Mutagenetix > Incidental Mutation

Incidental Mutation 'R5538:Prkdc'

434954

Institutional Source

Beutler Lab

Gene Symbol

Prkdc

Ensembl Gene

ENSMUSG00000022672

Gene Name

protein kinase, DNA activated, catalytic polypeptide

Synonyms

slip, DNA-PK, XRCC7, DNAPDcs, DOXNPH, dxnph, DNA-PKcs

MMRRC Submission

043096-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.953) question?

Stock #

R5538 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

15455730-15660099 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 15469333 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 146 (E146G)

Ref Sequence

ENSEMBL: ENSMUSP00000023352 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023352]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000023352
AA Change: E146G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000023352
Gene: ENSMUSG00000022672
AA Change: E146G

Domain	Start	End	E-Value	Type
low complexity region	125	138	N/A	INTRINSIC
low complexity region	1253	1263	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
NUC194	1810	2206	2.37e-246	SMART
SCOP:d1gw5a_	2210	2493	5e-3	SMART
low complexity region	2669	2681	N/A	INTRINSIC
low complexity region	2841	2855	N/A	INTRINSIC
Pfam:FAT	3024	3470	8.2e-75	PFAM
PI3Kc	3749	4068	3.67e-86	SMART
FATC	4096	4128	1.57e-9	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182134

