Incidental Mutation 'R0471:Trip12'
| ID |
46730 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip12
|
| Ensembl Gene |
ENSMUSG00000026219 |
| Gene Name |
thyroid hormone receptor interactor 12 |
| Synonyms |
Gtl6, 1110036I07Rik, 6720416K24Rik |
| MMRRC Submission |
038671-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0471 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
84698910-84818237 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 84703928 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 698
(E698G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140789
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027421]
[ENSMUST00000186465]
[ENSMUST00000186648]
[ENSMUST00000187733]
[ENSMUST00000189670]
|
| AlphaFold |
G5E870 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027421
AA Change: E1893G
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000027421
Gene: ENSMUSG00000026219
AA Change: E1893G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
765 |
831 |
7.6e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000185720
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186465
AA Change: E1893G
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000140224
Gene: ENSMUSG00000026219
AA Change: E1893G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
761 |
831 |
2.2e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186648
AA Change: E1860G
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000139563
Gene: ENSMUSG00000026219
AA Change: E1860G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
421 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
440 |
654 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
441 |
635 |
1e-5 |
PDB |
|
low complexity region
|
950 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1029 |
1040 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1311 |
N/A |
INTRINSIC |
|
low complexity region
|
1312 |
1329 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1330 |
1384 |
7e-8 |
BLAST |
|
Blast:HECTc
|
1540 |
1596 |
2e-24 |
BLAST |
|
HECTc
|
1603 |
1992 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187733
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000189670
AA Change: E698G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140789
Gene: ENSMUSG00000026219
AA Change: E698G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
138 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
150 |
167 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
168 |
222 |
5e-8 |
BLAST |
|
Blast:HECTc
|
378 |
434 |
1e-24 |
BLAST |
|
HECTc
|
441 |
830 |
6.2e-180 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000191187
|
| Meta Mutation Damage Score |
0.3769 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.1%
- 20x: 94.9%
|
| Validation Efficiency |
100% (67/67) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acp6 |
T |
C |
3: 97,075,891 (GRCm39) |
|
probably null |
Het |
| Adam33 |
C |
A |
2: 130,896,399 (GRCm39) |
G437C |
probably damaging |
Het |
| Aldh1a1 |
T |
A |
19: 20,579,377 (GRCm39) |
M1K |
probably null |
Het |
| Amotl2 |
C |
A |
9: 102,597,718 (GRCm39) |
P126Q |
probably damaging |
Het |
| Ap1g1 |
T |
A |
8: 110,580,275 (GRCm39) |
M576K |
possibly damaging |
Het |
| Apob |
C |
A |
12: 8,040,406 (GRCm39) |
A581E |
probably damaging |
Het |
| Asb7 |
A |
T |
7: 66,328,907 (GRCm39) |
D44E |
probably damaging |
Het |
| Bcl2 |
G |
A |
1: 106,640,292 (GRCm39) |
R107C |
probably damaging |
Het |
| C9orf72 |
G |
A |
4: 35,193,257 (GRCm39) |
T232I |
probably benign |
Het |
| Ccdc65 |
A |
T |
15: 98,615,348 (GRCm39) |
H118L |
probably benign |
Het |
| Cdc25b |
A |
G |
2: 131,039,204 (GRCm39) |
E523G |
probably damaging |
Het |
| Cdk11b |
A |
G |
4: 155,731,999 (GRCm39) |
|
probably benign |
Het |
| Cilk1 |
G |
T |
9: 78,062,799 (GRCm39) |
|
probably null |
Het |
| Clec1b |
A |
G |
6: 129,378,570 (GRCm39) |
|
probably benign |
Het |
| Cntrl |
A |
G |
2: 35,017,392 (GRCm39) |
T400A |
probably benign |
Het |
| Cpne4 |
T |
G |
9: 104,899,481 (GRCm39) |
|
probably null |
Het |
| Cyp2j6 |
T |
A |
4: 96,419,985 (GRCm39) |
R249* |
probably null |
Het |
| Dock2 |
T |
C |
11: 34,579,380 (GRCm39) |
I678V |
probably benign |
Het |
| Dqx1 |
C |
T |
6: 83,036,407 (GRCm39) |
|
probably benign |
Het |
| Dsp |
A |
T |
13: 38,377,326 (GRCm39) |
K1704* |
probably null |
Het |
| Eif2b2 |
T |
C |
12: 85,266,957 (GRCm39) |
F121S |
probably benign |
Het |
| Ephx4 |
T |
C |
5: 107,561,379 (GRCm39) |
V69A |
possibly damaging |
Het |
| Epn2 |
T |
C |
11: 61,426,134 (GRCm39) |
Q281R |
probably damaging |
Het |
| Fgf3 |
A |
C |
7: 144,396,547 (GRCm39) |
D187A |
probably damaging |
Het |
| Galnt18 |
C |
A |
7: 111,378,506 (GRCm39) |
|
probably benign |
Het |
| Gm4871 |
C |
T |
5: 144,968,402 (GRCm39) |
|
probably benign |
Het |
| Inpp4b |
T |
C |
8: 82,768,528 (GRCm39) |
I679T |
possibly damaging |
Het |
| Itpkb |
A |
G |
1: 180,245,820 (GRCm39) |
E779G |
probably damaging |
Het |
| Itsn1 |
G |
A |
16: 91,696,477 (GRCm39) |
V27M |
probably damaging |
Het |
| Lrp2 |
C |
A |
2: 69,355,578 (GRCm39) |
R422L |
probably damaging |
Het |
| Mmp25 |
G |
A |
17: 23,858,858 (GRCm39) |
A231V |
possibly damaging |
Het |
| Mprip |
T |
C |
11: 59,650,561 (GRCm39) |
S1422P |
probably damaging |
Het |
| Mro |
A |
T |
18: 74,009,860 (GRCm39) |
Q176L |
probably benign |
Het |
| Mrpl12 |
A |
G |
11: 120,379,229 (GRCm39) |
E192G |
probably damaging |
Het |
| Myo5b |
A |
T |
18: 74,862,025 (GRCm39) |
|
probably benign |
Het |
| Ncam2 |
G |
T |
16: 80,997,772 (GRCm39) |
|
probably benign |
Het |
| Nip7 |
T |
C |
8: 107,783,949 (GRCm39) |
L63P |
probably damaging |
Het |
| Nsd3 |
T |
C |
8: 26,138,450 (GRCm39) |
|
probably benign |
Het |
| Nup98 |
A |
T |
7: 101,788,004 (GRCm39) |
V1022D |
probably benign |
Het |
| Or2y1e |
T |
A |
11: 49,218,744 (GRCm39) |
C169S |
probably damaging |
Het |
| Or5d43 |
A |
G |
2: 88,104,559 (GRCm39) |
V278A |
possibly damaging |
Het |
| Or5h22 |
A |
G |
16: 58,894,633 (GRCm39) |
I270T |
probably benign |
Het |
| Or7g28 |
A |
T |
9: 19,272,177 (GRCm39) |
L158* |
probably null |
Het |
| P4ha2 |
T |
C |
11: 54,008,434 (GRCm39) |
Y214H |
possibly damaging |
Het |
| Pacrg |
A |
T |
17: 10,795,407 (GRCm39) |
F184L |
possibly damaging |
Het |
| Parpbp |
T |
A |
10: 87,929,569 (GRCm39) |
R426S |
probably damaging |
Het |
| Pcdhb5 |
T |
A |
18: 37,454,359 (GRCm39) |
Y246* |
probably null |
Het |
| Pik3cg |
T |
A |
12: 32,244,770 (GRCm39) |
T895S |
probably damaging |
Het |
| Prkch |
T |
C |
12: 73,738,426 (GRCm39) |
Y178H |
probably benign |
Het |
| Rusc2 |
G |
T |
4: 43,425,486 (GRCm39) |
R1197L |
probably damaging |
Het |
| Svep1 |
T |
C |
4: 58,054,700 (GRCm39) |
E3296G |
possibly damaging |
Het |
| Svs3a |
A |
G |
2: 164,131,801 (GRCm39) |
K123R |
probably benign |
Het |
| Sycp2l |
A |
G |
13: 41,304,006 (GRCm39) |
|
probably null |
Het |
| Syne3 |
T |
C |
12: 104,909,685 (GRCm39) |
H717R |
probably benign |
Het |
| Tiprl |
A |
G |
1: 165,050,092 (GRCm39) |
|
probably null |
Het |
| Trim24 |
T |
G |
6: 37,892,130 (GRCm39) |
V151G |
possibly damaging |
Het |
| Trim33 |
T |
C |
3: 103,234,217 (GRCm39) |
V56A |
possibly damaging |
Het |
| Trim67 |
C |
A |
8: 125,521,397 (GRCm39) |
T253K |
probably benign |
Het |
| Tspan14 |
T |
C |
14: 40,637,353 (GRCm39) |
D145G |
probably damaging |
Het |
| Ushbp1 |
G |
A |
8: 71,847,021 (GRCm39) |
Q204* |
probably null |
Het |
| Vmn1r71 |
G |
C |
7: 10,482,019 (GRCm39) |
S223C |
possibly damaging |
Het |
| Vmn2r75 |
G |
T |
7: 85,814,721 (GRCm39) |
N257K |
probably benign |
Het |
| Washc4 |
T |
C |
10: 83,394,598 (GRCm39) |
|
probably benign |
Het |
| Zc3h7b |
G |
A |
15: 81,666,169 (GRCm39) |
D560N |
probably damaging |
Het |
| Zscan21 |
T |
C |
5: 138,123,402 (GRCm39) |
V27A |
probably benign |
Het |
| Zzef1 |
A |
C |
11: 72,813,937 (GRCm39) |
E2842A |
probably damaging |
Het |
|
| Other mutations in Trip12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00331:Trip12
|
APN |
1 |
84,708,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00430:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00465:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00819:Trip12
|
APN |
1 |
84,731,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00900:Trip12
|
APN |
1 |
84,702,485 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL00990:Trip12
|
APN |
1 |
84,729,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01087:Trip12
|
APN |
1 |
84,735,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01400:Trip12
|
APN |
1 |
84,729,699 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01521:Trip12
|
APN |
1 |
84,743,919 (GRCm39) |
splice site |
probably benign |
|
|
IGL01619:Trip12
|
APN |
1 |
84,792,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01796:Trip12
|
APN |
1 |
84,705,999 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01975:Trip12
|
APN |
1 |
84,792,534 (GRCm39) |
splice site |
probably benign |
|
|
IGL02190:Trip12
|
APN |
1 |
84,743,791 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02474:Trip12
|
APN |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Trip12
|
APN |
1 |
84,721,535 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02631:Trip12
|
APN |
1 |
84,743,729 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02991:Trip12
|
APN |
1 |
84,716,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03161:Trip12
|
APN |
1 |
84,738,853 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03388:Trip12
|
APN |
1 |
84,720,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
cardamom
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
pungent
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
spices
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
sulfuric
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
Turmeric
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
LCD18:Trip12
|
UTSW |
1 |
84,754,482 (GRCm38) |
unclassified |
probably benign |
|
|
R0090:Trip12
|
UTSW |
1 |
84,709,857 (GRCm39) |
splice site |
probably benign |
|
|
R0111:Trip12
|
UTSW |
1 |
84,736,854 (GRCm39) |
unclassified |
probably benign |
|
|
R0486:Trip12
|
UTSW |
1 |
84,738,805 (GRCm39) |
nonsense |
probably null |
|
|
R0557:Trip12
|
UTSW |
1 |
84,702,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0570:Trip12
|
UTSW |
1 |
84,729,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Trip12
|
UTSW |
1 |
84,735,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Trip12
|
UTSW |
1 |
84,746,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Trip12
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0657:Trip12
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0741:Trip12
|
UTSW |
1 |
84,722,902 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0862:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0864:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1124:Trip12
|
UTSW |
1 |
84,714,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1252:Trip12
|
UTSW |
1 |
84,754,071 (GRCm39) |
nonsense |
probably null |
|
|
R1455:Trip12
|
UTSW |
1 |
84,736,821 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1487:Trip12
|
UTSW |
1 |
84,746,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Trip12
|
UTSW |
1 |
84,708,342 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1847:Trip12
|
UTSW |
1 |
84,726,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Trip12
|
UTSW |
1 |
84,705,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1866:Trip12
|
UTSW |
1 |
84,722,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1926:Trip12
|
UTSW |
1 |
84,727,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Trip12
|
UTSW |
1 |
84,771,822 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1950:Trip12
|
UTSW |
1 |
84,738,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1994:Trip12
|
UTSW |
1 |
84,726,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2014:Trip12
|
UTSW |
1 |
84,738,587 (GRCm39) |
nonsense |
probably null |
|
|
R2391:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2423:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2433:Trip12
|
UTSW |
1 |
84,721,544 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2905:Trip12
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3040:Trip12
|
UTSW |
1 |
84,719,966 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3735:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R3907:Trip12
|
UTSW |
1 |
84,709,827 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4394:Trip12
|
UTSW |
1 |
84,703,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4540:Trip12
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4859:Trip12
|
UTSW |
1 |
84,771,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5240:Trip12
|
UTSW |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
R5278:Trip12
|
UTSW |
1 |
84,739,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5377:Trip12
|
UTSW |
1 |
84,735,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Trip12
|
UTSW |
1 |
84,746,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5542:Trip12
|
UTSW |
1 |
84,727,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5550:Trip12
|
UTSW |
1 |
84,738,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5886:Trip12
|
UTSW |
1 |
84,708,179 (GRCm39) |
intron |
probably benign |
|
|
R5893:Trip12
|
UTSW |
1 |
84,736,884 (GRCm39) |
unclassified |
probably benign |
|
|
R5914:Trip12
|
UTSW |
1 |
84,741,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Trip12
|
UTSW |
1 |
84,726,974 (GRCm39) |
nonsense |
probably null |
|
|
R5985:Trip12
|
UTSW |
1 |
84,703,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6135:Trip12
|
UTSW |
1 |
84,738,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6158:Trip12
|
UTSW |
1 |
84,738,733 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6419:Trip12
|
UTSW |
1 |
84,771,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7144:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7194:Trip12
|
UTSW |
1 |
84,771,943 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7355:Trip12
|
UTSW |
1 |
84,792,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Trip12
|
UTSW |
1 |
84,728,163 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7588:Trip12
|
UTSW |
1 |
84,738,604 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7705:Trip12
|
UTSW |
1 |
84,755,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Trip12
|
UTSW |
1 |
84,738,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8127:Trip12
|
UTSW |
1 |
84,716,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8221:Trip12
|
UTSW |
1 |
84,743,771 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8336:Trip12
|
UTSW |
1 |
84,743,762 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8373:Trip12
|
UTSW |
1 |
84,773,488 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8719:Trip12
|
UTSW |
1 |
84,722,790 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8771:Trip12
|
UTSW |
1 |
84,721,018 (GRCm39) |
unclassified |
probably benign |
|
|
R8997:Trip12
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9146:Trip12
|
UTSW |
1 |
84,771,881 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9236:Trip12
|
UTSW |
1 |
84,703,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9338:Trip12
|
UTSW |
1 |
84,727,019 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9391:Trip12
|
UTSW |
1 |
84,773,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9516:Trip12
|
UTSW |
1 |
84,735,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Trip12
|
UTSW |
1 |
84,738,508 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0065:Trip12
|
UTSW |
1 |
84,726,884 (GRCm39) |
missense |
probably benign |
0.21 |
|
Z1088:Trip12
|
UTSW |
1 |
84,743,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTGTGCAACGCTACCAAGACC -3'
(R):5'- CCCCAAATTAGAAGTTCACCTGACTGG -3'
Sequencing Primer
(F):5'- ACAGCATGGCCTACAGTTTG -3'
(R):5'- atgagatttgtctgcctccc -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation