Incidental Mutation 'R5916:Zscan29'
ID 461310
Institutional Source Beutler Lab
Gene Symbol Zscan29
Ensembl Gene ENSMUSG00000050619
Gene Name zinc finger SCAN domains 29
Synonyms Zfp690
MMRRC Submission 044113-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.159) question?
Stock # R5916 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 120988754-121001606 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 120994518 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Asparagine at position 489 (T489N)
Ref Sequence ENSEMBL: ENSMUSP00000125987 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079024] [ENSMUST00000110661] [ENSMUST00000146243] [ENSMUST00000163766]
AlphaFold E9Q5B4
Predicted Effect possibly damaging
Transcript: ENSMUST00000079024
AA Change: T454N

PolyPhen 2 Score 0.770 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000078033
Gene: ENSMUSG00000050619
AA Change: T454N

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 3e-21 PFAM
Pfam:Myb_DNA-bind_4 399 484 4.1e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000110661
AA Change: T454N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106289
Gene: ENSMUSG00000050619
AA Change: T454N

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 5.4e-21 PFAM
Pfam:Myb_DNA-bind_4 399 484 7.4e-22 PFAM
low complexity region 518 532 N/A INTRINSIC
ZnF_C2H2 665 687 2.99e-4 SMART
ZnF_C2H2 693 715 2.75e-3 SMART
ZnF_C2H2 721 743 8.02e-5 SMART
ZnF_C2H2 749 771 1.13e-4 SMART
ZnF_C2H2 777 799 1.18e-2 SMART
ZnF_C2H2 805 827 1.33e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000146243
SMART Domains Protein: ENSMUSP00000120997
Gene: ENSMUSG00000050619

DomainStartEndE-ValueType
SCAN 13 118 4.23e-58 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156370
Predicted Effect probably damaging
Transcript: ENSMUST00000163766
AA Change: T489N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125987
Gene: ENSMUSG00000050619
AA Change: T489N

