Incidental Mutation 'R0408:Vmn2r86'
| ID |
40116 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r86
|
| Ensembl Gene |
ENSMUSG00000092162 |
| Gene Name |
vomeronasal 2, receptor 86 |
| Synonyms |
EG625109 |
| MMRRC Submission |
038610-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.068)
|
| Stock # |
R0408 (G1)
|
| Quality Score |
183 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130282068-130291763 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 130282723 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 631
(F631S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126596
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170257]
|
| AlphaFold |
G5E8Y4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170257
AA Change: F631S
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000126596
Gene: ENSMUSG00000092162
AA Change: F631S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
425 |
1.1e-25 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
2.4e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
6.4e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb1b |
T |
A |
5: 8,903,446 (GRCm39) |
N1032K |
probably damaging |
Het |
| Abcc8 |
A |
G |
7: 45,756,457 (GRCm39) |
I1416T |
probably damaging |
Het |
| Aco2 |
T |
C |
15: 81,797,319 (GRCm39) |
|
probably null |
Het |
| Akap13 |
C |
T |
7: 75,396,544 (GRCm39) |
L2514F |
probably damaging |
Het |
| Aldh1a3 |
A |
G |
7: 66,055,798 (GRCm39) |
V331A |
probably damaging |
Het |
| Arid3a |
T |
A |
10: 79,786,667 (GRCm39) |
D473E |
probably benign |
Het |
| Atg9a |
A |
G |
1: 75,161,939 (GRCm39) |
S536P |
probably damaging |
Het |
| Atxn7 |
A |
T |
14: 14,100,317 (GRCm38) |
S668C |
probably damaging |
Het |
| Bcar3 |
A |
T |
3: 122,302,033 (GRCm39) |
I243F |
probably damaging |
Het |
| Bend6 |
G |
A |
1: 33,901,834 (GRCm39) |
P183S |
probably damaging |
Het |
| Bfsp2 |
A |
T |
9: 103,357,299 (GRCm39) |
S43T |
probably benign |
Het |
| Camk4 |
G |
A |
18: 33,262,845 (GRCm39) |
D136N |
probably damaging |
Het |
| Ceacam3 |
G |
T |
7: 16,885,808 (GRCm39) |
|
probably benign |
Het |
| Chrm3 |
T |
C |
13: 9,927,969 (GRCm39) |
I356V |
probably benign |
Het |
| Clec9a |
T |
A |
6: 129,396,532 (GRCm39) |
I133N |
possibly damaging |
Het |
| Ctnnd2 |
T |
C |
15: 30,634,823 (GRCm39) |
L157P |
probably damaging |
Het |
| Ddhd2 |
T |
C |
8: 26,229,614 (GRCm39) |
|
probably null |
Het |
| Def8 |
T |
C |
8: 124,186,656 (GRCm39) |
V436A |
probably damaging |
Het |
| Dipk1c |
T |
A |
18: 84,738,488 (GRCm39) |
|
probably null |
Het |
| Dock10 |
T |
C |
1: 80,518,193 (GRCm39) |
K1293R |
probably benign |
Het |
| Dync1h1 |
T |
G |
12: 110,598,126 (GRCm39) |
D1772E |
probably benign |
Het |
| Ephx4 |
G |
T |
5: 107,561,387 (GRCm39) |
G72C |
probably damaging |
Het |
| Fam136a |
T |
G |
6: 86,343,707 (GRCm39) |
V68G |
possibly damaging |
Het |
| Fcgrt |
T |
C |
7: 44,751,363 (GRCm39) |
E195G |
probably damaging |
Het |
| Fut9 |
T |
A |
4: 25,620,319 (GRCm39) |
Q165L |
possibly damaging |
Het |
| Glb1l |
T |
C |
1: 75,185,479 (GRCm39) |
Y77C |
probably damaging |
Het |
| Gpr26 |
T |
C |
7: 131,569,249 (GRCm39) |
V198A |
possibly damaging |
Het |
| Gpr26 |
C |
A |
7: 131,576,001 (GRCm39) |
|
probably null |
Het |
| Gsdma3 |
A |
C |
11: 98,526,164 (GRCm39) |
E296A |
probably benign |
Het |
| Hyou1 |
G |
T |
9: 44,295,989 (GRCm39) |
G385W |
probably damaging |
Het |
| Il17rb |
T |
C |
14: 29,718,637 (GRCm39) |
S482G |
probably benign |
Het |
| Itgb4 |
A |
T |
11: 115,898,428 (GRCm39) |
R1715W |
probably damaging |
Het |
| Jak2 |
A |
G |
19: 29,263,717 (GRCm39) |
S411G |
probably benign |
Het |
| Kdm3a |
C |
T |
6: 71,588,663 (GRCm39) |
D449N |
probably benign |
Het |
| Kifbp |
T |
C |
10: 62,401,832 (GRCm39) |
I23M |
probably benign |
Het |
| Klhl26 |
T |
C |
8: 70,905,130 (GRCm39) |
D226G |
probably damaging |
