Incidental Mutation 'R5527:Naa15'
ID 431906
Institutional Source Beutler Lab
Gene Symbol Naa15
Ensembl Gene ENSMUSG00000063273
Gene Name N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms Narg1, 5730450D16Rik, ASTBDN, Tbdn-1, tubedown, mNAT1
MMRRC Submission 043085-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.964) question?
Stock # R5527 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 51323437-51383406 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 51349368 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 46 (Y46H)
Ref Sequence ENSEMBL: ENSMUSP00000141433 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029303] [ENSMUST00000192419] [ENSMUST00000193266]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000029303
AA Change: Y96H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000029303
Gene: ENSMUSG00000063273
AA Change: Y96H

DomainStartEndE-ValueType
TPR 46 79 6.24e1 SMART
TPR 80 113 1.01e0 SMART
Blast:TPR 224 257 3e-12 BLAST
TPR 374 407 1.87e1 SMART
TPR 408 441 5.06e1 SMART
low complexity region 603 641 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000192197
AA Change: Y14H
Predicted Effect probably damaging
Transcript: ENSMUST00000192419
AA Change: Y46H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141965
Gene: ENSMUSG00000063273
AA Change: Y46H

DomainStartEndE-ValueType
Blast:TPR 1 29 8e-12 BLAST
Pfam:TPR_2 30 63 3.4e-5 PFAM
Pfam:TPR_8 30 63 2.6e-4 PFAM
Pfam:TPR_11 31 95 4.8e-7 PFAM
Pfam:TPR_7 32 65 1.5e-2 PFAM
Pfam:TPR_1 37 63 1.6e-4 PFAM
Pfam:TPR_9 38 85 1e-2 PFAM
Pfam:TPR_9 88 126 1.2e0 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192523
Predicted Effect probably damaging
Transcript: ENSMUST00000193266
AA Change: Y46H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141433
Gene: ENSMUSG00000063273
AA Change: Y46H

DomainStartEndE-ValueType
Blast:TPR 1 29 3e-10 BLAST
TPR 30 63 4.9e-3 SMART
Blast:TPR 174 207 3e-12 BLAST
TPR 324 357 8.9e-2 SMART
TPR 358 391 2.4e-1 SMART
coiled coil region 533 585 N/A INTRINSIC
Blast:TPR 622 655 7e-10 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195430
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.2%
  • 10x: 94.9%
  • 20x: 89.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 T A 16: 14,278,842 (GRCm39) Y1051N probably benign Het
Bach1 T C 16: 87,516,433 (GRCm39) S325P probably benign Het
Baz2a T C 10: 127,960,786 (GRCm39) S1529P probably damaging Het
Bicd1 T C 6: 149,396,134 (GRCm39) L168P probably damaging Het
Cat A G 2: 103,303,318 (GRCm39) F153S probably damaging Het
Ccnt2 T C 1: 127,730,401 (GRCm39) M426T probably benign Het
Cdk7 C T 13: 100,866,980 (GRCm39) V38I probably damaging Het
Cenpj T C 14: 56,764,440 (GRCm39) Y1324C probably damaging Het
Cplane2 C A 4: 140,947,303 (GRCm39) A228D probably damaging Het
Ddx47 C A 6: 134,988,657 (GRCm39) A18E probably benign Het
Dnah2 G A 11: 69,328,014 (GRCm39) Q3370* probably null Het
Dnah6 C T 6: 73,136,212 (GRCm39) V976I probably benign Het
Dock7 C T 4: 98,842,105 (GRCm39) probably benign Het
Dpy19l3 A T 7: 35,413,555 (GRCm39) I362N possibly damaging Het
Fam118a A T 15: 84,942,999 (GRCm39) T343S probably benign Het
Fcgbp T A 7: 27,793,060 (GRCm39) D1021E probably benign Het
Fkbp1b T C 12: 4,883,746 (GRCm39) Y83C probably damaging Het
Flt4 T C 11: 49,525,581 (GRCm39) I709T probably damaging Het
Gga3 G T 11: 115,478,262 (GRCm39) A510D probably damaging Het
Heatr1 T C 13: 12,417,641 (GRCm39) I264T probably damaging Het
Heatr1 T C 13: 12,419,829 (GRCm39) I384T probably benign Het
Hes2 T C 4: 152,244,849 (GRCm39) V106A probably benign Het
Igf1r T A 7: 67,857,569 (GRCm39) M1083K probably damaging Het
Il7r A T 15: 9,513,010 (GRCm39) D166E probably benign Het
Ipo4 G A 14: 55,869,507 (GRCm39) probably null Het
Klk1b26 T C 7: 43,662,187 (GRCm39) I15T probably benign Het
Krt42 T C 11: 100,154,121 (GRCm39) probably benign Het
Lag3 T C 6: 124,885,592 (GRCm39) T263A probably damaging Het
Lilra6 T A 7: 3,917,586 (GRCm39) probably benign Het
Lrrc31 T A 3: 30,745,377 (GRCm39) H90L probably damaging Het
Lvrn G A 18: 47,006,870 (GRCm39) D331N probably damaging Het
Me2 A T 18: 73,924,187 (GRCm39) W342R probably damaging Het
Mob2 A G 7: 141,563,147 (GRCm39) F220S probably damaging Het
Mroh4 A G 15: 74,486,865 (GRCm39) I342T probably damaging Het
Neb A G 2: 52,224,465 (GRCm39) V10A unknown Het
Nlrc5 A G 8: 95,217,044 (GRCm39) H1011R probably damaging Het
Nr1i3 A G 1: 171,041,921 (GRCm39) T2A possibly damaging Het
Nrros T C 16: 31,963,288 (GRCm39) N207S probably damaging Het
Or52m2 A T 7: 102,263,768 (GRCm39) S143T probably benign Het
Or7c70 C T 10: 78,683,609 (GRCm39) V47M probably benign Het
Pcare A T 17: 72,059,635 (GRCm39) V14D probably damaging Het
Ptprz1 C T 6: 23,000,052 (GRCm39) T714I possibly damaging Het
Rp1 T C 1: 4,416,616 (GRCm39) T1499A possibly damaging Het
Rubcn T C 16: 32,647,081 (GRCm39) K771E probably damaging Het
Sbds T C 5: 130,275,247 (GRCm39) E227G possibly damaging Het
Setd1a C T 7: 127,384,801 (GRCm39) P8S probably damaging Het
Sh3tc2 A G 18: 62,144,932 (GRCm39) I1129V probably benign Het
Spef1 T A 2: 131,014,661 (GRCm39) D87V probably damaging Het
Supv3l1 C T 10: 62,265,608 (GRCm39) R644Q probably damaging Het
Thoc6 A G 17: 23,889,769 (GRCm39) F51S probably damaging Het
Tm4sf19 T C 16: 32,226,739 (GRCm39) L176P probably damaging Het
Tma16 A G 8: 66,936,776 (GRCm39) I17T possibly damaging Het
Tpd52l2 G A 2: 181,143,847 (GRCm39) probably null Het
Ube2j1 C T 4: 33,045,164 (GRCm39) P146S probably benign Het
Ubr4 T A 4: 139,208,099 (GRCm39) I4960N possibly damaging Het
Usp13 A G 3: 32,919,987 (GRCm39) D224G probably damaging Het
Uxs1 T C 1: 43,819,240 (GRCm39) T188A probably damaging Het
Vmn2r12 A T 5: 109,234,483 (GRCm39) Y576* probably null Het
Vmn2r73 T C 7: 85,507,575 (GRCm39) D579G possibly damaging Het
Xpr1 T C 1: 155,165,981 (GRCm39) N524D probably benign Het
Xrn2 A T 2: 146,871,675 (GRCm39) I366L probably benign Het
Zfp236 A T 18: 82,676,159 (GRCm39) V386E possibly damaging Het
Zfp292 A T 4: 34,806,261 (GRCm39) L2261Q probably damaging Het
Zpld1 C G 16: 55,046,725 (GRCm39) E415Q probably benign Het
Other mutations in Naa15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Naa15 APN 3 51,345,826 (GRCm39) missense probably damaging 1.00
IGL01753:Naa15 APN 3 51,350,274 (GRCm39) missense probably damaging 1.00
