Incidental Mutation 'R5157:Or5d16'
ID 396761
Institutional Source Beutler Lab
Gene Symbol Or5d16
Ensembl Gene ENSMUSG00000075145
Gene Name olfactory receptor family 5 subfamily D member 16
Synonyms Olfr1155, GA_x6K02T2Q125-49426894-49425950, MOR174-10
MMRRC Submission 042739-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # R5157 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87773026-87773970 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87773232 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 247 (M247L)
Ref Sequence ENSEMBL: ENSMUSP00000149428 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099843] [ENSMUST00000214641] [ENSMUST00000215903] [ENSMUST00000216191] [ENSMUST00000216726]
AlphaFold Q8VFR3
Predicted Effect probably benign
Transcript: ENSMUST00000099843
AA Change: M247L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000097431
Gene: ENSMUSG00000075145
AA Change: M247L

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 2.7e-44 PFAM
Pfam:7tm_1 43 292 5.3e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214641
AA Change: M247L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000215903
AA Change: M247L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216191
Predicted Effect probably benign
Transcript: ENSMUST00000216726
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 C T 17: 24,627,096 (GRCm39) R1266C probably damaging Het
Adap2 T C 11: 80,047,772 (GRCm39) F76S probably damaging Het
Adgb T A 10: 10,274,710 (GRCm39) H747L probably damaging Het
Aox1 T A 1: 58,109,222 (GRCm39) V670D probably damaging Het
Ap4e1 A G 2: 126,903,615 (GRCm39) D839G probably benign Het
Arhgef11 T A 3: 87,635,817 (GRCm39) probably null Het
AY074887 T C 9: 54,858,102 (GRCm39) probably benign Het
Bicd1 C G 6: 149,421,912 (GRCm39) Q878E probably benign Het
Catspere1 A T 1: 177,707,348 (GRCm39) noncoding transcript Het
Cnmd T C 14: 79,894,126 (GRCm39) Q87R probably benign Het
Col24a1 G T 3: 145,051,712 (GRCm39) G661* probably null Het
Crtap G A 9: 114,213,860 (GRCm39) L232F probably damaging Het
Ctsq T C 13: 61,184,913 (GRCm39) T258A probably benign Het
Cyp2d26 T C 15: 82,675,190 (GRCm39) Q388R probably benign Het
Ddb1 A T 19: 10,599,728 (GRCm39) T646S probably benign Het
Dnah6 G T 6: 73,172,617 (GRCm39) S280R probably benign Het
Dzank1 T C 2: 144,325,332 (GRCm39) H545R probably damaging Het
Ehhadh T A 16: 21,585,261 (GRCm39) M207L probably benign Het
Elmo2 T A 2: 165,133,627 (GRCm39) probably benign Het
Golga3 G A 5: 110,350,537 (GRCm39) A731T probably benign Het
Igsf21 T C 4: 139,755,378 (GRCm39) T426A possibly damaging Het
Kcnf1 T C 12: 17,224,742 (GRCm39) E493G probably benign Het
Lmna A T 3: 88,391,414 (GRCm39) D364E probably damaging Het
Lsr T C 7: 30,665,465 (GRCm39) Y163C probably damaging Het
Map3k20 A T 2: 72,268,558 (GRCm39) T522S probably benign Het
Mroh9 C A 1: 162,871,690 (GRCm39) A598S probably damaging Het
Msln T C 17: 25,971,957 (GRCm39) M87V probably benign Het
Or14c39 A G 7: 86,344,440 (GRCm39) K259E probably benign Het
Or1e26 T C 11: 73,480,549 (GRCm39) N5S probably damaging Het
Or4a27 T A 2: 88,559,892 (GRCm39) Q17L probably benign Het
Pals1 T A 12: 78,867,589 (GRCm39) M324K possibly damaging Het
