Mutagenetix > Incidental Mutation

Incidental Mutation 'R4842:Lrp1'

439444

Institutional Source

Beutler Lab

Gene Symbol

Lrp1

Ensembl Gene

ENSMUSG00000040249

Gene Name

low density lipoprotein receptor-related protein 1

Synonyms

b2b1554Clo, CD91, A2mr

MMRRC Submission

042455-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R4842 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

127374030-127457017 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 127419805 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 935 (R935S)

Ref Sequence

ENSEMBL: ENSMUSP00000044004 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049149]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000049149
AA Change: R935S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000044004
Gene: ENSMUSG00000040249
AA Change: R935S

Domain	Start	End	E-Value	Type
low complexity region	2	13	N/A	INTRINSIC
LDLa	27	67	1.03e-15	SMART
LDLa	72	111	1.04e-11	SMART
EGF	115	150	8.78e-2	SMART
EGF_CA	151	190	4.49e-8	SMART
low complexity region	222	232	N/A	INTRINSIC
LY	273	315	7.07e-6	SMART
LY	316	359	2.31e-10	SMART
LY	360	402	8.3e-12	SMART
EGF	478	521	9.93e-1	SMART
LY	552	594	8.84e-7	SMART
LY	595	638	6.54e-10	SMART
LY	641	690	2.5e-15	SMART
LY	691	734	1.06e-9	SMART
EGF	807	844	1.38e1	SMART
LDLa	854	893	3.39e-16	SMART
LDLa	895	934	1.73e-13	SMART
LDLa	936	974	4.47e-16	SMART
LDLa	976	1014	2.53e-15	SMART
LDLa	1015	1054	2.95e-16	SMART
LDLa	1062	1100	3.24e-13	SMART
LDLa	1104	1143	2.97e-12	SMART
LDLa	1145	1185	1.24e-9	SMART
EGF	1185	1223	4.97e-1	SMART
EGF	1227	1263	6.02e0	SMART
LY	1290	1332	3.76e-1	SMART
LY	1337	1379	8.56e-14	SMART
LY	1380	1424	8.43e-13	SMART
LY	1425	1469	3.05e-10	SMART
LY	1471	1513	3.88e-3	SMART
EGF	1540	1580	1.85e0	SMART
LY	1606	1650	2.83e-5	SMART
LY	1651	1695	2.01e-10	SMART
LY	1698	1735	1.87e-5	SMART
LY	1736	1777	3.54e-6	SMART
LY	1778	1820	4.17e1	SMART
EGF	1850	1888	1.24e-1	SMART
LY	1915	1957	3.2e-4	SMART
LY	1958	2000	2.33e-15	SMART
LY	2001	2044	7.45e-14	SMART
LY	2045	2087	3.87e-12	SMART
LY	2089	2131	1.37e0	SMART
EGF	2159	2196	1.66e1	SMART
LY	2276	2318	5.57e-4	SMART
LY	2324	2369	3.3e-6	SMART
LY	2370	2412	3.93e-13	SMART
LY	2413	2454	3.62e-3	SMART
EGF_like	2482	2519	3.16e1	SMART
LDLa	2524	2564	3.31e-10	SMART
LDLa	2566	2603	7.21e-11	SMART
LDLa	2605	2642	1.09e-10	SMART
LDLa	2660	2691	6.05e-4	SMART
LDLa	2696	2733	2.49e-14	SMART
LDLa	2734	2772	4.65e-14	SMART
LDLa	2774	2815	3.92e-12	SMART
LDLa	2818	2856	1.51e-13	SMART
LDLa	2858	2900	1.93e-11	SMART
LDLa	2904	2942	1.73e-13	SMART
EGF_CA	2941	2982	6.16e-6	SMART
EGF_CA	2983	3023	2.66e-10	SMART
LY	3050	3094	6.64e-11	SMART
LY	3095	3137	7.17e-16	SMART
LY	3138	3181	4.28e-14	SMART
LY	3182	3224	8.11e-15	SMART
LY	3225	3265	1.44e-6	SMART
EGF	3294	3332	1.02e-2	SMART
LDLa	3334	3372	2.25e-12	SMART
LDLa	3374	3411	9.81e-13	SMART
LDLa	3413	3451	9.81e-13	SMART
LDLa	3453	3492	5.67e-18	SMART
LDLa	3494	3534	7.15e-15	SMART
LDLa	3536	3573	1.79e-15	SMART
EGF_like	3575	3611	4.83e1	SMART
LDLa	3575	3612	1.92e-15	SMART
LDLa	3613	3650	1.18e-15	SMART
LDLa	3654	3693	7.55e-14	SMART
LDLa	3695	3734	1.14e-8	SMART
LDLa	3741	3779	6.28e-11	SMART
EGF	3785	3824	1.06e1	SMART
EGF	3828	3862	1.51e0	SMART
LY	3893	3935	9.43e0	SMART
LY	3951	3993	1.23e-14	SMART
LY	3994	4037	2.98e-13	SMART
LY	4038	4080	4.28e-14	SMART
EGF	4151	4184	3.76e-1	SMART
low complexity region	4185	4198	N/A	INTRINSIC
EGF	4200	4233	3.82e-2	SMART
EGF	4236	4269	4.03e-1	SMART
EGF	4272	4305	5.2e-4	SMART
EGF	4308	4341	1.22e0	SMART
EGF_like	4344	4376	4.11e1	SMART
EGF	4377	4410	5.12e-3	SMART
transmembrane domain	4423	4445	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125480

