Incidental Mutation 'R5536:Vmn2r54'
ID 434824
Institutional Source Beutler Lab
Gene Symbol Vmn2r54
Ensembl Gene ENSMUSG00000096593
Gene Name vomeronasal 2, receptor 54
Synonyms
MMRRC Submission 043094-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R5536 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 12349160-12374167 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 12366343 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 197 (V197G)
Ref Sequence ENSEMBL: ENSMUSP00000083386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086210]
AlphaFold A0A3B2W422
Predicted Effect probably benign
Transcript: ENSMUST00000086210
AA Change: V197G

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000083386
Gene: ENSMUSG00000096593
AA Change: V197G

DomainStartEndE-ValueType
Pfam:ANF_receptor 5 397 4.3e-58 PFAM
Pfam:NCD3G 442 495 2.2e-19 PFAM
Pfam:7tm_3 526 763 1.2e-54 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik G T 3: 137,772,149 (GRCm39) G446V possibly damaging Het
Aadac T G 3: 59,946,984 (GRCm39) N227K probably benign Het
Acap1 C T 11: 69,780,133 (GRCm39) G74R probably benign Het
Adrm1 A G 2: 179,813,981 (GRCm39) probably benign Het
Appl1 G C 14: 26,645,737 (GRCm39) S691* probably null Het
Atp2a2 T C 5: 122,595,245 (GRCm39) D1035G probably benign Het
AW551984 A G 9: 39,504,169 (GRCm39) I599T probably benign Het
Col23a1 C A 11: 51,458,776 (GRCm39) D304E probably damaging Het
Csmd1 T C 8: 16,338,674 (GRCm39) R478G probably damaging Het
Dnah7a T C 1: 53,464,412 (GRCm39) N3660D probably benign Het
Drosha T A 15: 12,929,797 (GRCm39) Y1331N possibly damaging Het
E2f6 T G 12: 16,874,685 (GRCm39) S256A probably benign Het
Evc A G 5: 37,483,927 (GRCm39) probably benign Het
Fsip2 A T 2: 82,817,403 (GRCm39) I4379F probably benign Het
Galnt2 T C 8: 125,050,412 (GRCm39) C91R probably damaging Het
Gm3095 G T 14: 15,170,371 (GRCm39) M73I probably benign Het
Gpr179 T A 11: 97,234,641 (GRCm39) Q480L probably damaging Het
Gucy2g T A 19: 55,226,359 (GRCm39) I186F probably benign Het
Hmcn1 T A 1: 150,631,042 (GRCm39) I919F probably benign Het
Kdm3a A C 6: 71,588,920 (GRCm39) V363G probably benign Het
Kmt2d G A 15: 98,749,990 (GRCm39) probably benign Het
Lama5 C T 2: 179,831,142 (GRCm39) R1839H probably damaging Het
Lpo T C 11: 87,707,389 (GRCm39) D208G probably damaging Het
Lpp A G 16: 24,663,956 (GRCm39) D411G possibly damaging Het
Marco T C 1: 120,432,464 (GRCm39) S8G possibly damaging Het
Mthfr T C 4: 148,128,940 (GRCm39) F171S probably damaging Het
Nlrx1 A T 9: 44,175,183 (GRCm39) S198T probably damaging Het
Nol10 C A 12: 17,466,138 (GRCm39) S511* probably null Het
Nup153 T C 13: 46,836,485 (GRCm39) T1375A probably benign Het
Obscn A G 11: 58,998,697 (GRCm39) S1367P probably damaging Het
Or4x6 A G 2: 89,949,183 (GRCm39) V253A probably benign Het
Pcdha7 G A 18: 37,108,303 (GRCm39) V443M probably damaging Het
Plekha1 G T 7: 130,511,331 (GRCm39) R305I probably damaging Het
Psmb2 T A 4: 126,578,002 (GRCm39) I60N probably damaging Het
Rad17 C A 13: 100,767,612 (GRCm39) G330C probably damaging Het
Slc5a6 A G 5: 31,200,446 (GRCm39) S80P probably damaging Het
Srgap2 T A 1: 131,228,128 (GRCm39) probably null Het
Taf8 C A 17: 47,805,407 (GRCm39) R164L possibly damaging Het
Tmem87a C A 2: 120,227,911 (GRCm39) D79Y probably damaging Het
Tmtc4 G A 14: 123,170,291 (GRCm39) R574W probably benign Het
Tprn G A 2: 25,153,369 (GRCm39) A224T probably benign Het
Usf3 A G 16: 44,037,733 (GRCm39) T738A probably benign Het
Zbtb40 G T 4: 136,714,642 (GRCm39) P1049Q probably damaging Het
Zfp551 A T 7: 12,149,488 (GRCm39) S640R possibly damaging Het
Zfp932 T A 5: 110,157,713 (GRCm39) C470* probably null Het
Zkscan8 T C 13: 21,710,838 (GRCm39) I91V probably damaging Het
Zmat4 T C 8: 24,238,508 (GRCm39) V30A probably damaging Het
Other mutations in Vmn2r54
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Vmn2r54 APN 7 12,365,840 (GRCm39) splice site probably benign
IGL01778:Vmn2r54 APN 7 12,366,009 (GRCm39) missense probably benign 0.07
IGL01998:Vmn2r54 APN 7 12,349,227 (GRCm39) missense probably benign
IGL02028:Vmn2r54 APN 7 12,366,088 (GRCm39) missense probably damaging 1.00
IGL02064:Vmn2r54 APN 7 12,349,533 (GRCm39) missense probably benign 0.02
IGL02238:Vmn2r54 APN 7 12,369,910 (GRCm39) missense probably damaging 1.00
IGL03062:Vmn2r54 APN 7 12,366,355 (GRCm39) missense probably damaging 0.98
IGL03120:Vmn2r54 APN 7 12,349,314 (GRCm39) missense probably damaging 1.00
PIT4453001:Vmn2r54 UTSW 7 12,363,669 (GRCm39) missense probably benign 0.06
R0212:Vmn2r54 UTSW 7 12,366,424 (GRCm39) missense probably benign
R0360:Vmn2r54 UTSW 7 12,349,576 (GRCm39) missense probably damaging 1.00
R1646:Vmn2r54 UTSW 7 12,366,434 (GRCm39) missense probably damaging 1.00
R1673:Vmn2r54 UTSW 7 12,350,138 (GRCm39) critical splice acceptor site probably null
R1738:Vmn2r54 UTSW 7 12,369,815 (GRCm39) missense probably benign 0.00
R1856:Vmn2r54 UTSW 7 12,366,238 (GRCm39) missense probably benign
R2012:Vmn2r54 UTSW 7 12,349,804 (GRCm39) missense probably damaging 1.00
R2038:Vmn2r54 UTSW 7 12,363,637 (GRCm39) missense possibly damaging 0.94
R2160:Vmn2r54 UTSW 7 12,349,420 (GRCm39) missense probably benign 0.29
R2397:Vmn2r54 UTSW 7 12,349,578 (GRCm39) missense probably damaging 0.98
R2430:Vmn2r54 UTSW 7 12,365,933 (GRCm39) missense probably damaging 0.99
R2829:Vmn2r54 UTSW 7 12,349,617 (GRCm39) missense possibly damaging 0.62
R2975:Vmn2r54 UTSW 7 12,369,919 (GRCm39) missense possibly damaging 0.92
R3005:Vmn2r54 UTSW 7 12,349,221 (GRCm39) missense probably benign 0.28
R3725:Vmn2r54 UTSW 7 12,366,223 (GRCm39) missense probably benign 0.42
R4486:Vmn2r54 UTSW 7 12,366,199 (GRCm39) nonsense probably null
R4881:Vmn2r54 UTSW 7 12,363,598 (GRCm39) missense probably benign 0.00
R4907:Vmn2r54 UTSW 7 12,350,150 (GRCm39) splice site probably null
R5637:Vmn2r54 UTSW 7 12,349,296 (GRCm39) missense probably benign 0.41
R5703:Vmn2r54 UTSW 7 12,363,594 (GRCm39) missense probably benign 0.22
