Incidental Mutation 'R0471:Mprip'
ID 46773
Institutional Source Beutler Lab
Gene Symbol Mprip
Ensembl Gene ENSMUSG00000005417
Gene Name myosin phosphatase Rho interacting protein
Synonyms p116 Rho interacting protein, p116Rip, Gm34094, RIP3, Rhoip3
MMRRC Submission 038671-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.669) question?
Stock # R0471 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 59552973-59671686 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 59650561 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 1422 (S1422P)
Ref Sequence ENSEMBL: ENSMUSP00000071081 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066330] [ENSMUST00000072031] [ENSMUST00000108751] [ENSMUST00000116371] [ENSMUST00000133861]
AlphaFold P97434
Predicted Effect probably damaging
Transcript: ENSMUST00000066330
AA Change: S1422P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071081
Gene: ENSMUSG00000005417
AA Change: S1422P

DomainStartEndE-ValueType
PH 44 152 3.33e-10 SMART
low complexity region 179 190 N/A INTRINSIC
low complexity region 221 234 N/A INTRINSIC
Blast:PH 249 320 1e-10 BLAST
PH 351 448 3.76e-18 SMART
low complexity region 492 501 N/A INTRINSIC
low complexity region 536 555 N/A INTRINSIC
coiled coil region 636 671 N/A INTRINSIC
Blast:PAC 806 848 2e-10 BLAST
low complexity region 1005 1023 N/A INTRINSIC
low complexity region 1047 1059 N/A INTRINSIC
low complexity region 1114 1128 N/A INTRINSIC
low complexity region 1183 1200 N/A INTRINSIC
coiled coil region 1267 1300 N/A INTRINSIC
coiled coil region 1617 1642 N/A INTRINSIC
coiled coil region 1729 1779 N/A INTRINSIC
coiled coil region 1899 1936 N/A INTRINSIC
coiled coil region 1960 2110 N/A INTRINSIC
coiled coil region 2132 2206 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000072031
SMART Domains Protein: ENSMUSP00000071914
Gene: ENSMUSG00000005417

DomainStartEndE-ValueType
PH 44 152 3.33e-10 SMART
low complexity region 179 190 N/A INTRINSIC
low complexity region 221 234 N/A INTRINSIC
Blast:PH 254 320 1e-10 BLAST
PH 387 484 3.76e-18 SMART
low complexity region 528 537 N/A INTRINSIC
low complexity region 572 591 N/A INTRINSIC
coiled coil region 672 707 N/A INTRINSIC
coiled coil region 728 878 N/A INTRINSIC
coiled coil region 900 974 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108751
SMART Domains Protein: ENSMUSP00000104382
Gene: ENSMUSG00000005417

DomainStartEndE-ValueType
PH 44 152 3.33e-10 SMART
low complexity region 183 196 N/A INTRINSIC
Blast:PH 216 282 1e-10 BLAST
PH 349 446 3.76e-18 SMART
low complexity region 490 499 N/A INTRINSIC
low complexity region 534 553 N/A INTRINSIC
coiled coil region 634 669 N/A INTRINSIC
coiled coil region 690 840 N/A INTRINSIC
coiled coil region 862 936 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000116371
SMART Domains Protein: ENSMUSP00000112072
Gene: ENSMUSG00000005417

DomainStartEndE-ValueType
PH 44 152 3.33e-10 SMART
low complexity region 179 190 N/A INTRINSIC
low complexity region 221 234 N/A INTRINSIC
Blast:PH 254 320 1e-10 BLAST
PH 387 484 3.76e-18 SMART
low complexity region 528 537 N/A INTRINSIC
low complexity region 572 591 N/A INTRINSIC
coiled coil region 672 707 N/A INTRINSIC
coiled coil region 728 878 N/A INTRINSIC
coiled coil region 900 974 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000132620
SMART Domains Protein: ENSMUSP00000119422
Gene: ENSMUSG00000005417

DomainStartEndE-ValueType
low complexity region 26 37 N/A INTRINSIC
low complexity region 68 81 N/A INTRINSIC
Blast:PH 101 167 9e-11 BLAST
PH 198 295 3.76e-18 SMART
low complexity region 339 348 N/A INTRINSIC
low complexity region 383 402 N/A INTRINSIC
coiled coil region 482 517 N/A INTRINSIC
coiled coil region 538 688 N/A INTRINSIC
coiled coil region 710 784 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000133861
SMART Domains Protein: ENSMUSP00000119562
Gene: ENSMUSG00000005417