Meta Mutation Damage Score

0.1015

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.3%
20x: 95.1%

Validation Efficiency

94% (73/78)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
PHENOTYPE: Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	C	A	13: 81,581,808 (GRCm39)	R4745S	probably benign	Het
Ank3	A	G	10: 69,823,257 (GRCm39)	E642G	probably damaging	Het
Arhgap11a	G	T	2: 113,667,875 (GRCm39)	D375E	probably benign	Het
Arl8b	C	A	6: 108,760,297 (GRCm39)	L28M	probably damaging	Het
Bbs2	G	A	8: 94,816,391 (GRCm39)	T157M	probably damaging	Het
C2cd3	T	A	7: 100,104,700 (GRCm39)		probably null	Het
C6	T	A	15: 4,844,311 (GRCm39)	I911N	possibly damaging	Het
Cc2d2a	T	C	5: 43,852,518 (GRCm39)	I365T	possibly damaging	Het
Cd46	T	G	1: 194,750,478 (GRCm39)		probably null	Het
Ceacam3	A	T	7: 16,892,346 (GRCm39)	D363V	probably damaging	Het
Cep63	A	T	9: 102,465,992 (GRCm39)	L678*	probably null	Het
Clasrp	A	C	7: 19,318,707 (GRCm39)		probably benign	Het
Clk2	T	A	3: 89,082,962 (GRCm39)	Y412N	probably damaging	Het
Col24a1	C	T	3: 144,998,882 (GRCm39)	A5V	probably damaging	Het
Cox16	T	C	12: 81,531,703 (GRCm39)	N13D	possibly damaging	Het
Cybb	C	G	X: 9,316,989 (GRCm39)	D246H	probably benign	Het
Dhx32	A	T	7: 133,324,946 (GRCm39)	M437K	probably benign	Het
Dnm2	T	C	9: 21,416,923 (GRCm39)	F819L	probably benign	Het
Dpysl4	A	G	7: 138,671,906 (GRCm39)	T85A	probably benign	Het
Dspp	A	T	5: 104,323,096 (GRCm39)	K80*	probably null	Het
Dync2h1	T	C	9: 7,168,630 (GRCm39)		probably benign	Het
Ern1	A	G	11: 106,312,727 (GRCm39)	V218A	possibly damaging	Het
Fbn2	G	A	18: 58,204,973 (GRCm39)	R1157C	probably benign	Het
Fez1	T	A	9: 36,780,172 (GRCm39)	I323N	probably damaging	Het
Fmo9	T	A	1: 166,501,198 (GRCm39)	T199S	probably benign	Het
Fry	T	A	5: 150,419,313 (GRCm39)	L915Q	probably damaging	Het
Gatd1	A	G	7: 140,986,758 (GRCm39)		probably benign	Het
Gm10719	T	C	9: 3,018,962 (GRCm39)	L69S	probably benign	Het
Gnpda2	A	T	5: 69,735,394 (GRCm39)	H230Q	probably damaging	Het
Gramd1c	T	A	16: 43,802,455 (GRCm39)	N652I	probably damaging	Het
H2-T13	T	A	17: 36,392,178 (GRCm39)	H178L	probably benign	Het
Hells	T	A	19: 38,942,096 (GRCm39)	F462Y	probably benign	Het
Htr7	A	G	19: 35,947,235 (GRCm39)	F260L	probably benign	Het
Itsn1	C	A	16: 91,580,990 (GRCm39)	A23D	probably damaging	Het
Jak3	A	G	8: 72,131,417 (GRCm39)	D94G	probably benign	Het
Kctd16	T	A	18: 40,390,319 (GRCm39)	Y97*	probably null	Het
Kif20b	A	T	19: 34,930,364 (GRCm39)	K25*	probably null	Het
Klf2	T	C	8: 73,073,316 (GRCm39)	L40P	probably damaging	Het
Kmt2a	A	G	9: 44,731,639 (GRCm39)		probably benign	Het
Kmt2d	G	A	15: 98,749,990 (GRCm39)		probably benign	Het
Lonrf1	T	A	8: 36,690,178 (GRCm39)		probably null	Het
Lrp1b	A	T	2: 40,587,486 (GRCm39)	I154K	unknown	Het
Mybpc1	T	A	10: 88,381,891 (GRCm39)	I600L	possibly damaging	Het
Npnt	T	C	3: 132,610,724 (GRCm39)	N285S	probably damaging	Het
Or4c12b	T	A	2: 89,646,964 (GRCm39)	F92Y	probably damaging	Het
Or51h5	A	G	7: 102,577,728 (GRCm39)	T298A	probably damaging	Het
Or6c69	T	A	10: 129,747,871 (GRCm39)	Y92F	probably benign	Het
Or6n1	T	C	1: 173,917,544 (GRCm39)	*313R	probably null	Het
Pcnx1	T	C	12: 81,907,183 (GRCm39)	V13A	probably damaging	Het
Phkb	G	A	8: 86,648,756 (GRCm39)	V191I	possibly damaging	Het
Pnpla6	A	G	8: 3,581,508 (GRCm39)	M594V	probably benign	Het
Potefam3e	A	C	8: 19,799,430 (GRCm39)		probably null	Het
Ror1	T	C	4: 100,298,208 (GRCm39)	M527T	probably benign	Het
Scnm1	A	G	3: 95,037,066 (GRCm39)		probably benign	Het
Skint11	A	T	4: 114,088,959 (GRCm39)	N251I	probably damaging	Het
Slc19a3	T	A	1: 83,000,282 (GRCm39)	N245I	possibly damaging	Het
Slc1a3	A	T	15: 8,675,188 (GRCm39)	D272E	probably damaging	Het
Smok2b	T	A	17: 13,454,440 (GRCm39)	V200D	possibly damaging	Het
Sspo	T	C	6: 48,429,112 (GRCm39)	Y417H	probably damaging	Het
Stk11ip	C	A	1: 75,504,979 (GRCm39)	S388R	probably damaging	Het
Svep1	T	C	4: 58,049,282 (GRCm39)		probably null	Het
Sytl2	A	G	7: 90,038,114 (GRCm39)	I525V	probably benign	Het
Tie1	T	C	4: 118,343,390 (GRCm39)	N158D	probably benign	Het
Tle2	T	C	10: 81,416,418 (GRCm39)	L180P	probably damaging	Het
Txlnb	T	C	10: 17,714,657 (GRCm39)	L363P	probably damaging	Het
Upk3b	C	G	5: 136,072,890 (GRCm39)	A258G	probably benign	Het
Usp32	A	T	11: 84,908,612 (GRCm39)	D1031E	possibly damaging	Het
Vmn2r116	C	T	17: 23,620,041 (GRCm39)	L592F	probably benign	Het
Zfp607b	A	G	7: 27,402,294 (GRCm39)	H250R	probably damaging	Het