Het |
| Klra1 |
T |
A |
6: 130,354,737 (GRCm39) |
I94F |
probably benign |
Het |
| Lama3 |
A |
G |
18: 12,589,894 (GRCm39) |
D808G |
probably benign |
Het |
| Lrp1b |
C |
T |
2: 40,567,603 (GRCm39) |
M272I |
probably damaging |
Het |
| Masp2 |
A |
G |
4: 148,690,496 (GRCm39) |
D251G |
probably benign |
Het |
| Mob3b |
T |
C |
4: 35,083,991 (GRCm39) |
D66G |
probably damaging |
Het |
| Myo7a |
T |
C |
7: 97,705,988 (GRCm39) |
Q1863R |
probably damaging |
Het |
| Naa12 |
T |
C |
18: 80,255,029 (GRCm39) |
S108P |
probably damaging |
Het |
| Or10al3 |
G |
A |
17: 38,012,190 (GRCm39) |
V210I |
probably benign |
Het |
| Or4c103 |
A |
T |
2: 88,513,999 (GRCm39) |
F26I |
probably benign |
Het |
| Pdgfd |
T |
A |
9: 6,293,928 (GRCm39) |
Y167* |
probably null |
Het |
| Pfas |
A |
G |
11: 68,891,931 (GRCm39) |
|
probably null |
Het |
| Plin1 |
T |
A |
7: 79,372,394 (GRCm39) |
T393S |
probably damaging |
Het |
| Prdm15 |
A |
T |
16: 97,636,986 (GRCm39) |
N110K |
possibly damaging |
Het |
| Prune2 |
T |
A |
19: 17,099,674 (GRCm39) |
V1726D |
probably benign |
Het |
| Sestd1 |
T |
A |
2: 77,022,137 (GRCm39) |
D518V |
probably damaging |
Het |
| Setd2 |
C |
T |
9: 110,423,310 (GRCm39) |
P344S |
probably damaging |
Het |
| Slc22a1 |
A |
T |
17: 12,875,828 (GRCm39) |
I462N |
probably damaging |
Het |
| Slc6a1 |
G |
A |
6: 114,279,761 (GRCm39) |
V142I |
probably benign |
Het |
| Tbc1d14 |
G |
T |
5: 36,728,643 (GRCm39) |
T241K |
possibly damaging |
Het |
| Uaca |
T |
C |
9: 60,779,141 (GRCm39) |
L1176P |
possibly damaging |
Het |
| Ube2g1 |
G |
C |
11: 72,563,791 (GRCm39) |
G52A |
probably damaging |
Het |
| Utrn |
A |
G |
10: 12,259,934 (GRCm39) |
*957R |
probably null |
Het |
| Vmn2r125 |
A |
T |
4: 156,703,153 (GRCm39) |
E177V |
probably damaging |
Het |
| Zc3h13 |
T |
A |
14: 75,529,626 (GRCm39) |
C42* |
probably null |
Het |
| Zc3h14 |
T |
G |
12: 98,730,082 (GRCm39) |
V13G |
probably damaging |
Het |
| Zfat |
A |
T |
15: 68,052,141 (GRCm39) |
V551D |
probably benign |
Het |
| Zfp618 |
C |
T |
4: 63,004,809 (GRCm39) |
R70W |
probably damaging |
Het |
|
| Other mutations in Vmn2r86 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01295:Vmn2r86
|
APN |
10 |
130,288,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01328:Vmn2r86
|
APN |
10 |
130,288,365 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL01377:Vmn2r86
|
APN |
10 |
130,288,855 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01548:Vmn2r86
|
APN |
10 |
130,282,151 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01804:Vmn2r86
|
APN |
10 |
130,288,858 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01921:Vmn2r86
|
APN |
10 |
130,291,610 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02406:Vmn2r86
|
APN |
10 |
130,284,508 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02625:Vmn2r86
|
APN |
10 |
130,288,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02960:Vmn2r86
|
APN |
10 |
130,289,636 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL03104:Vmn2r86
|
APN |
10 |
130,282,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0437:Vmn2r86
|
UTSW |
10 |
130,282,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0577:Vmn2r86
|
UTSW |
10 |
130,288,444 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0726:Vmn2r86
|
UTSW |
10 |
130,282,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0811:Vmn2r86
|
UTSW |
10 |
130,289,497 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0812:Vmn2r86
|
UTSW |
10 |
130,289,497 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1055:Vmn2r86
|
UTSW |
10 |
130,282,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1066:Vmn2r86
|
UTSW |
10 |
130,282,145 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1199:Vmn2r86
|
UTSW |
10 |
130,284,443 (GRCm39) |
splice site |
probably benign |
|
|
R1332:Vmn2r86
|
UTSW |
10 |
