Incidental Mutation 'R5536:Gucy2g'
ID 434850
Institutional Source Beutler Lab
Gene Symbol Gucy2g
Ensembl Gene ENSMUSG00000055523
Gene Name guanylate cyclase 2g
Synonyms 2410077I05Rik, GC-G
MMRRC Submission 043094-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5536 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 55186531-55229668 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 55226359 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 186 (I186F)
Ref Sequence ENSEMBL: ENSMUSP00000068253 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069183]
AlphaFold Q6TL19
Predicted Effect probably benign
Transcript: ENSMUST00000069183
AA Change: I186F

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000068253
Gene: ENSMUSG00000055523
AA Change: I186F

DomainStartEndE-ValueType
low complexity region 27 38 N/A INTRINSIC
Pfam:ANF_receptor 65 416 5.2e-36 PFAM
low complexity region 471 487 N/A INTRINSIC
Pfam:Pkinase 574 826 2e-26 PFAM
Pfam:Pkinase_Tyr 577 826 6e-35 PFAM
CYCc 865 1059 6.42e-96 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation are viable and fertile with no gross abnormalities and are protected against acute ischemia induced renal injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik G T 3: 137,772,149 (GRCm39) G446V possibly damaging Het
Aadac T G 3: 59,946,984 (GRCm39) N227K probably benign Het
Acap1 C T 11: 69,780,133 (GRCm39) G74R probably benign Het
Adrm1 A G 2: 179,813,981 (GRCm39) probably benign Het
Appl1 G C 14: 26,645,737 (GRCm39) S691* probably null Het
Atp2a2 T C 5: 122,595,245 (GRCm39) D1035G probably benign Het
AW551984 A G 9: 39,504,169 (GRCm39) I599T probably benign Het
Col23a1 C A 11: 51,458,776 (GRCm39) D304E probably damaging Het
Csmd1 T C 8: 16,338,674 (GRCm39) R478G probably damaging Het
Dnah7a T C 1: 53,464,412 (GRCm39) N3660D probably benign Het
Drosha T A 15: 12,929,797 (GRCm39) Y1331N possibly damaging Het
E2f6 T G 12: 16,874,685 (GRCm39) S256A probably benign Het
Evc A G 5: 37,483,927 (GRCm39) probably benign Het
Fsip2 A T 2: 82,817,403 (GRCm39) I4379F probably benign Het
Galnt2 T C 8: 125,050,412 (GRCm39) C91R probably damaging Het
Gm3095 G T 14: 15,170,371 (GRCm39) M73I probably benign Het
Gpr179 T A 11: 97,234,641 (GRCm39) Q480L probably damaging Het
Hmcn1 T A 1: 150,631,042 (GRCm39) I919F probably benign Het
Kdm3a A C 6: 71,588,920 (GRCm39) V363G probably benign Het
Kmt2d G A 15: 98,749,990 (GRCm39) probably benign Het
Lama5 C T 2: 179,831,142 (GRCm39) R1839H probably damaging Het
Lpo T C 11: 87,707,389 (GRCm39) D208G probably damaging Het
Lpp A G 16: 24,663,956 (GRCm39) D411G possibly damaging Het
Marco T C 1: 120,432,464 (GRCm39) S8G possibly damaging Het
Mthfr T C 4: 148,128,940 (GRCm39) F171S probably damaging Het
Nlrx1 A T 9: 44,175,183 (GRCm39) S198T probably damaging Het
Nol10 C A 12: 17,466,138 (GRCm39) S511* probably null Het
Nup153 T C 13: 46,836,485 (GRCm39) T1375A probably benign Het
Obscn A G 11: 58,998,697 (GRCm39) S1367P probably damaging Het
Or4x6 A G 2: 89,949,183 (GRCm39) V253A probably benign Het
Pcdha7 G A 18: 37,108,303 (GRCm39) V443M probably damaging Het
Plekha1 G T 7: 130,511,331 (GRCm39) R305I probably damaging Het
