Incidental Mutation 'R5156:Ppp1r37'
ID 396729
Institutional Source Beutler Lab
Gene Symbol Ppp1r37
Ensembl Gene ENSMUSG00000051403
Gene Name protein phosphatase 1, regulatory subunit 37
Synonyms Lrrc68
MMRRC Submission 042738-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.246) question?
Stock # R5156 (G1)
Quality Score 90
Status Not validated
Chromosome 7
Chromosomal Location 19264725-19297001 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 19295900 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147112 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051364] [ENSMUST00000058444] [ENSMUST00000117222] [ENSMUST00000119912] [ENSMUST00000122055] [ENSMUST00000122127] [ENSMUST00000208826] [ENSMUST00000151646]
AlphaFold Q8BKR5
Predicted Effect probably benign
Transcript: ENSMUST00000051364
SMART Domains Protein: ENSMUSP00000055844
Gene: ENSMUSG00000044709

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
Pfam:Gemin7 50 129 1.9e-45 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000058444
AA Change: D19G
SMART Domains Protein: ENSMUSP00000060233
Gene: ENSMUSG00000051403
AA Change: D19G

DomainStartEndE-ValueType
low complexity region 7 38 N/A INTRINSIC
Blast:LRR 139 166 1e-9 BLAST
LRR 224 251 1.77e2 SMART
LRR 252 280 3.52e-1 SMART
LRR 281 308 8.27e-7 SMART
LRR 310 337 3.05e1 SMART
LRR 338 365 1.4e-4 SMART
LRR 366 393 1.56e-2 SMART
LRR 394 421 2.36e-2 SMART
low complexity region 504 540 N/A INTRINSIC
low complexity region 566 574 N/A INTRINSIC
low complexity region 596 628 N/A INTRINSIC
low complexity region 660 679 N/A INTRINSIC
low complexity region 696 702 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000117222
SMART Domains Protein: ENSMUSP00000113266
Gene: ENSMUSG00000044709

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
Pfam:Gemin7 50 129 1.9e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000119912
SMART Domains Protein: ENSMUSP00000112742
Gene: ENSMUSG00000044709

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
Pfam:Gemin7 50 129 1.9e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000122055
SMART Domains Protein: ENSMUSP00000113583
Gene: ENSMUSG00000044709

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
Pfam:Gemin7 50 129 1.9e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000122127
SMART Domains Protein: ENSMUSP00000113709
Gene: ENSMUSG00000044709

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
Pfam:Gemin7 50 129 1.9e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208826
Predicted Effect probably benign
Transcript: ENSMUST00000151646
SMART Domains Protein: ENSMUSP00000116207
Gene: ENSMUSG00000044709

