Incidental Mutation 'R5157:Zfp672'
ID 396790
Institutional Source Beutler Lab
Gene Symbol Zfp672
Ensembl Gene ENSMUSG00000049755
Gene Name zinc finger protein 672
Synonyms 4930511N19Rik, 4930488P06Rik
MMRRC Submission 042739-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.143) question?
Stock # R5157 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 58205940-58221165 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 58207677 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 215 (S215P)
Ref Sequence ENSEMBL: ENSMUSP00000104457 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049353] [ENSMUST00000057836] [ENSMUST00000064786] [ENSMUST00000108829] [ENSMUST00000155662] [ENSMUST00000153510] [ENSMUST00000186859]
AlphaFold Q99LH4
Predicted Effect probably benign
Transcript: ENSMUST00000049353
SMART Domains Protein: ENSMUSP00000131896
Gene: ENSMUSG00000037243

DomainStartEndE-ValueType
low complexity region 10 23 N/A INTRINSIC
low complexity region 94 110 N/A INTRINSIC
low complexity region 159 175 N/A INTRINSIC
low complexity region 193 204 N/A INTRINSIC
low complexity region 215 232 N/A INTRINSIC
ZnF_C2H2 327 352 4.11e-2 SMART
ZnF_C2H2 358 382 2.05e-2 SMART
ZnF_C2H2 388 410 1.69e-3 SMART
ZnF_C2H2 416 438 1.69e-3 SMART
ZnF_C2H2 447 470 6.23e-2 SMART
low complexity region 502 520 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000057836
AA Change: S215P

PolyPhen 2 Score 0.856 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000060088
Gene: ENSMUSG00000049755
AA Change: S215P

DomainStartEndE-ValueType
ZnF_C2H2 15 37 4.17e-3 SMART
ZnF_C2H2 43 65 8.75e0 SMART
ZnF_C2H2 71 93 1.18e-2 SMART
ZnF_C2H2 100 123 1.76e-1 SMART
ZnF_C2H2 129 151 1.59e1 SMART
ZnF_C2H2 167 189 4.47e-3 SMART
ZnF_C2H2 202 224 9.58e-3 SMART
ZnF_C2H2 230 252 7.37e-4 SMART
ZnF_C2H2 258 280 3.16e-3 SMART
ZnF_C2H2 286 308 1.45e-2 SMART
ZnF_C2H2 314 336 4.01e-5 SMART
ZnF_C2H2 342 364 5.5e-3 SMART
ZnF_C2H2 370 392 1.12e-3 SMART
ZnF_C2H2 398 420 6.67e-2 SMART
low complexity region 421 441 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000064786
AA Change: S215P

PolyPhen 2 Score 0.856 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000070567
Gene: ENSMUSG00000049755
AA Change: S215P

DomainStartEndE-ValueType
ZnF_C2H2 15 37 4.17e-3 SMART
ZnF_C2H2 43 65 8.75e0 SMART
ZnF_C2H2 71 93 1.18e-2 SMART
ZnF_C2H2 100 123 1.76e-1 SMART
ZnF_C2H2 129 151 1.59e1 SMART
ZnF_C2H2 167 189 4.47e-3 SMART
ZnF_C2H2 202 224 9.58e-3 SMART
ZnF_C2H2 230 252 7.37e-4 SMART
ZnF_C2H2 258 280 3.16e-3 SMART
ZnF_C2H2 286 308 1.45e-2 SMART
ZnF_C2H2 314 336 4.01e-5 SMART
ZnF_C2H2 342 364 5.5e-3 SMART
ZnF_C2H2 370 392 1.12e-3 SMART
ZnF_C2H2 398 420 6.67e-2 SMART
low complexity region 421 441 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000108829
AA Change: S215P

PolyPhen 2 Score 0.856 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000104457
Gene: ENSMUSG00000049755
AA Change: S215P

DomainStartEndE-ValueType
ZnF_C2H2 15 37 4.17e-3 SMART
ZnF_C2H2 43 65 8.75e0 SMART
ZnF_C2H2 71 93 1.18e-2 SMART
ZnF_C2H2 100 123 1.76e-1 SMART
ZnF_C2H2 129 151 1.59e1 SMART
ZnF_C2H2 167 189 4.47e-3 SMART
ZnF_C2H2 202 224 9.58e-3 SMART
ZnF_C2H2 230 252 7.37e-4 SMART
ZnF_C2H2 258 280 3.16e-3 SMART
ZnF_C2H2 286 308 1.45e-2 SMART
ZnF_C2H2 314 336 4.01e-5 SMART
ZnF_C2H2 342 364 5.5e-3 SMART
ZnF_C2H2 370 392 1.12e-3 SMART
ZnF_C2H2 398 420 6.67e-2 SMART
low complexity region 421 441 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130217
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135097
Predicted Effect probably benign
Transcript: ENSMUST00000155662
SMART Domains Protein: ENSMUSP00000114561
Gene: ENSMUSG00000049755