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129877

Predicted Effect

probably benign
Transcript: ENSMUST00000133620

SMART Domains

Protein: ENSMUSP00000115305
Gene: ENSMUSG00000040249

Domain	Start	End	E-Value	Type
LDLa	4	42	8.94e-16	SMART
LDLa	60	98	1.41e-13	SMART

Meta Mutation Damage Score

0.1331

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.7%
20x: 93.6%

Validation Efficiency

95% (107/113)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit lethality during late organogenesis. [provided by MGI curators]

Allele List at MGI

All alleles(42) : Targeted(9) Gene trapped(33)

Other mutations in this stock

Total: 99 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600012H06Rik	A	T	17: 15,164,001 (GRCm39)	I43L	possibly damaging	Het
4930449A18Rik	T	A	3: 59,749,153 (GRCm39)		noncoding transcript	Het
Abcc8	T	C	7: 45,800,252 (GRCm39)	K510R	probably damaging	Het
Adamtsl3	C	T	7: 82,178,069 (GRCm39)	R511C	probably damaging	Het
Arhgap11a	T	C	2: 113,670,107 (GRCm39)	S339G	probably damaging	Het
C2cd3	A	G	7: 100,065,397 (GRCm39)	T728A	probably benign	Het
Cand1	C	A	10: 119,049,451 (GRCm39)		probably null	Het
Catspere1	A	T	1: 177,699,624 (GRCm39)		noncoding transcript	Het
Ccdc121rt2	A	T	5: 112,598,106 (GRCm39)	K218*	probably null	Het
Cd209c	G	T	8: 3,995,905 (GRCm39)	R2S	probably benign	Het
Cdc16	A	G	8: 13,831,644 (GRCm39)		probably benign	Het
Ces1g	C	T	8: 94,060,323 (GRCm39)	E99K	probably benign	Het
Chrna7	A	C	7: 62,862,196 (GRCm39)	L10R	probably benign	Het
Clnk	C	T	5: 38,870,412 (GRCm39)		probably null	Het
Cntrob	C	G	11: 69,206,220 (GRCm39)	L315F	possibly damaging	Het
Ctdp1	A	G	18: 80,451,941 (GRCm39)	S145P	unknown	Het
Dennd2a	T	C	6: 39,474,044 (GRCm39)	D430G	probably damaging	Het
Dnajc16	A	G	4: 141,501,936 (GRCm39)	F298S	probably damaging	Het
Dock5	T	C	14: 68,055,012 (GRCm39)	D618G	probably damaging	Het
Drc3	G	A	11: 60,261,361 (GRCm39)	A171T	probably benign	Het
Ecel1	A	T	1: 87,081,023 (GRCm39)	N322K	probably damaging	Het
Eftud2	A	G	11: 102,745,640 (GRCm39)	F362L	probably damaging	Het
Egfr	C	T	11: 16,861,607 (GRCm39)	H1129Y	probably benign	Het
Eif2b1	A	G	5: 124,714,971 (GRCm39)	S102P	probably damaging	Het
Erich3	T	A	3: 154,410,480 (GRCm39)	F112I	possibly damaging	Het
Fam107b	T	C	2: 3,779,580 (GRCm39)	L261S	probably damaging	Het
Fat3	A	C	9: 15,908,883 (GRCm39)	V2373G	probably damaging	Het
Fcgbpl1	T	A	7: 27,850,147 (GRCm39)	C1198S	probably damaging	Het
Gadd45a	A	T	6: 67,013,873 (GRCm39)	L58Q	probably damaging	Het
Gask1b	G	A	3: 79,843,912 (GRCm39)	R377H	probably damaging	Het
Gipr	C	T	7: 18,896,601 (GRCm39)	R165H	probably damaging	Het
Gje1	C	T	10: 14,593,082 (GRCm39)	G45R	probably null	Het
Gldc	T	A	19: 30,111,132 (GRCm39)	N548I	possibly damaging	Het
Gm13035	A	G	4: 146,009,993 (GRCm39)		noncoding transcript	Het
Gm27013	T	A	6: 130,497,700 (GRCm39)		noncoding transcript	Het
Gm5436	A	T	12: 84,305,584 (GRCm39)		noncoding transcript	Het
Grik3	C	A	4: 125,584,969 (GRCm39)	N612K	probably damaging	Het
H2bc13	C	T	13: 21,900,234 (GRCm39)		probably benign	Het
Hfm1	C	A	5: 107,040,617 (GRCm39)	W716L	probably damaging	Het
Il5ra	T	C	6: 106,715,336 (GRCm39)	Y166C	probably damaging	Het
Iqcb1	A	G	16: 36,655,952 (GRCm39)	E113G	probably benign	Het
Kcnk10	A	T	12: 98,401,175 (GRCm39)	M486K	probably benign	Het
Kcnv2	A	G	19: 27,301,190 (GRCm39)	D347G	probably damaging	Het
