Incidental Mutation 'R5206:Dop1b'
ID 402052
Institutional Source Beutler Lab
Gene Symbol Dop1b
Ensembl Gene ENSMUSG00000022946
Gene Name DOP1 leucine zipper like protein B
Synonyms Dopey2, 0610038M01Rik, 2610510B01Rik
MMRRC Submission 042781-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5206 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 93508795-93607476 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 93598472 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 1879 (L1879P)
Ref Sequence ENSEMBL: ENSMUSP00000154771 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045004] [ENSMUST00000227156] [ENSMUST00000228261]
AlphaFold Q3UHQ6
Predicted Effect probably damaging
Transcript: ENSMUST00000045004
AA Change: L1996P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000044437
Gene: ENSMUSG00000022946
AA Change: L1996P

DomainStartEndE-ValueType
Pfam:Dopey_N 11 308 3.9e-104 PFAM
low complexity region 651 666 N/A INTRINSIC
low complexity region 709 719 N/A INTRINSIC
low complexity region 747 759 N/A INTRINSIC
low complexity region 1186 1199 N/A INTRINSIC
low complexity region 1436 1451 N/A INTRINSIC
low complexity region 1893 1908 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000226215
AA Change: L1206P
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226535
Predicted Effect probably damaging
Transcript: ENSMUST00000227156
AA Change: L1879P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227278
Predicted Effect probably benign
Transcript: ENSMUST00000228261
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232210
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231882
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,772,272 (GRCm39) E487G probably benign Het
2610021A01Rik A T 7: 41,276,009 (GRCm39) K571* probably null Het
A2m T C 6: 121,651,766 (GRCm39) V1278A probably damaging Het
Abcc2 T C 19: 43,806,589 (GRCm39) V801A probably damaging Het
Acod1 T A 14: 103,292,731 (GRCm39) D418E possibly damaging Het
Bsn G A 9: 107,982,572 (GRCm39) A3727V unknown Het
Cmah T G 13: 24,648,267 (GRCm39) F501V probably damaging Het
Csf2rb2 T A 15: 78,176,952 (GRCm39) I173L probably benign Het
Dnah12 T C 14: 26,491,942 (GRCm39) W1126R probably damaging Het
Dock5 G T 14: 68,000,633 (GRCm39) A1690E probably benign Het
Eif3j2 A T 18: 43,610,647 (GRCm39) D55E probably benign Het
Fam83f G A 15: 80,576,255 (GRCm39) G302D possibly damaging Het
Fus G A 7: 127,568,969 (GRCm39) G40D unknown Het
Glrp1 GTGCTGCTGCTGCTGCTGCTGCTGCTG GTGCTGCTGCTGCTGCTGCTGCTG 1: 88,430,997 (GRCm39) probably benign Het
Gxylt2 T C 6: 100,781,576 (GRCm39) V417A probably damaging Het
Hhipl1 G A 12: 108,278,437 (GRCm39) R255H probably damaging Het
Ints8 A T 4: 11,216,477 (GRCm39) I838N possibly damaging Het
Lama5 C A 2: 179,833,097 (GRCm39) C1579F probably damaging Het
Med13 C T 11: 86,210,705 (GRCm39) R479H probably damaging Het
Or51ag1 A T 7: 103,155,309 (GRCm39) Y281* probably null Het
Or5b113 G T 19: 13,342,429 (GRCm39) G146C possibly damaging Het
Or5k15 G T 16: 58,710,381 (GRCm39) N67K probably damaging Het
Or6e1 T A 14: 54,520,155 (GRCm39) M66L probably benign Het
Or9g3 T A 2: 85,589,967 (GRCm39) Y251F probably benign Het
Pak6 A G 2: 118,523,784 (GRCm39) E313G probably benign Het
Pigs T A 11: 78,224,549 (GRCm39) Y145N probably damaging Het
Pla2g2f T A 4: 138,479,662 (GRCm39) D165V probably benign Het
