Incidental Mutation 'R5860:Zscan29'
ID 453824
Institutional Source Beutler Lab
Gene Symbol Zscan29
Ensembl Gene ENSMUSG00000050619
Gene Name zinc finger SCAN domains 29
Synonyms Zfp690
MMRRC Submission 044072-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.159) question?
Stock # R5860 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 120988754-121001606 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 120994518 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Asparagine at position 489 (T489N)
Ref Sequence ENSEMBL: ENSMUSP00000125987 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079024] [ENSMUST00000110661] [ENSMUST00000146243] [ENSMUST00000163766]
AlphaFold E9Q5B4
Predicted Effect possibly damaging
Transcript: ENSMUST00000079024
AA Change: T454N

PolyPhen 2 Score 0.770 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000078033
Gene: ENSMUSG00000050619
AA Change: T454N

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 3e-21 PFAM
Pfam:Myb_DNA-bind_4 399 484 4.1e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000110661
AA Change: T454N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106289
Gene: ENSMUSG00000050619
AA Change: T454N

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 5.4e-21 PFAM
Pfam:Myb_DNA-bind_4 399 484 7.4e-22 PFAM
low complexity region 518 532 N/A INTRINSIC
ZnF_C2H2 665 687 2.99e-4 SMART
ZnF_C2H2 693 715 2.75e-3 SMART
ZnF_C2H2 721 743 8.02e-5 SMART
ZnF_C2H2 749 771 1.13e-4 SMART
ZnF_C2H2 777 799 1.18e-2 SMART
ZnF_C2H2 805 827 1.33e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000146243
SMART Domains Protein: ENSMUSP00000120997
Gene: ENSMUSG00000050619

DomainStartEndE-ValueType
SCAN 13 118 4.23e-58 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156370
Predicted Effect probably damaging
Transcript: ENSMUST00000163766
AA Change: T489N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125987
Gene: ENSMUSG00000050619
AA Change: T489N