Kif21b	C	A	1: 136,072,958 (GRCm39)	H119N	probably damaging	Het
Lamb1	C	T	12: 31,337,432 (GRCm39)	H388Y	probably damaging	Het
Leng9	T	C	7: 4,152,385 (GRCm39)	D97G	probably damaging	Het
Lmbr1	G	A	5: 29,492,424 (GRCm39)	T55I	probably damaging	Het
Lrp2	A	T	2: 69,299,755 (GRCm39)	V3099E	probably benign	Het
Lrrcc1	C	A	3: 14,627,571 (GRCm39)	D503E	probably benign	Het
Map1a	T	A	2: 121,132,567 (GRCm39)	S890T	probably damaging	Het
Msh2	C	A	17: 88,030,841 (GRCm39)	A906E	probably benign	Het
Mybph	A	T	1: 134,126,233 (GRCm39)	E349V	probably damaging	Het
Myh7b	C	A	2: 155,475,909 (GRCm39)	L1935M	probably benign	Het
Myh9	T	C	15: 77,653,453 (GRCm39)	E1348G	probably damaging	Het
Myzap	A	G	9: 71,456,037 (GRCm39)	S328P	probably damaging	Het
Nbeal1	T	C	1: 60,292,534 (GRCm39)	L1062P	probably damaging	Het
Nepro	G	A	16: 44,555,160 (GRCm39)	S412N	probably null	Het
Nr1h3	A	G	2: 91,020,563 (GRCm39)	F257L	probably benign	Het
Nudt5	T	C	2: 5,869,239 (GRCm39)	V155A	probably benign	Het
Ofcc1	G	A	13: 40,168,864 (GRCm39)	T841I	probably damaging	Het
Or13a25	A	T	7: 140,247,502 (GRCm39)	I94F	probably damaging	Het
Or52d3	A	T	7: 104,229,422 (GRCm39)	I190L	probably benign	Het
Or6ae1	A	G	7: 139,742,602 (GRCm39)	L87P	possibly damaging	Het
Pde1a	T	A	2: 79,959,181 (GRCm39)		probably benign	Het
Pde4dip	T	A	3: 97,700,844 (GRCm39)	H220L	probably damaging	Het
Pde9a	T	A	17: 31,662,135 (GRCm39)		probably null	Het
Pnkp	C	A	7: 44,511,070 (GRCm39)		probably null	Het
Pnpla7	A	G	2: 24,870,064 (GRCm39)	T15A	probably benign	Het
Polq	G	T	16: 36,869,145 (GRCm39)		probably null	Het
Ppfia2	C	T	10: 106,690,818 (GRCm39)	T553I	probably benign	Het
Ptk6	T	G	2: 180,838,784 (GRCm39)	N323T	possibly damaging	Het
Rhox3c	G	A	X: 36,652,077 (GRCm39)	A60T	probably damaging	Het
Rnf4	T	A	5: 34,506,053 (GRCm39)	V61E	probably damaging	Het
Rnf5	A	G	17: 34,820,977 (GRCm39)		probably benign	Het
Sardh	A	G	2: 27,081,967 (GRCm39)	V853A	probably benign	Het
Scfd1	T	C	12: 51,436,109 (GRCm39)	V86A	probably damaging	Het
Scube3	G	A	17: 28,383,097 (GRCm39)	C425Y	probably damaging	Het
Sema5a	C	T	15: 32,609,563 (GRCm39)	H490Y	probably benign	Het
Sfta2	T	C	17: 35,960,773 (GRCm39)		probably benign	Het
Sh3d19	T	C	3: 86,031,049 (GRCm39)	Y738H	probably damaging	Het
Shc2	T	C	10: 79,458,295 (GRCm39)	R463G	probably damaging	Het
Socs7	T	A	11: 97,267,829 (GRCm39)	I320N	possibly damaging	Het
Speer2	A	T	16: 69,654,988 (GRCm39)	M159K	probably benign	Het
Sppl2c	A	C	11: 104,078,478 (GRCm39)	H426P	probably benign	Het
Stag3	T	G	5: 138,307,627 (GRCm39)		probably null	Het
Stxbp5	C	A	10: 9,638,635 (GRCm39)	V1055L	probably benign	Het
Synpo	A	T	18: 60,736,684 (GRCm39)	S421T	probably damaging	Het
Taf6l	A	G	19: 8,759,770 (GRCm39)	V135A	possibly damaging	Het
Tas2r116	G	A	6: 132,832,660 (GRCm39)	S87N	probably benign	Het
Tomm6	T	C	17: 47,998,994 (GRCm39)		probably benign	Het
Trabd	T	C	15: 88,966,915 (GRCm39)	M113T	probably benign	Het
Trim58	G	A	11: 58,542,150 (GRCm39)	G370E	probably damaging	Het
Ttc41	C	T	10: 86,566,989 (GRCm39)	R552C	probably benign	Het
Vit	T	C	17: 78,909,308 (GRCm39)	S252P	probably benign	Het
Vma21-ps	T	A	4: 52,496,943 (GRCm39)	D101V	probably damaging	Het
Vmn1r173	A	T	7: 23,402,361 (GRCm39)	I199F	probably damaging	Het
Vmn2r114	T	A	17: 23,529,336 (GRCm39)	R255S	probably benign	Het
Vmn2r17	A	G	5: 109,582,246 (GRCm39)	N545S	probably damaging	Het
Zfp865	A	G	7: 5,034,640 (GRCm39)	Y875C	probably damaging	Het