Plekhg5 T A 4: 152,192,322 (GRCm39) probably benign Het
Pprc1 G T 19: 46,053,197 (GRCm39) probably benign Het
Ptprm T A 17: 67,264,092 (GRCm39) K385I probably benign Het
Rfxap T A 3: 54,711,938 (GRCm39) N215I probably damaging Het
Slc16a7 A T 10: 125,069,333 (GRCm39) Y114* probably null Het
Smarcb1 G T 10: 75,747,628 (GRCm39) probably benign Het
Spef2 T A 15: 9,668,877 (GRCm39) R770* probably null Het
Stard9 A T 2: 120,528,342 (GRCm39) Y1533F probably benign Het
Tbcd A T 11: 121,500,853 (GRCm39) Y1142F probably benign Het
Trappc2b A T 11: 51,576,893 (GRCm39) S2T probably benign Het
Ttc23l G T 15: 10,551,636 (GRCm39) T30K possibly damaging Het
Uba7 G A 9: 107,857,246 (GRCm39) V703I probably benign Het
Upb1 T C 10: 75,248,638 (GRCm39) S53P possibly damaging Het
Zfp672 A G 11: 58,207,677 (GRCm39) S215P possibly damaging Het
Zfp978 T A 4: 147,475,437 (GRCm39) L328H probably damaging Het
Other mutations in Or5d16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02507:Or5d16 APN 2 87,773,262 (GRCm39) nonsense probably null
IGL03245:Or5d16 APN 2 87,773,086 (GRCm39) missense possibly damaging 0.75
B5639:Or5d16 UTSW 2 87,773,942 (GRCm39) missense probably benign 0.03
PIT4531001:Or5d16 UTSW 2 87,773,571 (GRCm39) missense probably damaging 1.00
R0212:Or5d16 UTSW 2 87,773,435 (GRCm39) missense probably damaging 1.00
R0393:Or5d16 UTSW 2 87,773,909 (GRCm39) missense possibly damaging 0.62
R1178:Or5d16 UTSW 2 87,773,490 (GRCm39) missense probably benign 0.02
R1180:Or5d16 UTSW 2 87,773,490 (GRCm39) missense probably benign 0.02
R1181:Or5d16 UTSW 2 87,773,490 (GRCm39) missense probably benign 0.02
R1266:Or5d16 UTSW 2 87,773,877 (GRCm39) missense probably benign 0.01
R1847:Or5d16 UTSW 2 87,773,065 (GRCm39) splice site probably null
R1998:Or5d16 UTSW 2 87,773,490 (GRCm39) missense probably benign 0.02
R2000:Or5d16 UTSW 2 87,773,490 (GRCm39) missense probably benign 0.02
R4119:Or5d16 UTSW 2 87,773,787 (GRCm39) missense probably damaging 1.00
R4213:Or5d16 UTSW 2 87,773,465 (GRCm39) missense probably benign 0.00
R5688:Or5d16 UTSW 2 87,773,552 (GRCm39) missense probably benign 0.02
R5731:Or5d16 UTSW 2 87,773,771 (GRCm39) missense possibly damaging 0.89
R6064:Or5d16 UTSW 2 87,773,828 (GRCm39) missense probably benign 0.00
R6372:Or5d16 UTSW 2 87,773,319 (GRCm39) missense probably benign 0.00
R6505:Or5d16 UTSW 2 87,773,518 (GRCm39) nonsense probably null
R6555:Or5d16 UTSW 2 87,773,632 (GRCm39) missense probably damaging 1.00
R6909:Or5d16 UTSW 2 87,773,034 (GRCm39) missense probably benign 0.27
R7257:Or5d16 UTSW 2 87,773,915 (GRCm39) missense probably damaging 1.00
R8037:Or5d16 UTSW 2 87,773,319 (GRCm39) missense probably benign 0.00
R8367:Or5d16 UTSW 2 87,773,441 (GRCm39) missense possibly damaging 0.75
R9301:Or5d16 UTSW 2 87,773,297 (GRCm39) missense probably benign 0.00
Z1088:Or5d16 UTSW 2 87,773,792 (GRCm39) missense probably damaging 1.00
Z1176:Or5d16 UTSW 2 87,773,811 (GRCm39) missense probably damaging 1.00
Z1176:Or5d16 UTSW 2 87,773,553 (GRCm39) missense possibly damaging 0.57
Predicted Primers PCR Primer
(F):5'- TCTTAAGGCTTACAGTCACTGAG -3'
(R):5'- TGAACTGTCATCCCTAATAGCCCTC -3'

Sequencing Primer
(F):5'- GGCTTACAGTCACTGAGAAAATTTTC -3'
(R):5'- GTCATCCCTAATAGCCCTCTCTTG -3'
Posted On 2016-06-21