Incidental Mutation 'R5372:Mtus2'
ID 428781
Institutional Source Beutler Lab
Gene Symbol Mtus2
Ensembl Gene ENSMUSG00000029651
Gene Name microtubule associated tumor suppressor candidate 2
Synonyms C130038G02Rik, A730013O20Rik, 5730592G18Rik
MMRRC Submission 042948-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.136) question?
Stock # R5372 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 147894130-148252875 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 148250222 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 1319 (T1319A)
Ref Sequence ENSEMBL: ENSMUSP00000082694 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071878] [ENSMUST00000085554] [ENSMUST00000085558] [ENSMUST00000110514] [ENSMUST00000110515] [ENSMUST00000146425] [ENSMUST00000152105]
AlphaFold Q3UHD3
Predicted Effect probably benign
Transcript: ENSMUST00000071878
SMART Domains Protein: ENSMUSP00000071775
Gene: ENSMUSG00000029651

DomainStartEndE-ValueType
coiled coil region 19 75 N/A INTRINSIC
low complexity region 161 181 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000085554
AA Change: T118A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000082690
Gene: ENSMUSG00000029651
AA Change: T118A

DomainStartEndE-ValueType
coiled coil region 15 118 N/A INTRINSIC
low complexity region 131 148 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000085558
AA Change: T1319A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000082694
Gene: ENSMUSG00000029651
AA Change: T1319A

DomainStartEndE-ValueType
internal_repeat_1 57 290 2.46e-5 PROSPERO
internal_repeat_1 312 525 2.46e-5 PROSPERO
low complexity region 530 541 N/A INTRINSIC
low complexity region 802 818 N/A INTRINSIC
low complexity region 841 852 N/A INTRINSIC
low complexity region 893 904 N/A INTRINSIC
coiled coil region 1029 1080 N/A INTRINSIC
SCOP:d1fxkc_ 1167 1294 3e-4 SMART
low complexity region 1332 1349 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110514
AA Change: T281A

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000106143
Gene: ENSMUSG00000029651
AA Change: T281A

DomainStartEndE-ValueType
coiled coil region 19 75 N/A INTRINSIC
coiled coil region 144 281 N/A INTRINSIC
low complexity region 294 311 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000110515
AA Change: T314A

PolyPhen 2 Score 0.839 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000106144
Gene: ENSMUSG00000029651
AA Change: T314A

DomainStartEndE-ValueType
coiled coil region 19 75 N/A INTRINSIC
coiled coil region 144 314 N/A INTRINSIC
low complexity region 327 344 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000146425
Predicted Effect possibly damaging
Transcript: ENSMUST00000152105
AA Change: T155A

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000123055
Gene: ENSMUSG00000029651
AA Change: T155A

DomainStartEndE-ValueType
low complexity region 40 51 N/A INTRINSIC
coiled coil region 52 155 N/A INTRINSIC
Meta Mutation Damage Score 0.2467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 96% (89/93)
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T A 3: 121,848,988 (GRCm39) D108E probably damaging Het
Abhd12b A G 12: 70,227,800 (GRCm39) D194G probably damaging Het
Adck5 A G 15: 76,478,707 (GRCm39) probably benign Het
Adgrb3 C T 1: 25,167,940 (GRCm39) V792I probably benign Het
Anxa8 G A 14: 33,815,868 (GRCm39) V174M probably damaging Het
Apol9b A T 15: 77,619,920 (GRCm39) R239W probably benign Het
Arhgap26 A G 18: 38,775,509 (GRCm39) noncoding transcript Het
Atrnl1 A G 19: 57,743,968 (GRCm39) Y1190C probably benign Het
Brinp3 T G 1: 146,707,464 (GRCm39) L376R probably damaging Het
Btbd2 A T 10: 80,484,475 (GRCm39) M132K probably damaging Het
C130073F10Rik A T 4: 101,747,684 (GRCm39) I115K probably damaging Het
C1ra T A 6: 124,498,584 (GRCm39) Y426N probably damaging Het
Cacna1b A T 2: 24,623,971 (GRCm39) V203E probably damaging Het
Catsperg1 T A 7: 28,910,137 (GRCm39) D68V probably benign Het
Ccdc158 A C 5: 92,780,419 (GRCm39) S885A possibly damaging Het
Cdc42bpa T C 1: 179,892,544 (GRCm39) V236A probably damaging Het
Cdca7 A T 2: 72,312,793 (GRCm39) E176D probably damaging Het
Cdk17 A G 10: 93,061,901 (GRCm39) D211G probably benign Het
Clca3a2 A C 3: 144,503,286 (GRCm39) M888R probably benign Het
Clcn7 T A 17: 25,376,153 (GRCm39) M568K possibly damaging Het
Clip1 G T 5: 123,768,303 (GRCm39) N811K probably benign Het
Col12a1 T A 9: 79,585,648 (GRCm39) Y1243F probably damaging Het
Dctn1 T A 6: 83,167,192 (GRCm39) D315E probably damaging Het
Dgcr2 T C 16: 17,690,508 (GRCm39) T41A probably benign Het
Dync2h1 G A 9: 7,176,962 (GRCm39) probably benign Het
Ep300 A G 15: 81,521,031 (GRCm39) I1264V unknown Het
Fam167b A T 4: 129,472,092 (GRCm39) L26Q possibly damaging Het
Fam178b T A 1: 36,603,929 (GRCm39) I457F possibly damaging Het
Fgd4 A T 16: 16,302,155 (GRCm39) N133K probably benign Het
Fndc1 C G 17: 7,984,042 (GRCm39) V1295L unknown Het
Gad2 A T 2: 22,580,255 (GRCm39) D552V possibly damaging Het
Hars2 T C 18: 36,923,534 (GRCm39) Y361H possibly damaging Het
Heca T A 10: 17,790,887 (GRCm39) S390C probably damaging Het
Hephl1 G T 9: 15,009,195 (GRCm39) Y132* probably null Het
Hormad1 T A 3: 95,483,735 (GRCm39) D182E probably damaging Het
Ifna15 G A 4: 88,476,338 (GRCm39) P49S probably damaging Het
Khsrp T C 17: 57,331,292 (GRCm39) T429A possibly damaging Het
Magi2 A G 5: 20,907,108 (GRCm39) Q1094R possibly damaging Het
Map3k11 T A 19: 5,740,990 (GRCm39) I239K probably damaging Het
Nup54 A G 5: 92,565,716 (GRCm39) I406T probably damaging Het
Nxpe2 T C 9: 48,250,819 (GRCm39) T43A possibly damaging Het
Nynrin A G 14: 56,105,948 (GRCm39) E889G probably benign Het
Opa1 A C 16: 29,404,937 (GRCm39) H45P probably benign Het
Or14c44 T A 7: 86,062,176 (GRCm39) I202N possibly damaging Het
Or4f60 A G 2: 111,902,454 (GRCm39) I158T probably benign Het
Or56b2j A G 7: 104,353,002 (GRCm39) D76G probably benign Het
Or8a1b T C 9: 37,623,234 (GRCm39) M114V possibly damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Papola A G 12: 105,793,309 (GRCm39) K543R probably benign Het
Plcxd3 G A 15: 4,604,270 (GRCm39) V293I probably benign Het
Polr2g T C 19: 8,774,667 (GRCm39) Y72C probably damaging Het
Ppp1r21 A G 17: 88,858,103 (GRCm39) K205E probably benign Het
Ptpre A G 7: 135,255,669 (GRCm39) K53E possibly damaging Het
Rasal3 T C 17: 32,610,318 (GRCm39) K990E probably benign Het
Rgs3 A T 4: 62,570,934 (GRCm39) probably benign Het
Rhd A G 4: 134,611,943 (GRCm39) T254A possibly damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Scube3 G T 17: 28,371,456 (GRCm39) C57F probably damaging Het
Sh2d5 A G 4: 137,982,010 (GRCm39) D57G possibly damaging Het
Slc12a6 T A 2: 112,177,705 (GRCm39) L608* probably null Het
Slk A T 19: 47,613,832 (GRCm39) N896I probably damaging Het
Smc6 A G 12: 11,332,431 (GRCm39) D211G probably damaging Het
Sox6 A T 7: 115,149,386 (GRCm39) Y371* probably null Het
Srcap G A 7: 127,156,785 (GRCm39) probably null Het
Stard5 T A 7: 83,282,428 (GRCm39) D80E probably damaging Het
Supv3l1 C T 10: 62,268,136 (GRCm39) V570M probably damaging Het
Syt7 G T 19: 10,403,985 (GRCm39) V180L probably damaging Het
Tacc2 T A 7: 130,224,990 (GRCm39) H558Q probably benign Het
Tas2r120 T A 6: 132,634,446 (GRCm39) M176K possibly damaging Het
Tmem135 A T 7: 88,814,382 (GRCm39) probably null Het
Trim35 T C 14: 66,534,715 (GRCm39) V66A possibly damaging Het
Tspan12 A G 6: 21,772,698 (GRCm39) S284P probably benign Het
Ttll3 A T 6: 113,378,382 (GRCm39) K257* probably null Het
Uggt1 C A 1: 36,283,141 (GRCm39) probably benign Het
Vmn2r7 T A 3: 64,623,745 (GRCm39) I283F probably damaging Het
Wdfy2 T G 14: 63,192,334 (GRCm39) H363Q probably damaging Het
Wdr4 T A 17: 31,729,554 (GRCm39) K95N probably damaging Het
Zfp141 T C 7: 42,126,620 (GRCm39) N91S possibly damaging Het
Zfp383 C T 7: 29,614,695 (GRCm39) R317* probably null Het
Other mutations in Mtus2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01104:Mtus2 APN 5 148,013,819 (GRCm39) splice site probably null
IGL01911:Mtus2 APN 5 148,015,030 (GRCm39) missense probably benign 0.00
IGL01973:Mtus2 APN 5 148,240,286 (GRCm39) splice site probably benign
IGL02452:Mtus2 APN 5 148,014,473 (GRCm39) missense probably benign 0.01
IGL02476:Mtus2 APN 5 148,014,748 (GRCm39) missense probably benign 0.01
IGL02716:Mtus2 APN 5 148,173,120 (GRCm39) missense probably benign 0.05
IGL03194:Mtus2 APN 5 148,043,913 (GRCm39) missense probably damaging 1.00
rumblado UTSW 5 148,243,518 (GRCm39) nonsense probably null
IGL02991:Mtus2 UTSW 5 148,250,310 (GRCm39) missense probably damaging 1.00
PIT4431001:Mtus2 UTSW 5 148,013,515 (GRCm39) missense probably benign 0.01
R0101:Mtus2 UTSW 5 148,019,845 (GRCm39) missense probably damaging 1.00
R0101:Mtus2 UTSW 5 148,019,845 (GRCm39) missense probably damaging 1.00
R0310:Mtus2 UTSW 5 148,043,829 (GRCm39) missense probably benign 0.17
R0729:Mtus2 UTSW 5 148,014,097 (GRCm39) missense probably benign 0.08
R0968:Mtus2 UTSW 5 148,014,994 (GRCm39) missense probably benign 0.09
R1231:Mtus2 UTSW 5 148,014,198 (GRCm39) missense probably benign 0.01
R1253:Mtus2 UTSW 5 148,240,380 (GRCm39) nonsense probably null
R1556:Mtus2 UTSW 5 148,014,198 (GRCm39) missense probably benign 0.01
R1561:Mtus2 UTSW 5 148,013,362 (GRCm39) missense probably benign 0.07
R1574:Mtus2 UTSW 5 148,013,362 (GRCm39) missense probably benign 0.07
R1750:Mtus2 UTSW 5 148,214,443 (GRCm39) missense probably damaging 0.97
R2318:Mtus2 UTSW 5 148,043,892 (GRCm39) nonsense probably null
R2327:Mtus2 UTSW 5 148,014,725 (GRCm39) missense probably benign 0.00
R3153:Mtus2 UTSW 5 148,019,870 (GRCm39) missense probably damaging 1.00
R3154:Mtus2 UTSW 5 148,240,083 (GRCm39) intron probably benign
R3158:Mtus2 UTSW 5 148,168,637 (GRCm39) missense probably damaging 1.00
R3548:Mtus2 UTSW 5 148,232,316 (GRCm39) missense probably damaging 1.00
R3861:Mtus2 UTSW 5 148,250,223 (GRCm39) missense probably damaging 1.00
R4395:Mtus2 UTSW 5 148,013,432 (GRCm39) missense probably benign 0.17
R4396:Mtus2 UTSW 5 148,140,748 (GRCm39) missense possibly damaging 0.81
R4667:Mtus2 UTSW 5 148,235,070 (GRCm39) missense possibly damaging 0.64
R4887:Mtus2 UTSW 5 148,013,913 (GRCm39) nonsense probably null
R4931:Mtus2 UTSW 5 148,014,226 (GRCm39) missense probably benign 0.09
R5097:Mtus2 UTSW 5 148,232,392 (GRCm39) missense probably damaging 0.99
R5318:Mtus2 UTSW 5 148,013,382 (GRCm39) missense probably benign 0.05
R5388:Mtus2 UTSW 5 148,243,518 (GRCm39) nonsense probably null
R5622:Mtus2 UTSW 5 148,015,244 (GRCm39) missense probably benign 0.09
R6009:Mtus2 UTSW 5 148,243,462 (GRCm39) missense probably damaging 1.00
R6379:Mtus2 UTSW 5 148,014,008 (GRCm39) missense probably benign 0.00
R6409:Mtus2 UTSW 5 148,014,425 (GRCm39) missense probably benign
R6527:Mtus2 UTSW 5 148,214,408 (GRCm39) critical splice acceptor site probably null
R6853:Mtus2 UTSW 5 148,043,821 (GRCm39) missense probably damaging 1.00
R7001:Mtus2 UTSW 5 148,214,438 (GRCm39) missense probably damaging 1.00
R7187:Mtus2 UTSW 5 148,013,515 (GRCm39) missense probably benign 0.01
R7276:Mtus2 UTSW 5 148,013,368 (GRCm39) missense probably benign
R7594:Mtus2 UTSW 5 148,014,216 (GRCm39) missense probably benign 0.44
R7790:Mtus2 UTSW 5 148,014,998 (GRCm39) missense probably benign 0.09
R7967:Mtus2 UTSW 5 148,014,656 (GRCm39) missense probably benign 0.32
R7987:Mtus2 UTSW 5 148,168,836 (GRCm39) splice site probably null
R8112:Mtus2 UTSW 5 148,013,713 (GRCm39) nonsense probably null
R8273:Mtus2 UTSW 5 148,043,815 (GRCm39) missense probably damaging 1.00
R8527:Mtus2 UTSW 5 148,240,408 (GRCm39) missense probably damaging 1.00
R8542:Mtus2 UTSW 5 148,240,408 (GRCm39) missense probably damaging 1.00
R8783:Mtus2 UTSW 5 148,019,861 (GRCm39) missense probably damaging 1.00
R8805:Mtus2 UTSW 5 148,015,303 (GRCm39) missense possibly damaging 0.58
R9204:Mtus2 UTSW 5 148,238,293 (GRCm39) missense probably damaging 1.00
R9210:Mtus2 UTSW 5 148,014,124 (GRCm39) missense probably benign 0.00
R9261:Mtus2 UTSW 5 148,243,453 (GRCm39) nonsense probably null
R9419:Mtus2 UTSW 5 148,243,451 (GRCm39) missense probably damaging 1.00
R9477:Mtus2 UTSW 5 148,014,740 (GRCm39) missense probably benign
R9483:Mtus2 UTSW 5 148,232,300 (GRCm39) missense possibly damaging 0.80
R9563:Mtus2 UTSW 5 148,250,217 (GRCm39) missense
R9643:Mtus2 UTSW 5 148,014,025 (GRCm39) missense probably benign 0.04
R9716:Mtus2 UTSW 5 148,013,464 (GRCm39) missense possibly damaging 0.82
R9745:Mtus2 UTSW 5 148,013,311 (GRCm39) missense possibly damaging 0.81
X0017:Mtus2 UTSW 5 148,214,410 (GRCm39) missense possibly damaging 0.83
X0028:Mtus2 UTSW 5 148,014,128 (GRCm39) missense probably benign 0.03
Z1088:Mtus2 UTSW 5 148,240,073 (GRCm39) intron probably benign
Z1176:Mtus2 UTSW 5 148,014,068 (GRCm39) missense probably benign 0.05
Z1176:Mtus2 UTSW 5 148,013,552 (GRCm39) missense probably benign 0.31
Z1177:Mtus2 UTSW 5 148,140,887 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCAGCCTCAGTTGCGTTAG -3'
(R):5'- CTTGCACAAGGGTCAGAGAG -3'

Sequencing Primer
(F):5'- CCTCAGTTGCGTTAGTAGGCC -3'
(R):5'- ACGCTGCCTAAGATGCATTG -3'
Posted On 2016-09-06