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 5.9e-21 PFAM
Pfam:Myb_DNA-bind_4 434 519 1.3e-21 PFAM
low complexity region 553 567 N/A INTRINSIC
ZnF_C2H2 700 722 2.99e-4 SMART
ZnF_C2H2 728 750 2.75e-3 SMART
ZnF_C2H2 756 778 8.02e-5 SMART
ZnF_C2H2 784 806 1.13e-4 SMART
ZnF_C2H2 812 834 1.18e-2 SMART
ZnF_C2H2 840 862 1.33e-1 SMART
Meta Mutation Damage Score 0.1673 question?
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.3%
  • 10x: 97.2%
  • 20x: 92.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 A T 4: 144,349,550 (GRCm39) N269I possibly damaging Het
Abcc1 G T 16: 14,283,006 (GRCm39) V1161F possibly damaging Het
Adam3 A T 8: 25,174,555 (GRCm39) probably null Het
Agt A T 8: 125,290,597 (GRCm39) S237T possibly damaging Het
Ano3 A T 2: 110,512,181 (GRCm39) F674L probably benign Het
Asb2 G T 12: 103,290,135 (GRCm39) A504E probably damaging Het
Atp13a1 T A 8: 70,259,748 (GRCm39) I1113N probably damaging Het
Atxn7l2 T C 3: 108,112,978 (GRCm39) probably null Het
Bambi A G 18: 3,511,463 (GRCm39) T95A probably benign Het
Cfap210 A T 2: 69,619,806 (GRCm39) M1K probably null Het
Clrn1 T C 3: 58,753,783 (GRCm39) T193A probably benign Het
Colgalt2 T A 1: 152,379,873 (GRCm39) D437E probably damaging Het
Dchs1 C A 7: 105,408,373 (GRCm39) A1820S probably damaging Het
Dnah12 T A 14: 26,428,073 (GRCm39) I233N possibly damaging Het
Dsc3 T C 18: 20,120,077 (GRCm39) N194D probably damaging Het
Dync2h1 A G 9: 7,102,309 (GRCm39) probably null Het
Erich3 A T 3: 154,401,460 (GRCm39) R36S probably damaging Het
Fam243 T A 16: 92,117,559 (GRCm39) E243V probably damaging Het
Fmnl3 A T 15: 99,219,709 (GRCm39) C680S probably damaging Het
Focad T C 4: 88,275,778 (GRCm39) L1129P unknown Het
Fzd3 G A 14: 65,440,178 (GRCm39) T664I probably benign Het
Glb1l3 T C 9: 26,766,032 (GRCm39) I129V probably benign Het
Heatr1 T C 13: 12,449,352 (GRCm39) F1950S probably damaging Het
Herc6 G A 6: 57,623,188 (GRCm39) G597E probably benign Het
Hmcn2 T A 2: 31,286,151 (GRCm39) V2101D probably damaging Het
Il17re T A 6: 113,447,084 (GRCm39) C612S probably damaging Het
Il36g T G 2: 24,082,806 (GRCm39) *194E probably null Het
Junb T C 8: 85,704,505 (GRCm39) Y185C probably benign Het
Lrriq1 G A 10: 103,057,243 (GRCm39) Q186* probably null Het
Lrrn2 T A 1: 132,865,538 (GRCm39) V201E probably damaging Het
Ly6l A T 15: 75,323,027 (GRCm39) T68S probably benign Het
Marchf1 G T 8: 66,839,763 (GRCm39) R182L possibly damaging Het
Megf6 A G 4: 154,333,882 (GRCm39) probably null Het
Mga T A 2: 119,794,793 (GRCm39) S2708T probably benign Het
Mx1 T C 16: 97,252,933 (GRCm39) T396A probably benign Het
Naip5 A C 13: 100,359,209 (GRCm39) S676A probably benign Het
Npepl1 G T 2: 173,963,337 (GRCm39) W456C probably benign Het
Ntrk2 A G 13: 58,956,543 (GRCm39) M1V probably null Het
Nufip1 T C 14: 76,372,340 (GRCm39) *485Q probably null Het
Ocln T G 13: 100,642,687 (GRCm39) D216A possibly damaging Het
Or10x1 A T 1: 174,196,698 (GRCm39) T72S probably damaging Het
Or1o11 C T 17: 37,756,570 (GRCm39) L53F probably benign Het
Or4f57 A G 2: 111,791,175 (GRCm39) M81T probably damaging Het
Or55b4 G A 7: 102,133,586 (GRCm39) S247F probably damaging Het
Ptprq A T 10: 107,359,374 (GRCm39) M2243K probably damaging Het
Rad51b C T 12: 79,371,856 (GRCm39) Q190* probably null Het
Resf1 C T 6: 149,228,076 (GRCm39) T374I probably damaging Het
Rfx8 T C 1: 39,727,779 (GRCm39) Y182C probably benign Het
Rpgrip1l C A 8: 91,979,541 (GRCm39) R967L possibly damaging Het
Scube2 A G 7: 109,430,931 (GRCm39) Y423H possibly damaging Het
Sipa1l2 A T 8: 126,195,312 (GRCm39) Y809N probably damaging Het
Slc35f1 C A 10: 52,809,317 (GRCm39) Y101* probably null Het
Tbc1d22a A G 15: 86,098,809 (GRCm39) K12E possibly damaging Het
Tent2 T C 13: 93,312,055 (GRCm39) D215G probably damaging Het
Tmcc2 C T 1: 132,285,429 (GRCm39) V646M probably damaging Het
Tpp1 A T 7: 105,398,587 (GRCm39) M243K probably damaging Het
Trappc12 A G 12: 28,741,513 (GRCm39) L732P probably damaging Het
U2af2 A T 7: 5,082,179 (GRCm39) probably null Het
Utrn T A 10: 12,540,795 (GRCm39) N1877Y probably damaging Het
Vsir C T 10: 60,193,816 (GRCm39) T93I probably damaging Het
Zkscan5 T A 5: 145,142,112 (GRCm39) M3K possibly damaging Het
Other mutations in Zscan29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01935:Zscan29 APN 2 121,000,538 (GRCm39) missense probably damaging 1.00
IGL01938:Zscan29 APN 2 120,996,690 (GRCm39) missense probably benign 0.16
IGL02220:Zscan29 APN 2 120,997,170 (GRCm39) missense probably damaging 0.99
IGL02370:Zscan29 APN 2 120,994,314 (GRCm39) missense probably benign 0.00
IGL02585:Zscan29 APN 2 120,994,357 (GRCm39) nonsense probably null
R0284:Zscan29 UTSW 2 120,997,214 (GRCm39) unclassified probably benign
R0842:Zscan29 UTSW 2 120,991,960 (GRCm39) missense possibly damaging 0.84
R1245:Zscan29 UTSW 2 120,996,984 (GRCm39) missense probably damaging 1.00
R1586:Zscan29 UTSW 2 120,991,641 (GRCm39) missense probably damaging 1.00
R1654:Zscan29 UTSW 2 120,995,260 (GRCm39) missense probably benign 0.06
R1958:Zscan29 UTSW 2 121,000,289 (GRCm39) critical splice donor site probably null
R2073:Zscan29 UTSW 2 120,991,336 (GRCm39) nonsense probably null
R2085:Zscan29 UTSW 2 121,000,427 (GRCm39) nonsense probably null
R2145:Zscan29 UTSW 2 121,000,587 (GRCm39) missense probably damaging 1.00
R2201:Zscan29 UTSW 2 120,999,883 (GRCm39) missense probably damaging 1.00
R2875:Zscan29 UTSW 2 120,994,581 (GRCm39) missense probably damaging 1.00
R2876:Zscan29 UTSW 2 120,994,581 (GRCm39) missense probably damaging 1.00
R3861:Zscan29 UTSW 2 120,991,212 (GRCm39) missense probably benign 0.01
R4244:Zscan29 UTSW 2 120,995,275 (GRCm39) splice site probably null
R4245:Zscan29 UTSW 2 120,995,275 (GRCm39) splice site probably null
R4447:Zscan29 UTSW 2 121,000,367 (GRCm39) splice site probably null
R4662:Zscan29 UTSW 2 120,997,096 (GRCm39) missense probably benign 0.26
R4757:Zscan29 UTSW 2 120,991,392 (GRCm39) missense possibly damaging 0.92
R4777:Zscan29 UTSW 2 120,999,805 (GRCm39) missense probably damaging 0.96
R4905:Zscan29 UTSW 2 120,991,864 (GRCm39) missense possibly damaging 0.53
R4970:Zscan29 UTSW 2 120,999,676 (GRCm39) splice site probably null
R5860:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5861:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5862:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5917:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5918:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R6335:Zscan29 UTSW 2 120,991,917 (GRCm39) missense possibly damaging 0.49
R7214:Zscan29 UTSW 2 120,999,761 (GRCm39) nonsense probably null
R7326:Zscan29 UTSW 2 120,991,469 (GRCm39) missense probably damaging 1.00
R7997:Zscan29 UTSW 2 120,991,221 (GRCm39) missense probably benign 0.01
R8787:Zscan29 UTSW 2 120,996,876 (GRCm39) missense probably damaging 1.00
RF001:Zscan29 UTSW 2 120,994,477 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CTGGTTCTCTGGAGGCAACAAG -3'
(R):5'- ACTGGTTTTCCTAGAAGCCGG -3'

Sequencing Primer
(F):5'- CTCTGGAGGCAACAAGAAACTGTTTC -3'
(R):5'- GTTTTCCTAGAAGCCGGCAGTAAAAC -3'
Posted On 2017-02-28