R5769:Vmn2r54 UTSW 7 12,349,209 (GRCm39) missense possibly damaging 0.73
R5972:Vmn2r54 UTSW 7 12,369,874 (GRCm39) missense probably damaging 1.00
R5972:Vmn2r54 UTSW 7 12,349,279 (GRCm39) missense probably damaging 1.00
R5977:Vmn2r54 UTSW 7 12,366,143 (GRCm39) missense probably damaging 1.00
R6084:Vmn2r54 UTSW 7 12,366,205 (GRCm39) missense probably damaging 0.98
R6176:Vmn2r54 UTSW 7 12,349,908 (GRCm39) missense probably damaging 1.00
R6229:Vmn2r54 UTSW 7 12,365,883 (GRCm39) missense probably benign 0.00
R6371:Vmn2r54 UTSW 7 12,349,362 (GRCm39) missense probably damaging 1.00
R6374:Vmn2r54 UTSW 7 12,349,420 (GRCm39) missense probably damaging 1.00
R6804:Vmn2r54 UTSW 7 12,363,792 (GRCm39) missense probably benign
R6886:Vmn2r54 UTSW 7 12,366,080 (GRCm39) missense probably benign 0.02
R7041:Vmn2r54 UTSW 7 12,363,751 (GRCm39) missense probably damaging 0.99
R7058:Vmn2r54 UTSW 7 12,349,722 (GRCm39) missense possibly damaging 0.70
R7113:Vmn2r54 UTSW 7 12,350,001 (GRCm39) missense probably damaging 1.00
R7124:Vmn2r54 UTSW 7 12,356,078 (GRCm39) missense probably benign 0.00
R7126:Vmn2r54 UTSW 7 12,366,088 (GRCm39) missense possibly damaging 0.91
R7236:Vmn2r54 UTSW 7 12,365,917 (GRCm39) missense possibly damaging 0.84
R7337:Vmn2r54 UTSW 7 12,356,044 (GRCm39) missense probably benign 0.00
R7406:Vmn2r54 UTSW 7 12,350,150 (GRCm39) splice site probably null
R7634:Vmn2r54 UTSW 7 12,349,630 (GRCm39) missense probably damaging 1.00
R7793:Vmn2r54 UTSW 7 12,366,196 (GRCm39) missense probably damaging 0.98
R8139:Vmn2r54 UTSW 7 12,349,743 (GRCm39) missense possibly damaging 0.92
R8158:Vmn2r54 UTSW 7 12,349,888 (GRCm39) missense probably damaging 1.00
R8179:Vmn2r54 UTSW 7 12,366,018 (GRCm39) nonsense probably null
R8440:Vmn2r54 UTSW 7 12,350,013 (GRCm39) missense possibly damaging 0.72
R8712:Vmn2r54 UTSW 7 12,369,877 (GRCm39) missense probably benign 0.22
R8853:Vmn2r54 UTSW 7 12,349,782 (GRCm39) missense probably damaging 1.00
R8859:Vmn2r54 UTSW 7 12,363,702 (GRCm39) missense possibly damaging 0.70
R9146:Vmn2r54 UTSW 7 12,366,647 (GRCm39) missense probably benign 0.05
R9157:Vmn2r54 UTSW 7 12,366,055 (GRCm39) missense possibly damaging 0.93
R9344:Vmn2r54 UTSW 7 12,366,283 (GRCm39) missense probably benign
R9423:Vmn2r54 UTSW 7 12,349,441 (GRCm39) missense probably damaging 1.00
R9534:Vmn2r54 UTSW 7 12,366,093 (GRCm39) missense probably benign 0.03
R9632:Vmn2r54 UTSW 7 12,363,753 (GRCm39) missense possibly damaging 0.74
R9661:Vmn2r54 UTSW 7 12,349,166 (GRCm39) missense probably benign
R9710:Vmn2r54 UTSW 7 12,363,753 (GRCm39) missense possibly damaging 0.74
U24488:Vmn2r54 UTSW 7 12,349,356 (GRCm39) missense possibly damaging 0.84
X0066:Vmn2r54 UTSW 7 12,349,297 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r54 UTSW 7 12,366,035 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATAGCCCTGCTGCTGTGATAC -3'
(R):5'- ATGCAGTTACCCAGCTGATAATTC -3'

Sequencing Primer
(F):5'- TACAGAAGGCCAAATGTGCCTTG -3'
(R):5'- AATTCACTTTCAATGGTCCTGGG -3'
Posted On 2016-10-24