Incidental Mutation 'R0560:Fam161b'
ID 45840
Institutional Source Beutler Lab
Gene Symbol Fam161b
Ensembl Gene ENSMUSG00000021234
Gene Name family with sequence similarity 161, member B
Synonyms 9830169C18Rik
MMRRC Submission 038752-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R0560 (G1)
Quality Score 189
Status Validated
Chromosome 12
Chromosomal Location 84392083-84408607 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 84404492 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 63 (D63N)
Ref Sequence ENSEMBL: ENSMUSP00000070407 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021659] [ENSMUST00000021661] [ENSMUST00000065536] [ENSMUST00000110276] [ENSMUST00000110278] [ENSMUST00000152913]
AlphaFold Q8CB59
Predicted Effect probably damaging
Transcript: ENSMUST00000021659
AA Change: D63N

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000021659
Gene: ENSMUSG00000021234
AA Change: D63N

DomainStartEndE-ValueType
low complexity region 57 65 N/A INTRINSIC
low complexity region 93 107 N/A INTRINSIC
Pfam:UPF0564 168 535 5.3e-100 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000021661
SMART Domains Protein: ENSMUSP00000021661
Gene: ENSMUSG00000021235

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 46 56 N/A INTRINSIC
Pfam:FAD_binding_3 195 328 3.9e-8 PFAM
Pfam:FAD_binding_3 334 435 1.3e-11 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000065536
AA Change: D63N

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000070407
Gene: ENSMUSG00000021234
AA Change: D63N

DomainStartEndE-ValueType
low complexity region 57 65 N/A INTRINSIC
low complexity region 93 107 N/A INTRINSIC
Pfam:UPF0564 168 535 8.3e-112 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110276
SMART Domains Protein: ENSMUSP00000105905
Gene: ENSMUSG00000021235

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 46 56 N/A INTRINSIC
Pfam:FAD_binding_3 195 328 5.1e-8 PFAM
Pfam:FAD_binding_3 334 435 1.7e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110278
SMART Domains Protein: ENSMUSP00000105907
Gene: ENSMUSG00000021235

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 46 56 N/A INTRINSIC
Pfam:FAD_binding_3 195 328 6.8e-8 PFAM
Pfam:FAD_binding_3 334 410 1.1e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124257
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153450
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133230
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126752
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150391
Predicted Effect probably benign
Transcript: ENSMUST00000145522
SMART Domains Protein: ENSMUSP00000117609
Gene: ENSMUSG00000021235

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
SCOP:d1foha5 35 167 2e-6 SMART
PDB:4K22|B 90 156 3e-8 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000152913
SMART Domains Protein: ENSMUSP00000115676
Gene: ENSMUSG00000021235

