Mutagenetix > Incidental Mutation

Incidental Mutation 'R0491:Alms1'

42462

Institutional Source

Beutler Lab

Gene Symbol

Alms1

Ensembl Gene

ENSMUSG00000063810

Gene Name

ALMS1, centrosome and basal body associated

Synonyms

Alstrom syndrome 1

MMRRC Submission

038689-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0491 (G1)

Quality Score

146

Status

Validated

Chromosome

Chromosomal Location

85564513-85679735 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 85679582 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 3240 (T3240A)

Ref Sequence

ENSEMBL: ENSMUSP00000071904 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072018] [ENSMUST00000160534] [ENSMUST00000179613] [ENSMUST00000213058]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000072018
AA Change: T3240A

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000071904
Gene: ENSMUSG00000063810
AA Change: T3240A

Domain	Start	End	E-Value	Type
coiled coil region	10	39	N/A	INTRINSIC
low complexity region	67	80	N/A	INTRINSIC
low complexity region	98	119	N/A	INTRINSIC
Blast:MYSc	127	233	1e-21	BLAST
internal_repeat_3	408	511	2.48e-7	PROSPERO
internal_repeat_2	414	804	2.09e-12	PROSPERO
internal_repeat_1	438	834	4.54e-18	PROSPERO
internal_repeat_3	652	757	2.48e-7	PROSPERO
low complexity region	903	908	N/A	INTRINSIC
internal_repeat_1	916	1385	4.54e-18	PROSPERO
internal_repeat_2	1024	1390	2.09e-12	PROSPERO
low complexity region	1572	1586	N/A	INTRINSIC
low complexity region	2004	2017	N/A	INTRINSIC
low complexity region	2760	2773	N/A	INTRINSIC
low complexity region	2950	2968	N/A	INTRINSIC
low complexity region	3013	3030	N/A	INTRINSIC
Pfam:ALMS_motif	3125	3247	1.8e-42	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000160534

SMART Domains

Protein: ENSMUSP00000123947
Gene: ENSMUSG00000089694

Domain	Start	End	E-Value	Type
transmembrane domain	37	56	N/A	INTRINSIC
Pfam:Acetyltransf_10	71	193	1.8e-10	PFAM
Pfam:Acetyltransf_4	75	204	2e-9	PFAM
Pfam:Acetyltransf_7	105	195	5.9e-11	PFAM
Pfam:Acetyltransf_1	112	194	1.2e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000179613

SMART Domains

Protein: ENSMUSP00000136338
Gene: ENSMUSG00000089694

Domain	Start	End	E-Value	Type
transmembrane domain	37	56	N/A	INTRINSIC
Pfam:Acetyltransf_10	71	193	2.2e-10	PFAM
Pfam:Acetyltransf_4	75	202	1.8e-8	PFAM
Pfam:Acetyltransf_7	105	195	5.7e-10	PFAM
Pfam:Acetyltransf_1	112	194	1.2e-13	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000213058
AA Change: T3709A

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)

