 (GRCm39)	S512T	probably benign	Het
Camta1	C	A	4: 151,159,597 (GRCm39)	R1614L	probably damaging	Het
Car10	T	C	11: 93,381,408 (GRCm39)	Y100H	probably damaging	Het
Ccdc81	T	A	7: 89,542,504 (GRCm39)	E124V	probably damaging	Het
Cd84	A	G	1: 171,700,494 (GRCm39)	T204A	probably benign	Het
Chat	G	A	14: 32,130,976 (GRCm39)	T555M	probably damaging	Het
Chd6	A	G	2: 160,834,111 (GRCm39)	F917S	probably damaging	Het
Chrna2	C	A	14: 66,386,553 (GRCm39)	T233N	probably damaging	Het
Cnpy2	T	C	10: 128,162,054 (GRCm39)	V109A	probably benign	Het
Col4a1	T	C	8: 11,258,333 (GRCm39)		probably null	Het
Csmd1	C	T	8: 15,982,529 (GRCm39)	V2713M	possibly damaging	Het
Cuedc1	G	A	11: 88,074,231 (GRCm39)	R255Q	probably damaging	Het
Cxcl15	A	T	5: 90,945,897 (GRCm39)		probably benign	Het
Dach1	A	T	14: 98,138,765 (GRCm39)	H559Q	possibly damaging	Het
Dele1	T	C	18: 38,387,124 (GRCm39)		probably null	Het
Dennd4c	C	T	4: 86,744,259 (GRCm39)	T1367M	probably damaging	Het
Depdc5	T	A	5: 33,102,372 (GRCm39)	Y365*	probably null	Het
Dicer1	T	C	12: 104,669,100 (GRCm39)	Y1194C	possibly damaging	Het
Dmxl1	C	G	18: 50,024,534 (GRCm39)	S1736*	probably null	Het
Dnah7a	C	T	1: 53,536,285 (GRCm39)	R2586K	probably benign	Het
Dnajb8	T	C	6: 88,199,467 (GRCm39)	M1T	probably null	Het
Dync2h1	G	A	9: 7,122,692 (GRCm39)	P2088L	probably benign	Het
Eftud2	T	G	11: 102,735,048 (GRCm39)	H617P	probably damaging	Het
Ephb1	A	G	9: 101,873,179 (GRCm39)		probably benign	Het
Fam184a	G	T	10: 53,574,975 (GRCm39)	H155Q	probably benign	Het
Firrm	T	C	1: 163,799,412 (GRCm39)		probably null	Het
Ganc	G	T	2: 120,278,882 (GRCm39)	E700*	probably null	Het
Gm10912	A	G	2: 103,897,290 (GRCm39)		probably benign	Het
Haus5	A	T	7: 30,358,492 (GRCm39)	I294N	probably damaging	Het
Hmgcr	G	T	13: 96,796,651 (GRCm39)		probably null	Het
Hr	T	A	14: 70,799,352 (GRCm39)	C641*	probably null	Het
Itga10	A	G	3: 96,565,490 (GRCm39)	N1038S	probably damaging	Het
Itgb1bp1	T	G	12: 21,321,436 (GRCm39)	Y172S	probably damaging	Het
Kprp	T	C	3: 92,732,030 (GRCm39)	N340S	probably damaging	Het
Kremen1	A	G	11: 5,165,447 (GRCm39)	I41T	probably damaging	Het
Krt6b	A	G	15: 101,586,042 (GRCm39)		probably benign	Het
Krt81	C	A	15: 101,361,508 (GRCm39)	R24L	possibly damaging	Het
Ldhd	A	G	8: 112,356,309 (GRCm39)	Y86H	probably benign	Het
Lilra6	A	T	7: 3,915,784 (GRCm39)	I76N	possibly damaging	Het
Mak	T	C	13: 41,199,743 (GRCm39)	T299A	probably benign	Het
Med25	A	G	7: 44,534,502 (GRCm39)		probably null	Het
Mpg	A	T	11: 32,180,039 (GRCm39)	N189I	probably damaging	Het
Mroh8	A	G	2: 157,071,838 (GRCm39)	Y556H	probably damaging	Het
Myh8	T	A	11: 67,175,333 (GRCm39)	S294T	probably benign	Het
Myom1	T	A	17: 71,391,312 (GRCm39)	D842E	probably benign	Het
Myorg	A	G	4: 41,498,538 (GRCm39)	F364S	probably damaging	Het
Nat2	C	T	8: 67,953,982 (GRCm39)	Q31*	probably null	Het
Nf1	T	A	11: 79,329,595 (GRCm39)	M653K	probably benign	Het
Nhs	C	A	X: 160,620,355 (GRCm39)	R1467I	probably damaging	Het
Npr2	A	G	4: 43,632,801 (GRCm39)	E206G	probably benign	Het
Nsd3	G	A	8: 26,168,732 (GRCm39)	G629D	possibly damaging	Het
Nwd1	G	A	8: 73,408,633 (GRCm39)	C831Y	probably damaging	Het
Or52r1c	T	C	7: 102,735,058 (GRCm39)	I111T	probably damaging	Het