Other mutations in Lrp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00793:Lrp1	APN	10	127,378,074 (GRCm39)	missense	possibly damaging	0.89
IGL01065:Lrp1	APN	10	127,410,907 (GRCm39)	missense	probably benign	0.10
IGL01121:Lrp1	APN	10	127,419,722 (GRCm39)	nonsense	probably null
IGL01360:Lrp1	APN	10	127,381,689 (GRCm39)	missense	possibly damaging	0.93
IGL01402:Lrp1	APN	10	127,430,901 (GRCm39)	missense	probably damaging	1.00
IGL01404:Lrp1	APN	10	127,430,901 (GRCm39)	missense	probably damaging	1.00
IGL01411:Lrp1	APN	10	127,417,634 (GRCm39)	nonsense	probably null
IGL01469:Lrp1	APN	10	127,420,283 (GRCm39)	missense	probably damaging	1.00
IGL01552:Lrp1	APN	10	127,424,379 (GRCm39)	nonsense	probably null
IGL01682:Lrp1	APN	10	127,410,847 (GRCm39)	missense	probably benign	0.00
IGL01760:Lrp1	APN	10	127,409,370 (GRCm39)	missense	probably benign	0.00
IGL01918:Lrp1	APN	10	127,390,458 (GRCm39)	missense	probably damaging	0.99
IGL01989:Lrp1	APN	10	127,413,998 (GRCm39)	missense	probably damaging	1.00
IGL02105:Lrp1	APN	10	127,380,448 (GRCm39)	missense	probably damaging	1.00
IGL02158:Lrp1	APN	10	127,390,140 (GRCm39)	missense	probably benign	0.02
IGL02164:Lrp1	APN	10	127,399,536 (GRCm39)	missense	probably benign	0.39
IGL02337:Lrp1	APN	10	127,412,756 (GRCm39)	missense	possibly damaging	0.87
IGL02425:Lrp1	APN	10	127,407,756 (GRCm39)	critical splice donor site	probably null
IGL02493:Lrp1	APN	10	127,417,647 (GRCm39)	missense	probably damaging	0.99
IGL02563:Lrp1	APN	10	127,387,555 (GRCm39)	missense	probably damaging	1.00
IGL02590:Lrp1	APN	10	127,388,660 (GRCm39)	missense	probably damaging	1.00
IGL02624:Lrp1	APN	10	127,408,291 (GRCm39)	missense	probably damaging	0.98
IGL02625:Lrp1	APN	10	127,410,355 (GRCm39)	missense	probably damaging	1.00
IGL02825:Lrp1	APN	10	127,378,474 (GRCm39)	missense	probably damaging	1.00
IGL02880:Lrp1	APN	10	127,376,091 (GRCm39)	missense	probably benign	0.12
IGL02900:Lrp1	APN	10	127,412,516 (GRCm39)	splice site	probably benign
IGL02956:Lrp1	APN	10	127,380,428 (GRCm39)	missense	probably benign	0.00
IGL02974:Lrp1	APN	10	127,390,885 (GRCm39)	missense	probably damaging	0.99
IGL02983:Lrp1	APN	10	127,386,068 (GRCm39)	missense	probably damaging	1.00
IGL03002:Lrp1	APN	10	127,425,505 (GRCm39)	missense	probably damaging	1.00
IGL03091:Lrp1	APN	10	127,394,993 (GRCm39)	missense	probably benign	0.30
IGL03109:Lrp1	APN	10	127,402,514 (GRCm39)	missense	probably benign
IGL03194:Lrp1	APN	10	127,404,554 (GRCm39)	missense	probably damaging	1.00
IGL03232:Lrp1	APN	10	127,375,245 (GRCm39)	missense	probably damaging	1.00
calculus	UTSW	10	127,393,937 (GRCm39)	splice site	probably null
Delimiter	UTSW	10	127,382,731 (GRCm39)	missense	probably damaging	1.00
extremis	UTSW	10	127,392,857 (GRCm39)	missense	probably benign	0.00
Jockey	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
peripheral	UTSW	10	127,446,250 (GRCm39)	missense	probably damaging	1.00
tangential	UTSW	10	127,429,717 (GRCm39)	missense	probably damaging	0.99
P0015:Lrp1	UTSW	10	127,402,532 (GRCm39)	missense	probably damaging	0.99
PIT4519001:Lrp1	UTSW	10	127,443,843 (GRCm39)	missense	possibly damaging	0.91
PIT4520001:Lrp1	UTSW	10	127,443,843 (GRCm39)	missense	possibly damaging	0.91
R0004:Lrp1	UTSW	10	127,377,694 (GRCm39)	splice site	probably null
R0034:Lrp1	UTSW	10	127,381,520 (GRCm39)	missense	probably benign	0.42
R0091:Lrp1	UTSW	10	127,376,848 (GRCm39)	missense	probably damaging	1.00