IGL01837:Naa15 APN 3 51,351,369 (GRCm39) nonsense probably null
IGL02619:Naa15 APN 3 51,367,552 (GRCm39) missense probably benign 0.03
IGL02691:Naa15 APN 3 51,358,747 (GRCm39) missense probably damaging 0.97
IGL02974:Naa15 APN 3 51,368,628 (GRCm39) missense possibly damaging 0.95
R0009:Naa15 UTSW 3 51,377,640 (GRCm39) missense probably damaging 1.00
R0010:Naa15 UTSW 3 51,343,634 (GRCm39) critical splice acceptor site probably null
R0114:Naa15 UTSW 3 51,355,859 (GRCm39) critical splice donor site probably null
R0411:Naa15 UTSW 3 51,373,060 (GRCm39) missense possibly damaging 0.81
R1348:Naa15 UTSW 3 51,373,091 (GRCm39) missense probably damaging 1.00
R1941:Naa15 UTSW 3 51,363,355 (GRCm39) nonsense probably null
R3082:Naa15 UTSW 3 51,367,471 (GRCm39) missense probably damaging 1.00
R4377:Naa15 UTSW 3 51,355,786 (GRCm39) missense possibly damaging 0.91
R4591:Naa15 UTSW 3 51,349,345 (GRCm39) missense probably damaging 1.00
R4980:Naa15 UTSW 3 51,366,173 (GRCm39) critical splice donor site probably null
R5087:Naa15 UTSW 3 51,364,706 (GRCm39) splice site probably null
R5139:Naa15 UTSW 3 51,351,261 (GRCm39) missense probably damaging 1.00
R5289:Naa15 UTSW 3 51,363,315 (GRCm39) missense probably damaging 1.00
R5776:Naa15 UTSW 3 51,367,447 (GRCm39) missense probably damaging 0.96
R5909:Naa15 UTSW 3 51,367,485 (GRCm39) missense probably damaging 1.00
R6034:Naa15 UTSW 3 51,350,242 (GRCm39) missense probably damaging 0.98
R6034:Naa15 UTSW 3 51,350,242 (GRCm39) missense probably damaging 0.98
R6194:Naa15 UTSW 3 51,370,721 (GRCm39) missense probably benign 0.00
R6291:Naa15 UTSW 3 51,350,212 (GRCm39) missense probably damaging 1.00
R6522:Naa15 UTSW 3 51,378,935 (GRCm39) missense probably damaging 1.00
R6731:Naa15 UTSW 3 51,363,294 (GRCm39) missense probably damaging 1.00
R6984:Naa15 UTSW 3 51,380,021 (GRCm39) missense probably benign 0.10
R7040:Naa15 UTSW 3 51,380,205 (GRCm39) missense possibly damaging 0.89
R7091:Naa15 UTSW 3 51,366,177 (GRCm39) splice site probably null
R7380:Naa15 UTSW 3 51,367,268 (GRCm39) splice site probably null
R7685:Naa15 UTSW 3 51,377,395 (GRCm39) splice site probably null
R7781:Naa15 UTSW 3 51,378,904 (GRCm39) critical splice acceptor site probably null
R7797:Naa15 UTSW 3 51,356,031 (GRCm39) missense probably damaging 0.99
R7836:Naa15 UTSW 3 51,370,688 (GRCm39) nonsense probably null
R7981:Naa15 UTSW 3 51,366,092 (GRCm39) missense probably damaging 0.96
R8513:Naa15 UTSW 3 51,367,444 (GRCm39) missense probably damaging 0.99
R8923:Naa15 UTSW 3 51,367,443 (GRCm39) missense probably damaging 1.00
R9159:Naa15 UTSW 3 51,358,802 (GRCm39) missense probably benign 0.01
R9701:Naa15 UTSW 3 51,349,370 (GRCm39) nonsense probably null
R9802:Naa15 UTSW 3 51,349,370 (GRCm39) nonsense probably null
X0020:Naa15 UTSW 3 51,377,553 (GRCm39) missense probably benign 0.00
X0061:Naa15 UTSW 3 51,356,022 (GRCm39) missense probably benign 0.11
X0061:Naa15 UTSW 3 51,356,021 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGACCTAAGGCTATCTGTCTCTG -3'
(R):5'- GATGTAATCACTAAGGGGCAGTC -3'

Sequencing Primer
(F):5'- AAGGCTATCTGTCTCTGCTTTCTAAG -3'
(R):5'- CCCTCAAGATCTCGCATT -3'
Posted On 2016-10-05