Or5t9	A	G	2: 86,659,950 (GRCm39)	I285V	probably benign	Het
P2ry14	A	G	3: 59,023,449 (GRCm39)	S4P	possibly damaging	Het
Parp4	A	G	14: 56,873,172 (GRCm39)		probably benign	Het
Pate14	A	T	9: 36,549,873 (GRCm39)		probably null	Het
Pclo	A	G	5: 14,728,299 (GRCm39)		probably benign	Het
Pclo	T	C	5: 14,729,412 (GRCm39)		probably benign	Het
Pcnt	A	T	10: 76,240,429 (GRCm39)	S1202T	possibly damaging	Het
Pfkfb4	A	G	9: 108,856,825 (GRCm39)	Y412C	probably damaging	Het
Pgm2	T	A	5: 64,267,898 (GRCm39)	V449D	probably damaging	Het
Poldip3	T	A	15: 83,022,436 (GRCm39)	D116V	probably damaging	Het
Pom121	G	T	5: 135,410,686 (GRCm39)	Q824K	unknown	Het
Prkdc	G	T	16: 15,649,146 (GRCm39)	G3707*	probably null	Het
Prr14l	T	C	5: 33,001,560 (GRCm39)		probably benign	Het
Ptbp2	T	G	3: 119,514,613 (GRCm39)	I405L	probably benign	Het
Rad21l	A	T	2: 151,490,989 (GRCm39)		probably benign	Het
Rbm6	G	A	9: 107,724,488 (GRCm39)	Q488*	probably null	Het
Rdh1	T	A	10: 127,600,652 (GRCm39)	M225K	probably benign	Het
Recql5	T	C	11: 115,819,209 (GRCm39)	D119G	probably benign	Het
Rif1	GCCACCA	GCCA	2: 52,000,336 (GRCm39)		probably benign	Het
Robo1	T	C	16: 72,810,013 (GRCm39)		probably null	Het
Samd12	G	A	15: 53,723,567 (GRCm39)	T42I	probably benign	Het
Scn10a	A	T	9: 119,442,766 (GRCm39)	M1494K	probably damaging	Het
Sec31a	G	A	5: 100,523,099 (GRCm39)	P864L	probably benign	Het
Senp2	T	C	16: 21,855,320 (GRCm39)	V344A	probably benign	Het
Serpina5	G	A	12: 104,069,621 (GRCm39)	D278N	probably benign	Het
Sh3tc1	A	T	5: 35,860,806 (GRCm39)	V1017D	probably damaging	Het
Sin3a	T	A	9: 57,004,179 (GRCm39)	Y310*	probably null	Het
Slc25a32	T	C	15: 38,960,940 (GRCm39)	T248A	probably benign	Het
Slc35e1	T	C	8: 73,246,415 (GRCm39)		probably benign	Het
Slc4a10	G	A	2: 62,117,206 (GRCm39)	V722M	probably damaging	Het
Slco1a4	A	G	6: 141,776,586 (GRCm39)		probably benign	Het
Smg6	T	A	11: 74,819,884 (GRCm39)	Y52N	probably damaging	Het
Sncb	T	G	13: 54,913,400 (GRCm39)	T33P	probably damaging	Het
Spef2	A	G	15: 9,584,070 (GRCm39)		probably null	Het
Spmip1	G	T	6: 29,478,169 (GRCm39)		probably benign	Het
Sugp1	A	G	8: 70,512,013 (GRCm39)	E203G	probably damaging	Het
Suv39h2	A	T	2: 3,473,616 (GRCm39)	C105S	probably damaging	Het
Tlr1	A	T	5: 65,083,963 (GRCm39)	F205I	probably damaging	Het
Tnip1	A	T	11: 54,808,699 (GRCm39)	M496K	probably damaging	Het
Tnxb	G	A	17: 34,937,219 (GRCm39)	E2889K	probably damaging	Het
Trim30b	T	A	7: 104,015,010 (GRCm39)	H126L	possibly damaging	Het
Trpm7	A	T	2: 126,668,638 (GRCm39)	Y759*	probably null	Het
Ttc17	A	G	2: 94,153,465 (GRCm39)	I1000T	possibly damaging	Het
Ttc27	A	T	17: 75,025,710 (GRCm39)	N61I	probably benign	Het
Uba6	T	C	5: 86,260,609 (GRCm39)	Y990C	probably damaging	Het
Vav3	A	G	3: 109,571,756 (GRCm39)		probably benign	Het
Vmn2r55	C	T	7: 12,404,945 (GRCm39)	A153T	possibly damaging	Het
Wars2	A	G	3: 99,123,865 (GRCm39)	D242G	probably damaging	Het
Xylt2	G	A	11: 94,560,762 (GRCm39)	Q259*	probably null	Het
Zfp27	G	A	7: 29,593,947 (GRCm39)	P673S	probably damaging	Het
Zgrf1	T	C	3: 127,378,309 (GRCm39)	I1023T	possibly damaging	Het

Other mutations in Celf2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00925:Celf2	APN	2	6,726,388 (GRCm39)	missense	probably benign	0.00
