Incidental Mutation 'R5759:Zfp599'
ID 445195
Institutional Source Beutler Lab
Gene Symbol Zfp599
Ensembl Gene ENSMUSG00000062794
Gene Name zinc finger protein 599
Synonyms
MMRRC Submission 043361-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R5759 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 22158726-22171191 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 22160957 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 403 (K403E)
Ref Sequence ENSEMBL: ENSMUSP00000083462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086281]
AlphaFold E9PWP1
Predicted Effect probably damaging
Transcript: ENSMUST00000086281
AA Change: K403E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083462
Gene: ENSMUSG00000062794
AA Change: K403E

DomainStartEndE-ValueType
KRAB 4 64 5.35e-33 SMART
ZnF_C2H2 228 250 5.59e-4 SMART
ZnF_C2H2 256 278 2.43e-4 SMART
ZnF_C2H2 284 306 1.69e-3 SMART
ZnF_C2H2 312 334 8.94e-3 SMART
ZnF_C2H2 340 362 8.47e-4 SMART
ZnF_C2H2 368 390 5.06e-2 SMART
ZnF_C2H2 396 418 7.9e-4 SMART
ZnF_C2H2 424 446 7.67e-2 SMART
ZnF_C2H2 452 474 1.64e-1 SMART
ZnF_C2H2 480 503 7.37e-4 SMART
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.8%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T C 3: 137,774,419 (GRCm39) S1203P probably benign Het
Adamts1 A G 16: 85,594,936 (GRCm39) V341A possibly damaging Het
Arf2 G A 11: 103,874,459 (GRCm39) G144S probably benign Het
Atr A G 9: 95,756,455 (GRCm39) N862D probably benign Het
Cep295nl T C 11: 118,224,472 (GRCm39) H124R possibly damaging Het
Chd6 C T 2: 160,825,682 (GRCm39) V1141I possibly damaging Het
Chst5 C A 8: 112,616,842 (GRCm39) K259N probably benign Het
Dchs1 T A 7: 105,413,383 (GRCm39) D1144V probably damaging Het
Dmxl2 T C 9: 54,282,792 (GRCm39) Y2795C probably damaging Het
Dnah7b A G 1: 46,316,280 (GRCm39) N3131S probably damaging Het
Dnah7c G A 1: 46,654,527 (GRCm39) G1436R probably damaging Het
Emp2 T A 16: 10,102,374 (GRCm39) Y146F probably damaging Het
Exoc6 C T 19: 37,562,189 (GRCm39) Q148* probably null Het
Fam13b T C 18: 34,630,488 (GRCm39) D90G probably damaging Het
Fam186b T G 15: 99,177,598 (GRCm39) Y576S probably benign Het
Fras1 T C 5: 96,857,775 (GRCm39) V2023A probably benign Het
Grm5 A C 7: 87,675,808 (GRCm39) M441L probably damaging Het
Hhatl A G 9: 121,617,343 (GRCm39) Y297H probably damaging Het
Ifi30 A G 8: 71,219,188 (GRCm39) probably benign Het
Ing2 G T 8: 48,122,040 (GRCm39) N169K possibly damaging Het
Kat6a T G 8: 23,428,028 (GRCm39) S1128A probably benign Het
Madd T C 2: 90,992,420 (GRCm39) E1041G possibly damaging Het
Mcm3 CT CTT 1: 20,878,972 (GRCm39) probably null Het
Mfsd5 G A 15: 102,189,513 (GRCm39) G295D possibly damaging Het
Minar1 A T 9: 89,483,125 (GRCm39) N757K probably benign Het
Mmp20 T A 9: 7,628,378 (GRCm39) probably null Het
Mybphl T C 3: 108,282,070 (GRCm39) V100A probably benign Het
Ndfip2 T A 14: 105,539,750 (GRCm39) probably null Het
Or7e170 A G 9: 19,795,484 (GRCm39) V39A probably benign Het
Or7e175 T A 9: 20,049,228 (GRCm39) V272E probably benign Het
Or8b1c T A 9: 38,384,831 (GRCm39) S263T possibly damaging Het
Phf19 T G 2: 34,787,135 (GRCm39) D443A probably damaging Het
Piezo1 A G 8: 123,234,394 (GRCm39) V84A probably damaging Het
Septin9 A G 11: 117,243,094 (GRCm39) I94V probably benign Het