DomainStartEndE-ValueType
ZnF_C2H2 15 37 4.17e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000153510
SMART Domains Protein: ENSMUSP00000126674
Gene: ENSMUSG00000037243

DomainStartEndE-ValueType
low complexity region 10 23 N/A INTRINSIC
low complexity region 94 110 N/A INTRINSIC
low complexity region 159 175 N/A INTRINSIC
low complexity region 193 204 N/A INTRINSIC
low complexity region 215 232 N/A INTRINSIC
ZnF_C2H2 327 352 4.11e-2 SMART
ZnF_C2H2 358 382 2.05e-2 SMART
ZnF_C2H2 388 410 1.69e-3 SMART
ZnF_C2H2 416 438 1.69e-3 SMART
ZnF_C2H2 447 470 6.23e-2 SMART
low complexity region 502 520 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000186859
SMART Domains Protein: ENSMUSP00000140236
Gene: ENSMUSG00000049755

DomainStartEndE-ValueType
ZnF_C2H2 15 37 1.8e-5 SMART
ZnF_C2H2 43 65 3.6e-2 SMART
ZnF_C2H2 71 90 6.1e-1 SMART
Meta Mutation Damage Score 0.4743 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency 100% (57/57)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 C T 17: 24,627,096 (GRCm39) R1266C probably damaging Het
Adap2 T C 11: 80,047,772 (GRCm39) F76S probably damaging Het
Adgb T A 10: 10,274,710 (GRCm39) H747L probably damaging Het
Aox1 T A 1: 58,109,222 (GRCm39) V670D probably damaging Het
Ap4e1 A G 2: 126,903,615 (GRCm39) D839G probably benign Het
Arhgef11 T A 3: 87,635,817 (GRCm39) probably null Het
AY074887 T C 9: 54,858,102 (GRCm39) probably benign Het
Bicd1 C G 6: 149,421,912 (GRCm39) Q878E probably benign Het
Catspere1 A T 1: 177,707,348 (GRCm39) noncoding transcript Het
Cnmd T C 14: 79,894,126 (GRCm39) Q87R probably benign Het
Col24a1 G T 3: 145,051,712 (GRCm39) G661* probably null Het
Crtap G A 9: 114,213,860 (GRCm39) L232F probably damaging Het
Ctsq T C 13: 61,184,913 (GRCm39) T258A probably benign Het
Cyp2d26 T C 15: 82,675,190 (GRCm39) Q388R probably benign Het
Ddb1 A T 19: 10,599,728 (GRCm39) T646S probably benign Het
Dnah6 G T 6: 73,172,617 (GRCm39) S280R probably benign Het
Dzank1 T C 2: 144,325,332 (GRCm39) H545R probably damaging Het
Ehhadh T A 16: 21,585,261 (GRCm39) M207L probably benign Het
Elmo2 T A 2: 165,133,627 (GRCm39) probably benign Het
Golga3 G A 5: 110,350,537 (GRCm39) A731T probably benign Het
Igsf21 T C 4: 139,755,378 (GRCm39) T426A possibly damaging Het
Kcnf1 T C 12: 17,224,742 (GRCm39) E493G probably benign Het
Lmna A T 3: 88,391,414 (GRCm39) D364E probably damaging Het
Lsr T C 7: 30,665,465 (GRCm39) Y163C probably damaging Het
Map3k20 A T 2: 72,268,558 (GRCm39) T522S probably benign Het
Mroh9 C A 1: 162,871,690 (GRCm39) A598S probably damaging Het
Msln T C 17: 25,971,957 (GRCm39) M87V probably benign Het
Or14c39 A G 7: 86,344,440 (GRCm39) K259E probably benign Het
Or1e26 T C 11: 73,480,549 (GRCm39) N5S probably damaging Het
Or4a27 T A 2: 88,559,892 (GRCm39) Q17L probably benign Het
Or5d16 T A 2: 87,773,232 (GRCm39) M247L probably benign Het
Pals1 T A 12: 78,867,589 (GRCm39) M324K possibly damaging Het
Plekhg5 T A 4: 152,192,322 (GRCm39) probably benign Het
Pprc1 G T 19: 46,053,197 (GRCm39) probably benign Het
Ptprm T A 17: 67,264,092 (GRCm39) K385I probably benign Het
