Incidental Mutation 'R5264:Socs5'
ID 401623
Institutional Source Beutler Lab
Gene Symbol Socs5
Ensembl Gene ENSMUSG00000037104
Gene Name suppressor of cytokine signaling 5
Synonyms SOCS-5, Cish5, 1810018L08Rik
MMRRC Submission 042832-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5264 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 87415107-87445267 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87441769 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 236 (H236Q)
Ref Sequence ENSEMBL: ENSMUSP00000038591 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041369]
AlphaFold O54928
Predicted Effect probably damaging
Transcript: ENSMUST00000041369
AA Change: H236Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000038591
Gene: ENSMUSG00000037104
AA Change: H236Q

DomainStartEndE-ValueType
Pfam:SOCS 145 197 8.4e-20 PFAM
low complexity region 258 270 N/A INTRINSIC
SH2 379 465 4.59e-18 SMART
SOCS 475 518 1.65e-19 SMART
SOCS_box 481 517 3.74e-10 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.8%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are viable and fertile with normal immune system morphology and function. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ckap2l A T 2: 129,127,299 (GRCm39) M293K probably benign Het
Col4a4 C T 1: 82,471,312 (GRCm39) G681E unknown Het
Dnai7 A G 6: 145,127,502 (GRCm39) V469A probably benign Het
Efcab7 G A 4: 99,735,372 (GRCm39) R132H probably benign Het
Elovl4 T C 9: 83,662,817 (GRCm39) T239A probably benign Het
Fank1 A G 7: 133,481,621 (GRCm39) D240G probably damaging Het
Fbln5 T A 12: 101,723,703 (GRCm39) M346L possibly damaging Het
Fbxl21 T C 13: 56,680,136 (GRCm39) F174L probably benign Het
Gns A G 10: 121,216,090 (GRCm39) D279G probably benign Het
Hmcn1 A G 1: 150,555,265 (GRCm39) V2502A probably benign Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Large2 A G 2: 92,205,088 (GRCm39) probably benign Het
Lrrc8b A T 5: 105,628,118 (GRCm39) I155F probably damaging Het
Morc2b T C 17: 33,357,353 (GRCm39) I140V probably benign Het
Mrgprb5 G A 7: 47,817,796 (GRCm39) S313L probably benign Het
Nectin4 A T 1: 171,211,273 (GRCm39) T266S probably benign Het
Nsd1 C T 13: 55,395,159 (GRCm39) A1023V possibly damaging Het
Or51a39 T C 7: 102,363,558 (GRCm39) T21A probably benign Het
Paqr8 A G 1: 21,005,332 (GRCm39) H162R possibly damaging Het
Pclo G A 5: 14,726,937 (GRCm39) probably benign Het
Phactr4 T C 4: 132,098,293 (GRCm39) D325G probably damaging Het
Plcg2 A T 8: 118,361,532 (GRCm39) E1255V possibly damaging Het
Polr3a T C 14: 24,505,009 (GRCm39) I1084V possibly damaging Het
Polr3b A T 10: 84,503,280 (GRCm39) Q399L probably benign Het
Ppp1r35 G A 5: 137,778,286 (GRCm39) probably benign Het
Psd3 A T 8: 68,166,377 (GRCm39) D919E probably benign Het
Ptgs2 A G 1: 149,978,481 (GRCm39) T198A possibly damaging Het
Ptpn14 T C 1: 189,564,997 (GRCm39) probably null Het
Ptprk A G 10: 28,461,582 (GRCm39) Y39C probably damaging Het
R3hdm4 A G 10: 79,749,175 (GRCm39) Y75H probably benign Het
Rsph4a A G 10: 33,785,379 (GRCm39) Y430C probably damaging Het
Samd12 C T 15: 53,723,669 (GRCm39) C8Y probably damaging Het
Sema3e A C 5: 14,276,662 (GRCm39) L314F probably damaging Het
Sis A G 3: 72,857,089 (GRCm39) F401L probably damaging Het
Smoc1 T A 12: 81,151,474 (GRCm39) S64T probably damaging Het
Spaca1 C A 4: 34,049,863 (GRCm39) R45L possibly damaging Het
Spag6 A G 2: 18,750,324 (GRCm39) K457E probably benign Het
Stat2 T A 10: 128,116,934 (GRCm39) probably null Het
Tcp11l2 A G 10: 84,449,524 (GRCm39) I496M probably damaging Het
Ttll4 A G 1: 74,725,535 (GRCm39) I648V possibly damaging Het
Vmn2r67 T C 7: 84,801,453 (GRCm39) Y161C probably damaging Het
Wnt5b A T 6: 119,410,813 (GRCm39) V171E probably damaging Het
Zfp236 T C 18: 82,648,219 (GRCm39) K933E probably damaging Het
Zfp236 T C 18: 82,676,198 (GRCm39) E373G probably damaging Het
Zfp617 A G 8: 72,686,885 (GRCm39) Y405C probably damaging Het
Zranb1 CTGATGATGATG CTGATGATGATGATG 7: 132,584,556 (GRCm39) probably benign Het
Other mutations in Socs5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02426:Socs5 APN 17 87,442,320 (GRCm39) missense probably damaging 1.00
IGL02553:Socs5 APN 17 87,442,419 (GRCm39) missense probably damaging 1.00
PIT1430001:Socs5 UTSW 17 87,441,044 (GRCm39) splice site probably benign
R0909:Socs5 UTSW 17 87,441,201 (GRCm39) missense probably benign 0.11
R1595:Socs5 UTSW 17 87,441,623 (GRCm39) missense probably damaging 1.00
R2397:Socs5 UTSW 17 87,442,377 (GRCm39) missense probably damaging 1.00
R3160:Socs5 UTSW 17 87,442,146 (GRCm39) missense probably damaging 1.00
R3162:Socs5 UTSW 17 87,442,146 (GRCm39) missense probably damaging 1.00
R5483:Socs5 UTSW 17 87,442,402 (GRCm39) missense probably damaging 1.00
R6604:Socs5 UTSW 17 87,442,553 (GRCm39) missense probably damaging 1.00
R7790:Socs5 UTSW 17 87,441,791 (GRCm39) missense probably benign 0.03
R8205:Socs5 UTSW 17 87,441,138 (GRCm39) missense probably benign 0.01
R9411:Socs5 UTSW 17 87,442,521 (GRCm39) missense possibly damaging 0.63
R9428:Socs5 UTSW 17 87,441,067 (GRCm39) missense probably benign
R9456:Socs5 UTSW 17 87,442,266 (GRCm39) missense probably damaging 1.00
X0011:Socs5 UTSW 17 87,442,368 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATGGACAGCGTTTCTAGCC -3'
(R):5'- ACAATGGGTTGACCTGTGC -3'

Sequencing Primer
(F):5'- TTTCTAGCCGCGCGGTC -3'
(R):5'- TGACCTGTGCAGTAGCTTCAAAG -3'
Posted On 2016-07-06