Incidental Mutation 'R5700:Or5h25'
ID 450870
Institutional Source Beutler Lab
Gene Symbol Or5h25
Ensembl Gene ENSMUSG00000060057
Gene Name olfactory receptor family 5 subfamily H member 25
Synonyms MOR113-7P, MOR183-7P, Olfr1540-ps1, MOR113-7P, GA_x54KRFPKG5P-55338697-55337768, Olfr193
MMRRC Submission 043328-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R5700 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 58929988-58930996 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 58930356 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 206 (I206F)
Ref Sequence ENSEMBL: ENSMUSP00000146393 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076262] [ENSMUST00000207935] [ENSMUST00000208455]
AlphaFold Q7TS43
Predicted Effect probably damaging
Transcript: ENSMUST00000076262
AA Change: I206F

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000075611
Gene: ENSMUSG00000060057
AA Change: I206F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.3e-48 PFAM
Pfam:7tm_1 41 290 5.4e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207935
Predicted Effect probably damaging
Transcript: ENSMUST00000208455
AA Change: I206F

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Meta Mutation Damage Score 0.2363 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 98% (50/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc2 A T 19: 43,786,633 (GRCm39) Q155L probably benign Het
Acadvl A C 11: 69,904,029 (GRCm39) Y242D probably damaging Het
Armc8 A G 9: 99,378,202 (GRCm39) probably null Het
Barx2 A T 9: 31,770,061 (GRCm39) F156I probably damaging Het
Best1 T C 19: 9,974,563 (GRCm39) probably benign Het
Btbd8 T C 5: 107,651,514 (GRCm39) S136P possibly damaging Het
Btla T A 16: 45,070,936 (GRCm39) Y298* probably null Het
Casr T A 16: 36,329,979 (GRCm39) I452F probably damaging Het
Ccser1 C A 6: 61,288,260 (GRCm39) P141H probably benign Het
Cr2 A G 1: 194,842,065 (GRCm39) V296A probably damaging Het
Csl T A 10: 99,594,877 (GRCm39) I63F probably damaging Het
Dbt G A 3: 116,313,952 (GRCm39) V40M probably damaging Het
Fam53b A T 7: 132,361,749 (GRCm39) L93Q probably damaging Het
Fdps T C 3: 89,002,956 (GRCm39) I105V probably damaging Het
Gm4884 A G 7: 40,692,643 (GRCm39) D204G probably benign Het
Gm5592 A G 7: 40,808,003 (GRCm39) probably benign Het
Gm7367 A T 7: 59,805,510 (GRCm39) noncoding transcript Het
Grid2 T A 6: 64,071,416 (GRCm39) V413D possibly damaging Het
Hgf C T 5: 16,815,122 (GRCm39) P471L probably damaging Het
Hoxc9 T C 15: 102,890,313 (GRCm39) Y77H possibly damaging Het
Hs6st3 C T 14: 119,376,199 (GRCm39) R125* probably null Het
Kdm4b T C 17: 56,658,700 (GRCm39) I15T possibly damaging Het
Klhl1 T C 14: 96,755,476 (GRCm39) N93S probably benign Het
Klhl6 G A 16: 19,775,968 (GRCm39) Q197* probably null Het
Medag T C 5: 149,345,682 (GRCm39) V7A probably benign Het
Mptx2 G A 1: 173,102,414 (GRCm39) L92F probably benign Het
Nckap5 C T 1: 125,904,662 (GRCm39) probably null Het
Obscn T C 11: 59,024,020 (GRCm39) K550R probably benign Het
Or2d36 A G 7: 106,746,748 (GRCm39) N75S probably benign Het
Or2w1b T A 13: 21,300,171 (GRCm39) V103E probably damaging Het
Or7a42 T C 10: 78,791,318 (GRCm39) I93T probably damaging Het
Parp6 T C 9: 59,532,010 (GRCm39) S101P probably damaging Het
Plcd3 T C 11: 102,964,589 (GRCm39) N594S probably benign Het
Plscr5 A T 9: 92,087,564 (GRCm39) K178* probably null Het