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 5.9e-21 PFAM
Pfam:Myb_DNA-bind_4 434 519 1.3e-21 PFAM
low complexity region 553 567 N/A INTRINSIC
ZnF_C2H2 700 722 2.99e-4 SMART
ZnF_C2H2 728 750 2.75e-3 SMART
ZnF_C2H2 756 778 8.02e-5 SMART
ZnF_C2H2 784 806 1.13e-4 SMART
ZnF_C2H2 812 834 1.18e-2 SMART
ZnF_C2H2 840 862 1.33e-1 SMART
Meta Mutation Damage Score 0.1673 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.1%
  • 20x: 90.8%
Validation Efficiency 97% (75/77)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930568A12Rik A G 1: 34,524,661 (GRCm39) noncoding transcript Het
A2ml1 T C 6: 128,518,024 (GRCm39) T1421A probably benign Het
Actr8 T A 14: 29,708,242 (GRCm39) Y150* probably null Het
Adamts1 A G 16: 85,595,432 (GRCm39) C249R probably damaging Het
Adgre1 T A 17: 57,752,034 (GRCm39) I594N probably damaging Het
Atf6 A T 1: 170,669,344 (GRCm39) L119H probably damaging Het
Atf6 G A 1: 170,669,345 (GRCm39) L119F possibly damaging Het
B3gat2 G A 1: 23,854,400 (GRCm39) W33* probably null Het
Bach2 A G 4: 32,580,268 (GRCm39) D831G probably damaging Het
Ccnk A T 12: 108,153,466 (GRCm39) I76F probably damaging Het
Cdyl A C 13: 36,042,066 (GRCm39) K368T possibly damaging Het
Chi3l1 A G 1: 134,112,909 (GRCm39) T114A probably benign Het
Cnppd1 A G 1: 75,113,131 (GRCm39) V379A probably benign Het
Col11a2 C A 17: 34,283,159 (GRCm39) probably benign Het
Creb3l1 T C 2: 91,854,399 (GRCm39) S18G probably benign Het
Crybg3 A C 16: 59,385,632 (GRCm39) D197E probably damaging Het
Cryga T C 1: 65,142,527 (GRCm39) probably benign Het
Cthrc1 T C 15: 38,950,080 (GRCm39) C146R probably damaging Het
Cyp2c39 A T 19: 39,525,270 (GRCm39) D191V probably damaging Het
Dchs1 C T 7: 105,421,242 (GRCm39) A393T probably damaging Het
Dhx30 G A 9: 109,913,645 (GRCm39) T1126I probably damaging Het
Dock2 C T 11: 34,206,562 (GRCm39) G1345R probably damaging Het
Dsc1 T C 18: 20,228,081 (GRCm39) E425G probably damaging Het
Dynlt2b A G 16: 32,247,614 (GRCm39) Y143C probably damaging Het
Exosc8 C T 3: 54,642,463 (GRCm39) probably benign Het
Fat1 C T 8: 45,504,166 (GRCm39) A4553V probably benign Het
Flnb T A 14: 7,931,135 (GRCm38) L2119Q probably damaging Het
Fnbp4 T A 2: 90,587,826 (GRCm39) D401E probably benign Het
Glyctk T C 9: 106,032,906 (GRCm39) E369G possibly damaging Het
Gm14149 C A 2: 151,066,225 (GRCm39) noncoding transcript Het
Golga4 T C 9: 118,387,174 (GRCm39) L1432P probably damaging Het
Gtpbp4 A T 13: 9,023,196 (GRCm39) S623T probably benign Het
Insc A C 7: 114,390,383 (GRCm39) S85R probably damaging Het
Lgr4 G A 2: 109,821,496 (GRCm39) R126H probably damaging Het
M1ap T A 6: 82,980,795 (GRCm39) L227Q probably damaging Het
Marchf7 T C 2: 60,067,187 (GRCm39) I569T probably damaging Het
Mbd1 C A 18: 74,409,768 (GRCm39) C339* probably null Het
Moxd2 T A 6: 40,857,341 (GRCm39) Y473F probably damaging Het
Mrgpra6 T C 7: 46,839,099 (GRCm39) H2R probably benign Het
Mtus1 T G 8: 41,529,303 (GRCm39) L742F probably damaging Het
Nek11 A G 9: 105,270,160 (GRCm39) Y21H probably benign Het
Notch4 G T 17: 34,801,392 (GRCm39) C1080F probably damaging Het
Nsd3 C A 8: 26,156,107 (GRCm39) P558Q probably damaging Het
Oas1e A T 5: 120,930,015 (GRCm39) S168T probably benign Het
Ogfr T C 2: 180,234,285 (GRCm39) S119P probably damaging Het
Or2y15 A G 11: 49,350,563 (GRCm39) D19G probably damaging Het
Or8g20 T A 9: 39,395,767 (GRCm39) M261L probably benign Het
Pde4dip A G 3: 97,631,504 (GRCm39) I1135T possibly damaging Het
Prex1 G A 2: 166,486,604 (GRCm39) probably benign Het
Ptprf T C 4: 118,068,486 (GRCm39) probably benign Het
Rapsn T C 2: 90,875,859 (GRCm39) V359A probably damaging Het
Ric1 A G 19: 29,577,245 (GRCm39) S1050G possibly damaging Het
Rnft2 A G 5: 118,366,868 (GRCm39) I290T possibly damaging Het
Senp7 C A 16: 55,975,722 (GRCm39) A476E possibly damaging Het
Serpinh1 G A 7: 98,995,571 (GRCm39) S337L probably damaging Het
Slc5a12 C A 2: 110,427,969 (GRCm39) A8D probably benign Het
Smg5 T A 3: 88,250,214 (GRCm39) C109S probably damaging Het
Speer4b T C 5: 27,705,226 (GRCm39) H49R possibly damaging Het
Tas2r109 T C 6: 132,957,664 (GRCm39) I89V probably benign Het
Tet1 A G 10: 62,648,399 (GRCm39) probably null Het
Tmed6 G T 8: 107,790,786 (GRCm39) T87K probably damaging Het
Tpgs1 G A 10: 79,505,545 (GRCm39) G101D probably damaging Het
Trim13 T G 14: 61,842,188 (GRCm39) S68R probably damaging Het
Vwf A G 6: 125,620,053 (GRCm39) N1577S Het
Vwf G T 6: 125,656,228 (GRCm39) probably benign Het
Xpr1 T C 1: 155,207,868 (GRCm39) probably benign Het
Ylpm1 C T 12: 85,087,660 (GRCm39) P1148L probably damaging Het
Zftraf1 A T 15: 76,532,391 (GRCm39) I239N probably damaging Het
Zftraf1 T C 15: 76,540,615 (GRCm39) Y101C probably damaging Het
Other mutations in Zscan29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01935:Zscan29 APN 2 121,000,538 (GRCm39) missense probably damaging 1.00
IGL01938:Zscan29 APN 2 120,996,690 (GRCm39) missense probably benign 0.16
IGL02220:Zscan29 APN 2 120,997,170 (GRCm39) missense probably damaging 0.99
IGL02370:Zscan29 APN 2 120,994,314 (GRCm39) missense probably benign 0.00
IGL02585:Zscan29 APN 2 120,994,357 (GRCm39) nonsense probably null
R0284:Zscan29 UTSW 2 120,997,214 (GRCm39) unclassified probably benign
R0842:Zscan29 UTSW 2 120,991,960 (GRCm39) missense possibly damaging 0.84
R1245:Zscan29 UTSW 2 120,996,984 (GRCm39) missense probably damaging 1.00
R1586:Zscan29 UTSW 2 120,991,641 (GRCm39) missense probably damaging 1.00
R1654:Zscan29 UTSW 2 120,995,260 (GRCm39) missense probably benign 0.06
R1958:Zscan29 UTSW 2 121,000,289 (GRCm39) critical splice donor site probably null
R2073:Zscan29 UTSW 2 120,991,336 (GRCm39) nonsense probably null
R2085:Zscan29 UTSW 2 121,000,427 (GRCm39) nonsense probably null
R2145:Zscan29 UTSW 2 121,000,587 (GRCm39) missense probably damaging 1.00
R2201:Zscan29 UTSW 2 120,999,883 (GRCm39) missense probably damaging 1.00
R2875:Zscan29 UTSW 2 120,994,581 (GRCm39) missense probably damaging 1.00
R2876:Zscan29 UTSW 2 120,994,581 (GRCm39) missense probably damaging 1.00
R3861:Zscan29 UTSW 2 120,991,212 (GRCm39) missense probably benign 0.01
R4244:Zscan29 UTSW 2 120,995,275 (GRCm39) splice site probably null
R4245:Zscan29 UTSW 2 120,995,275 (GRCm39) splice site probably null
R4447:Zscan29 UTSW 2 121,000,367 (GRCm39) splice site probably null
R4662:Zscan29 UTSW 2 120,997,096 (GRCm39) missense probably benign 0.26
R4757:Zscan29 UTSW 2 120,991,392 (GRCm39) missense possibly damaging 0.92
R4777:Zscan29 UTSW 2 120,999,805 (GRCm39) missense probably damaging 0.96
R4905:Zscan29 UTSW 2 120,991,864 (GRCm39) missense possibly damaging 0.53
R4970:Zscan29 UTSW 2 120,999,676 (GRCm39) splice site probably null
R5861:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5862:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5916:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5917:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5918:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R6335:Zscan29 UTSW 2 120,991,917 (GRCm39) missense possibly damaging 0.49
R7214:Zscan29 UTSW 2 120,999,761 (GRCm39) nonsense probably null
R7326:Zscan29 UTSW 2 120,991,469 (GRCm39) missense probably damaging 1.00
R7997:Zscan29 UTSW 2 120,991,221 (GRCm39) missense probably benign 0.01
R8787:Zscan29 UTSW 2 120,996,876 (GRCm39) missense probably damaging 1.00
RF001:Zscan29 UTSW 2 120,994,477 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- TGGTTCTCTGGAGGCAACAAG -3'
(R):5'- TTTCCTAGAAGCCGGCAGTAAAAC -3'

Sequencing Primer
(F):5'- CTCTGGAGGCAACAAGAAACTGTTTC -3'
(R):5'- AGGTGATGCTGAAATCTCTCTTC -3'
Posted On 2017-02-10