Other mutations in Prkdc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Prkdc	APN	16	15,515,090 (GRCm39)	missense	probably damaging	1.00
IGL00225:Prkdc	APN	16	15,627,508 (GRCm39)	missense	possibly damaging	0.64
IGL00481:Prkdc	APN	16	15,608,330 (GRCm39)	missense	probably benign	0.41
IGL00488:Prkdc	APN	16	15,593,711 (GRCm39)	splice site	probably null
IGL00489:Prkdc	APN	16	15,617,790 (GRCm39)	missense	possibly damaging	0.51
IGL00579:Prkdc	APN	16	15,482,103 (GRCm39)	missense	probably damaging	1.00
IGL00587:Prkdc	APN	16	15,470,222 (GRCm39)	splice site	probably benign
IGL00666:Prkdc	APN	16	15,554,699 (GRCm39)	missense	probably damaging	1.00
IGL00675:Prkdc	APN	16	15,605,022 (GRCm39)	missense	probably benign	0.05
IGL00708:Prkdc	APN	16	15,597,290 (GRCm39)	missense	probably damaging	0.97
IGL00725:Prkdc	APN	16	15,634,503 (GRCm39)	missense	probably benign	0.10
IGL00818:Prkdc	APN	16	15,577,618 (GRCm39)	missense	possibly damaging	0.92
IGL00917:Prkdc	APN	16	15,557,428 (GRCm39)	missense	probably damaging	0.98
IGL00990:Prkdc	APN	16	15,519,979 (GRCm39)	missense	probably benign	0.03
IGL01126:Prkdc	APN	16	15,487,185 (GRCm39)	missense	probably benign	0.01
IGL01141:Prkdc	APN	16	15,544,568 (GRCm39)	missense	probably damaging	0.99
IGL01306:Prkdc	APN	16	15,485,595 (GRCm39)	missense	possibly damaging	0.67
IGL01326:Prkdc	APN	16	15,647,556 (GRCm39)	missense	probably benign
IGL01335:Prkdc	APN	16	15,634,760 (GRCm39)	critical splice donor site	probably null
IGL01419:Prkdc	APN	16	15,653,030 (GRCm39)	missense	probably damaging	1.00
IGL01434:Prkdc	APN	16	15,531,451 (GRCm39)	missense	probably benign	0.00
IGL01554:Prkdc	APN	16	15,470,166 (GRCm39)	missense	probably benign	0.05
IGL01671:Prkdc	APN	16	15,485,609 (GRCm39)	missense	possibly damaging	0.90
IGL01871:Prkdc	APN	16	15,600,951 (GRCm39)	missense	probably benign	0.00
IGL01874:Prkdc	APN	16	15,552,858 (GRCm39)	missense	possibly damaging	0.89
IGL01930:Prkdc	APN	16	15,516,751 (GRCm39)	missense	probably damaging	1.00
IGL01984:Prkdc	APN	16	15,526,643 (GRCm39)	missense	probably benign
IGL02121:Prkdc	APN	16	15,535,048 (GRCm39)	missense	probably benign	0.18
IGL02152:Prkdc	APN	16	15,487,149 (GRCm39)	missense	probably benign	0.15
IGL02172:Prkdc	APN	16	15,627,623 (GRCm39)	missense	probably benign	0.10
IGL02336:Prkdc	APN	16	15,603,843 (GRCm39)	missense	probably benign	0.01
IGL02336:Prkdc	APN	16	15,603,842 (GRCm39)	missense	possibly damaging	0.47
IGL02393:Prkdc	APN	16	15,634,622 (GRCm39)	missense	probably benign	0.42
IGL02406:Prkdc	APN	16	15,488,399 (GRCm39)	missense	probably benign	0.00
IGL02500:Prkdc	APN	16	15,532,146 (GRCm39)	critical splice donor site	probably null
IGL02568:Prkdc	APN	16	15,544,406 (GRCm39)	missense	probably damaging	0.98
IGL02579:Prkdc	APN	16	15,488,465 (GRCm39)	missense	possibly damaging	0.83
IGL02652:Prkdc	APN	16	15,600,951 (GRCm39)	missense	probably benign	0.00
IGL02661:Prkdc	APN	16	15,587,689 (GRCm39)	missense	possibly damaging	0.92
IGL02685:Prkdc	APN	16	15,653,907 (GRCm39)	missense	possibly damaging	0.61
IGL02741:Prkdc	APN	16	15,570,590 (GRCm39)	splice site	probably benign
IGL02803:Prkdc	APN	16	15,651,530 (GRCm39)	splice site	probably benign
IGL02866:Prkdc	APN	16	15,649,191 (GRCm39)	missense	probably damaging	1.00
IGL02882:Prkdc	APN	16	15,469,383 (GRCm39)	nonsense	probably null
IGL02989:Prkdc	APN	16	15,617,880 (GRCm39)	missense	possibly damaging	0.67
IGL03053:Prkdc	APN	16	15,652,030 (GRCm39)	missense	probably benign	0.02
IGL03071:Prkdc	APN	16	15,617,848 (GRCm39)	missense	probably benign	0.01
IGL03091:Prkdc	APN	16	15,523,174 (GRCm39)	splice site	probably benign
IGL03100:Prkdc	APN	16	15,531,499 (GRCm39)	missense	probably benign	0.08
IGL03128:Prkdc	APN	16	15,518,608 (GRCm39)	splice site	probably benign
IGL03168:Prkdc	APN	16	15,652,030 (GRCm39)	missense	probably benign	0.02
IGL03204:Prkdc	APN	16	15,587,665 (GRCm39)	missense	probably benign	0.01
IGL03390:Prkdc	APN	16	15,488,490 (GRCm39)	nonsense	probably null
anhimid	UTSW	16	15,543,325 (GRCm39)	critical splice donor site	probably null
anhinga	UTSW	16	15,526,796 (GRCm39)	critical splice donor site	probably null
Bushtit	UTSW	16	15,570,628 (GRCm39)	missense	probably damaging	0.97
clover	UTSW	16	15,520,020 (GRCm39)	splice site	probably benign
crackle	UTSW	16	15,603,914 (GRCm39)	critical splice donor site	probably null
Daffy	UTSW	16	15,647,561 (GRCm39)	missense	possibly damaging	0.86
darter	UTSW	16	15,591,477 (GRCm39)	missense	possibly damaging	0.93
Elmer_fudd	UTSW	16	15,625,922 (GRCm39)	missense	probably benign	0.01
envenomation	UTSW	16	15,653,091 (GRCm39)	nonsense	probably null
hobgoblin	UTSW	16	15,633,850 (GRCm39)	missense	probably damaging	1.00
Incubus	UTSW	16	15,490,191 (GRCm39)	missense	probably damaging	1.00
liming	UTSW	16	15,570,693 (GRCm39)	nonsense	probably null
newt	UTSW	16	15,545,590 (GRCm39)	missense	probably benign	0.04
ornithorhynchus	UTSW	16	15,634,523 (GRCm39)	critical splice donor site	probably null
primitive	UTSW	16	15,653,022 (GRCm39)	frame shift	probably null
roadrunner	UTSW	16	15,651,751 (GRCm39)	missense	probably damaging	1.00
Schreier	UTSW	16	15,488,392 (GRCm39)	missense	probably benign	0.00
screamer	UTSW	16	15,649,146 (GRCm39)	nonsense	probably null
Screamer10	UTSW	16	15,585,889 (GRCm39)	missense	probably damaging	0.98
screamer2	UTSW	16	15,470,416 (GRCm39)	critical splice donor site	probably null
screamer3	UTSW	16	15,558,196 (GRCm39)	critical splice donor site	probably null
screamer4	UTSW	16	15,600,943 (GRCm39)	missense	probably benign	0.00
screamer5	UTSW	16	15,505,268 (GRCm39)	missense	probably benign
screamer6	UTSW	16	15,577,469 (GRCm39)	missense	probably damaging	1.00
screamer7	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
Screamer8	UTSW	16	15,537,297 (GRCm39)	missense	probably benign	0.00
Screamer9	UTSW	16	15,552,786 (GRCm39)	missense	probably benign	0.01
Tweetie	UTSW	16	15,535,665 (GRCm39)	missense	probably damaging	1.00
updock	UTSW	16	15,612,958 (GRCm39)	missense	probably benign
ANU23:Prkdc	UTSW	16	15,485,595 (GRCm39)	missense	possibly damaging	0.67
R0008:Prkdc	UTSW	16	15,526,565 (GRCm39)	splice site	probably benign
R0018:Prkdc	UTSW	16	15,544,406 (GRCm39)	missense	probably benign	0.03
R0018:Prkdc	UTSW	16	15,544,406 (GRCm39)	missense	probably benign	0.03
R0069:Prkdc	UTSW	16	15,544,368 (GRCm39)	missense	probably benign	0.03
R0125:Prkdc	UTSW	16	15,516,871 (GRCm39)	missense	probably damaging	0.98
R0131:Prkdc	UTSW	16	15,531,517 (GRCm39)	missense	probably benign	0.09
R0131:Prkdc	UTSW	16	15,531,517 (GRCm39)	missense	probably benign	0.09
R0132:Prkdc	UTSW	16	15,531,517 (GRCm39)	missense	probably benign	0.09
R0137:Prkdc	UTSW	16	15,558,196 (GRCm39)	critical splice donor site	probably null