Plbd1 C T 6: 136,618,154 (GRCm39) V133M probably benign Het
Ppp1r14bl C T 1: 23,141,183 (GRCm39) G44R probably benign Het
Ryr3 T C 2: 112,675,056 (GRCm39) Y1352C probably damaging Het
Scamp1 C T 13: 94,368,615 (GRCm39) R51H probably damaging Het
Skic3 G A 13: 76,295,886 (GRCm39) E1050K possibly damaging Het
Slc2a2 G A 3: 28,762,756 (GRCm39) V100M probably damaging Het
Slc38a10 C G 11: 119,995,888 (GRCm39) A1062P probably damaging Het
Snai1 T C 2: 167,380,888 (GRCm39) I127T probably benign Het
Stat4 G A 1: 52,144,395 (GRCm39) G692D probably damaging Het
Stc1 A T 14: 69,269,048 (GRCm39) D72V probably damaging Het
Tmc1 T C 19: 20,804,024 (GRCm39) N351S probably damaging Het
Trim28 A G 7: 12,759,275 (GRCm39) I130V probably benign Het
Trim39 A G 17: 36,571,382 (GRCm39) Y459H probably damaging Het
Ugt1a6b C A 1: 88,035,170 (GRCm39) Y169* probably null Het
Vasp T C 7: 18,992,780 (GRCm39) probably benign Het
Vmn2r99 G T 17: 19,598,868 (GRCm39) G184V probably benign Het
Xrcc1 C T 7: 24,266,988 (GRCm39) T358I probably damaging Het
Zfp219 A G 14: 52,247,022 (GRCm39) V35A probably benign Het
Other mutations in Dop1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00476:Dop1b APN 16 93,596,914 (GRCm39) unclassified probably benign
IGL00492:Dop1b APN 16 93,577,670 (GRCm39) missense probably benign 0.00
IGL00753:Dop1b APN 16 93,566,512 (GRCm39) missense probably benign
IGL00832:Dop1b APN 16 93,560,289 (GRCm39) missense probably benign 0.01
IGL00939:Dop1b APN 16 93,570,971 (GRCm39) missense possibly damaging 0.83
IGL01019:Dop1b APN 16 93,607,117 (GRCm39) missense probably benign 0.32
IGL01288:Dop1b APN 16 93,536,181 (GRCm39) missense possibly damaging 0.78
IGL01505:Dop1b APN 16 93,554,004 (GRCm39) missense possibly damaging 0.87
IGL01535:Dop1b APN 16 93,566,846 (GRCm39) nonsense probably null
IGL01696:Dop1b APN 16 93,567,128 (GRCm39) missense probably benign 0.00
IGL02077:Dop1b APN 16 93,577,648 (GRCm39) missense probably damaging 0.96
IGL02163:Dop1b APN 16 93,559,315 (GRCm39) missense possibly damaging 0.48
IGL02234:Dop1b APN 16 93,549,039 (GRCm39) missense probably benign
IGL02302:Dop1b APN 16 93,607,005 (GRCm39) missense probably benign 0.08
IGL02485:Dop1b APN 16 93,567,710 (GRCm39) missense probably damaging 1.00
IGL02563:Dop1b APN 16 93,574,293 (GRCm39) missense probably damaging 0.99
IGL02733:Dop1b APN 16 93,536,079 (GRCm39) missense possibly damaging 0.80
IGL02792:Dop1b APN 16 93,598,460 (GRCm39) missense possibly damaging 0.75
IGL02941:Dop1b APN 16 93,552,361 (GRCm39) missense probably benign 0.09
IGL03143:Dop1b APN 16 93,556,543 (GRCm39) missense probably benign
PIT4519001:Dop1b UTSW 16 93,558,942 (GRCm39) missense probably benign
R0320:Dop1b UTSW 16 93,607,035 (GRCm39) missense probably benign 0.02
R0499:Dop1b UTSW 16 93,567,325 (GRCm39) missense probably benign 0.00
R0501:Dop1b UTSW 16 93,549,750 (GRCm39) missense probably benign 0.00
R0534:Dop1b UTSW 16 93,559,393 (GRCm39) missense probably benign 0.04
R0583:Dop1b UTSW 16 93,552,374 (GRCm39) missense probably benign 0.30
R0626:Dop1b UTSW 16 93,560,844 (GRCm39) missense probably damaging 1.00
R0724:Dop1b UTSW 16 93,559,213 (GRCm39) missense probably benign 0.01
R0907:Dop1b UTSW 16 93,598,481 (GRCm39) missense probably damaging 1.00
R1263:Dop1b UTSW 16 93,574,274 (GRCm39) missense probably benign
R1378:Dop1b UTSW 16 93,567,280 (GRCm39) missense probably benign
