Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03297:Ifitm6'

416125

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifitm6

Ensembl Gene

ENSMUSG00000059108

Gene Name

interferon induced transmembrane protein 6

Synonyms

fragilis5

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03297

Quality Score

Status

Chromosome

Chromosomal Location

140595725-140596805 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 140595948 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 115 (Y115C)

Ref Sequence

ENSEMBL: ENSMUSP00000147821 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081924] [ENSMUST00000209328] [ENSMUST00000211330]

AlphaFold

A0A1B0GS75

Predicted Effect

probably damaging
Transcript: ENSMUST00000081924
AA Change: Y95C

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000080594
Gene: ENSMUSG00000059108
AA Change: Y95C

Domain	Start	End	E-Value	Type
Pfam:CD225	10	91	2.3e-31	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000209328
AA Change: Y95C

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)

Predicted Effect

probably damaging
Transcript: ENSMUST00000211330
AA Change: Y115C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl1	G	A	4: 86,341,663 (GRCm39)	G1624S	probably damaging	Het
Adhfe1	A	G	1: 9,620,173 (GRCm39)		probably benign	Het
Ano6	C	A	15: 95,860,158 (GRCm39)	T760N	probably damaging	Het
Camsap2	T	C	1: 136,225,539 (GRCm39)	M196V	probably benign	Het
Cd209d	T	C	8: 3,928,476 (GRCm39)	D3G	possibly damaging	Het
Cdh5	T	A	8: 104,854,831 (GRCm39)	F253Y	probably damaging	Het
Cnot10	T	C	9: 114,427,784 (GRCm39)	E610G	possibly damaging	Het
Cnot4	T	C	6: 35,001,158 (GRCm39)	N579S	probably benign	Het
Csmd1	G	T	8: 16,059,432 (GRCm39)	S2101*	probably null	Het
Dgkq	C	A	5: 108,798,140 (GRCm39)	R706L	probably damaging	Het
Gm5422	T	C	10: 31,125,727 (GRCm39)		noncoding transcript	Het
Gpr34	A	G	X: 13,505,681 (GRCm39)	Y70C	probably damaging	Het
Herc6	T	A	6: 57,639,374 (GRCm39)	L914Q	probably benign	Het
Iqcg	G	T	16: 32,856,002 (GRCm39)		probably benign	Het
Myo15a	A	G	11: 60,369,967 (GRCm39)	D909G	probably damaging	Het
Nefl	A	G	14: 68,321,673 (GRCm39)	T88A	possibly damaging	Het
Nfatc2	T	A	2: 168,378,138 (GRCm39)	N509I	probably damaging	Het
Nkd1	T	C	8: 89,300,902 (GRCm39)		probably benign	Het
Npas2	T	C	1: 39,331,771 (GRCm39)	V62A	possibly damaging	Het
Oas2	T	G	5: 120,873,150 (GRCm39)	D635A	possibly damaging	Het
Obscn	C	T	11: 58,951,712 (GRCm39)	V4014M	possibly damaging	Het
Ogfr	C	A	2: 180,236,200 (GRCm39)	H262N	possibly damaging	Het
Or10aa1	T	G	1: 173,869,683 (GRCm39)	S56A	probably benign	Het
Or8b49	A	T	9: 38,505,821 (GRCm39)	L101F	probably benign	Het
Pa2g4	T	C	10: 128,399,105 (GRCm39)	D104G	probably damaging	Het
Parp11	T	C	6: 127,467,045 (GRCm39)		probably benign	Het
Ppp2r5a	C	T	1: 191,086,959 (GRCm39)	V360I	probably benign	Het
Ptpn13	A	T	5: 103,688,943 (GRCm39)	K912I	probably benign	Het
Sec16a	A	G	2: 26,329,202 (GRCm39)	S938P	probably benign	Het
Slc15a1	A	C	14: 121,724,096 (GRCm39)	I170S	probably damaging	Het
Smchd1	T	C	17: 71,656,695 (GRCm39)	N1924S	probably benign	Het
Sprr4	G	A	3: 92,407,731 (GRCm39)	P24S	unknown	Het
Trim30b	A	T	7: 104,015,102 (GRCm39)	N95K	probably benign	Het
Tyw1	C	T	5: 130,369,575 (GRCm39)	A687V	probably damaging	Het
Vmn2r14	T	A	5: 109,363,973 (GRCm39)	I648F	probably damaging	Het
Vmn2r78	T	A	7: 86,569,969 (GRCm39)	C162*	probably null	Het

Other mutations in Ifitm6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01469:Ifitm6	APN	7	140,596,725 (GRCm39)	missense	probably damaging	0.98
PIT4802001:Ifitm6	UTSW	7	140,596,648 (GRCm39)	missense	probably damaging	1.00
R0076:Ifitm6	UTSW	7	140,595,920 (GRCm39)	missense	possibly damaging	0.53
R4007:Ifitm6	UTSW	7	140,596,627 (GRCm39)	missense	possibly damaging	0.86
R4418:Ifitm6	UTSW	7	140,595,984 (GRCm39)	missense	probably damaging	0.96
R5558:Ifitm6	UTSW	7	140,595,985 (GRCm39)	missense	probably benign	0.02
R6778:Ifitm6	UTSW	7	140,596,056 (GRCm39)	missense	possibly damaging	0.93
R8742:Ifitm6	UTSW	7	140,596,008 (GRCm39)	missense	probably benign	0.04
R8995:Ifitm6	UTSW	7	140,596,617 (GRCm39)	missense	probably damaging	0.98

Posted On

2016-08-02