Incidental Mutation 'R5374:Fcrl5'
ID 428919
Institutional Source Beutler Lab
Gene Symbol Fcrl5
Ensembl Gene ENSMUSG00000048031
Gene Name Fc receptor-like 5
Synonyms Fcrh3, BXMAS1-like protein 2, mBXMH2
MMRRC Submission 042950-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R5374 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 87343084-87407985 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87353698 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 348 (T348A)
Ref Sequence ENSEMBL: ENSMUSP00000142210 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049926] [ENSMUST00000166297] [ENSMUST00000178261] [ENSMUST00000193229] [ENSMUST00000194102]
AlphaFold Q68SN8
Predicted Effect probably benign
Transcript: ENSMUST00000049926
AA Change: T348A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000050151
Gene: ENSMUSG00000048031
AA Change: T348A

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000166297
AA Change: T260A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000131176
Gene: ENSMUSG00000048031
AA Change: T260A

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IGc2 40 100 6.16e-4 SMART
IG_like 125 208 4.41e1 SMART
IGc2 228 292 3.97e-7 SMART
IG_like 322 385 2.94e-1 SMART
transmembrane domain 407 429 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000178261
AA Change: T348A

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000136046
Gene: ENSMUSG00000048031
AA Change: T348A

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193229
AA Change: T260A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000141311
Gene: ENSMUSG00000048031
AA Change: T260A

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IGc2 40 100 6.16e-4 SMART
IG_like 125 208 4.41e1 SMART
IGc2 228 292 3.97e-7 SMART
IG_like 322 385 2.94e-1 SMART
transmembrane domain 407 429 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000194102
AA Change: T348A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000142210
Gene: ENSMUSG00000048031
AA Change: T348A