IGL01974:Celf2	APN	2	6,608,842 (GRCm39)	missense	probably damaging	1.00
IGL02159:Celf2	APN	2	6,608,988 (GRCm39)	nonsense	probably null
LCD18:Celf2	UTSW	2	6,779,076 (GRCm38)	intron	probably benign
R0113:Celf2	UTSW	2	6,629,525 (GRCm39)	missense	probably damaging	1.00
R0711:Celf2	UTSW	2	6,726,226 (GRCm39)	critical splice donor site	probably null
R1755:Celf2	UTSW	2	6,889,769 (GRCm39)	start codon destroyed	probably benign	0.01
R1802:Celf2	UTSW	2	6,554,744 (GRCm39)	missense	probably damaging	1.00
R1898:Celf2	UTSW	2	6,608,975 (GRCm39)	missense	probably damaging	1.00
R1912:Celf2	UTSW	2	6,620,564 (GRCm39)	missense	probably damaging	1.00
R2422:Celf2	UTSW	2	6,558,700 (GRCm39)	missense	probably damaging	1.00
R2848:Celf2	UTSW	2	6,608,936 (GRCm39)	missense	probably damaging	0.96
R2849:Celf2	UTSW	2	6,608,936 (GRCm39)	missense	probably damaging	0.96
R3708:Celf2	UTSW	2	6,629,489 (GRCm39)	missense	probably damaging	1.00
R4295:Celf2	UTSW	2	6,608,875 (GRCm39)	missense	probably benign	0.10
R4601:Celf2	UTSW	2	6,590,831 (GRCm39)	missense	possibly damaging	0.87
R4602:Celf2	UTSW	2	6,590,831 (GRCm39)	missense	possibly damaging	0.87
R4610:Celf2	UTSW	2	6,590,831 (GRCm39)	missense	possibly damaging	0.87
R4611:Celf2	UTSW	2	6,590,831 (GRCm39)	missense	possibly damaging	0.87
R4667:Celf2	UTSW	2	6,726,339 (GRCm39)	missense	probably benign	0.44
R4668:Celf2	UTSW	2	6,726,339 (GRCm39)	missense	probably benign	0.44
R4669:Celf2	UTSW	2	6,726,339 (GRCm39)	missense	probably benign	0.44
R4790:Celf2	UTSW	2	6,554,714 (GRCm39)	missense	probably damaging	1.00
R5022:Celf2	UTSW	2	6,612,658 (GRCm39)	intron	probably benign
R5369:Celf2	UTSW	2	7,085,892 (GRCm39)	intron	probably benign
R5540:Celf2	UTSW	2	6,558,743 (GRCm39)	missense	probably benign	0.43
R5805:Celf2	UTSW	2	6,558,598 (GRCm39)	missense	probably damaging	1.00
R5913:Celf2	UTSW	2	7,085,969 (GRCm39)	start codon destroyed	probably null	0.02
R6330:Celf2	UTSW	2	6,889,766 (GRCm39)	missense	probably benign	0.05
R7505:Celf2	UTSW	2	6,629,511 (GRCm39)	missense	probably damaging	1.00
R7662:Celf2	UTSW	2	6,558,728 (GRCm39)	missense	probably damaging	1.00
R8316:Celf2	UTSW	2	6,551,914 (GRCm39)	missense	probably benign	0.03
R8437:Celf2	UTSW	2	6,551,956 (GRCm39)	missense	probably damaging	1.00
R8860:Celf2	UTSW	2	6,565,468 (GRCm39)	critical splice donor site	probably null
R9170:Celf2	UTSW	2	6,554,646 (GRCm39)	missense	possibly damaging	0.75
R9373:Celf2	UTSW	2	6,551,915 (GRCm39)	missense	probably benign	0.24
R9374:Celf2	UTSW	2	6,590,886 (GRCm39)	missense	possibly damaging	0.95
R9382:Celf2	UTSW	2	6,726,404 (GRCm39)	missense	probably damaging	1.00
R9623:Celf2	UTSW	2	6,620,522 (GRCm39)	missense	probably damaging	1.00
R9626:Celf2	UTSW	2	6,590,835 (GRCm39)	missense	probably benign	0.33
R9718:Celf2	UTSW	2	6,726,349 (GRCm39)	missense	probably damaging	1.00
X0018:Celf2	UTSW	2	6,558,724 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CAGTTGCCAACAGGCCAAAGTTAAG -3'
(R):5'- ACATCAGTGGCAGGATATGGAGTTTTC -3'

Sequencing Primer
(F):5'- AAAATCCTGCCCTAATGCTGATTTC -3'
(R):5'- GCAGGATATGGAGTTTTCTGTTG -3'

Posted On

2013-06-11