R1572:Dop1b UTSW 16 93,567,041 (GRCm39) missense probably damaging 1.00
R1604:Dop1b UTSW 16 93,559,458 (GRCm39) missense probably benign
R1642:Dop1b UTSW 16 93,559,203 (GRCm39) missense probably benign 0.00
R1668:Dop1b UTSW 16 93,562,404 (GRCm39) missense probably damaging 1.00
R1669:Dop1b UTSW 16 93,566,548 (GRCm39) missense probably damaging 1.00
R1702:Dop1b UTSW 16 93,544,509 (GRCm39) missense possibly damaging 0.47
R1711:Dop1b UTSW 16 93,596,814 (GRCm39) missense probably damaging 1.00
R1917:Dop1b UTSW 16 93,513,150 (GRCm39) missense probably damaging 1.00
R1968:Dop1b UTSW 16 93,579,307 (GRCm39) missense probably damaging 1.00
R1988:Dop1b UTSW 16 93,563,061 (GRCm39) missense probably damaging 1.00
R2029:Dop1b UTSW 16 93,566,323 (GRCm39) missense probably benign 0.36
R2139:Dop1b UTSW 16 93,567,895 (GRCm39) missense possibly damaging 0.78
R2355:Dop1b UTSW 16 93,567,565 (GRCm39) missense probably damaging 1.00
R3609:Dop1b UTSW 16 93,536,220 (GRCm39) missense probably damaging 1.00
R3792:Dop1b UTSW 16 93,568,734 (GRCm39) missense possibly damaging 0.54
R4364:Dop1b UTSW 16 93,567,812 (GRCm39) missense probably benign 0.00
R4380:Dop1b UTSW 16 93,513,120 (GRCm39) missense possibly damaging 0.53
R4455:Dop1b UTSW 16 93,563,103 (GRCm39) missense probably damaging 1.00
R4779:Dop1b UTSW 16 93,553,969 (GRCm39) missense probably damaging 1.00
R4820:Dop1b UTSW 16 93,589,978 (GRCm39) missense probably benign 0.00
R4834:Dop1b UTSW 16 93,536,892 (GRCm39) start codon destroyed probably null 0.70
R4866:Dop1b UTSW 16 93,560,318 (GRCm39) critical splice donor site probably null
R4882:Dop1b UTSW 16 93,549,802 (GRCm39) missense possibly damaging 0.95
R4900:Dop1b UTSW 16 93,560,318 (GRCm39) critical splice donor site probably null
R5153:Dop1b UTSW 16 93,570,891 (GRCm39) missense probably damaging 0.98
R5176:Dop1b UTSW 16 93,536,931 (GRCm39) missense probably damaging 1.00
R5320:Dop1b UTSW 16 93,536,874 (GRCm39) missense probably damaging 1.00
R5361:Dop1b UTSW 16 93,567,392 (GRCm39) missense probably damaging 1.00
R5380:Dop1b UTSW 16 93,560,298 (GRCm39) missense probably damaging 0.96
R5476:Dop1b UTSW 16 93,570,801 (GRCm39) splice site probably null
R5502:Dop1b UTSW 16 93,590,114 (GRCm39) missense probably benign 0.00
R5543:Dop1b UTSW 16 93,595,808 (GRCm39) missense probably damaging 0.98
R5557:Dop1b UTSW 16 93,560,819 (GRCm39) missense probably damaging 0.96
R5901:Dop1b UTSW 16 93,566,639 (GRCm39) missense possibly damaging 0.88
R5907:Dop1b UTSW 16 93,598,469 (GRCm39) missense probably damaging 1.00
R6174:Dop1b UTSW 16 93,563,110 (GRCm39) missense probably damaging 1.00
R6256:Dop1b UTSW 16 93,604,102 (GRCm39) missense possibly damaging 0.94
R6383:Dop1b UTSW 16 93,579,136 (GRCm39) missense possibly damaging 0.76
R6525:Dop1b UTSW 16 93,606,304 (GRCm39) missense probably damaging 1.00
R6554:Dop1b UTSW 16 93,557,346 (GRCm39) missense probably benign 0.22
R6823:Dop1b UTSW 16 93,552,373 (GRCm39) missense possibly damaging 0.75
R7036:Dop1b UTSW 16 93,574,378 (GRCm39) missense probably benign 0.01
R7058:Dop1b UTSW 16 93,573,878 (GRCm39) missense probably benign 0.00
R7061:Dop1b UTSW 16 93,558,951 (GRCm39) missense probably benign 0.00
R7209:Dop1b UTSW 16 93,566,733 (GRCm39) missense probably benign
R7214:Dop1b UTSW 16 93,607,023 (GRCm39) missense possibly damaging 0.69