Ppp2r1b T C 9: 50,789,457 (GRCm39) Y443H probably damaging Het
Prnd G A 2: 131,795,263 (GRCm39) V128I probably benign Het
Rftn1 G T 17: 50,309,697 (GRCm39) P156Q probably damaging Het
Scmh1 T C 4: 120,374,143 (GRCm39) V445A probably benign Het
Serpinb6c A T 13: 34,083,291 (GRCm39) M41K probably damaging Het
Slc66a1 C T 4: 139,027,565 (GRCm39) S259N probably damaging Het
Spns1 A G 7: 125,971,641 (GRCm39) V303A possibly damaging Het
Ston1 T A 17: 88,951,767 (GRCm39) S639R probably damaging Het
Thbs4 T C 13: 92,913,461 (GRCm39) D153G probably benign Het
Timm44 T C 8: 4,324,171 (GRCm39) Y36C probably damaging Het
Trim34b G T 7: 103,985,618 (GRCm39) V418F probably damaging Het
Vmn1r72 C T 7: 11,404,350 (GRCm39) V33M probably damaging Het
Zcchc7 T C 4: 44,931,084 (GRCm39) V412A probably benign Het
Zfand1 T A 3: 10,406,079 (GRCm39) N210I probably damaging Het
Zfhx3 A G 8: 109,660,499 (GRCm39) H1251R probably damaging Het
Other mutations in Or5h25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Or5h25 APN 16 58,930,961 (GRCm39) missense probably benign
IGL01613:Or5h25 APN 16 58,930,284 (GRCm39) missense probably damaging 1.00
IGL02280:Or5h25 APN 16 58,930,695 (GRCm39) missense probably damaging 1.00
IGL02533:Or5h25 APN 16 58,930,047 (GRCm39) missense probably benign
IGL02544:Or5h25 APN 16 58,930,507 (GRCm39) missense probably damaging 1.00
IGL02576:Or5h25 APN 16 58,930,134 (GRCm39) missense probably benign
IGL02719:Or5h25 APN 16 58,930,536 (GRCm39) missense probably benign 0.01
IGL03215:Or5h25 APN 16 58,930,325 (GRCm39) missense possibly damaging 0.46
IGL03272:Or5h25 APN 16 58,930,919 (GRCm39) missense probably benign 0.01
PIT4802001:Or5h25 UTSW 16 58,930,964 (GRCm39) missense probably benign
R0544:Or5h25 UTSW 16 58,930,588 (GRCm39) missense probably benign 0.03
R0783:Or5h25 UTSW 16 58,930,532 (GRCm39) nonsense probably null
R1070:Or5h25 UTSW 16 58,930,182 (GRCm39) missense probably benign 0.08
R1211:Or5h25 UTSW 16 58,930,523 (GRCm39) missense possibly damaging 0.68
R1662:Or5h25 UTSW 16 58,930,967 (GRCm39) missense probably benign 0.00
R1754:Or5h25 UTSW 16 58,930,944 (GRCm39) missense probably benign 0.03
R1765:Or5h25 UTSW 16 58,930,118 (GRCm39) missense probably damaging 1.00
R1937:Or5h25 UTSW 16 58,930,157 (GRCm39) missense probably benign 0.11
R2875:Or5h25 UTSW 16 58,930,165 (GRCm39) missense probably benign 0.01
R2910:Or5h25 UTSW 16 58,930,544 (GRCm39) missense probably benign 0.00
R2911:Or5h25 UTSW 16 58,930,544 (GRCm39) missense probably benign 0.00
R5084:Or5h25 UTSW 16 58,930,436 (GRCm39) missense possibly damaging 0.90
R7018:Or5h25 UTSW 16 58,930,970 (GRCm39) start codon destroyed probably null 0.98
R7083:Or5h25 UTSW 16 58,930,400 (GRCm39) missense probably damaging 1.00
R7572:Or5h25 UTSW 16 58,930,793 (GRCm39) missense probably damaging 1.00
R7720:Or5h25 UTSW 16 58,930,134 (GRCm39) missense probably benign
R8045:Or5h25 UTSW 16 58,930,402 (GRCm39) missense probably benign 0.01
R8869:Or5h25 UTSW 16 58,930,121 (GRCm39) missense
R8960:Or5h25 UTSW 16 58,930,555 (GRCm39) missense probably benign 0.01
R9045:Or5h25 UTSW 16 58,930,365 (GRCm39) missense probably benign 0.13
R9049:Or5h25 UTSW 16 58,930,763 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TACTTGTGGAGATGCAGGGC -3'
(R):5'- GTGATCATGACAAATAGACTCTGTG -3'

Sequencing Primer
(F):5'- GCAGGGCGCACATACATG -3'
(R):5'- CATGACAAATAGACTCTGTGTACGTC -3'
Posted On 2017-01-03