R0098:Lrp1	UTSW	10	127,388,607 (GRCm39)	missense	probably benign
R0098:Lrp1	UTSW	10	127,388,607 (GRCm39)	missense	probably benign
R0143:Lrp1	UTSW	10	127,429,811 (GRCm39)	missense	probably damaging	1.00
R0372:Lrp1	UTSW	10	127,428,005 (GRCm39)	missense	probably damaging	1.00
R0379:Lrp1	UTSW	10	127,430,838 (GRCm39)	missense	probably damaging	1.00
R0445:Lrp1	UTSW	10	127,426,505 (GRCm39)	nonsense	probably null
R0529:Lrp1	UTSW	10	127,377,463 (GRCm39)	splice site	probably null
R0551:Lrp1	UTSW	10	127,407,827 (GRCm39)	missense	probably benign
R0570:Lrp1	UTSW	10	127,390,878 (GRCm39)	nonsense	probably null
R0600:Lrp1	UTSW	10	127,403,252 (GRCm39)	missense	probably benign	0.00
R0626:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R0647:Lrp1	UTSW	10	127,407,346 (GRCm39)	missense	probably damaging	1.00
R0680:Lrp1	UTSW	10	127,425,530 (GRCm39)	missense	probably damaging	1.00
R0792:Lrp1	UTSW	10	127,411,155 (GRCm39)	missense	probably benign	0.04
R0792:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R0848:Lrp1	UTSW	10	127,389,231 (GRCm39)	splice site	probably null
R0866:Lrp1	UTSW	10	127,375,147 (GRCm39)	missense	probably damaging	1.00
R0918:Lrp1	UTSW	10	127,429,834 (GRCm39)	missense	probably damaging	1.00
R1076:Lrp1	UTSW	10	127,399,666 (GRCm39)	splice site	probably benign
R1107:Lrp1	UTSW	10	127,393,304 (GRCm39)	missense	probably damaging	1.00
R1346:Lrp1	UTSW	10	127,441,735 (GRCm39)	missense	probably damaging	1.00
R1403:Lrp1	UTSW	10	127,417,760 (GRCm39)	critical splice acceptor site	probably null
R1403:Lrp1	UTSW	10	127,417,760 (GRCm39)	critical splice acceptor site	probably null
R1496:Lrp1	UTSW	10	127,374,880 (GRCm39)	missense	probably damaging	1.00
R1522:Lrp1	UTSW	10	127,411,155 (GRCm39)	missense	probably benign	0.04
R1522:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R1525:Lrp1	UTSW	10	127,375,398 (GRCm39)	missense	probably damaging	1.00
R1539:Lrp1	UTSW	10	127,420,250 (GRCm39)	splice site	probably null
R1589:Lrp1	UTSW	10	127,441,475 (GRCm39)	missense	probably benign	0.00
R1591:Lrp1	UTSW	10	127,441,475 (GRCm39)	missense	probably benign	0.00
R1663:Lrp1	UTSW	10	127,392,790 (GRCm39)	missense	probably damaging	1.00
R1682:Lrp1	UTSW	10	127,410,201 (GRCm39)	missense	probably damaging	1.00
R1717:Lrp1	UTSW	10	127,399,534 (GRCm39)	missense	probably damaging	1.00
R1717:Lrp1	UTSW	10	127,392,138 (GRCm39)	missense	possibly damaging	0.59
R1758:Lrp1	UTSW	10	127,424,453 (GRCm39)	missense	possibly damaging	0.76
R1826:Lrp1	UTSW	10	127,389,576 (GRCm39)	missense	probably damaging	1.00
R1842:Lrp1	UTSW	10	127,409,337 (GRCm39)	missense	possibly damaging	0.93
R1844:Lrp1	UTSW	10	127,431,152 (GRCm39)	critical splice donor site	probably null
R1845:Lrp1	UTSW	10	127,414,542 (GRCm39)	missense	probably damaging	1.00
R1896:Lrp1	UTSW	10	127,395,867 (GRCm39)	missense	possibly damaging	0.64
R1952:Lrp1	UTSW	10	127,403,300 (GRCm39)	missense	probably damaging	1.00
R2009:Lrp1	UTSW	10	127,380,385 (GRCm39)	missense	probably damaging	1.00
R2015:Lrp1	UTSW	10	127,376,563 (GRCm39)	missense	probably benign	0.00
R2116:Lrp1	UTSW	10	127,412,362 (GRCm39)	nonsense	probably null
R2161:Lrp1	UTSW	10	127,391,607 (GRCm39)	missense	probably damaging	1.00
R2199:Lrp1	UTSW	10	127,382,709 (GRCm39)	missense	probably damaging	1.00
R2213:Lrp1	UTSW	10	127,376,571 (GRCm39)	missense	probably damaging	1.00
R2300:Lrp1	UTSW	10	127,392,784 (GRCm39)	nonsense	probably null
R2324:Lrp1	UTSW	10	127,402,455 (GRCm39)	missense	possibly damaging	0.92
