Incidental Mutation 'R5453:Spmip4'
ID 432623
Institutional Source Beutler Lab
Gene Symbol Spmip4
Ensembl Gene ENSMUSG00000029828
Gene Name sperm microtubule inner protein 4
Synonyms 4921507P07Rik
MMRRC Submission 043017-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R5453 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 50550282-50573612 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 50572776 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000031852 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031852]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000031852
SMART Domains Protein: ENSMUSP00000031852
Gene: ENSMUSG00000029828

DomainStartEndE-ValueType
Pfam:DUF4555 1 283 2e-149 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126537
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147260
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203814
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca5 G A 11: 110,210,622 (GRCm39) Q186* probably null Het
Adamts20 T C 15: 94,223,969 (GRCm39) E1253G possibly damaging Het
Adgrd1 T C 5: 129,256,647 (GRCm39) F640S probably damaging Het
Anxa1 C T 19: 20,357,703 (GRCm39) probably null Het
Babam2 A G 5: 32,164,590 (GRCm39) E288G probably damaging Het
Cd163 C T 6: 124,289,500 (GRCm39) A406V probably damaging Het
Cdh13 A T 8: 119,925,706 (GRCm39) D358V probably damaging Het
Cdk10 A G 8: 123,953,131 (GRCm39) I45V probably benign Het
Crybg2 A T 4: 133,806,147 (GRCm39) probably null Het
Dnhd1 A G 7: 105,359,330 (GRCm39) D3555G probably damaging Het
Dync1h1 A G 12: 110,599,099 (GRCm39) D1818G probably benign Het
Emsy T C 7: 98,250,013 (GRCm39) K758R probably damaging Het
Fat3 A G 9: 15,908,160 (GRCm39) V2614A probably damaging Het
Hivep2 T C 10: 14,003,972 (GRCm39) I190T possibly damaging Het
Hoxb3 T C 11: 96,235,480 (GRCm39) S136P probably damaging Het
Hras A C 7: 140,772,768 (GRCm39) V29G probably damaging Het
Hycc1 A G 5: 24,192,877 (GRCm39) probably null Het
Igll1 A G 16: 16,681,558 (GRCm39) probably null Het
Insr G A 8: 3,205,694 (GRCm39) T1365I probably benign Het
Kitl T A 10: 99,923,247 (GRCm39) W187R probably damaging Het
Klb T A 5: 65,540,728 (GRCm39) F940L probably benign Het
Lrp1b C T 2: 41,172,249 (GRCm39) R725K probably damaging Het
Map4 C T 9: 109,866,851 (GRCm39) probably benign Het
Mrps35 A G 6: 146,972,115 (GRCm39) S253G probably benign Het
Mycbp2 C T 14: 103,438,837 (GRCm39) E2015K probably damaging Het
Nyap2 A C 1: 81,169,857 (GRCm39) I205L probably benign Het
Or12d13 T C 17: 37,647,953 (GRCm39) M57V possibly damaging Het
Or6k14 A G 1: 173,927,033 (GRCm39) K3R probably benign Het
Rab11fip3 C T 17: 26,211,555 (GRCm39) probably null Het
Rbm47 A G 5: 66,184,525 (GRCm39) V26A probably benign Het
Ripk2 A T 4: 16,151,989 (GRCm39) I190N probably damaging Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Ttc17 A T 2: 94,133,905 (GRCm39) N1150K probably damaging Het
Zfp108 G T 7: 23,960,689 (GRCm39) G427W probably damaging Het
Zfp84 A G 7: 29,475,722 (GRCm39) E138G possibly damaging Het
Other mutations in Spmip4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00852:Spmip4 APN 6 50,566,164 (GRCm39) critical splice acceptor site probably null
IGL01310:Spmip4 APN 6 50,551,175 (GRCm39) missense probably benign
IGL01568:Spmip4 APN 6 50,550,678 (GRCm39) utr 3 prime probably benign
IGL01794:Spmip4 APN 6 50,554,826 (GRCm39) missense probably damaging 1.00
IGL02718:Spmip4 APN 6 50,561,367 (GRCm39) missense probably damaging 1.00
IGL03146:Spmip4 APN 6 50,550,853 (GRCm39) missense probably damaging 0.97
IGL03381:Spmip4 APN 6 50,566,116 (GRCm39) missense probably damaging 1.00
R1173:Spmip4 UTSW 6 50,566,121 (GRCm39) missense probably damaging 0.98
R1174:Spmip4 UTSW 6 50,566,121 (GRCm39) missense probably damaging 0.98
R1175:Spmip4 UTSW 6 50,566,121 (GRCm39) missense probably damaging 0.98
R1769:Spmip4 UTSW 6 50,568,801 (GRCm39) splice site probably benign
R1883:Spmip4 UTSW 6 50,551,433 (GRCm39) missense probably benign 0.01
R2056:Spmip4 UTSW 6 50,550,725 (GRCm39) missense possibly damaging 0.71
R2437:Spmip4 UTSW 6 50,560,959 (GRCm39) missense probably damaging 1.00
R2929:Spmip4 UTSW 6 50,551,285 (GRCm39) missense probably benign 0.07
R4357:Spmip4 UTSW 6 50,551,190 (GRCm39) missense probably benign
R4666:Spmip4 UTSW 6 50,572,808 (GRCm39) missense possibly damaging 0.69
R4791:Spmip4 UTSW 6 50,572,817 (GRCm39) missense probably damaging 1.00
R4827:Spmip4 UTSW 6 50,572,836 (GRCm39) missense possibly damaging 0.76
R4976:Spmip4 UTSW 6 50,566,164 (GRCm39) critical splice acceptor site probably null
R6689:Spmip4 UTSW 6 50,566,089 (GRCm39) critical splice donor site probably null
R6897:Spmip4 UTSW 6 50,566,145 (GRCm39) missense possibly damaging 0.82
R7718:Spmip4 UTSW 6 50,566,078 (GRCm39) splice site probably null
R8475:Spmip4 UTSW 6 50,566,107 (GRCm39) missense probably damaging 0.99
R8885:Spmip4 UTSW 6 50,551,028 (GRCm39) missense possibly damaging 0.95
R8975:Spmip4 UTSW 6 50,561,391 (GRCm39) missense probably damaging 1.00
R9626:Spmip4 UTSW 6 50,550,930 (GRCm39) missense
X0021:Spmip4 UTSW 6 50,550,906 (GRCm39) missense probably benign
Z1176:Spmip4 UTSW 6 50,551,001 (GRCm39) missense possibly damaging 0.55
Z1177:Spmip4 UTSW 6 50,568,672 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- TGGAAGAATATGCCTCCCTTG -3'
(R):5'- AACCAAGGCAGTTTACAAGTCC -3'

Sequencing Primer
(F):5'- GAAGAATATGCCTCCCTTGTTATAGC -3'
(R):5'- GGCAGTTTACAAGTCCAAATTTTC -3'
Posted On 2016-10-06