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
SCOP:d1foha5 39 269 1e-10 SMART
PDB:4K22|B 94 274 1e-20 PDB
Meta Mutation Damage Score 0.1066 question?
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.0%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency 100% (26/26)
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apob T C 12: 8,055,101 (GRCm39) Y1334H probably damaging Het
Arsb A G 13: 93,926,706 (GRCm39) T159A possibly damaging Het
Asb18 A C 1: 89,942,250 (GRCm39) V17G probably damaging Het
Bicd1 A G 6: 149,413,460 (GRCm39) K284E probably benign Het
Bspry A G 4: 62,404,686 (GRCm39) R161G probably damaging Het
Ccdc138 A G 10: 58,411,539 (GRCm39) T636A probably damaging Het
Cubn A T 2: 13,433,491 (GRCm39) W1140R probably damaging Het
Cyp2t4 A G 7: 26,857,936 (GRCm39) T479A probably damaging Het
Dele1 T A 18: 38,387,551 (GRCm39) L230Q probably damaging Het
Dtx3l A G 16: 35,753,305 (GRCm39) S434P probably damaging Het
Duox2 A G 2: 122,122,035 (GRCm39) V611A probably benign Het
Epb41l3 T G 17: 69,581,892 (GRCm39) probably null Het
Gm5422 G A 10: 31,125,240 (GRCm39) noncoding transcript Het
Gpr158 A T 2: 21,830,085 (GRCm39) D710V probably damaging Het
Krtcap2 T C 3: 89,156,449 (GRCm39) probably null Het
Mtrf1 T A 14: 79,644,290 (GRCm39) D199E probably damaging Het
Myorg G A 4: 41,498,167 (GRCm39) R488W probably damaging Het
Naip6 C T 13: 100,437,108 (GRCm39) A472T probably benign Het
Ncf2 T A 1: 152,697,273 (GRCm39) Y47N probably damaging Het
Ovgp1 T C 3: 105,893,726 (GRCm39) probably benign Het
Siglec1 G T 2: 130,912,266 (GRCm39) T1692N probably benign Het
Slc10a2 T C 8: 5,139,092 (GRCm39) N284S probably benign Het
Slfn3 T C 11: 83,103,978 (GRCm39) F283S probably damaging Het
Trank1 T C 9: 111,220,154 (GRCm39) F2297S possibly damaging Het
Vmn2r69 A G 7: 85,058,922 (GRCm39) probably null Het
Vps13d T C 4: 144,780,760 (GRCm39) E3957G probably damaging Het
Other mutations in Fam161b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00540:Fam161b APN 12 84,408,525 (GRCm39) unclassified probably benign
IGL00900:Fam161b APN 12 84,402,743 (GRCm39) missense probably benign 0.05
IGL00905:Fam161b APN 12 84,404,459 (GRCm39) missense probably benign 0.00
IGL01123:Fam161b APN 12 84,404,438 (GRCm39) missense probably benign 0.00
IGL02156:Fam161b APN 12 84,401,527 (GRCm39) missense probably benign 0.00
IGL02630:Fam161b APN 12 84,400,688 (GRCm39) missense probably benign 0.03
IGL02670:Fam161b APN 12 84,404,368 (GRCm39) missense probably benign 0.00
IGL03160:Fam161b APN 12 84,400,599 (GRCm39) missense probably benign 0.05
R0569:Fam161b UTSW 12 84,395,413 (GRCm39) missense probably damaging 1.00
R1834:Fam161b UTSW 12 84,395,552 (GRCm39) splice site probably benign
R2070:Fam161b UTSW 12 84,403,202 (GRCm39) missense probably benign 0.00
R3784:Fam161b UTSW 12 84,408,464 (GRCm39) critical splice donor site probably null
R3786:Fam161b UTSW 12 84,408,464 (GRCm39) critical splice donor site probably null
R4697:Fam161b UTSW 12 84,395,332 (GRCm39) unclassified probably benign
R5247:Fam161b UTSW 12 84,404,524 (GRCm39) missense probably damaging 1.00
R5390:Fam161b UTSW 12 84,395,408 (GRCm39) missense probably damaging 0.99
R5668:Fam161b UTSW 12 84,403,124 (GRCm39) missense probably damaging 0.96
R6891:Fam161b UTSW 12 84,401,554 (GRCm39) missense probably damaging 1.00
R7189:Fam161b UTSW 12 84,395,420 (GRCm39) missense probably damaging 1.00
R7410:Fam161b UTSW 12 84,404,575 (GRCm39) missense probably benign 0.04
R7514:Fam161b UTSW 12 84,404,512 (GRCm39) missense possibly damaging 0.76
R8035:Fam161b UTSW 12 84,395,430 (GRCm39) missense probably damaging 1.00
R8219:Fam161b UTSW 12 84,393,648 (GRCm39) missense probably benign 0.00
R8428:Fam161b UTSW 12 84,404,369 (GRCm39) missense probably benign 0.00
R8921:Fam161b UTSW 12 84,395,056 (GRCm39) missense probably benign 0.02
R9638:Fam161b UTSW 12 84,403,187 (GRCm39) missense probably benign 0.00
X0019:Fam161b UTSW 12 84,401,747 (GRCm39) missense probably benign 0.30
Z1176:Fam161b UTSW 12 84,402,827 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCTGCTCTTGTCTTGGAAGAAGCTC -3'
(R):5'- ACACGCTGTGTTGTTCAGTGCC -3'

Sequencing Primer
(F):5'- TTGGAAGAAGCTCTCCAAGTC -3'
(R):5'- AGACACTGAGCCAGAAGATG -3'
Posted On 2013-06-11