Meta Mutation Damage Score

0.0856

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.4%

Validation Efficiency

100% (65/65)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing a large tandem-repeat domain as well as additional low complexity regions. The encoded protein functions in microtubule organization, particularly in the formation and maintanance of cilia. Mutations in this gene cause Alstrom syndrome. There is a pseudogene for this gene located adjacent in the same region of chromosome 2. Alternative splice variants have been described but their full length nature has not been determined. [provided by RefSeq, Apr 2014]
PHENOTYPE: Homozygous null mice display obesity starting after puberty, hypogonadism, hyperinsulinemia, male-specific hyperglycemia, retinal dysfunction, and late-onset hearing loss. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	C	11: 9,248,235 (GRCm39)	F2661L	probably benign	Het
Acadsb	A	G	7: 131,031,836 (GRCm39)	D224G	probably benign	Het
Acsm1	A	G	7: 119,239,920 (GRCm39)	H288R	probably damaging	Het
Adamts2	A	G	11: 50,667,457 (GRCm39)	D465G	probably damaging	Het
Akap9	A	T	5: 4,022,851 (GRCm39)		probably benign	Het
Ap3d1	A	G	10: 80,555,075 (GRCm39)	W417R	probably damaging	Het
Arfgef1	C	A	1: 10,250,212 (GRCm39)		probably benign	Het
Atf6	A	G	1: 170,614,913 (GRCm39)		probably null	Het
Cacna1s	T	A	1: 136,016,746 (GRCm39)		probably benign	Het
Clcn1	T	C	6: 42,287,515 (GRCm39)	F740L	probably benign	Het
Clec12a	T	A	6: 129,341,016 (GRCm39)	D265E	probably benign	Het
Clic3	T	A	2: 25,347,797 (GRCm39)		probably benign	Het
Cntnap3	T	G	13: 64,909,859 (GRCm39)	T749P	probably benign	Het
Col11a2	T	A	17: 34,261,186 (GRCm39)	D45E	probably null	Het
Cplane1	T	A	15: 8,211,727 (GRCm39)	S356T	probably damaging	Het
Crxos	T	A	7: 15,632,460 (GRCm39)	S89T	probably benign	Het
Cxcr1	G	T	1: 74,231,468 (GRCm39)	P185T	possibly damaging	Het
Cyp20a1	T	A	1: 60,410,486 (GRCm39)	N262K	possibly damaging	Het
Dennd2b	T	A	7: 109,156,411 (GRCm39)	Q113L	probably benign	Het
Dpy19l2	T	C	9: 24,607,324 (GRCm39)	R46G	probably benign	Het
Dpysl2	A	T	14: 67,045,411 (GRCm39)	L454Q	probably damaging	Het
Dvl3	C	T	16: 20,346,173 (GRCm39)		probably benign	Het
Eppin	T	A	2: 164,431,332 (GRCm39)	E98V	possibly damaging	Het
Fancm	A	T	12: 65,152,835 (GRCm39)	H1097L	probably benign	Het
Fkbp4	A	G	6: 128,412,705 (GRCm39)	I75T	probably damaging	Het
Fmn2	A	G	1: 174,409,525 (GRCm39)	H586R	unknown	Het