Psmb2 T A 4: 126,578,002 (GRCm39) I60N probably damaging Het
Rad17 C A 13: 100,767,612 (GRCm39) G330C probably damaging Het
Slc5a6 A G 5: 31,200,446 (GRCm39) S80P probably damaging Het
Srgap2 T A 1: 131,228,128 (GRCm39) probably null Het
Taf8 C A 17: 47,805,407 (GRCm39) R164L possibly damaging Het
Tmem87a C A 2: 120,227,911 (GRCm39) D79Y probably damaging Het
Tmtc4 G A 14: 123,170,291 (GRCm39) R574W probably benign Het
Tprn G A 2: 25,153,369 (GRCm39) A224T probably benign Het
Usf3 A G 16: 44,037,733 (GRCm39) T738A probably benign Het
Vmn2r54 A C 7: 12,366,343 (GRCm39) V197G probably benign Het
Zbtb40 G T 4: 136,714,642 (GRCm39) P1049Q probably damaging Het
Zfp551 A T 7: 12,149,488 (GRCm39) S640R possibly damaging Het
Zfp932 T A 5: 110,157,713 (GRCm39) C470* probably null Het
Zkscan8 T C 13: 21,710,838 (GRCm39) I91V probably damaging Het
Zmat4 T C 8: 24,238,508 (GRCm39) V30A probably damaging Het
Other mutations in Gucy2g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Gucy2g APN 19 55,221,535 (GRCm39) missense probably benign 0.01
IGL01954:Gucy2g APN 19 55,187,123 (GRCm39) missense probably benign 0.01
IGL01969:Gucy2g APN 19 55,215,870 (GRCm39) missense probably benign 0.00
IGL02164:Gucy2g APN 19 55,226,455 (GRCm39) missense probably benign
IGL02534:Gucy2g APN 19 55,229,500 (GRCm39) missense probably damaging 1.00
IGL02667:Gucy2g APN 19 55,194,609 (GRCm39) missense possibly damaging 0.64
IGL02755:Gucy2g APN 19 55,198,786 (GRCm39) missense probably benign 0.10
IGL03187:Gucy2g APN 19 55,219,484 (GRCm39) missense possibly damaging 0.91
IGL03354:Gucy2g APN 19 55,221,512 (GRCm39) missense possibly damaging 0.95
PIT4366001:Gucy2g UTSW 19 55,226,214 (GRCm39) missense probably null 0.51
R0040:Gucy2g UTSW 19 55,205,734 (GRCm39) missense possibly damaging 0.73
R0126:Gucy2g UTSW 19 55,229,598 (GRCm39) missense probably benign
R0318:Gucy2g UTSW 19 55,226,230 (GRCm39) missense probably benign 0.00
R0576:Gucy2g UTSW 19 55,187,202 (GRCm39) missense probably damaging 1.00
R0604:Gucy2g UTSW 19 55,191,519 (GRCm39) missense probably benign 0.00
R0962:Gucy2g UTSW 19 55,198,716 (GRCm39) nonsense probably null
R1348:Gucy2g UTSW 19 55,211,338 (GRCm39) missense possibly damaging 0.68
R1458:Gucy2g UTSW 19 55,203,468 (GRCm39) splice site probably benign
R1693:Gucy2g UTSW 19 55,211,358 (GRCm39) missense probably damaging 1.00
R1795:Gucy2g UTSW 19 55,187,973 (GRCm39) missense probably damaging 1.00
R1804:Gucy2g UTSW 19 55,198,741 (GRCm39) missense probably benign 0.34
R1830:Gucy2g UTSW 19 55,211,362 (GRCm39) missense possibly damaging 0.94
R1902:Gucy2g UTSW 19 55,198,669 (GRCm39) missense probably benign 0.20
R1927:Gucy2g UTSW 19 55,226,191 (GRCm39) missense probably benign 0.02
R1969:Gucy2g UTSW 19 55,221,485 (GRCm39) missense probably benign 0.42
R1969:Gucy2g UTSW 19 55,211,328 (GRCm39) missense possibly damaging 0.90
R2071:Gucy2g UTSW 19 55,210,772 (GRCm39) missense possibly damaging 0.72
R2842:Gucy2g UTSW 19 55,229,379 (GRCm39) missense probably damaging 1.00
R2971:Gucy2g UTSW 19 55,198,708 (GRCm39) missense probably damaging 1.00
R4202:Gucy2g UTSW 19 55,218,201 (GRCm39) missense possibly damaging 0.96
R4405:Gucy2g UTSW 19 55,226,269 (GRCm39) missense probably benign 0.08