R0334:Prkdc	UTSW	16	15,554,663 (GRCm39)	missense	probably benign	0.00
R0373:Prkdc	UTSW	16	15,609,791 (GRCm39)	missense	probably damaging	1.00
R0485:Prkdc	UTSW	16	15,651,604 (GRCm39)	missense	probably damaging	0.97
R0511:Prkdc	UTSW	16	15,649,146 (GRCm39)	nonsense	probably null
R0538:Prkdc	UTSW	16	15,651,652 (GRCm39)	missense	probably damaging	1.00
R0595:Prkdc	UTSW	16	15,625,952 (GRCm39)	missense	probably damaging	1.00
R0607:Prkdc	UTSW	16	15,589,921 (GRCm39)	missense	probably damaging	0.98
R0616:Prkdc	UTSW	16	15,508,271 (GRCm39)	missense	probably damaging	1.00
R0630:Prkdc	UTSW	16	15,628,665 (GRCm39)	missense	probably damaging	1.00
R0694:Prkdc	UTSW	16	15,586,501 (GRCm39)	missense	probably damaging	1.00
R0702:Prkdc	UTSW	16	15,603,835 (GRCm39)	missense	possibly damaging	0.95
R0965:Prkdc	UTSW	16	15,647,580 (GRCm39)	missense	probably benign
R1027:Prkdc	UTSW	16	15,468,576 (GRCm39)	missense	possibly damaging	0.80
R1029:Prkdc	UTSW	16	15,472,613 (GRCm39)	splice site	probably benign
R1033:Prkdc	UTSW	16	15,585,815 (GRCm39)	missense	probably damaging	1.00
R1067:Prkdc	UTSW	16	15,570,646 (GRCm39)	missense	probably damaging	0.99
R1116:Prkdc	UTSW	16	15,600,943 (GRCm39)	missense	probably benign	0.00
R1187:Prkdc	UTSW	16	15,577,610 (GRCm39)	missense	probably damaging	0.98
R1226:Prkdc	UTSW	16	15,491,861 (GRCm39)	missense	possibly damaging	0.80
R1279:Prkdc	UTSW	16	15,508,146 (GRCm39)	missense	probably damaging	1.00
R1304:Prkdc	UTSW	16	15,577,587 (GRCm39)	missense	probably damaging	0.99
R1314:Prkdc	UTSW	16	15,482,091 (GRCm39)	missense	possibly damaging	0.68
R1351:Prkdc	UTSW	16	15,485,564 (GRCm39)	missense	possibly damaging	0.62
R1509:Prkdc	UTSW	16	15,549,430 (GRCm39)	missense	probably damaging	1.00
R1512:Prkdc	UTSW	16	15,505,268 (GRCm39)	missense	probably benign
R1531:Prkdc	UTSW	16	15,589,970 (GRCm39)	missense	probably benign	0.01
R1579:Prkdc	UTSW	16	15,493,192 (GRCm39)	missense	probably benign	0.00
R1669:Prkdc	UTSW	16	15,551,922 (GRCm39)	missense	probably damaging	1.00
R1682:Prkdc	UTSW	16	15,494,853 (GRCm39)	missense	probably benign	0.19
R1713:Prkdc	UTSW	16	15,612,958 (GRCm39)	missense	probably benign
R1762:Prkdc	UTSW	16	15,455,825 (GRCm39)	missense	probably benign
R1789:Prkdc	UTSW	16	15,557,388 (GRCm39)	missense	probably damaging	1.00
R1822:Prkdc	UTSW	16	15,577,469 (GRCm39)	missense	probably damaging	1.00
R1848:Prkdc	UTSW	16	15,625,922 (GRCm39)	missense	probably benign	0.01
R1887:Prkdc	UTSW	16	15,647,499 (GRCm39)	missense	probably benign	0.00
R1891:Prkdc	UTSW	16	15,543,300 (GRCm39)	missense	probably benign	0.02
R1921:Prkdc	UTSW	16	15,532,079 (GRCm39)	missense	possibly damaging	0.80
R1922:Prkdc	UTSW	16	15,532,130 (GRCm39)	missense	probably benign	0.00
R1929:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R1939:Prkdc	UTSW	16	15,653,777 (GRCm39)	missense	possibly damaging	0.95
R2021:Prkdc	UTSW	16	15,494,873 (GRCm39)	missense	probably benign	0.00
R2033:Prkdc	UTSW	16	15,505,216 (GRCm39)	splice site	probably benign
R2056:Prkdc	UTSW	16	15,545,469 (GRCm39)	missense	probably benign	0.03
R2057:Prkdc	UTSW	16	15,545,469 (GRCm39)	missense	probably benign	0.03
R2058:Prkdc	UTSW	16	15,545,469 (GRCm39)	missense	probably benign	0.03
R2082:Prkdc	UTSW	16	15,533,827 (GRCm39)	missense	probably damaging	1.00
R2109:Prkdc	UTSW	16	15,505,254 (GRCm39)	missense	probably benign	0.01