Slc35a1 C A 4: 34,675,032 (GRCm39) V132L probably benign Het
Sntg1 G A 1: 8,484,494 (GRCm39) S442L probably benign Het
Tcf25 A G 8: 124,108,196 (GRCm39) T84A probably benign Het
Tchhl1 C G 3: 93,378,863 (GRCm39) S522R probably damaging Het
Tmem106b A G 6: 13,075,041 (GRCm39) E76G probably damaging Het
Tnk2 C T 16: 32,499,482 (GRCm39) P932S probably benign Het
Trib1 G A 15: 59,526,350 (GRCm39) V307I probably benign Het
Trib3 A T 2: 152,185,215 (GRCm39) D11E probably benign Het
Trim34b T C 7: 103,980,640 (GRCm39) S243P possibly damaging Het
Vmn2r50 A G 7: 9,781,905 (GRCm39) I280T probably damaging Het
Zfp1010 A T 2: 176,956,765 (GRCm39) C244* probably null Het
Zfp445 G T 9: 122,682,211 (GRCm39) Q577K probably benign Het
Other mutations in Zfp599
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00580:Zfp599 APN 9 22,160,768 (GRCm39) missense possibly damaging 0.94
IGL00845:Zfp599 APN 9 22,162,814 (GRCm39) splice site probably benign
R0136:Zfp599 UTSW 9 22,161,038 (GRCm39) missense probably benign 0.13
R0239:Zfp599 UTSW 9 22,161,055 (GRCm39) missense probably damaging 1.00
R0239:Zfp599 UTSW 9 22,161,055 (GRCm39) missense probably damaging 1.00
R0421:Zfp599 UTSW 9 22,161,843 (GRCm39) splice site probably benign
R1699:Zfp599 UTSW 9 22,161,700 (GRCm39) missense probably benign 0.20
R1723:Zfp599 UTSW 9 22,169,361 (GRCm39) missense probably damaging 1.00
R1899:Zfp599 UTSW 9 22,162,845 (GRCm39) missense probably benign 0.00
R4231:Zfp599 UTSW 9 22,161,041 (GRCm39) nonsense probably null
R4233:Zfp599 UTSW 9 22,161,041 (GRCm39) nonsense probably null
R4236:Zfp599 UTSW 9 22,161,041 (GRCm39) nonsense probably null
R4931:Zfp599 UTSW 9 22,169,419 (GRCm39) missense probably damaging 0.98
R5117:Zfp599 UTSW 9 22,161,396 (GRCm39) nonsense probably null
R5615:Zfp599 UTSW 9 22,165,165 (GRCm39) missense probably benign
R5915:Zfp599 UTSW 9 22,161,130 (GRCm39) missense probably damaging 1.00
R6184:Zfp599 UTSW 9 22,160,947 (GRCm39) missense probably benign 0.18
R6188:Zfp599 UTSW 9 22,161,286 (GRCm39) missense probably damaging 1.00
R6657:Zfp599 UTSW 9 22,161,538 (GRCm39) missense probably damaging 1.00
R6736:Zfp599 UTSW 9 22,161,140 (GRCm39) missense probably damaging 1.00
R6752:Zfp599 UTSW 9 22,160,840 (GRCm39) missense probably damaging 1.00
R7071:Zfp599 UTSW 9 22,169,392 (GRCm39) missense probably benign 0.38
R7643:Zfp599 UTSW 9 22,161,188 (GRCm39) missense probably benign 0.19
R7714:Zfp599 UTSW 9 22,161,811 (GRCm39) missense probably benign 0.07
R7951:Zfp599 UTSW 9 22,160,764 (GRCm39) missense probably damaging 1.00
R7967:Zfp599 UTSW 9 22,160,830 (GRCm39) missense possibly damaging 0.66
R8014:Zfp599 UTSW 9 22,160,777 (GRCm39) missense probably benign 0.03
R8187:Zfp599 UTSW 9 22,161,111 (GRCm39) nonsense probably null
R9562:Zfp599 UTSW 9 22,160,999 (GRCm39) missense probably damaging 0.98
R9684:Zfp599 UTSW 9 22,160,824 (GRCm39) missense probably damaging 1.00
R9722:Zfp599 UTSW 9 22,160,741 (GRCm39) missense probably damaging 0.96
RF005:Zfp599 UTSW 9 22,165,180 (GRCm39) missense probably benign 0.03
RF024:Zfp599 UTSW 9 22,165,180 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- ATACTTTGATGTCGAATGAGGTGTGAC -3'
(R):5'- TGCTCTCAGGGAAAACTTACTC -3'

Sequencing Primer
(F):5'- GGGAGAAAGCTTTCCCACAGTC -3'
(R):5'- CTGAATGTGGGAAAGCTTTCTACC -3'
Posted On 2016-11-21