Rfxap T A 3: 54,711,938 (GRCm39) N215I probably damaging Het
Slc16a7 A T 10: 125,069,333 (GRCm39) Y114* probably null Het
Smarcb1 G T 10: 75,747,628 (GRCm39) probably benign Het
Spef2 T A 15: 9,668,877 (GRCm39) R770* probably null Het
Stard9 A T 2: 120,528,342 (GRCm39) Y1533F probably benign Het
Tbcd A T 11: 121,500,853 (GRCm39) Y1142F probably benign Het
Trappc2b A T 11: 51,576,893 (GRCm39) S2T probably benign Het
Ttc23l G T 15: 10,551,636 (GRCm39) T30K possibly damaging Het
Uba7 G A 9: 107,857,246 (GRCm39) V703I probably benign Het
Upb1 T C 10: 75,248,638 (GRCm39) S53P possibly damaging Het
Zfp978 T A 4: 147,475,437 (GRCm39) L328H probably damaging Het
Other mutations in Zfp672
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01391:Zfp672 APN 11 58,208,192 (GRCm39) missense probably damaging 1.00
R0326:Zfp672 UTSW 11 58,207,173 (GRCm39) missense possibly damaging 0.86
R1485:Zfp672 UTSW 11 58,220,395 (GRCm39) intron probably benign
R1664:Zfp672 UTSW 11 58,208,138 (GRCm39) missense probably damaging 0.99
R1667:Zfp672 UTSW 11 58,206,921 (GRCm39) missense possibly damaging 0.53
R1853:Zfp672 UTSW 11 58,207,790 (GRCm39) missense probably benign
R2074:Zfp672 UTSW 11 58,207,462 (GRCm39) missense possibly damaging 0.71
R3817:Zfp672 UTSW 11 58,207,462 (GRCm39) missense possibly damaging 0.71
R4623:Zfp672 UTSW 11 58,207,281 (GRCm39) missense probably benign 0.34
R4745:Zfp672 UTSW 11 58,220,324 (GRCm39) intron probably benign
R5240:Zfp672 UTSW 11 58,220,527 (GRCm39) intron probably benign
R5510:Zfp672 UTSW 11 58,207,456 (GRCm39) nonsense probably null
R6207:Zfp672 UTSW 11 58,208,349 (GRCm39) start gained probably benign
R6279:Zfp672 UTSW 11 58,208,094 (GRCm39) missense probably damaging 0.99
R6300:Zfp672 UTSW 11 58,208,094 (GRCm39) missense probably damaging 0.99
R6432:Zfp672 UTSW 11 58,207,758 (GRCm39) missense possibly damaging 0.53
R6438:Zfp672 UTSW 11 58,207,563 (GRCm39) missense probably benign 0.07
R7777:Zfp672 UTSW 11 58,208,081 (GRCm39) missense possibly damaging 0.71
R8401:Zfp672 UTSW 11 58,207,628 (GRCm39) missense probably benign 0.28
R8489:Zfp672 UTSW 11 58,220,681 (GRCm39) intron probably benign
R8826:Zfp672 UTSW 11 58,220,590 (GRCm39) missense unknown
R8858:Zfp672 UTSW 11 58,208,145 (GRCm39) missense possibly damaging 0.91
R9298:Zfp672 UTSW 11 58,220,590 (GRCm39) missense unknown
RF012:Zfp672 UTSW 11 58,206,938 (GRCm39) missense probably benign
Z1186:Zfp672 UTSW 11 58,220,786 (GRCm39) intron probably benign
Z1186:Zfp672 UTSW 11 58,220,452 (GRCm39) missense unknown
Z1187:Zfp672 UTSW 11 58,220,452 (GRCm39) missense unknown
Z1188:Zfp672 UTSW 11 58,220,452 (GRCm39) missense unknown
Z1189:Zfp672 UTSW 11 58,220,452 (GRCm39) missense unknown
Z1190:Zfp672 UTSW 11 58,220,452 (GRCm39) missense unknown
Z1191:Zfp672 UTSW 11 58,220,786 (GRCm39) intron probably benign
Z1191:Zfp672 UTSW 11 58,220,452 (GRCm39) missense unknown
Z1192:Zfp672 UTSW 11 58,220,452 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AAAGCCCTTGCCACAAGTG -3'
(R):5'- GAGATCATCACTGTCACCGC -3'

Sequencing Primer
(F):5'- TTCACCCTGATGGCTGCG -3'
(R):5'- ATCACTGTCACCGCCCCTTC -3'
Posted On 2016-06-21