R2849:Lrp1	UTSW	10	127,378,165 (GRCm39)	missense	probably damaging	1.00
R2926:Lrp1	UTSW	10	127,423,982 (GRCm39)	missense	probably damaging	0.98
R2993:Lrp1	UTSW	10	127,446,250 (GRCm39)	missense	probably damaging	1.00
R3522:Lrp1	UTSW	10	127,389,424 (GRCm39)	missense	probably damaging	1.00
R3702:Lrp1	UTSW	10	127,430,972 (GRCm39)	missense	probably damaging	1.00
R3789:Lrp1	UTSW	10	127,407,838 (GRCm39)	missense	possibly damaging	0.94
R3898:Lrp1	UTSW	10	127,427,969 (GRCm39)	nonsense	probably null
R3941:Lrp1	UTSW	10	127,389,265 (GRCm39)	missense	probably damaging	1.00
R3958:Lrp1	UTSW	10	127,407,827 (GRCm39)	missense	probably benign
R4369:Lrp1	UTSW	10	127,386,155 (GRCm39)	missense	possibly damaging	0.87
R4510:Lrp1	UTSW	10	127,429,717 (GRCm39)	missense	probably damaging	0.99
R4511:Lrp1	UTSW	10	127,429,717 (GRCm39)	missense	probably damaging	0.99
R4576:Lrp1	UTSW	10	127,376,057 (GRCm39)	small deletion	probably benign
R4583:Lrp1	UTSW	10	127,377,241 (GRCm39)	missense	probably benign	0.00
R4662:Lrp1	UTSW	10	127,388,054 (GRCm39)	nonsense	probably null
R4721:Lrp1	UTSW	10	127,390,928 (GRCm39)	missense	possibly damaging	0.58
R4728:Lrp1	UTSW	10	127,399,606 (GRCm39)	missense	probably damaging	1.00
R4745:Lrp1	UTSW	10	127,385,813 (GRCm39)	missense	probably benign	0.20
R4785:Lrp1	UTSW	10	127,394,002 (GRCm39)	missense	probably benign	0.12
R4841:Lrp1	UTSW	10	127,419,805 (GRCm39)	missense	probably damaging	1.00
R4855:Lrp1	UTSW	10	127,446,311 (GRCm39)	missense	probably benign	0.03
R4860:Lrp1	UTSW	10	127,389,693 (GRCm39)	missense	probably damaging	1.00
R4860:Lrp1	UTSW	10	127,389,693 (GRCm39)	missense	probably damaging	1.00
R4891:Lrp1	UTSW	10	127,377,621 (GRCm39)	missense	probably damaging	1.00
R4925:Lrp1	UTSW	10	127,410,944 (GRCm39)	nonsense	probably null
R4970:Lrp1	UTSW	10	127,375,389 (GRCm39)	missense	probably benign	0.11
R4999:Lrp1	UTSW	10	127,389,648 (GRCm39)	missense	probably damaging	1.00
R5044:Lrp1	UTSW	10	127,403,364 (GRCm39)	missense	probably damaging	1.00
R5127:Lrp1	UTSW	10	127,375,503 (GRCm39)	intron	probably benign
R5188:Lrp1	UTSW	10	127,443,821 (GRCm39)	missense	probably damaging	1.00
R5218:Lrp1	UTSW	10	127,384,488 (GRCm39)	missense	probably damaging	1.00
R5225:Lrp1	UTSW	10	127,391,965 (GRCm39)	missense	probably benign	0.04
R5291:Lrp1	UTSW	10	127,429,747 (GRCm39)	missense	probably damaging	1.00
R5386:Lrp1	UTSW	10	127,427,983 (GRCm39)	missense	probably damaging	1.00
R5395:Lrp1	UTSW	10	127,431,166 (GRCm39)	missense	probably damaging	1.00
R5413:Lrp1	UTSW	10	127,423,936 (GRCm39)	critical splice donor site	probably null
R5430:Lrp1	UTSW	10	127,376,930 (GRCm39)	missense	probably damaging	0.99
R5499:Lrp1	UTSW	10	127,408,813 (GRCm39)	missense	possibly damaging	0.58
R5526:Lrp1	UTSW	10	127,391,593 (GRCm39)	missense	probably benign	0.37
R5580:Lrp1	UTSW	10	127,424,389 (GRCm39)	missense	probably benign
R5583:Lrp1	UTSW	10	127,424,332 (GRCm39)	missense	probably benign	0.08
R5599:Lrp1	UTSW	10	127,429,738 (GRCm39)	missense	probably damaging	1.00
R5639:Lrp1	UTSW	10	127,429,708 (GRCm39)	missense	probably damaging	0.99
R5677:Lrp1	UTSW	10	127,410,298 (GRCm39)	missense	probably damaging	1.00
R5730:Lrp1	UTSW	10	127,419,703 (GRCm39)	missense	probably benign	0.00
R5742:Lrp1	UTSW	10	127,384,216 (GRCm39)	missense	probably damaging	0.98
R5764:Lrp1	UTSW	10	127,431,187 (GRCm39)	missense	probably benign	0.41
R5864:Lrp1	UTSW	10	127,403,374 (GRCm39)	missense	possibly damaging	0.58