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 96% (81/84)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,773,396 (GRCm39) S862G probably benign Het
Adgrf1 G A 17: 43,601,896 (GRCm39) probably benign Het
Adss2 T G 1: 177,623,954 (GRCm39) I3L probably benign Het
Anapc7 T A 5: 122,576,280 (GRCm39) D302E probably benign Het
Ank3 A G 10: 69,789,306 (GRCm39) probably null Het
Astn2 A C 4: 65,315,242 (GRCm39) V1145G probably damaging Het
Babam2 C T 5: 32,164,574 (GRCm39) probably benign Het
Blvrb A G 7: 27,165,271 (GRCm39) H238R possibly damaging Het
Cacna1b C T 2: 24,596,228 (GRCm39) V488I probably damaging Het
Ccdc88a C T 11: 29,413,409 (GRCm39) T649M possibly damaging Het
Cdh12 A C 15: 21,583,998 (GRCm39) S613R probably damaging Het
Cisd2 A G 3: 135,114,596 (GRCm39) V125A probably benign Het
Clcn2 C A 16: 20,528,419 (GRCm39) G478W possibly damaging Het
Cntnap2 T A 6: 47,084,903 (GRCm39) H1121Q probably benign Het
Corin A T 5: 72,462,296 (GRCm39) C876S probably damaging Het
Cox7c T C 13: 86,194,739 (GRCm39) Y19C probably benign Het
Cplane1 T C 15: 8,300,287 (GRCm39) V3198A unknown Het
Cspp1 T G 1: 10,204,351 (GRCm39) L1038R probably damaging Het
Cwc15 A G 9: 14,416,234 (GRCm39) K147E possibly damaging Het
Dlgap2 A G 8: 14,873,614 (GRCm39) D739G probably benign Het
Dmxl2 A G 9: 54,276,473 (GRCm39) probably benign Het
Dock5 A G 14: 68,043,205 (GRCm39) V864A possibly damaging Het
Dock7 A G 4: 98,877,275 (GRCm39) F1088L possibly damaging Het
Dpysl3 T C 18: 43,494,101 (GRCm39) Y193C probably damaging Het
Dtna T C 18: 23,784,670 (GRCm39) Y730H probably damaging Het
Dusp3 A G 11: 101,875,451 (GRCm39) Y38H possibly damaging Het
Eif3m A T 2: 104,843,277 (GRCm39) I151N probably damaging Het
Entpd2 C T 2: 25,289,738 (GRCm39) T380I probably damaging Het
Epb41l3 C A 17: 69,593,795 (GRCm39) H810N probably damaging Het
Ginm1 A G 10: 7,655,078 (GRCm39) S55P probably damaging Het
Glt1d1 C A 5: 127,734,148 (GRCm39) probably null Het
Gm15433 T A 1: 84,941,833 (GRCm39) noncoding transcript Het
Gm8221 A G 15: 77,510,352 (GRCm39) noncoding transcript Het
Gramd1c A G 16: 43,803,604 (GRCm39) V603A probably benign Het
Grm1 A G 10: 10,956,186 (GRCm39) S33P probably benign Het
Gstp3 T C 19: 4,107,922 (GRCm39) N137S possibly damaging Het
Kdm5d C T Y: 927,995 (GRCm39) P756S probably benign Het
Ly75 A T 2: 60,142,115 (GRCm39) L1332M possibly damaging Het
Med1 T A 11: 98,054,789 (GRCm39) K378N probably damaging Het
Mn1 A G 5: 111,569,752 (GRCm39) probably null Het
Mpo T C 11: 87,694,437 (GRCm39) probably null Het
Nom1 C G 5: 29,646,377 (GRCm39) R555G probably damaging Het
Nsmce4a C T 7: 130,139,900 (GRCm39) R276Q probably benign Het
Nt5c G A 11: 115,381,643 (GRCm39) probably null Het
Olfr908 CACAACAACA CACAACA 9: 38,427,434 (GRCm39) probably benign Het
Or52e18 G T 7: 104,609,203 (GRCm39) H245Q probably damaging Het
Or5p52 T C 7: 107,502,698 (GRCm39) I258T possibly damaging Het
Pcdhga4 T C 18: 37,818,649 (GRCm39) V66A probably damaging Het
Pik3c3 T C 18: 30,445,614 (GRCm39) S534P probably benign Het
Pla2g4e A T 2: 120,016,876 (GRCm39) C222S probably benign Het
Plch1 A C 3: 63,605,499 (GRCm39) H1468Q probably benign Het
Psd2 T A 18: 36,140,556 (GRCm39) W610R probably damaging Het
Ptgs1 A T 2: 36,141,198 (GRCm39) K548N probably damaging Het
Ptprz1 T A 6: 23,007,354 (GRCm39) V1639E probably damaging Het
Rangap1 A T 15: 81,590,695 (GRCm39) S466T probably benign Het
Rgsl1 C T 1: 153,666,053 (GRCm39) V986I probably benign Het
Rhobtb3 T C 13: 76,027,014 (GRCm39) Y453C probably damaging Het
Rspry1 T C 8: 95,349,636 (GRCm39) V8A probably benign Het
Rspry1 C A 8: 95,380,892 (GRCm39) R399S probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Rxfp2 A G 5: 149,993,725 (GRCm39) T596A probably benign Het
Sap18b G A 8: 96,551,998 (GRCm39) A3T unknown Het
Serpina3j A G 12: 104,280,986 (GRCm39) D53G probably damaging Het
Skint3 T A 4: 112,155,386 (GRCm39) D381E possibly damaging Het
Slirp T C 12: 87,496,192 (GRCm39) S96P possibly damaging Het
Snx6 T C 12: 54,817,513 (GRCm39) E128G probably damaging Het
Stap1 A G 5: 86,238,787 (GRCm39) T152A possibly damaging Het