130,282,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Vmn2r86
|
UTSW |
10 |
130,289,010 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1866:Vmn2r86
|
UTSW |
10 |
130,282,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1897:Vmn2r86
|
UTSW |
10 |
130,288,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Vmn2r86
|
UTSW |
10 |
130,282,582 (GRCm39) |
missense |
probably benign |
0.39 |
|
R3162:Vmn2r86
|
UTSW |
10 |
130,291,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3162:Vmn2r86
|
UTSW |
10 |
130,291,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3858:Vmn2r86
|
UTSW |
10 |
130,291,594 (GRCm39) |
missense |
probably benign |
|
|
R4049:Vmn2r86
|
UTSW |
10 |
130,282,966 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4378:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4411:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4413:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4422:Vmn2r86
|
UTSW |
10 |
130,288,845 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4738:Vmn2r86
|
UTSW |
10 |
130,282,939 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4767:Vmn2r86
|
UTSW |
10 |
130,291,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4872:Vmn2r86
|
UTSW |
10 |
130,289,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4880:Vmn2r86
|
UTSW |
10 |
130,289,484 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5092:Vmn2r86
|
UTSW |
10 |
130,282,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5421:Vmn2r86
|
UTSW |
10 |
130,282,805 (GRCm39) |
missense |
probably benign |
0.41 |
|
R6007:Vmn2r86
|
UTSW |
10 |
130,289,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6330:Vmn2r86
|
UTSW |
10 |
130,282,396 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6355:Vmn2r86
|
UTSW |
10 |
130,291,763 (GRCm39) |
start codon destroyed |
probably damaging |
0.98 |
|
R6397:Vmn2r86
|
UTSW |
10 |
130,282,131 (GRCm39) |
nonsense |
probably null |
|
|
R6419:Vmn2r86
|
UTSW |
10 |
130,282,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6933:Vmn2r86
|
UTSW |
10 |
130,282,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6937:Vmn2r86
|
UTSW |
10 |
130,284,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6959:Vmn2r86
|
UTSW |
10 |
130,282,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7010:Vmn2r86
|
UTSW |
10 |
130,291,726 (GRCm39) |
missense |
probably benign |
|
|
R7549:Vmn2r86
|
UTSW |
10 |
130,282,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8179:Vmn2r86
|
UTSW |
10 |
130,288,953 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8257:Vmn2r86
|
UTSW |
10 |
130,288,279 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8286:Vmn2r86
|
UTSW |
10 |
130,285,855 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8479:Vmn2r86
|
UTSW |
10 |
130,282,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8805:Vmn2r86
|
UTSW |
10 |
130,282,396 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8960:Vmn2r86
|
UTSW |
10 |
130,289,672 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9021:Vmn2r86
|
UTSW |
10 |
130,282,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9120:Vmn2r86
|
UTSW |
10 |
130,289,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9137:Vmn2r86
|
UTSW |
10 |
130,282,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9311:Vmn2r86
|
UTSW |
10 |
130,288,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9312:Vmn2r86
|
UTSW |
10 |
130,288,406 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9433:Vmn2r86
|
UTSW |
10 |
130,282,567 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9696:Vmn2r86
|
UTSW |
10 |
130,285,702 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCCTAGCCAGGAAAGCCACAATG -3'
(R):5'- GCCAATTTAGAGCAAATGCACTGCC -3'
Sequencing Primer
(F):5'- AAGGACAGAGCCTTTGTTGC -3'
(R):5'- CCAAAGAGCTGTGTCATTTCTG -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation