Incidental Mutation 'R5602:Naa25'
ID 439071
Institutional Source Beutler Lab
Gene Symbol Naa25
Ensembl Gene ENSMUSG00000042719
Gene Name N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms C330023M02Rik, 4833422K13Rik
MMRRC Submission 043154-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5602 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 121535977-121580612 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 121558558 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 300 (E300G)
Ref Sequence ENSEMBL: ENSMUSP00000038977 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042163] [ENSMUST00000151458] [ENSMUST00000173895]
AlphaFold Q8BWZ3
Predicted Effect probably benign
Transcript: ENSMUST00000042163
AA Change: E300G

PolyPhen 2 Score 0.296 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000038977
Gene: ENSMUSG00000042719
AA Change: E300G

DomainStartEndE-ValueType
low complexity region 35 45 N/A INTRINSIC
Pfam:NatB_MDM20 263 658 1.6e-121 PFAM
low complexity region 672 683 N/A INTRINSIC
low complexity region 687 700 N/A INTRINSIC
low complexity region 721 734 N/A INTRINSIC
low complexity region 915 935 N/A INTRINSIC
low complexity region 958 971 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131598
Predicted Effect probably benign
Transcript: ENSMUST00000151458
SMART Domains Protein: ENSMUSP00000120970
Gene: ENSMUSG00000042719