DomainStartEndE-ValueType
low complexity region 18 29 N/A INTRINSIC
low complexity region 47 58 N/A INTRINSIC
low complexity region 89 102 N/A INTRINSIC
low complexity region 152 162 N/A INTRINSIC
low complexity region 259 269 N/A INTRINSIC
PH 373 470 3.76e-18 SMART
low complexity region 514 523 N/A INTRINSIC
low complexity region 558 577 N/A INTRINSIC
coiled coil region 658 693 N/A INTRINSIC
coiled coil region 714 864 N/A INTRINSIC
coiled coil region 886 960 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000156111
SMART Domains Protein: ENSMUSP00000114446
Gene: ENSMUSG00000005417

DomainStartEndE-ValueType
internal_repeat_1 5 38 1.61e-7 PROSPERO
internal_repeat_2 9 51 2.4e-6 PROSPERO
internal_repeat_1 59 92 1.61e-7 PROSPERO
internal_repeat_2 85 129 2.4e-6 PROSPERO
coiled coil region 140 177 N/A INTRINSIC
coiled coil region 201 351 N/A INTRINSIC
coiled coil region 373 447 N/A INTRINSIC
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 100% (67/67)
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp6 T C 3: 97,075,891 (GRCm39) probably null Het
Adam33 C A 2: 130,896,399 (GRCm39) G437C probably damaging Het
Aldh1a1 T A 19: 20,579,377 (GRCm39) M1K probably null Het
Amotl2 C A 9: 102,597,718 (GRCm39) P126Q probably damaging Het
Ap1g1 T A 8: 110,580,275 (GRCm39) M576K possibly damaging Het
Apob C A 12: 8,040,406 (GRCm39) A581E probably damaging Het
Asb7 A T 7: 66,328,907 (GRCm39) D44E probably damaging Het
Bcl2 G A 1: 106,640,292 (GRCm39) R107C probably damaging Het
C9orf72 G A 4: 35,193,257 (GRCm39) T232I probably benign Het
Ccdc65 A T 15: 98,615,348 (GRCm39) H118L probably benign Het
Cdc25b A G 2: 131,039,204 (GRCm39) E523G probably damaging Het
Cdk11b A G 4: 155,731,999 (GRCm39) probably benign Het
Cilk1 G T 9: 78,062,799 (GRCm39) probably null Het
Clec1b A G 6: 129,378,570 (GRCm39) probably benign Het
Cntrl A G 2: 35,017,392 (GRCm39) T400A probably benign Het
Cpne4 T G 9: 104,899,481 (GRCm39) probably null Het
Cyp2j6 T A 4: 96,419,985 (GRCm39) R249* probably null Het
Dock2 T C 11: 34,579,380 (GRCm39) I678V probably benign Het
Dqx1 C T 6: 83,036,407 (GRCm39) probably benign Het
Dsp A T 13: 38,377,326 (GRCm39) K1704* probably null Het
Eif2b2 T C 12: 85,266,957 (GRCm39) F121S probably benign Het
Ephx4 T C 5: 107,561,379 (GRCm39) V69A possibly damaging Het
Epn2 T C 11: 61,426,134 (GRCm39) Q281R probably damaging Het
Fgf3 A C 7: 144,396,547 (GRCm39) D187A probably damaging Het
Galnt18 C A 7: 111,378,506 (GRCm39) probably benign Het
Gm4871 C T 5: 144,968,402 (GRCm39) probably benign Het
Inpp4b T C 8: 82,768,528 (GRCm39) I679T possibly damaging Het
Itpkb A G 1: 180,245,820 (GRCm39) E779G probably damaging Het
Itsn1 G A 16: 91,696,477 (GRCm39) V27M probably damaging Het
Lrp2 C A 2: 69,355,578 (GRCm39) R422L probably damaging Het
Mmp25 G A 17: 23,858,858 (GRCm39) A231V possibly damaging Het
Mro A T 18: 74,009,860 (GRCm39) Q176L probably benign Het
Mrpl12 A G 11: 120,379,229 (GRCm39) E192G probably damaging Het
Myo5b A T 18: 74,862,025 (GRCm39) probably benign Het
Ncam2 G T 16: 80,997,772 (GRCm39) probably benign Het
Nip7 T C 8: 107,783,949 (GRCm39) L63P probably damaging Het
Nsd3 T C 8: 26,138,450 (GRCm39) probably benign Het
Nup98 A T 7: 101,788,004 (GRCm39) V1022D probably benign Het
Or2y1e T A 11: 49,218,744 (GRCm39) C169S probably damaging Het
Or5d43 A G 2: 88,104,559 (GRCm39) V278A possibly damaging Het
Or5h22 A G 16: 58,894,633 (GRCm39) I270T probably benign Het