R5937:Lrp1	UTSW	10	127,419,745 (GRCm39)	missense	possibly damaging	0.93
R5947:Lrp1	UTSW	10	127,425,423 (GRCm39)	critical splice donor site	probably null
R5976:Lrp1	UTSW	10	127,419,770 (GRCm39)	missense	probably damaging	1.00
R6021:Lrp1	UTSW	10	127,413,883 (GRCm39)	missense	probably damaging	1.00
R6026:Lrp1	UTSW	10	127,409,272 (GRCm39)	missense	probably damaging	1.00
R6045:Lrp1	UTSW	10	127,402,469 (GRCm39)	missense	probably damaging	0.98
R6057:Lrp1	UTSW	10	127,403,359 (GRCm39)	missense	probably damaging	1.00
R6084:Lrp1	UTSW	10	127,396,422 (GRCm39)	missense	probably benign	0.09
R6131:Lrp1	UTSW	10	127,396,026 (GRCm39)	missense	probably benign
R6235:Lrp1	UTSW	10	127,424,046 (GRCm39)	missense	probably damaging	1.00
R6280:Lrp1	UTSW	10	127,425,453 (GRCm39)	missense	probably benign	0.04
R6307:Lrp1	UTSW	10	127,427,944 (GRCm39)	missense	probably damaging	1.00
R6532:Lrp1	UTSW	10	127,385,276 (GRCm39)	missense	probably damaging	1.00
R6532:Lrp1	UTSW	10	127,377,551 (GRCm39)	missense	probably damaging	1.00
R6536:Lrp1	UTSW	10	127,393,937 (GRCm39)	splice site	probably null
R6605:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6607:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6631:Lrp1	UTSW	10	127,410,201 (GRCm39)	missense	probably damaging	1.00
R6676:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6678:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6809:Lrp1	UTSW	10	127,390,925 (GRCm39)	missense	probably benign	0.04
R6884:Lrp1	UTSW	10	127,394,986 (GRCm39)	missense	probably benign	0.00
R6925:Lrp1	UTSW	10	127,392,857 (GRCm39)	missense	probably benign	0.00
R6987:Lrp1	UTSW	10	127,410,874 (GRCm39)	missense	probably damaging	1.00
R7016:Lrp1	UTSW	10	127,395,836 (GRCm39)	critical splice donor site	probably null
R7030:Lrp1	UTSW	10	127,388,745 (GRCm39)	missense	probably damaging	0.97
R7053:Lrp1	UTSW	10	127,376,963 (GRCm39)	missense	probably damaging	1.00
R7076:Lrp1	UTSW	10	127,386,052 (GRCm39)	critical splice donor site	probably null
R7136:Lrp1	UTSW	10	127,394,491 (GRCm39)	missense	probably damaging	1.00
R7180:Lrp1	UTSW	10	127,392,834 (GRCm39)	missense	probably damaging	1.00
R7199:Lrp1	UTSW	10	127,409,325 (GRCm39)	missense	probably damaging	0.99
R7219:Lrp1	UTSW	10	127,393,097 (GRCm39)	missense	probably benign	0.40
R7233:Lrp1	UTSW	10	127,430,930 (GRCm39)	missense	probably damaging	1.00
R7251:Lrp1	UTSW	10	127,408,423 (GRCm39)	missense	probably damaging	1.00
R7264:Lrp1	UTSW	10	127,427,962 (GRCm39)	missense	probably damaging	1.00
R7302:Lrp1	UTSW	10	127,374,856 (GRCm39)	missense	probably benign	0.01
R7313:Lrp1	UTSW	10	127,389,337 (GRCm39)	missense	probably damaging	1.00
R7322:Lrp1	UTSW	10	127,381,433 (GRCm39)	missense	probably benign	0.24
R7354:Lrp1	UTSW	10	127,407,277 (GRCm39)	missense	probably damaging	1.00
R7375:Lrp1	UTSW	10	127,375,217 (GRCm39)	missense	probably damaging	1.00
R7388:Lrp1	UTSW	10	127,419,766 (GRCm39)	nonsense	probably null
R7404:Lrp1	UTSW	10	127,418,577 (GRCm39)	missense
R7405:Lrp1	UTSW	10	127,417,620 (GRCm39)	missense	possibly damaging	0.93
R7477:Lrp1	UTSW	10	127,404,789 (GRCm39)	missense	probably damaging	1.00
R7555:Lrp1	UTSW	10	127,382,731 (GRCm39)	missense	probably damaging	1.00
R7600:Lrp1	UTSW	10	127,391,575 (GRCm39)	missense	probably benign
R7678:Lrp1	UTSW	10	127,409,922 (GRCm39)	missense	probably damaging	1.00
R7679:Lrp1	UTSW	10	127,424,297 (GRCm39)	nonsense	probably null
R7951:Lrp1	UTSW	10	127,374,933 (GRCm39)	nonsense	probably null