R2124:Prkdc	UTSW	16	15,537,297 (GRCm39)	missense	probably benign	0.00
R2164:Prkdc	UTSW	16	15,523,071 (GRCm39)	missense	probably damaging	1.00
R2174:Prkdc	UTSW	16	15,552,786 (GRCm39)	missense	probably benign	0.01
R2191:Prkdc	UTSW	16	15,516,688 (GRCm39)	missense	probably damaging	1.00
R2270:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R2271:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R2272:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R2356:Prkdc	UTSW	16	15,502,068 (GRCm39)	missense	probably benign
R2852:Prkdc	UTSW	16	15,470,416 (GRCm39)	critical splice donor site	probably null
R3115:Prkdc	UTSW	16	15,482,222 (GRCm39)	missense	probably benign	0.01
R3116:Prkdc	UTSW	16	15,482,222 (GRCm39)	missense	probably benign	0.01
R3499:Prkdc	UTSW	16	15,585,889 (GRCm39)	missense	probably damaging	0.98
R3687:Prkdc	UTSW	16	15,617,831 (GRCm39)	missense	probably benign
R3834:Prkdc	UTSW	16	15,609,810 (GRCm39)	missense	probably damaging	1.00
R3835:Prkdc	UTSW	16	15,609,810 (GRCm39)	missense	probably damaging	1.00
R3961:Prkdc	UTSW	16	15,647,475 (GRCm39)	splice site	probably null
R4151:Prkdc	UTSW	16	15,634,637 (GRCm39)	missense	probably benign
R4233:Prkdc	UTSW	16	15,653,783 (GRCm39)	missense	probably benign	0.11
R4281:Prkdc	UTSW	16	15,623,963 (GRCm39)	splice site	probably null
R4296:Prkdc	UTSW	16	15,555,769 (GRCm39)	missense	probably damaging	0.99
R4344:Prkdc	UTSW	16	15,585,886 (GRCm39)	missense	probably damaging	0.98
R4424:Prkdc	UTSW	16	15,653,946 (GRCm39)	missense	probably damaging	1.00
R4424:Prkdc	UTSW	16	15,591,603 (GRCm39)	missense	probably damaging	0.98
R4497:Prkdc	UTSW	16	15,518,517 (GRCm39)	missense	probably benign	0.43
R4549:Prkdc	UTSW	16	15,554,734 (GRCm39)	missense	possibly damaging	0.89
R4594:Prkdc	UTSW	16	15,585,830 (GRCm39)	missense	possibly damaging	0.64
R4603:Prkdc	UTSW	16	15,628,688 (GRCm39)	missense	probably damaging	0.98
R4615:Prkdc	UTSW	16	15,480,938 (GRCm39)	missense	probably damaging	0.99
R4648:Prkdc	UTSW	16	15,634,638 (GRCm39)	missense	probably benign	0.05
R4662:Prkdc	UTSW	16	15,551,916 (GRCm39)	missense	probably damaging	1.00
R4680:Prkdc	UTSW	16	15,589,894 (GRCm39)	missense	probably benign	0.00
R4700:Prkdc	UTSW	16	15,519,976 (GRCm39)	missense	probably damaging	1.00
R4716:Prkdc	UTSW	16	15,628,701 (GRCm39)	missense	probably benign	0.32
R4720:Prkdc	UTSW	16	15,485,579 (GRCm39)	missense	probably benign
R4785:Prkdc	UTSW	16	15,466,840 (GRCm39)	missense	probably benign	0.21
R4822:Prkdc	UTSW	16	15,468,576 (GRCm39)	missense	possibly damaging	0.80
R4829:Prkdc	UTSW	16	15,519,939 (GRCm39)	missense	possibly damaging	0.80
R4981:Prkdc	UTSW	16	15,496,173 (GRCm39)	missense	probably damaging	1.00
R4989:Prkdc	UTSW	16	15,491,861 (GRCm39)	missense	possibly damaging	0.80
R5059:Prkdc	UTSW	16	15,655,882 (GRCm39)	missense	probably damaging	1.00
R5074:Prkdc	UTSW	16	15,589,912 (GRCm39)	missense	probably damaging	1.00
R5115:Prkdc	UTSW	16	15,608,444 (GRCm39)	missense	probably benign
R5151:Prkdc	UTSW	16	15,533,899 (GRCm39)	missense	probably damaging	1.00
R5165:Prkdc	UTSW	16	15,496,136 (GRCm39)	missense	probably damaging	1.00
R5215:Prkdc	UTSW	16	15,589,985 (GRCm39)	missense	possibly damaging	0.64
R5270:Prkdc	UTSW	16	15,552,819 (GRCm39)	missense	probably damaging	1.00
R5278:Prkdc	UTSW	16	15,532,838 (GRCm39)	missense	probably damaging	1.00