R4407:Gucy2g UTSW 19 55,226,269 (GRCm39) missense probably benign 0.08
R4614:Gucy2g UTSW 19 55,190,579 (GRCm39) nonsense probably null
R4671:Gucy2g UTSW 19 55,226,500 (GRCm39) missense probably damaging 1.00
R4684:Gucy2g UTSW 19 55,194,688 (GRCm39) missense probably damaging 1.00
R4837:Gucy2g UTSW 19 55,214,485 (GRCm39) missense probably benign
R4969:Gucy2g UTSW 19 55,214,445 (GRCm39) missense probably benign
R5050:Gucy2g UTSW 19 55,229,367 (GRCm39) missense probably benign 0.05
R5059:Gucy2g UTSW 19 55,214,503 (GRCm39) missense probably benign 0.00
R5070:Gucy2g UTSW 19 55,218,219 (GRCm39) missense probably damaging 0.98
R5288:Gucy2g UTSW 19 55,203,548 (GRCm39) missense probably damaging 1.00
R5384:Gucy2g UTSW 19 55,203,548 (GRCm39) missense probably damaging 1.00
R5386:Gucy2g UTSW 19 55,203,548 (GRCm39) missense probably damaging 1.00
R5497:Gucy2g UTSW 19 55,187,133 (GRCm39) missense probably benign 0.00
R5531:Gucy2g UTSW 19 55,229,572 (GRCm39) missense probably benign 0.24
R5679:Gucy2g UTSW 19 55,219,511 (GRCm39) missense possibly damaging 0.87
R5715:Gucy2g UTSW 19 55,221,587 (GRCm39) missense possibly damaging 0.93
R5941:Gucy2g UTSW 19 55,203,563 (GRCm39) missense probably damaging 1.00
R6250:Gucy2g UTSW 19 55,205,856 (GRCm39) missense probably damaging 0.99
R6288:Gucy2g UTSW 19 55,215,945 (GRCm39) missense probably benign 0.01
R6378:Gucy2g UTSW 19 55,229,377 (GRCm39) missense probably benign 0.00
R6605:Gucy2g UTSW 19 55,229,460 (GRCm39) missense probably damaging 1.00
R7020:Gucy2g UTSW 19 55,221,482 (GRCm39) missense probably damaging 0.98
R7064:Gucy2g UTSW 19 55,198,764 (GRCm39) missense probably benign 0.01
R7078:Gucy2g UTSW 19 55,229,583 (GRCm39) missense probably damaging 1.00
R7402:Gucy2g UTSW 19 55,194,725 (GRCm39) missense probably damaging 1.00
R7539:Gucy2g UTSW 19 55,191,586 (GRCm39) missense probably damaging 0.99
R7561:Gucy2g UTSW 19 55,194,772 (GRCm39) missense probably benign 0.38
R7583:Gucy2g UTSW 19 55,224,047 (GRCm39) missense probably damaging 1.00
R7804:Gucy2g UTSW 19 55,216,584 (GRCm39) missense probably benign 0.02
R7880:Gucy2g UTSW 19 55,194,712 (GRCm39) missense probably damaging 1.00
R8442:Gucy2g UTSW 19 55,205,833 (GRCm39) missense probably benign 0.00
R8559:Gucy2g UTSW 19 55,198,786 (GRCm39) missense probably benign 0.10
R8970:Gucy2g UTSW 19 55,191,478 (GRCm39) missense possibly damaging 0.56
R8972:Gucy2g UTSW 19 55,226,406 (GRCm39) missense probably benign 0.17
R9085:Gucy2g UTSW 19 55,221,597 (GRCm39) nonsense probably null
R9390:Gucy2g UTSW 19 55,190,607 (GRCm39) missense probably null 1.00
R9462:Gucy2g UTSW 19 55,221,469 (GRCm39) critical splice donor site probably null
R9502:Gucy2g UTSW 19 55,198,816 (GRCm39) missense probably damaging 1.00
R9610:Gucy2g UTSW 19 55,194,605 (GRCm39) missense probably damaging 1.00
R9611:Gucy2g UTSW 19 55,194,605 (GRCm39) missense probably damaging 1.00
R9644:Gucy2g UTSW 19 55,219,537 (GRCm39) missense probably benign 0.05
Z1177:Gucy2g UTSW 19 55,198,809 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TACGACATGTTCCTGAGGCC -3'
(R):5'- CACCATGTCTGAAGTGTGAGTG -3'

Sequencing Primer
(F):5'- GTTCCTGAGGCCTTCCTGCAG -3'
(R):5'- CGTCACGGAAAACTACTCTCTTG -3'
Posted On 2016-10-24