Or7g28 A T 9: 19,272,177 (GRCm39) L158* probably null Het
P4ha2 T C 11: 54,008,434 (GRCm39) Y214H possibly damaging Het
Pacrg A T 17: 10,795,407 (GRCm39) F184L possibly damaging Het
Parpbp T A 10: 87,929,569 (GRCm39) R426S probably damaging Het
Pcdhb5 T A 18: 37,454,359 (GRCm39) Y246* probably null Het
Pik3cg T A 12: 32,244,770 (GRCm39) T895S probably damaging Het
Prkch T C 12: 73,738,426 (GRCm39) Y178H probably benign Het
Rusc2 G T 4: 43,425,486 (GRCm39) R1197L probably damaging Het
Svep1 T C 4: 58,054,700 (GRCm39) E3296G possibly damaging Het
Svs3a A G 2: 164,131,801 (GRCm39) K123R probably benign Het
Sycp2l A G 13: 41,304,006 (GRCm39) probably null Het
Syne3 T C 12: 104,909,685 (GRCm39) H717R probably benign Het
Tiprl A G 1: 165,050,092 (GRCm39) probably null Het
Trim24 T G 6: 37,892,130 (GRCm39) V151G possibly damaging Het
Trim33 T C 3: 103,234,217 (GRCm39) V56A possibly damaging Het
Trim67 C A 8: 125,521,397 (GRCm39) T253K probably benign Het
Trip12 T C 1: 84,703,928 (GRCm39) E698G probably damaging Het
Tspan14 T C 14: 40,637,353 (GRCm39) D145G probably damaging Het
Ushbp1 G A 8: 71,847,021 (GRCm39) Q204* probably null Het
Vmn1r71 G C 7: 10,482,019 (GRCm39) S223C possibly damaging Het
Vmn2r75 G T 7: 85,814,721 (GRCm39) N257K probably benign Het
Washc4 T C 10: 83,394,598 (GRCm39) probably benign Het
Zc3h7b G A 15: 81,666,169 (GRCm39) D560N probably damaging Het
Zscan21 T C 5: 138,123,402 (GRCm39) V27A probably benign Het
Zzef1 A C 11: 72,813,937 (GRCm39) E2842A probably damaging Het
Other mutations in Mprip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00334:Mprip APN 11 59,639,417 (GRCm39) missense probably benign 0.07
IGL00563:Mprip APN 11 59,643,443 (GRCm39) missense probably damaging 1.00
IGL00905:Mprip APN 11 59,662,994 (GRCm39) missense possibly damaging 0.79
IGL00928:Mprip APN 11 59,635,578 (GRCm39) missense probably damaging 1.00
IGL01161:Mprip APN 11 59,622,399 (GRCm39) missense possibly damaging 0.93
IGL01991:Mprip APN 11 59,645,838 (GRCm39) missense probably damaging 0.99
IGL02491:Mprip APN 11 59,660,857 (GRCm39) missense probably benign 0.13
IGL03030:Mprip APN 11 59,631,941 (GRCm39) splice site probably null
IGL03056:Mprip APN 11 59,662,518 (GRCm39) missense probably damaging 1.00
IGL03293:Mprip APN 11 59,586,989 (GRCm39) missense probably damaging 1.00
R0049:Mprip UTSW 11 59,657,571 (GRCm39) missense probably damaging 0.99
R0097:Mprip UTSW 11 59,649,317 (GRCm39) missense possibly damaging 0.90
R0097:Mprip UTSW 11 59,649,317 (GRCm39) missense possibly damaging 0.90
R0147:Mprip UTSW 11 59,627,899 (GRCm39) missense possibly damaging 0.68
R0319:Mprip UTSW 11 59,587,864 (GRCm39) splice site probably benign
R0539:Mprip UTSW 11 59,631,943 (GRCm39) splice site probably benign
R0627:Mprip UTSW 11 59,660,798 (GRCm39) missense probably damaging 1.00
R0864:Mprip UTSW 11 59,649,587 (GRCm39) missense probably benign
R1218:Mprip UTSW 11 59,634,640 (GRCm39) missense probably damaging 1.00
R1469:Mprip UTSW 11 59,650,016 (GRCm39) missense probably damaging 1.00
R1469:Mprip UTSW 11 59,650,016 (GRCm39) missense probably damaging 1.00
R1695:Mprip UTSW 11 59,643,357 (GRCm39) missense probably damaging 0.99
R1698:Mprip UTSW 11 59,651,084 (GRCm39) missense possibly damaging 0.75
R1802:Mprip UTSW 11 59,645,867 (GRCm39) missense probably damaging 1.00
R1837:Mprip UTSW 11 59,657,571 (GRCm39) missense probably damaging 0.99