DomainStartEndE-ValueType
SCOP:d1a17__ 21 94 1e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173895
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik G A 2: 151,315,459 (GRCm39) S73F possibly damaging Het
4932414N04Rik A T 2: 68,578,712 (GRCm39) *753L probably null Het
Acyp2 C T 11: 30,456,354 (GRCm39) E98K possibly damaging Het
Adam19 T C 11: 46,027,142 (GRCm39) S592P probably benign Het
Adamtsl3 A G 7: 82,206,447 (GRCm39) K843R possibly damaging Het
Ap2a2 A T 7: 141,184,855 (GRCm39) T213S probably benign Het
Asb5 A G 8: 55,038,974 (GRCm39) E280G probably benign Het
Becn1 T C 11: 101,179,778 (GRCm39) D403G probably damaging Het
Ccr7 G T 11: 99,036,315 (GRCm39) N202K probably benign Het
Cd36 T C 5: 18,019,790 (GRCm39) T104A possibly damaging Het
Cnot4 C T 6: 35,028,464 (GRCm39) W384* probably null Het
Col15a1 G A 4: 47,312,087 (GRCm39) V1301M probably damaging Het
Dock2 C A 11: 34,204,391 (GRCm39) A1384S probably benign Het
Ehbp1l1 T C 19: 5,758,698 (GRCm39) E1648G possibly damaging Het
Fbn1 G T 2: 125,163,661 (GRCm39) A2065E possibly damaging Het
Fras1 A G 5: 96,884,880 (GRCm39) Y2586C probably damaging Het
Galm T A 17: 80,457,568 (GRCm39) Y28* probably null Het
Ggt7 A G 2: 155,332,919 (GRCm39) V648A possibly damaging Het
Gm17067 T A 7: 42,357,839 (GRCm39) D221V probably damaging Het
Gpr3 T C 4: 132,937,805 (GRCm39) N289S probably damaging Het
Ighv11-2 A G 12: 114,012,277 (GRCm39) probably benign Het
Ighv11-2 G A 12: 114,012,099 (GRCm39) L39F probably damaging Het
Ipo9 G A 1: 135,329,983 (GRCm39) L486F probably damaging Het
Jak2 T A 19: 29,275,739 (GRCm39) N726K probably benign Het
Map4 T C 9: 109,881,768 (GRCm39) S211P possibly damaging Het
Mlh1 A T 9: 111,081,946 (GRCm39) L259Q probably damaging Het
Or8g34 A T 9: 39,373,326 (GRCm39) M200L probably benign Het
Or8g54 T A 9: 39,707,490 (GRCm39) V273E possibly damaging Het
Parva G A 7: 112,166,972 (GRCm39) V182I probably benign Het
Pcdhgb4 T C 18: 37,854,697 (GRCm39) I364T probably damaging Het
Pdik1l A G 4: 134,011,580 (GRCm39) S164P probably damaging Het
Pfas A T 11: 68,881,871 (GRCm39) I938N probably benign Het
Plscr1l1 G A 9: 92,234,721 (GRCm39) C152Y possibly damaging Het
Prdm4 TCTCCTCCT TCTCCT 10: 85,728,987 (GRCm39) probably null Het
Prob1 C T 18: 35,787,079 (GRCm39) V392M possibly damaging Het
Rasgrf1 T C 9: 89,793,624 (GRCm39) S134P possibly damaging Het
Rorb T A 19: 18,955,301 (GRCm39) Y20F probably damaging Het
Rsph9 G T 17: 46,445,909 (GRCm39) D220E probably damaging Het
Safb2 C A 17: 56,882,630 (GRCm39) K334N possibly damaging Het
Sall3 T C 18: 81,016,027 (GRCm39) T634A probably benign Het
Scaf1 A G 7: 44,657,007 (GRCm39) probably benign Het
Slco1a5 T A 6: 142,221,255 (GRCm39) probably benign Het
Spata21 C T 4: 140,824,210 (GRCm39) R158C probably benign Het
Srrm2 G A 17: 24,038,311 (GRCm39) probably benign Het
Stk38l C A 6: 146,659,998 (GRCm39) T10N probably benign Het
Supv3l1 G A 10: 62,266,371 (GRCm39) P602S possibly damaging Het
Timm44 C T 8: 4,316,769 (GRCm39) probably null Het
Tll2 T A 19: 41,093,420 (GRCm39) R465S possibly damaging Het
Tmem104 G A 11: 115,095,950 (GRCm39) A164T probably damaging Het
Tmem151b A G 17: 45,856,526 (GRCm39) S305P probably damaging Het
Utrn T C 10: 12,625,839 (GRCm39) D114G probably damaging Het
Vmn2r109 A T 17: 20,760,933 (GRCm39) M808K possibly damaging Het
Washc2 T A 6: 116,225,056 (GRCm39) D801E possibly damaging Het
Xkr4 T C 1: 3,286,751 (GRCm39) I480V probably benign Het
Zfp507 G T 7: 35,475,663 (GRCm39) S58* probably null Het
Zfp768 T A 7: 126,943,804 (GRCm39) D108V possibly damaging Het
Other mutations in Naa25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02025:Naa25 APN 5 121,577,928 (GRCm39) missense probably damaging 1.00
IGL02142:Naa25 APN 5 121,564,825 (GRCm39) missense possibly damaging 0.52
IGL02541:Naa25 APN 5 121,562,594 (GRCm39) missense possibly damaging 0.92
IGL02747:Naa25 APN 5 121,552,668 (GRCm39) splice site probably benign
IGL03074:Naa25 APN 5 121,546,400 (GRCm39) critical splice donor site probably null
IGL03119:Naa25 APN 5 121,573,041 (GRCm39) missense probably null 1.00
IGL03218:Naa25 APN 5 121,564,133 (GRCm39) missense probably damaging 1.00
R0003:Naa25 UTSW 5 121,545,247 (GRCm39) intron probably benign
R0022:Naa25 UTSW 5 121,556,039 (GRCm39) missense probably damaging 1.00
R0022:Naa25 UTSW 5 121,556,039 (GRCm39) missense probably damaging 1.00
R0102:Naa25 UTSW 5 121,573,632 (GRCm39) missense possibly damaging 0.69
R0102:Naa25 UTSW 5 121,573,632 (GRCm39) missense possibly damaging 0.69
R0399:Naa25 UTSW 5 121,573,553 (GRCm39) missense probably benign 0.00
R0973:Naa25 UTSW 5 121,576,779 (GRCm39) splice site probably benign
R1418:Naa25 UTSW 5 121,561,797 (GRCm39) missense probably damaging 1.00
R1582:Naa25 UTSW 5 121,572,892 (GRCm39) missense probably benign
R1793:Naa25 UTSW 5 121,558,656 (GRCm39) missense probably damaging 1.00
R1793:Naa25 UTSW 5 121,555,478 (GRCm39) missense possibly damaging 0.82
R1863:Naa25 UTSW 5 121,573,611 (GRCm39) missense probably benign 0.00
R3160:Naa25 UTSW 5 121,573,135 (GRCm39) splice site probably null
R3162:Naa25 UTSW 5 121,573,135 (GRCm39) splice site probably null
R3721:Naa25 UTSW 5 121,569,619 (GRCm39) missense probably benign
R3864:Naa25 UTSW 5 121,547,260 (GRCm39) missense probably damaging 0.96
R4852:Naa25 UTSW 5 121,568,755 (GRCm39) missense probably damaging 1.00
R5077:Naa25 UTSW 5 121,562,639 (GRCm39) missense probably benign 0.02
R5855:Naa25 UTSW 5 121,561,755 (GRCm39) missense possibly damaging 0.94
R6464:Naa25 UTSW 5 121,556,024 (GRCm39) missense probably damaging 1.00
R6734:Naa25 UTSW 5 121,576,888 (GRCm39) missense possibly damaging 0.65
R6750:Naa25 UTSW 5 121,546,372 (GRCm39) missense probably damaging 1.00
R6767:Naa25 UTSW 5 121,577,928 (GRCm39) missense probably damaging 1.00
R6856:Naa25 UTSW 5 121,576,867 (GRCm39) missense probably damaging 1.00
R7145:Naa25 UTSW 5 121,555,552 (GRCm39) critical splice donor site probably null
R7631:Naa25 UTSW 5 121,576,791 (GRCm39) missense possibly damaging 0.92
R7701:Naa25 UTSW 5 121,564,042 (GRCm39) missense probably benign
R7800:Naa25 UTSW 5 121,562,594 (GRCm39) missense possibly damaging 0.92
R7804:Naa25 UTSW 5 121,562,652 (GRCm39) missense probably benign 0.00
R7822:Naa25 UTSW 5 121,545,276 (GRCm39) missense probably damaging 1.00
R8707:Naa25 UTSW 5 121,552,875 (GRCm39) missense probably damaging 1.00
R8944:Naa25 UTSW 5 121,552,573 (GRCm39) missense probably benign 0.34
R9486:Naa25 UTSW 5 121,577,958 (GRCm39) missense probably damaging 1.00
X0004:Naa25 UTSW 5 121,551,144 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTGCTAAGCCACACTTCTGG -3'
(R):5'- GCCTGCACTCAAGATTTGGG -3'

Sequencing Primer
(F):5'- TCAGGGAGATCTATCAGCCTAGC -3'
(R):5'- TGGTCTCAGCTTCTCAGGGC -3'
Posted On 2016-10-26