Tcf20 A T 15: 82,736,158 (GRCm39) N1764K probably damaging Het
Thap2 A T 10: 115,208,744 (GRCm39) Y125* probably null Het
Ticrr T G 7: 79,340,690 (GRCm39) Y1031* probably null Het
Tnrc18 G A 5: 142,725,911 (GRCm39) R1793C unknown Het
Trpm3 C T 19: 22,903,548 (GRCm39) R945* probably null Het
Ugt1a10 T A 1: 87,983,632 (GRCm39) D143E probably damaging Het
Ush2a C T 1: 188,487,403 (GRCm39) T3057M probably benign Het
Zc3h6 A T 2: 128,844,076 (GRCm39) I207F possibly damaging Het
Zfp518a T C 19: 40,901,954 (GRCm39) S628P probably benign Het
Zup1 T C 10: 33,803,462 (GRCm39) N541D possibly damaging Het
Other mutations in Fcrl5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01743:Fcrl5 APN 3 87,351,598 (GRCm39) missense probably damaging 0.96
IGL01868:Fcrl5 APN 3 87,351,014 (GRCm39) missense possibly damaging 0.58
IGL01939:Fcrl5 APN 3 87,353,606 (GRCm39) missense probably damaging 0.99
IGL02817:Fcrl5 APN 3 87,343,220 (GRCm39) missense probably benign 0.35
IGL03106:Fcrl5 APN 3 87,343,190 (GRCm39) splice site probably null
R0381:Fcrl5 UTSW 3 87,353,767 (GRCm39) missense probably damaging 1.00
R0523:Fcrl5 UTSW 3 87,365,099 (GRCm39) missense possibly damaging 0.72
R0646:Fcrl5 UTSW 3 87,349,320 (GRCm39) missense probably benign 0.00
R1231:Fcrl5 UTSW 3 87,349,486 (GRCm39) missense probably benign 0.13
R1353:Fcrl5 UTSW 3 87,355,669 (GRCm39) missense probably damaging 1.00
R1711:Fcrl5 UTSW 3 87,364,721 (GRCm39) missense possibly damaging 0.61
R1714:Fcrl5 UTSW 3 87,353,713 (GRCm39) missense probably damaging 1.00
R1719:Fcrl5 UTSW 3 87,364,704 (GRCm39) missense probably damaging 0.98
R2084:Fcrl5 UTSW 3 87,351,537 (GRCm39) missense probably benign 0.24
R2358:Fcrl5 UTSW 3 87,353,726 (GRCm39) missense probably damaging 0.99
R2884:Fcrl5 UTSW 3 87,364,698 (GRCm39) missense probably damaging 1.00
R2885:Fcrl5 UTSW 3 87,364,698 (GRCm39) missense probably damaging 1.00
R3085:Fcrl5 UTSW 3 87,353,771 (GRCm39) missense probably damaging 1.00
R3153:Fcrl5 UTSW 3 87,350,987 (GRCm39) missense probably benign 0.09
R4288:Fcrl5 UTSW 3 87,349,531 (GRCm39) missense probably benign 0.09
R4289:Fcrl5 UTSW 3 87,349,531 (GRCm39) missense probably benign 0.09
R4614:Fcrl5 UTSW 3 87,355,733 (GRCm39) missense probably damaging 1.00
R4719:Fcrl5 UTSW 3 87,351,496 (GRCm39) missense probably damaging 1.00
R4788:Fcrl5 UTSW 3 87,364,495 (GRCm39) missense probably damaging 1.00
R4920:Fcrl5 UTSW 3 87,351,480 (GRCm39) missense probably damaging 1.00
R4972:Fcrl5 UTSW 3 87,361,957 (GRCm39) missense probably benign 0.00
R5373:Fcrl5 UTSW 3 87,353,698 (GRCm39) missense probably benign 0.01
R5963:Fcrl5 UTSW 3 87,351,480 (GRCm39) missense probably damaging 1.00
R5975:Fcrl5 UTSW 3 87,349,410 (GRCm39) missense probably benign 0.00
R6022:Fcrl5 UTSW 3 87,363,070 (GRCm39) missense probably benign 0.42
R6267:Fcrl5 UTSW 3 87,355,631 (GRCm39) missense probably damaging 1.00
R6372:Fcrl5 UTSW 3 87,351,501 (GRCm39) nonsense probably null
R6393:Fcrl5 UTSW 3 87,355,634 (GRCm39) missense probably damaging 1.00
R7088:Fcrl5 UTSW 3 87,365,141 (GRCm39) makesense probably null
R7175:Fcrl5 UTSW 3 87,353,645 (GRCm39) missense probably benign 0.37
R7210:Fcrl5 UTSW 3 87,353,719 (GRCm39) missense possibly damaging 0.85
R7217:Fcrl5 UTSW 3 87,351,081 (GRCm39) missense probably damaging 1.00
R7243:Fcrl5 UTSW 3 87,349,552 (GRCm39) missense probably benign
R7776:Fcrl5 UTSW 3 87,351,502 (GRCm39) missense possibly damaging 0.84
R7813:Fcrl5 UTSW 3 87,350,930 (GRCm39) missense probably benign 0.09
R8357:Fcrl5 UTSW 3 87,351,567 (GRCm39) missense probably damaging 0.99
R8457:Fcrl5 UTSW 3 87,351,567 (GRCm39) missense probably damaging 0.99
R9257:Fcrl5 UTSW 3 87,343,195 (GRCm39) missense probably benign 0.11
R9276:Fcrl5 UTSW 3 87,343,138 (GRCm39) start gained probably benign
R9748:Fcrl5 UTSW 3 87,364,469 (GRCm39) missense possibly damaging 0.93
X0054:Fcrl5 UTSW 3 87,353,606 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAAAAGTCCCATGCATGTC -3'
(R):5'- GGCAAACATTACAGAATTGGGC -3'

Sequencing Primer
(F):5'- AAGTCCCATGCATGTCATTGTTATTC -3'
(R):5'- AATGATGGCTGACTAGGCCATCTTC -3'
Posted On 2016-09-06