R5351:Prkdc	UTSW	16	15,649,176 (GRCm39)	missense	probably benign	0.03
R5416:Prkdc	UTSW	16	15,623,814 (GRCm39)	missense	probably damaging	1.00
R5418:Prkdc	UTSW	16	15,612,961 (GRCm39)	missense	probably benign	0.20
R5437:Prkdc	UTSW	16	15,587,739 (GRCm39)	missense	possibly damaging	0.46
R5452:Prkdc	UTSW	16	15,586,501 (GRCm39)	missense	possibly damaging	0.96
R5518:Prkdc	UTSW	16	15,496,172 (GRCm39)	missense	probably damaging	1.00
R5589:Prkdc	UTSW	16	15,524,655 (GRCm39)	missense	probably benign	0.02
R5618:Prkdc	UTSW	16	15,627,476 (GRCm39)	missense	probably damaging	1.00
R5640:Prkdc	UTSW	16	15,647,633 (GRCm39)	missense	possibly damaging	0.86
R5661:Prkdc	UTSW	16	15,628,634 (GRCm39)	missense	possibly damaging	0.81
R5771:Prkdc	UTSW	16	15,482,097 (GRCm39)	missense	probably damaging	1.00
R5772:Prkdc	UTSW	16	15,597,252 (GRCm39)	missense	possibly damaging	0.49
R5783:Prkdc	UTSW	16	15,535,665 (GRCm39)	missense	probably damaging	1.00
R5792:Prkdc	UTSW	16	15,634,616 (GRCm39)	missense	probably damaging	1.00
R5797:Prkdc	UTSW	16	15,555,698 (GRCm39)	nonsense	probably null
R5826:Prkdc	UTSW	16	15,551,962 (GRCm39)	missense	probably benign
R5883:Prkdc	UTSW	16	15,533,778 (GRCm39)	missense	probably benign
R5895:Prkdc	UTSW	16	15,570,693 (GRCm39)	nonsense	probably null
R5998:Prkdc	UTSW	16	15,601,021 (GRCm39)	missense	probably damaging	1.00
R6000:Prkdc	UTSW	16	15,647,561 (GRCm39)	missense	possibly damaging	0.86
R6120:Prkdc	UTSW	16	15,557,335 (GRCm39)	missense	probably benign	0.00
R6145:Prkdc	UTSW	16	15,589,937 (GRCm39)	missense	probably damaging	1.00
R6209:Prkdc	UTSW	16	15,608,456 (GRCm39)	missense	probably damaging	1.00
R6293:Prkdc	UTSW	16	15,605,019 (GRCm39)	missense	probably benign	0.00
R6321:Prkdc	UTSW	16	15,532,783 (GRCm39)	missense	probably benign
R6376:Prkdc	UTSW	16	15,587,749 (GRCm39)	missense	probably benign	0.06
R6387:Prkdc	UTSW	16	15,516,679 (GRCm39)	missense	probably benign	0.01
R6406:Prkdc	UTSW	16	15,535,665 (GRCm39)	missense	probably damaging	1.00
R6469:Prkdc	UTSW	16	15,612,939 (GRCm39)	missense	probably benign	0.10
R6486:Prkdc	UTSW	16	15,570,628 (GRCm39)	missense	probably damaging	0.97
R6665:Prkdc	UTSW	16	15,603,914 (GRCm39)	critical splice donor site	probably null
R6703:Prkdc	UTSW	16	15,488,392 (GRCm39)	missense	probably benign	0.00
R6774:Prkdc	UTSW	16	15,543,325 (GRCm39)	critical splice donor site	probably null
R6854:Prkdc	UTSW	16	15,469,402 (GRCm39)	missense	probably damaging	1.00
R6878:Prkdc	UTSW	16	15,594,936 (GRCm39)	missense	probably benign	0.31
R6882:Prkdc	UTSW	16	15,626,020 (GRCm39)	missense	probably benign	0.33
R6882:Prkdc	UTSW	16	15,601,127 (GRCm39)	critical splice donor site	probably null
R6949:Prkdc	UTSW	16	15,617,853 (GRCm39)	missense	probably benign
R6950:Prkdc	UTSW	16	15,633,850 (GRCm39)	missense	probably damaging	1.00
R7019:Prkdc	UTSW	16	15,587,830 (GRCm39)	missense	probably benign	0.00
R7064:Prkdc	UTSW	16	15,608,317 (GRCm39)	missense	probably benign	0.00
R7097:Prkdc	UTSW	16	15,507,207 (GRCm39)	missense	probably damaging	1.00
R7201:Prkdc	UTSW	16	15,516,667 (GRCm39)	missense	probably benign	0.12
R7235:Prkdc	UTSW	16	15,532,127 (GRCm39)	missense	probably benign
R7283:Prkdc	UTSW	16	15,535,628 (GRCm39)	missense	probably benign	0.00
R7401:Prkdc	UTSW	16	15,466,602 (GRCm39)	missense	probably damaging	1.00
R7525:Prkdc	UTSW	16	15,490,191 (GRCm39)	missense	probably damaging	1.00
R7647:Prkdc	UTSW	16	15,555,807 (GRCm39)	missense	probably damaging	1.00
R7679:Prkdc	UTSW	16	15,649,183 (GRCm39)	missense	probably damaging	1.00
R7803:Prkdc	UTSW	16	15,623,960 (GRCm39)	missense	probably null	0.05
R7858:Prkdc	UTSW	16	15,507,141 (GRCm39)	missense	probably benign	0.11
R7872:Prkdc	UTSW	16	15,532,870 (GRCm39)	missense	probably benign	0.05
R7896:Prkdc	UTSW	16	15,526,767 (GRCm39)	missense	probably damaging	0.97
R8032:Prkdc	UTSW	16	15,597,315 (GRCm39)	missense	probably benign	0.00
R8055:Prkdc	UTSW	16	15,634,749 (GRCm39)	missense	probably benign	0.09
R8153:Prkdc	UTSW	16	15,482,108 (GRCm39)	missense	probably damaging	1.00
R8281:Prkdc	UTSW	16	15,523,117 (GRCm39)	missense	probably damaging	1.00
R8302:Prkdc	UTSW	16	15,653,946 (GRCm39)	missense	probably damaging	1.00
R8322:Prkdc	UTSW	16	15,532,005 (GRCm39)	splice site	probably benign
R8401:Prkdc	UTSW	16	15,591,477 (GRCm39)	missense	possibly damaging	0.93
R8440:Prkdc	UTSW	16	15,653,022 (GRCm39)	frame shift	probably null
R8458:Prkdc	UTSW	16	15,608,540 (GRCm39)	critical splice donor site	probably null
R8472:Prkdc	UTSW	16	15,469,400 (GRCm39)	missense	probably damaging	1.00
R8478:Prkdc	UTSW	16	15,466,788 (GRCm39)	missense	probably benign	0.00
R8515:Prkdc	UTSW	16	15,482,232 (GRCm39)	missense	probably damaging	1.00
R8546:Prkdc	UTSW	16	15,480,899 (GRCm39)	missense	probably damaging	1.00
R8678:Prkdc	UTSW	16	15,526,796 (GRCm39)	critical splice donor site	probably null
R8739:Prkdc	UTSW	16	15,626,068 (GRCm39)	missense	probably benign	0.01
R8749:Prkdc	UTSW	16	15,601,029 (GRCm39)	missense	possibly damaging	0.85
R8836:Prkdc	UTSW	16	15,545,523 (GRCm39)	missense	probably damaging	1.00
R8904:Prkdc	UTSW	16	15,545,590 (GRCm39)	missense	probably benign	0.04
R8952:Prkdc	UTSW	16	15,491,624 (GRCm39)	intron	probably benign
R8971:Prkdc	UTSW	16	15,493,229 (GRCm39)	missense	probably null	0.99
R8974:Prkdc	UTSW	16	15,617,726 (GRCm39)	splice site	probably null
R9052:Prkdc	UTSW	16	15,508,160 (GRCm39)	missense	probably benign	0.05
R9069:Prkdc	UTSW	16	15,653,091 (GRCm39)	nonsense	probably null
R9200:Prkdc	UTSW	16	15,523,153 (GRCm39)	missense	probably damaging	1.00
R9235:Prkdc	UTSW	16	15,651,751 (GRCm39)	missense	probably damaging	1.00
R9278:Prkdc	UTSW	16	15,634,523 (GRCm39)	critical splice donor site	probably null
R9309:Prkdc	UTSW	16	15,526,792 (GRCm39)	nonsense	probably null
R9386:Prkdc	UTSW	16	15,496,136 (GRCm39)	missense	probably damaging	0.99
R9452:Prkdc	UTSW	16	15,485,465 (GRCm39)	missense	possibly damaging	0.90
R9500:Prkdc	UTSW	16	15,657,079 (GRCm39)	missense	possibly damaging	0.76
R9608:Prkdc	UTSW	16	15,548,335 (GRCm39)	missense	probably damaging	1.00
R9608:Prkdc	UTSW	16	15,548,334 (GRCm39)	missense	possibly damaging	0.96
R9636:Prkdc	UTSW	16	15,548,341 (GRCm39)	missense	probably benign	0.19
R9656:Prkdc	UTSW	16	15,617,818 (GRCm39)	missense	probably benign	0.00
R9674:Prkdc	UTSW	16	15,533,819 (GRCm39)	missense	probably damaging	0.98
R9760:Prkdc	UTSW	16	15,657,044 (GRCm39)	nonsense	probably null
X0023:Prkdc	UTSW	16	15,558,142 (GRCm39)	missense	probably benign
Z1176:Prkdc	UTSW	16	15,505,286 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- AAGTTACAGTTATGTTTAGCCTGCC -3'
(R):5'- AGGAATCCTTTTGTTTCCATTGTGC -3'

Sequencing Primer
(F):5'- TGATCACTCAAGCCAGACTTTC -3'
(R):5'- GCATCTCACCTGTATCAGG -3'

Posted On

2016-10-24