R7232:Dop1b UTSW 16 93,557,373 (GRCm39) critical splice donor site probably null
R7255:Dop1b UTSW 16 93,567,034 (GRCm39) missense probably damaging 1.00
R7335:Dop1b UTSW 16 93,544,396 (GRCm39) missense probably benign 0.04
R7535:Dop1b UTSW 16 93,603,249 (GRCm39) missense probably damaging 1.00
R7700:Dop1b UTSW 16 93,595,649 (GRCm39) splice site probably null
R7763:Dop1b UTSW 16 93,552,402 (GRCm39) missense probably benign 0.00
R7814:Dop1b UTSW 16 93,596,859 (GRCm39) missense probably damaging 1.00
R7839:Dop1b UTSW 16 93,560,829 (GRCm39) missense probably damaging 1.00
R7862:Dop1b UTSW 16 93,546,851 (GRCm39) missense probably damaging 1.00
R7894:Dop1b UTSW 16 93,607,092 (GRCm39) missense probably benign 0.01
R7952:Dop1b UTSW 16 93,546,848 (GRCm39) missense possibly damaging 0.93
R7956:Dop1b UTSW 16 93,567,916 (GRCm39) critical splice donor site probably null
R8033:Dop1b UTSW 16 93,566,371 (GRCm39) missense probably benign
R8061:Dop1b UTSW 16 93,546,884 (GRCm39) missense probably damaging 1.00
R8067:Dop1b UTSW 16 93,562,336 (GRCm39) nonsense probably null
R8146:Dop1b UTSW 16 93,546,827 (GRCm39) missense possibly damaging 0.95
R8184:Dop1b UTSW 16 93,573,881 (GRCm39) missense probably benign 0.13
R8221:Dop1b UTSW 16 93,546,847 (GRCm39) missense probably benign 0.01
R8263:Dop1b UTSW 16 93,559,083 (GRCm39) missense possibly damaging 0.87
R8329:Dop1b UTSW 16 93,568,675 (GRCm39) missense probably damaging 1.00
R8555:Dop1b UTSW 16 93,568,698 (GRCm39) missense probably damaging 1.00
R8683:Dop1b UTSW 16 93,570,809 (GRCm39) missense probably benign
R8683:Dop1b UTSW 16 93,568,699 (GRCm39) missense probably damaging 0.98
R8716:Dop1b UTSW 16 93,577,673 (GRCm39) nonsense probably null
R8807:Dop1b UTSW 16 93,558,973 (GRCm39) missense probably benign 0.03
R8840:Dop1b UTSW 16 93,607,005 (GRCm39) missense probably benign 0.08
R8851:Dop1b UTSW 16 93,559,398 (GRCm39) missense probably benign 0.39
R8884:Dop1b UTSW 16 93,556,550 (GRCm39) missense probably benign
R8976:Dop1b UTSW 16 93,558,969 (GRCm39) missense probably benign 0.01
R9219:Dop1b UTSW 16 93,567,184 (GRCm39) missense probably damaging 1.00
R9238:Dop1b UTSW 16 93,546,018 (GRCm39) missense probably benign 0.14
R9284:Dop1b UTSW 16 93,557,196 (GRCm39) missense probably damaging 1.00
R9289:Dop1b UTSW 16 93,568,681 (GRCm39) missense probably damaging 1.00
R9298:Dop1b UTSW 16 93,597,087 (GRCm39) missense probably damaging 0.96
R9338:Dop1b UTSW 16 93,600,448 (GRCm39) missense probably damaging 1.00
R9346:Dop1b UTSW 16 93,577,702 (GRCm39) critical splice donor site probably null
R9444:Dop1b UTSW 16 93,607,127 (GRCm39) missense probably benign 0.00
R9500:Dop1b UTSW 16 93,607,171 (GRCm39) missense probably benign
R9601:Dop1b UTSW 16 93,544,531 (GRCm39) missense possibly damaging 0.87
R9793:Dop1b UTSW 16 93,598,503 (GRCm39) missense probably benign 0.30
Z1088:Dop1b UTSW 16 93,560,214 (GRCm39) missense probably benign 0.00
Z1176:Dop1b UTSW 16 93,604,756 (GRCm39) missense possibly damaging 0.82
Z1176:Dop1b UTSW 16 93,600,434 (GRCm39) missense probably damaging 1.00
Z1176:Dop1b UTSW 16 93,566,469 (GRCm39) missense probably benign 0.00
Z1177:Dop1b UTSW 16 93,560,783 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCTGACAAATTCTGGAGAGC -3'
(R):5'- ACTCAGCACCTCAGAAGTCTG -3'

Sequencing Primer
(F):5'- TGTCATCCTCCATTGAGAGACAGG -3'
(R):5'- AAGTCTGACATGGCGGGCTG -3'
Posted On 2016-07-22