Incidental Mutation 'IGL03251:Ppp2cb'
ID 414936
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ppp2cb
Ensembl Gene ENSMUSG00000009630
Gene Name protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Synonyms PP2Ac, D8Ertd766e
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03251
Quality Score
Status
Chromosome 8
Chromosomal Location 34089653-34109469 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 34100679 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000009774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009774]
AlphaFold P62715
Predicted Effect probably benign
Transcript: ENSMUST00000009774
SMART Domains Protein: ENSMUSP00000009774
Gene: ENSMUSG00000009630

DomainStartEndE-ValueType
PP2Ac 23 293 2.48e-156 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 T C 7: 45,631,661 (GRCm39) probably benign Het
Cdkl2 A G 5: 92,181,585 (GRCm39) I132T probably damaging Het
Ckap4 A T 10: 84,364,469 (GRCm39) I198N probably damaging Het
Col6a3 C T 1: 90,737,898 (GRCm39) R600H probably damaging Het
Dnah7a A G 1: 53,686,433 (GRCm39) I239T probably benign Het
Ei24 A G 9: 36,691,405 (GRCm39) *359R probably null Het
Elk3 A T 10: 93,090,683 (GRCm39) probably null Het
Eps8l2 T A 7: 140,922,875 (GRCm39) M46K probably damaging Het
Frem2 G T 3: 53,479,729 (GRCm39) T1988N probably benign Het
Gm5431 T C 11: 48,785,548 (GRCm39) K276E probably benign Het
Gm8220 T A 14: 44,525,729 (GRCm39) C133S possibly damaging Het
Hectd2 T C 19: 36,562,926 (GRCm39) L168P probably damaging Het
Hydin A T 8: 111,217,228 (GRCm39) D1372V probably damaging Het
Isl1 T C 13: 116,441,985 (GRCm39) S83G probably benign Het
Lrp1b A G 2: 40,490,279 (GRCm39) I107T probably benign Het
Mlc1 A T 15: 88,858,934 (GRCm39) V117D possibly damaging Het
Ndc1 A G 4: 107,237,856 (GRCm39) E220G possibly damaging Het
Nlrp4b T A 7: 10,448,427 (GRCm39) M210K probably benign Het
Or2z8 A T 8: 72,811,920 (GRCm39) Y132F probably damaging Het
Plch1 T C 3: 63,691,423 (GRCm39) E60G possibly damaging Het
Pld1 G A 3: 28,142,814 (GRCm39) R674H probably benign Het
Ppp1r13l G A 7: 19,102,794 (GRCm39) probably benign Het
Rchy1 G T 5: 92,110,502 (GRCm39) A26D probably benign Het
Rrm1 T C 7: 102,106,413 (GRCm39) F311L probably damaging Het
Scrn1 G A 6: 54,525,322 (GRCm39) R16* probably null Het
Slc24a4 T C 12: 102,189,084 (GRCm39) L173P probably damaging Het
Srgap1 T C 10: 121,640,826 (GRCm39) probably null Het
Tube1 T A 10: 39,010,977 (GRCm39) probably benign Het
Utp20 C T 10: 88,653,188 (GRCm39) probably null Het
Vmn2r55 T C 7: 12,405,120 (GRCm39) probably benign Het
Other mutations in Ppp2cb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01566:Ppp2cb APN 8 34,101,791 (GRCm39) missense probably benign 0.38
IGL02985:Ppp2cb APN 8 34,105,474 (GRCm39) unclassified probably benign
Breakthrough UTSW 8 34,105,502 (GRCm39) missense probably damaging 1.00
R0940:Ppp2cb UTSW 8 34,105,689 (GRCm39) splice site probably null
R1688:Ppp2cb UTSW 8 34,105,480 (GRCm39) missense probably benign 0.02
R2187:Ppp2cb UTSW 8 34,100,705 (GRCm39) missense possibly damaging 0.95
R2350:Ppp2cb UTSW 8 34,101,855 (GRCm39) missense probably null 1.00
R4418:Ppp2cb UTSW 8 34,107,077 (GRCm39) missense probably benign
R4566:Ppp2cb UTSW 8 34,100,723 (GRCm39) missense possibly damaging 0.67
R6187:Ppp2cb UTSW 8 34,105,502 (GRCm39) missense probably damaging 1.00
R6990:Ppp2cb UTSW 8 34,109,161 (GRCm39) missense probably benign 0.01
R7477:Ppp2cb UTSW 8 34,105,502 (GRCm39) missense probably benign 0.01
R9018:Ppp2cb UTSW 8 34,105,787 (GRCm39) missense probably benign 0.17
R9301:Ppp2cb UTSW 8 34,090,038 (GRCm39) missense possibly damaging 0.68
Posted On 2016-08-02