R7964:Lrp1	UTSW	10	127,410,913 (GRCm39)	missense	possibly damaging	0.94
R8006:Lrp1	UTSW	10	127,425,488 (GRCm39)	missense	probably damaging	1.00
R8021:Lrp1	UTSW	10	127,384,215 (GRCm39)	missense	possibly damaging	0.92
R8098:Lrp1	UTSW	10	127,410,324 (GRCm39)	missense	possibly damaging	0.78
R8112:Lrp1	UTSW	10	127,441,715 (GRCm39)	missense	probably damaging	1.00
R8210:Lrp1	UTSW	10	127,412,354 (GRCm39)	missense	probably damaging	1.00
R8249:Lrp1	UTSW	10	127,441,412 (GRCm39)	missense	probably benign
R8291:Lrp1	UTSW	10	127,425,572 (GRCm39)	missense	probably damaging	1.00
R8332:Lrp1	UTSW	10	127,407,805 (GRCm39)	missense	probably damaging	1.00
R8435:Lrp1	UTSW	10	127,392,199 (GRCm39)	missense	probably damaging	0.97
R8467:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8468:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8474:Lrp1	UTSW	10	127,375,572 (GRCm39)	missense	probably damaging	1.00
R8481:Lrp1	UTSW	10	127,404,779 (GRCm39)	missense	probably damaging	1.00
R8483:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8485:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8488:Lrp1	UTSW	10	127,396,356 (GRCm39)	missense	probably damaging	1.00
R8715:Lrp1	UTSW	10	127,396,490 (GRCm39)	missense	possibly damaging	0.77
R8790:Lrp1	UTSW	10	127,374,946 (GRCm39)	missense	probably damaging	1.00
R8854:Lrp1	UTSW	10	127,378,968 (GRCm39)	missense	probably damaging	1.00
R8926:Lrp1	UTSW	10	127,381,671 (GRCm39)	missense	probably benign
R8949:Lrp1	UTSW	10	127,425,405 (GRCm39)	intron	probably benign
R8971:Lrp1	UTSW	10	127,391,896 (GRCm39)	missense	possibly damaging	0.94
R9103:Lrp1	UTSW	10	127,430,979 (GRCm39)	nonsense	probably null
R9108:Lrp1	UTSW	10	127,390,206 (GRCm39)	missense	probably damaging	0.99
R9130:Lrp1	UTSW	10	127,382,281 (GRCm39)	missense	probably benign	0.18
R9157:Lrp1	UTSW	10	127,410,209 (GRCm39)	missense	probably damaging	1.00
R9162:Lrp1	UTSW	10	127,441,368 (GRCm39)	missense	probably benign	0.32
R9205:Lrp1	UTSW	10	127,430,850 (GRCm39)	nonsense	probably null
R9228:Lrp1	UTSW	10	127,382,807 (GRCm39)	missense	probably damaging	0.98
R9231:Lrp1	UTSW	10	127,382,268 (GRCm39)	missense	probably benign	0.06
R9287:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R9381:Lrp1	UTSW	10	127,441,337 (GRCm39)	missense	probably benign	0.17
R9412:Lrp1	UTSW	10	127,409,287 (GRCm39)	missense	probably damaging	1.00
R9434:Lrp1	UTSW	10	127,381,689 (GRCm39)	missense	possibly damaging	0.93
R9463:Lrp1	UTSW	10	127,429,334 (GRCm39)	nonsense	probably null
R9526:Lrp1	UTSW	10	127,431,229 (GRCm39)	missense	probably damaging	0.96
R9548:Lrp1	UTSW	10	127,388,733 (GRCm39)	missense	probably damaging	0.99
R9599:Lrp1	UTSW	10	127,410,246 (GRCm39)	missense	probably damaging	1.00
R9649:Lrp1	UTSW	10	127,409,368 (GRCm39)	missense	probably benign	0.14
R9687:Lrp1	UTSW	10	127,402,562 (GRCm39)	missense	probably damaging	1.00
R9707:Lrp1	UTSW	10	127,408,414 (GRCm39)	missense	probably benign	0.08
R9770:Lrp1	UTSW	10	127,420,268 (GRCm39)	missense	probably damaging	1.00
V3553:Lrp1	UTSW	10	127,407,311 (GRCm39)	missense	probably damaging	1.00
Y5406:Lrp1	UTSW	10	127,390,152 (GRCm39)	missense	probably damaging	1.00
Z1088:Lrp1	UTSW	10	127,420,248 (GRCm39)	missense	probably damaging	1.00
Z1176:Lrp1	UTSW	10	127,390,831 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGGCCACAGTGACAACTTAC -3'
(R):5'- ACCAACAGGACTGGGTGTAC -3'

Sequencing Primer
(F):5'- GGCCACAGTGACAACTTACTCAAG -3'
(R):5'- GGATGGAGCCTTTTCCCAAAAAC -3'

Posted On

2016-10-28