R1862:Mprip UTSW 11 59,649,047 (GRCm39) missense possibly damaging 0.90
R2094:Mprip UTSW 11 59,640,334 (GRCm39) splice site probably benign
R2107:Mprip UTSW 11 59,660,717 (GRCm39) missense probably damaging 1.00
R2108:Mprip UTSW 11 59,660,717 (GRCm39) missense probably damaging 1.00
R2510:Mprip UTSW 11 59,640,334 (GRCm39) splice site probably benign
R3003:Mprip UTSW 11 59,618,381 (GRCm39) missense possibly damaging 0.95
R3115:Mprip UTSW 11 59,656,229 (GRCm39) splice site probably null
R3941:Mprip UTSW 11 59,622,328 (GRCm39) splice site probably benign
R4347:Mprip UTSW 11 59,650,279 (GRCm39) missense possibly damaging 0.86
R4603:Mprip UTSW 11 59,622,399 (GRCm39) missense probably damaging 1.00
R4807:Mprip UTSW 11 59,648,846 (GRCm39) missense probably benign 0.00
R5011:Mprip UTSW 11 59,650,721 (GRCm39) missense possibly damaging 0.75
R5338:Mprip UTSW 11 59,651,399 (GRCm39) missense probably damaging 1.00
R5549:Mprip UTSW 11 59,651,644 (GRCm39) missense probably benign 0.00
R5569:Mprip UTSW 11 59,651,789 (GRCm39) missense probably damaging 1.00
R5604:Mprip UTSW 11 59,649,293 (GRCm39) missense probably benign
R5615:Mprip UTSW 11 59,649,313 (GRCm39) missense probably benign 0.08
R5846:Mprip UTSW 11 59,649,380 (GRCm39) missense probably damaging 1.00
R5970:Mprip UTSW 11 59,648,547 (GRCm39) missense probably damaging 0.96
R6054:Mprip UTSW 11 59,649,251 (GRCm39) missense probably benign
R6452:Mprip UTSW 11 59,643,609 (GRCm39) missense probably damaging 1.00
R6457:Mprip UTSW 11 59,649,815 (GRCm39) missense possibly damaging 0.69
R6544:Mprip UTSW 11 59,648,552 (GRCm39) missense probably benign 0.15
R6750:Mprip UTSW 11 59,586,957 (GRCm39) missense probably damaging 1.00
R6843:Mprip UTSW 11 59,650,554 (GRCm39) missense possibly damaging 0.54
R6851:Mprip UTSW 11 59,649,841 (GRCm39) missense probably damaging 0.99
R6867:Mprip UTSW 11 59,640,456 (GRCm39) critical splice donor site probably null
R7002:Mprip UTSW 11 59,652,016 (GRCm39) missense probably benign 0.22
R7023:Mprip UTSW 11 59,628,215 (GRCm39) missense probably damaging 1.00
R7764:Mprip UTSW 11 59,655,242 (GRCm39) missense probably damaging 0.99
R7765:Mprip UTSW 11 59,649,047 (GRCm39) missense possibly damaging 0.90
R7828:Mprip UTSW 11 59,627,915 (GRCm39) missense probably damaging 1.00
R7866:Mprip UTSW 11 59,643,756 (GRCm39) missense possibly damaging 0.60
R7911:Mprip UTSW 11 59,651,681 (GRCm39) missense
R7979:Mprip UTSW 11 59,657,682 (GRCm39) missense probably damaging 1.00
R8292:Mprip UTSW 11 59,650,340 (GRCm39) missense probably benign 0.21
R8481:Mprip UTSW 11 59,648,982 (GRCm39) nonsense probably null
R8717:Mprip UTSW 11 59,650,526 (GRCm39) missense probably benign
R8810:Mprip UTSW 11 59,587,851 (GRCm39) critical splice donor site probably benign
R8981:Mprip UTSW 11 59,622,383 (GRCm39) missense probably damaging 1.00
R9214:Mprip UTSW 11 59,650,901 (GRCm39) missense possibly damaging 0.69
R9245:Mprip UTSW 11 59,628,403 (GRCm39) missense possibly damaging 0.68
R9748:Mprip UTSW 11 59,656,348 (GRCm39) missense probably damaging 1.00
Z1176:Mprip UTSW 11 59,650,310 (GRCm39) missense probably benign 0.05
Z1176:Mprip UTSW 11 59,628,230 (GRCm39) missense possibly damaging 0.83
Z1177:Mprip UTSW 11 59,648,463 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCCCTGACATGCTTAGAAAACTGC -3'
(R):5'- TACTTAGTGACTCGACCTGGCTCC -3'

Sequencing Primer
(F):5'- GCCTCCCTGGCTAACATAGAG -3'
(R):5'- TCGACCTGGCTCCAGAAC -3'
Posted On 2013-06-11