Gm973	C	T	1: 59,597,393 (GRCm39)		probably benign	Het
Haus6	A	C	4: 86,521,083 (GRCm39)	V185G	possibly damaging	Het
Herc2	T	A	7: 55,772,114 (GRCm39)	C1098S	possibly damaging	Het
Hic1	C	A	11: 75,057,136 (GRCm39)	L584F	possibly damaging	Het
Itgb1bp1	C	A	12: 21,326,896 (GRCm39)		probably benign	Het
Kbtbd2	G	A	6: 56,757,374 (GRCm39)	R121*	probably null	Het
Lgr4	C	T	2: 109,837,626 (GRCm39)		probably benign	Het
Lrrc55	T	C	2: 85,022,264 (GRCm39)	E309G	probably damaging	Het
Mertk	T	C	2: 128,635,027 (GRCm39)		probably null	Het
Micu3	A	G	8: 40,819,294 (GRCm39)		probably benign	Het
Mmp11	G	A	10: 75,762,592 (GRCm39)	A287V	probably benign	Het
Mpzl2	A	G	9: 44,954,039 (GRCm39)	Y47C	probably damaging	Het
Muc5b	A	C	7: 141,415,752 (GRCm39)	R2899S	probably benign	Het
Myo1b	A	G	1: 51,794,857 (GRCm39)	Y1078H	probably benign	Het
Naip1	A	T	13: 100,559,727 (GRCm39)	D1092E	probably benign	Het
Ncapd3	T	G	9: 26,969,179 (GRCm39)	V611G	probably damaging	Het
Ntpcr	C	T	8: 126,464,093 (GRCm39)	R73*	probably null	Het
Or4c120	A	T	2: 89,000,704 (GRCm39)	V284E	probably benign	Het
Or5b119	G	A	19: 13,456,857 (GRCm39)	A235V	probably damaging	Het
Osbp2	A	G	11: 3,664,709 (GRCm39)	F88S	probably damaging	Het
Pkn3	A	T	2: 29,979,889 (GRCm39)	T711S	probably damaging	Het
Plekhm1	T	C	11: 103,285,602 (GRCm39)	K278E	probably benign	Het
Ppp1r36	A	G	12: 76,486,065 (GRCm39)	T408A	probably benign	Het
Prss41	T	C	17: 24,061,477 (GRCm39)	T105A	possibly damaging	Het
Psme1	G	T	14: 55,817,378 (GRCm39)		probably benign	Het
Ptprq	A	T	10: 107,444,036 (GRCm39)	Y1523N	probably damaging	Het
Ric8b	A	G	10: 84,828,086 (GRCm39)	D470G	probably damaging	Het
Scarb1	A	G	5: 125,375,795 (GRCm39)		probably benign	Het
Slc25a54	G	A	3: 109,010,112 (GRCm39)	A204T	probably damaging	Het
Spink10	T	C	18: 62,793,036 (GRCm39)	C67R	probably damaging	Het
Tmtc1	A	T	6: 148,314,138 (GRCm39)		probably null	Het
Tprkb	A	G	6: 85,901,446 (GRCm39)	D28G	probably benign	Het
Ttll13	A	G	7: 79,910,098 (GRCm39)	H747R	probably benign	Het
Usp24	A	G	4: 106,259,302 (GRCm39)	S1608G	probably benign	Het
Utp20	A	T	10: 88,596,774 (GRCm39)	F2115L	probably damaging	Het
Vmn1r200	A	T	13: 22,579,361 (GRCm39)	I46L	probably benign	Het
Zdhhc8	A	T	16: 18,046,254 (GRCm39)	M103K	probably damaging	Het
Zfp595	C	T	13: 67,465,369 (GRCm39)	G298E	probably damaging	Het
Zfp738	T	G	13: 67,818,140 (GRCm39)	H617P	possibly damaging	Het
Zfp9	A	T	6: 118,442,163 (GRCm39)	H166Q	probably damaging	Het
Zp3r	C	A	1: 130,546,071 (GRCm39)	D80Y	probably damaging	Het

Other mutations in Alms1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00227:Alms1	APN	6	85,654,946 (GRCm39)	missense	probably damaging	1.00
IGL00331:Alms1	APN	6	85,618,353 (GRCm39)	missense	possibly damaging	0.94
IGL00658:Alms1	APN	6	85,605,943 (GRCm39)	missense	probably damaging	1.00
IGL00835:Alms1	APN	6	85,599,116 (GRCm39)	missense	probably damaging	1.00
IGL00930:Alms1	APN	6	85,578,292 (GRCm39)	missense	probably damaging	0.98
IGL01446:Alms1	APN	6	85,673,683 (GRCm39)	missense	probably damaging	1.00
IGL01448:Alms1	APN	6	85,654,881 (GRCm39)	missense	possibly damaging	0.93
IGL01563:Alms1	APN	6	85,604,965 (GRCm39)	missense	probably damaging	1.00
IGL01632:Alms1	APN	6	85,604,928 (GRCm39)	missense	probably benign	0.07
IGL01651:Alms1	APN	6	85,633,458 (GRCm39)	missense	probably benign	0.05
IGL01670:Alms1	APN	6	85,655,132 (GRCm39)	missense	probably benign	0.00
IGL01716:Alms1	APN	6	85,605,076 (GRCm39)	missense	probably benign	0.01
IGL01719:Alms1	APN	6	85,605,076 (GRCm39)	missense	probably benign	0.01
IGL01720:Alms1	APN	6	85,605,076 (GRCm39)	missense	probably benign	0.01
IGL01723:Alms1	APN	6	85,605,076 (GRCm39)	missense	probably benign	0.01
IGL01877:Alms1	APN	6	85,599,393 (GRCm39)	missense	possibly damaging	0.55
IGL01919:Alms1	APN	6	85,604,986 (GRCm39)	missense	possibly damaging	0.77
IGL01976:Alms1	APN	6	85,599,647 (GRCm39)	missense	possibly damaging	0.73
IGL02003:Alms1	APN	6	85,599,205 (GRCm39)	missense	possibly damaging	0.54
IGL02069:Alms1	APN	6	85,605,805 (GRCm39)	missense	probably benign	0.12
IGL02070:Alms1	APN	6	85,628,385 (GRCm39)	missense	possibly damaging	0.74
IGL02079:Alms1	APN	6	85,605,616 (GRCm39)	missense	probably damaging	0.98
IGL02081:Alms1	APN	6	85,597,285 (GRCm39)	missense	possibly damaging	0.55
IGL02379:Alms1	APN	6	85,606,615 (GRCm39)	missense	probably damaging	0.98
IGL02412:Alms1	APN	6	85,605,854 (GRCm39)	missense	possibly damaging	0.91
IGL02606:Alms1	APN	6	85,576,949 (GRCm39)	missense	probably benign
IGL02636:Alms1	APN	6	85,605,636 (GRCm39)	missense	probably benign	0.28
IGL02702:Alms1	APN	6	85,576,831 (GRCm39)	missense	probably benign	0.12
IGL02815:Alms1	APN	6	85,644,939 (GRCm39)	critical splice donor site	probably null
IGL02926:Alms1	APN	6	85,618,432 (GRCm39)	missense	probably damaging	1.00
IGL02945:Alms1	APN	6	85,597,915 (GRCm39)	missense	probably damaging	0.96
IGL02959:Alms1	APN	6	85,606,034 (GRCm39)	nonsense	probably null
IGL03124:Alms1	APN	6	85,655,401 (GRCm39)	missense	probably benign	0.03
IGL03199:Alms1	APN	6	85,599,479 (GRCm39)	missense	possibly damaging	0.68
IGL03209:Alms1	APN	6	85,576,955 (GRCm39)	splice site	probably benign
IGL03247:Alms1	APN	6	85,655,579 (GRCm39)	missense	possibly damaging	0.85
ares	UTSW	6	85,598,257 (GRCm39)	nonsense	probably null
ares2	UTSW	6	85,654,972 (GRCm39)	nonsense	probably null
butterball	UTSW	6	85,673,753 (GRCm39)	missense	probably damaging	0.99
earthquake	UTSW	6	85,605,717 (GRCm39)	nonsense	probably null
fatty	UTSW	6	85,604,916 (GRCm39)	nonsense	probably null
gut_check	UTSW	6	85,597,351 (GRCm39)	nonsense	probably null
portly	UTSW	6	85,596,694 (GRCm39)	missense	probably benign	0.00
replete	UTSW	6	85,606,190 (GRCm39)	missense	possibly damaging	0.87
PIT4468001:Alms1	UTSW	6	85,601,701 (GRCm39)	critical splice donor site	probably null
R0003:Alms1	UTSW	6	85,606,192 (GRCm39)	missense	possibly damaging	0.90
R0095:Alms1	UTSW	6	85,597,235 (GRCm39)	missense	possibly damaging	0.90
R0110:Alms1	UTSW	6	85,597,351 (GRCm39)	nonsense	probably null
R0114:Alms1	UTSW	6	85,596,785 (GRCm39)	missense	probably benign	0.00
R0153:Alms1	UTSW	6	85,618,363 (GRCm39)	missense	possibly damaging	0.94
R0217:Alms1	UTSW	6	85,599,912 (GRCm39)	missense	probably damaging	0.99
R0328:Alms1	UTSW	6	85,587,796 (GRCm39)	splice site	probably null
R0410:Alms1	UTSW	6	85,564,785 (GRCm39)	missense	unknown
R0469:Alms1	UTSW	6	85,597,351 (GRCm39)	nonsense	probably null
R0510:Alms1	UTSW	6	85,597,351 (GRCm39)	nonsense	probably null
R0522:Alms1	UTSW	6	85,598,597 (GRCm39)	missense	probably benign
R0525:Alms1	UTSW	6	85,564,742 (GRCm39)	missense	unknown
R0611:Alms1	UTSW	6	85,655,653 (GRCm39)	missense	possibly damaging	0.61
R0637:Alms1	UTSW	6	85,600,015 (GRCm39)	missense	possibly damaging	0.85
R0718:Alms1	UTSW	6	85,598,803 (GRCm39)	missense	probably benign	0.00
R0831:Alms1	UTSW	6	85,605,502 (GRCm39)	missense	probably benign	0.00
R1318:Alms1	UTSW	6	85,605,531 (GRCm39)	missense	possibly damaging	0.62
R1340:Alms1	UTSW	6	85,644,939 (GRCm39)	critical splice donor site	probably null
R1561:Alms1	UTSW	6	85,606,034 (GRCm39)	nonsense	probably null
R1648:Alms1	UTSW	6	85,655,384 (GRCm39)	missense	probably damaging	0.99
R1697:Alms1	UTSW	6	85,599,436 (GRCm39)	missense	possibly damaging	0.94
R1699:Alms1	UTSW	6	85,599,862 (GRCm39)	missense	possibly damaging	0.46
R1715:Alms1	UTSW	6	85,606,034 (GRCm39)	nonsense	probably null
R1723:Alms1	UTSW	6	85,605,735 (GRCm39)	missense	probably damaging	1.00
R1734:Alms1	UTSW	6	85,618,532 (GRCm39)	critical splice donor site	probably null
R1758:Alms1	UTSW	6	85,605,487 (GRCm39)	missense	probably damaging	0.99
R1804:Alms1	UTSW	6	85,598,257 (GRCm39)	nonsense	probably null
R1835:Alms1	UTSW	6	85,655,485 (GRCm39)	missense	possibly damaging	0.94
R1836:Alms1	UTSW	6	85,655,485 (GRCm39)	missense	possibly damaging	0.94
R2077:Alms1	UTSW	6	85,599,291 (GRCm39)	missense	possibly damaging	0.93
R2246:Alms1	UTSW	6	85,599,949 (GRCm39)	missense	possibly damaging	0.91
R2254:Alms1	UTSW	6	85,596,830 (GRCm39)	missense	probably damaging	1.00
R2280:Alms1	UTSW	6	85,654,955 (GRCm39)	missense	probably damaging	0.99
R2516:Alms1	UTSW	6	85,644,945 (GRCm39)	splice site	probably benign
R2519:Alms1	UTSW	6	85,644,945 (GRCm39)	splice site	probably benign
R2566:Alms1	UTSW	6	85,599,464 (GRCm39)	missense	possibly damaging	0.84
R2850:Alms1	UTSW	6	85,644,945 (GRCm39)	splice site	probably benign
R2850:Alms1	UTSW	6	85,598,281 (GRCm39)	missense	probably benign	0.00
R2932:Alms1	UTSW	6	85,597,544 (GRCm39)	missense	possibly damaging	0.89
R2944:Alms1	UTSW	6	85,605,373 (GRCm39)	missense	probably damaging	1.00
R2980:Alms1	UTSW	6	85,605,817 (GRCm39)	missense	probably damaging	1.00
R3084:Alms1	UTSW	6	85,655,122 (GRCm39)	missense	probably benign
R3086:Alms1	UTSW	6	85,655,122 (GRCm39)	missense	probably benign
R3122:Alms1	UTSW	6	85,644,945 (GRCm39)	splice site	probably benign
R3404:Alms1	UTSW	6	85,644,945 (GRCm39)	splice site	probably benign
R3405:Alms1	UTSW	6	85,644,945 (GRCm39)	splice site	probably benign
R3804:Alms1	UTSW	6	85,596,629 (GRCm39)	missense	probably damaging	1.00
R3904:Alms1	UTSW	6	85,598,660 (GRCm39)	missense	probably benign	0.00
R4014:Alms1	UTSW	6	85,655,334 (GRCm39)	missense	probably benign	0.41
R4056:Alms1	UTSW	6	85,564,785 (GRCm39)	missense	unknown
R4067:Alms1	UTSW	6	85,598,271 (GRCm39)	missense	probably damaging	1.00
R4110:Alms1	UTSW	6	85,597,870 (GRCm39)	missense	probably benign	0.00
R4111:Alms1	UTSW	6	85,597,870 (GRCm39)	missense	probably benign	0.00
R4112:Alms1	UTSW	6	85,597,870 (GRCm39)	missense	probably benign	0.00
R4194:Alms1	UTSW	6	85,654,972 (GRCm39)	nonsense	probably null
R4464:Alms1	UTSW	6	85,597,003 (GRCm39)	missense	possibly damaging	0.66
R4539:Alms1	UTSW	6	85,597,460 (GRCm39)	missense	possibly damaging	0.78
R4554:Alms1	UTSW	6	85,601,599 (GRCm39)	missense	probably benign
R4696:Alms1	UTSW	6	85,597,504 (GRCm39)	missense	probably damaging	1.00
R4825:Alms1	UTSW	6	85,655,227 (GRCm39)	missense	probably damaging	0.99
R4921:Alms1	UTSW	6	85,605,528 (GRCm39)	missense	probably benign	0.13
R5030:Alms1	UTSW	6	85,604,946 (GRCm39)	missense	probably damaging	0.98
R5051:Alms1	UTSW	6	85,604,916 (GRCm39)	nonsense	probably null
R5085:Alms1	UTSW	6	85,597,714 (GRCm39)	missense	possibly damaging	0.55
R5141:Alms1	UTSW	6	85,598,414 (GRCm39)	missense	probably benign	0.01
R5233:Alms1	UTSW	6	85,633,353 (GRCm39)	splice site	probably null
R5310:Alms1	UTSW	6	85,592,350 (GRCm39)	missense	possibly damaging	0.79
R5344:Alms1	UTSW	6	85,673,771 (GRCm39)	missense	probably benign	0.04
R5394:Alms1	UTSW	6	85,600,070 (GRCm39)	missense	probably benign	0.01
R5460:Alms1	UTSW	6	85,673,713 (GRCm39)	missense	probably benign	0.08
R5558:Alms1	UTSW	6	85,618,311 (GRCm39)	nonsense	probably null
R5650:Alms1	UTSW	6	85,597,253 (GRCm39)	missense	probably damaging	1.00
R5667:Alms1	UTSW	6	85,673,753 (GRCm39)	missense	probably damaging	0.99
R5671:Alms1	UTSW	6	85,606,190 (GRCm39)	missense	possibly damaging	0.87
R5688:Alms1	UTSW	6	85,576,877 (GRCm39)	missense	possibly damaging	0.92
R5815:Alms1	UTSW	6	85,599,820 (GRCm39)	missense	probably damaging	0.99
R5892:Alms1	UTSW	6	85,597,885 (GRCm39)	missense	probably damaging	0.99
R5947:Alms1	UTSW	6	85,596,694 (GRCm39)	missense	probably benign	0.00
R6031:Alms1	UTSW	6	85,599,937 (GRCm39)	missense	probably damaging	1.00
R6031:Alms1	UTSW	6	85,599,937 (GRCm39)	missense	probably damaging	1.00
R6144:Alms1	UTSW	6	85,600,056 (GRCm39)	missense	probably damaging	0.98
R6258:Alms1	UTSW	6	85,605,717 (GRCm39)	nonsense	probably null
R6260:Alms1	UTSW	6	85,605,717 (GRCm39)	nonsense	probably null
R6455:Alms1	UTSW	6	85,673,639 (GRCm39)	missense	probably damaging	0.99
R6569:Alms1	UTSW	6	85,618,321 (GRCm39)	missense	probably benign	0.07
R6637:Alms1	UTSW	6	85,596,716 (GRCm39)	missense	possibly damaging	0.78
R6866:Alms1	UTSW	6	85,598,080 (GRCm39)	missense	possibly damaging	0.85
R6918:Alms1	UTSW	6	85,599,643 (GRCm39)	missense	possibly damaging	0.87
R7121:Alms1	UTSW	6	85,601,604 (GRCm39)	missense	probably damaging	1.00
R7179:Alms1	UTSW	6	85,598,351 (GRCm39)	missense	probably benign	0.09
R7334:Alms1	UTSW	6	85,618,432 (GRCm39)	missense	probably damaging	0.99
R7376:Alms1	UTSW	6	85,599,088 (GRCm39)	missense	probably benign	0.10
R7394:Alms1	UTSW	6	85,599,205 (GRCm39)	missense	possibly damaging	0.54
R7413:Alms1	UTSW	6	85,605,288 (GRCm39)	missense	probably benign	0.03
R7511:Alms1	UTSW	6	85,586,407 (GRCm39)	missense	unknown
R7542:Alms1	UTSW	6	85,606,344 (GRCm39)	missense	possibly damaging	0.62
R7562:Alms1	UTSW	6	85,597,394 (GRCm39)	missense	probably damaging	1.00
R7575:Alms1	UTSW	6	85,599,141 (GRCm39)	missense	possibly damaging	0.49
R7577:Alms1	UTSW	6	85,592,302 (GRCm39)	missense	probably benign	0.09
R7618:Alms1	UTSW	6	85,655,399 (GRCm39)	missense	probably benign	0.07
R7653:Alms1	UTSW	6	85,597,577 (GRCm39)	missense	possibly damaging	0.47
R7672:Alms1	UTSW	6	85,592,333 (GRCm39)	missense	probably damaging	1.00
R7807:Alms1	UTSW	6	85,599,958 (GRCm39)	missense	possibly damaging	0.91
R7815:Alms1	UTSW	6	85,592,340 (GRCm39)	missense	probably benign	0.42
R7849:Alms1	UTSW	6	85,598,479 (GRCm39)	missense	possibly damaging	0.48
R7944:Alms1	UTSW	6	85,618,362 (GRCm39)	missense	probably benign	0.03
R7954:Alms1	UTSW	6	85,598,144 (GRCm39)	missense	probably damaging	0.98
R7971:Alms1	UTSW	6	85,605,661 (GRCm39)	missense	probably benign
R8048:Alms1	UTSW	6	85,618,316 (GRCm39)	missense	probably benign	0.13
R8223:Alms1	UTSW	6	85,620,222 (GRCm39)	nonsense	probably null
R8332:Alms1	UTSW	6	85,597,561 (GRCm39)	missense	probably benign	0.05
R8374:Alms1	UTSW	6	85,585,973 (GRCm39)	missense	probably benign	0.41
R8470:Alms1	UTSW	6	85,618,357 (GRCm39)	missense	probably damaging	0.99
R8755:Alms1	UTSW	6	85,598,556 (GRCm39)	missense	probably benign	0.01
R8979:Alms1	UTSW	6	85,598,009 (GRCm39)	missense	probably damaging	0.98
R9044:Alms1	UTSW	6	85,673,735 (GRCm39)	missense	probably damaging	0.98
R9057:Alms1	UTSW	6	85,586,814 (GRCm39)	missense	unknown
R9224:Alms1	UTSW	6	85,598,770 (GRCm39)	missense	possibly damaging	0.69
R9259:Alms1	UTSW	6	85,644,873 (GRCm39)	missense	possibly damaging	0.94
R9401:Alms1	UTSW	6	85,655,001 (GRCm39)	nonsense	probably null
R9459:Alms1	UTSW	6	85,604,946 (GRCm39)	missense	probably damaging	0.98
R9633:Alms1	UTSW	6	85,600,125 (GRCm39)	missense	probably damaging	0.99
R9716:Alms1	UTSW	6	85,578,234 (GRCm39)	missense	possibly damaging	0.84
R9730:Alms1	UTSW	6	85,606,420 (GRCm39)	missense	probably benign	0.00
R9790:Alms1	UTSW	6	85,596,425 (GRCm39)	missense	probably benign	0.04
R9791:Alms1	UTSW	6	85,596,425 (GRCm39)	missense	probably benign	0.04
R9802:Alms1	UTSW	6	85,606,220 (GRCm39)	missense	possibly damaging	0.61
X0013:Alms1	UTSW	6	85,633,437 (GRCm39)	missense	probably damaging	1.00
X0025:Alms1	UTSW	6	85,597,192 (GRCm39)	missense	probably damaging	0.96
Z1176:Alms1	UTSW	6	85,655,400 (GRCm39)	missense	probably benign	0.41

Predicted Primers

PCR Primer
(F):5'- TGTGCTGGGATGCAGTCAGAAC -3'
(R):5'- ACCTGCTCCTCTCCAGATAGGAAAG -3'

Sequencing Primer
(F):5'- GAACTCTAGATCATCTGCTATGGAGG -3'
(R):5'- AGGATTCCTAGGCTCTGAAGA -3'

Posted On

2013-05-23