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
Pfam:Gemin7 50 81 7e-16 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 100% (52/52)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921513D11Rik G T 17: 79,935,638 (GRCm39) probably benign Het
Apeh C T 9: 107,971,486 (GRCm39) A29T probably damaging Het
Arap2 A T 5: 62,826,524 (GRCm39) Y1013* probably null Het
Arhgef4 A G 1: 34,762,355 (GRCm39) E537G unknown Het
Asf1b T C 8: 84,682,540 (GRCm39) F28S probably damaging Het
Cd46 T A 1: 194,767,693 (GRCm39) I123L possibly damaging Het
Cdca7 A T 2: 72,309,370 (GRCm39) T48S probably damaging Het
Cfap53 T A 18: 74,492,838 (GRCm39) probably benign Het
Clca3a2 T A 3: 144,511,599 (GRCm39) T599S probably benign Het
Csf1 T A 3: 107,656,252 (GRCm39) T148S probably benign Het
Dmbt1 T C 7: 130,699,400 (GRCm39) probably null Het
Dmpk A G 7: 18,818,050 (GRCm39) D44G probably damaging Het
Dnajb12 T A 10: 59,728,782 (GRCm39) N223K probably damaging Het
Dync1h1 T A 12: 110,595,264 (GRCm39) M1392K probably benign Het
Edrf1 C T 7: 133,261,908 (GRCm39) A867V probably damaging Het
Efemp2 T A 19: 5,527,706 (GRCm39) C94S possibly damaging Het
Epha8 C T 4: 136,666,037 (GRCm39) S373N probably benign Het
Foxk1 A G 5: 142,434,588 (GRCm39) D284G possibly damaging Het
Fzd10 C A 5: 128,678,366 (GRCm39) R29S possibly damaging Het
Gm13991 T C 2: 116,358,665 (GRCm39) noncoding transcript Het
Gm6818 A T 7: 38,101,471 (GRCm39) noncoding transcript Het
Hydin T A 8: 111,336,333 (GRCm39) C5037S probably benign Het
Ikzf1 T A 11: 11,719,448 (GRCm39) M492K probably damaging Het
Krt20 G T 11: 99,320,879 (GRCm39) S394R possibly damaging Het
Lrrc71 T A 3: 87,653,094 (GRCm39) R107S probably benign Het
Mia2 A G 12: 59,219,323 (GRCm39) T436A possibly damaging Het
Muc19 T A 15: 91,784,614 (GRCm39) noncoding transcript Het
Neu4 T C 1: 93,952,177 (GRCm39) V182A probably damaging Het
Notch2 T G 3: 98,031,626 (GRCm39) F1167V possibly damaging Het
Nrap A G 19: 56,360,277 (GRCm39) M189T possibly damaging Het
Nt5m A T 11: 59,765,487 (GRCm39) I172F probably damaging Het
Or5b118 G T 19: 13,449,037 (GRCm39) K234N probably damaging Het
Or5w15 G A 2: 87,568,119 (GRCm39) P183L possibly damaging Het
Or8k41 A T 2: 86,313,362 (GRCm39) C241* probably null Het
Plekha5 C T 6: 140,372,254 (GRCm39) T68M probably damaging Het
Ppef2 A G 5: 92,392,461 (GRCm39) probably null Het
Rfx4 T C 10: 84,704,218 (GRCm39) Y238H probably damaging Het
Sanbr A G 11: 23,543,424 (GRCm39) probably null Het
Sec13 G A 6: 113,707,837 (GRCm39) A161V probably benign Het
Serhl G A 15: 82,986,895 (GRCm39) probably benign Het
Slco4a1 T C 2: 180,114,572 (GRCm39) V588A probably benign Het
Slitrk3 T C 3: 72,956,592 (GRCm39) T727A probably benign Het
Sp100 T A 1: 85,601,404 (GRCm39) D241E probably damaging Het
Spata2 G T 2: 167,325,494 (GRCm39) H442N probably damaging Het
Speg T C 1: 75,404,731 (GRCm39) V2588A probably damaging Het
Tnfsf12 A G 11: 69,578,155 (GRCm39) S141P probably damaging Het
Trank1 A G 9: 111,219,762 (GRCm39) I2166M probably damaging Het
Trim10 T A 17: 37,187,948 (GRCm39) V388E probably damaging Het
Ttc23l G T 15: 10,551,636 (GRCm39) T30K possibly damaging Het
Vmn2r10 A G 5: 109,143,466 (GRCm39) V828A probably benign Het
Vmn2r75 T A 7: 85,813,436 (GRCm39) L455F possibly damaging Het
Vwa8 T A 14: 79,221,666 (GRCm39) S541T probably benign Het
Other mutations in Ppp1r37
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0313:Ppp1r37 UTSW 7 19,267,923 (GRCm39) missense probably damaging 1.00
R0718:Ppp1r37 UTSW 7 19,266,179 (GRCm39) missense probably benign
R0883:Ppp1r37 UTSW 7 19,266,102 (GRCm39) missense probably benign 0.01
R1606:Ppp1r37 UTSW 7 19,268,924 (GRCm39) missense probably damaging 0.97
R2220:Ppp1r37 UTSW 7 19,266,371 (GRCm39) missense probably null 0.43
R2256:Ppp1r37 UTSW 7 19,295,943 (GRCm39) unclassified probably benign
R2257:Ppp1r37 UTSW 7 19,295,943 (GRCm39) unclassified probably benign
R2325:Ppp1r37 UTSW 7 19,266,609 (GRCm39) missense probably damaging 1.00
R2510:Ppp1r37 UTSW 7 19,266,357 (GRCm39) missense possibly damaging 0.79
R3401:Ppp1r37 UTSW 7 19,266,712 (GRCm39) missense probably damaging 0.99
R3402:Ppp1r37 UTSW 7 19,266,712 (GRCm39) missense probably damaging 0.99
R4006:Ppp1r37 UTSW 7 19,268,994 (GRCm39) missense probably damaging 1.00
R4750:Ppp1r37 UTSW 7 19,265,445 (GRCm39) missense probably benign
R4956:Ppp1r37 UTSW 7 19,266,636 (GRCm39) nonsense probably null
R5582:Ppp1r37 UTSW 7 19,266,219 (GRCm39) missense probably damaging 1.00
R5659:Ppp1r37 UTSW 7 19,269,448 (GRCm39) missense probably damaging 1.00
R5918:Ppp1r37 UTSW 7 19,266,036 (GRCm39) missense probably benign 0.02
R6172:Ppp1r37 UTSW 7 19,266,329 (GRCm39) missense possibly damaging 0.93
R6659:Ppp1r37 UTSW 7 19,266,048 (GRCm39) missense probably benign 0.00
R7626:Ppp1r37 UTSW 7 19,295,778 (GRCm39) missense probably damaging 0.99
R7779:Ppp1r37 UTSW 7 19,266,712 (GRCm39) missense possibly damaging 0.81
R7785:Ppp1r37 UTSW 7 19,265,996 (GRCm39) missense probably damaging 1.00
R7819:Ppp1r37 UTSW 7 19,267,989 (GRCm39) missense probably damaging 1.00
R7965:Ppp1r37 UTSW 7 19,265,868 (GRCm39) missense probably damaging 0.99
R8185:Ppp1r37 UTSW 7 19,266,873 (GRCm39) missense probably damaging 1.00
R9125:Ppp1r37 UTSW 7 19,269,014 (GRCm39) missense probably benign 0.12
R9224:Ppp1r37 UTSW 7 19,265,729 (GRCm39) missense probably damaging 0.98
R9417:Ppp1r37 UTSW 7 19,269,658 (GRCm39) missense probably damaging 0.98
R9453:Ppp1r37 UTSW 7 19,295,796 (GRCm39) missense probably damaging 0.99
R9777:Ppp1r37 UTSW 7 19,295,783 (GRCm39) missense probably benign 0.23
Z1177:Ppp1r37 UTSW 7 19,268,997 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CAAAGCTACCGTGTCTCCAG -3'
(R):5'- AAGCTTGAGTCGGTGCTATGC -3'

Sequencing Primer
(F):5'- AGGGGTCTTTGGGCTCCAC -3'
(R):5'- CCTTCGGCTTGTAGCGAAAG -3'
Posted On 2016-06-21