Incidental Mutation 'R5156:Vmn2r10'
| ID |
396723 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r10
|
| Ensembl Gene |
ENSMUSG00000067010 |
| Gene Name |
vomeronasal 2, receptor 10 |
| Synonyms |
VR16, V2r16 |
| MMRRC Submission |
042738-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R5156 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109141278-109154337 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 109143466 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 828
(V828A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078162
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079163]
[ENSMUST00000176594]
|
| AlphaFold |
K7N621 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079163
AA Change: V828A
PolyPhen 2
Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: V828A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
8.5e-29 |
PFAM |
|
Pfam:NCD3G
|
506 |
560 |
3.8e-17 |
PFAM |
|
Pfam:7tm_3
|
593 |
828 |
4e-55 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176594
|
| SMART Domains |
Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
100% (52/52) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 52 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921513D11Rik |
G |
T |
17: 79,935,638 (GRCm39) |
|
probably benign |
Het |
| Apeh |
C |
T |
9: 107,971,486 (GRCm39) |
A29T |
probably damaging |
Het |
| Arap2 |
A |
T |
5: 62,826,524 (GRCm39) |
Y1013* |
probably null |
Het |
| Arhgef4 |
A |
G |
1: 34,762,355 (GRCm39) |
E537G |
unknown |
Het |
| Asf1b |
T |
C |
8: 84,682,540 (GRCm39) |
F28S |
probably damaging |
Het |
| Cd46 |
T |
A |
1: 194,767,693 (GRCm39) |
I123L |
possibly damaging |
Het |
| Cdca7 |
A |
T |
2: 72,309,370 (GRCm39) |
T48S |
probably damaging |
Het |
| Cfap53 |
T |
A |
18: 74,492,838 (GRCm39) |
|
probably benign |
Het |
| Clca3a2 |
T |
A |
3: 144,511,599 (GRCm39) |
T599S |
probably benign |
Het |
| Csf1 |
T |
A |
3: 107,656,252 (GRCm39) |
T148S |
probably benign |
Het |
| Dmbt1 |
T |
C |
7: 130,699,400 (GRCm39) |
|
probably null |
Het |
| Dmpk |
A |
G |
7: 18,818,050 (GRCm39) |
D44G |
probably damaging |
Het |
| Dnajb12 |
T |
A |
10: 59,728,782 (GRCm39) |
N223K |
probably damaging |
Het |
| Dync1h1 |
T |
A |
12: 110,595,264 (GRCm39) |
M1392K |
probably benign |
Het |
| Edrf1 |
C |
T |
7: 133,261,908 (GRCm39) |
A867V |
probably damaging |
Het |
| Efemp2 |
T |
A |
19: 5,527,706 (GRCm39) |
C94S |
possibly damaging |
Het |
| Epha8 |
C |
T |
4: 136,666,037 (GRCm39) |
S373N |
probably benign |
Het |
| Foxk1 |
A |
G |
5: 142,434,588 (GRCm39) |
D284G |
possibly damaging |
Het |
| Fzd10 |
C |
A |
5: 128,678,366 (GRCm39) |
R29S |
possibly damaging |
Het |
| Gm13991 |
T |
C |
2: 116,358,665 (GRCm39) |
|
noncoding transcript |
Het |
| Gm6818 |
A |
T |
7: 38,101,471 (GRCm39) |
|
noncoding transcript |
Het |
| Hydin |
T |
A |
8: 111,336,333 (GRCm39) |
C5037S |
probably benign |
Het |
| Ikzf1 |
T |
A |
11: 11,719,448 (GRCm39) |
M492K |
probably damaging |
Het |
| Krt20 |
G |
T |
11: 99,320,879 (GRCm39) |
S394R |
possibly damaging |
Het |
| Lrrc71 |
T |
A |
3: 87,653,094 (GRCm39) |
R107S |
probably benign |
Het |
| Mia2 |
A |
G |
12: 59,219,323 (GRCm39) |
T436A |
possibly damaging |
Het |
| Muc19 |
T |
A |
15: 91,784,614 (GRCm39) |
|
noncoding transcript |
Het |
| Neu4 |
T |
C |
1: 93,952,177 (GRCm39) |
V182A |
probably damaging |
Het |
| Notch2 |
T |
G |
3: 98,031,626 (GRCm39) |
F1167V |
possibly damaging |
Het |
| Nrap |
A |
G |
19: 56,360,277 (GRCm39) |
M189T |
possibly damaging |
Het |
| Nt5m |
A |
T |
11: 59,765,487 (GRCm39) |
I172F |
probably damaging |
Het |
| Or5b118 |
G |
T |
19: 13,449,037 (GRCm39) |
K234N |
probably damaging |
Het |
| Or5w15 |
G |
A |
2: 87,568,119 (GRCm39) |
P183L |
possibly damaging |
Het |
| Or8k41 |
A |
T |
2: 86,313,362 (GRCm39) |
C241* |
probably null |
Het |
| Plekha5 |
C |
T |
6: 140,372,254 (GRCm39) |
T68M |
probably damaging |
Het |
| Ppef2 |
A |
G |
5: 92,392,461 (GRCm39) |
|
probably null |
Het |
| Ppp1r37 |
T |
C |
7: 19,295,900 (GRCm39) |
|
probably benign |
Het |
| Rfx4 |
T |
C |
10: 84,704,218 (GRCm39) |
Y238H |
probably damaging |
Het |
| Sanbr |
A |
G |
11: 23,543,424 (GRCm39) |
|
probably null |
Het |
| Sec13 |
G |
A |
6: 113,707,837 (GRCm39) |
A161V |
probably benign |
Het |
| Serhl |
G |
A |
15: 82,986,895 (GRCm39) |
|
probably benign |
Het |
| Slco4a1 |
T |
C |
2: 180,114,572 (GRCm39) |
V588A |
probably benign |
Het |
| Slitrk3 |
T |
C |
3: 72,956,592 (GRCm39) |
T727A |
probably benign |
Het |
| Sp100 |
T |
A |
1: 85,601,404 (GRCm39) |
D241E |
probably damaging |
Het |
| Spata2 |
G |
T |
2: 167,325,494 (GRCm39) |
H442N |
probably damaging |
Het |
| Speg |
T |
C |
1: 75,404,731 (GRCm39) |
V2588A |
probably damaging |
Het |
| Tnfsf12 |
A |
G |
11: 69,578,155 (GRCm39) |
S141P |
probably damaging |
Het |
| Trank1 |
A |
G |
9: 111,219,762 (GRCm39) |
I2166M |
probably damaging |
Het |
| Trim10 |
T |
A |
17: 37,187,948 (GRCm39) |
V388E |
probably damaging |
Het |
| Ttc23l |
G |
T |
15: 10,551,636 (GRCm39) |
T30K |
possibly damaging |
Het |
| Vmn2r75 |
T |
A |
7: 85,813,436 (GRCm39) |
L455F |
possibly damaging |
Het |
| Vwa8 |
T |
A |
14: 79,221,666 (GRCm39) |
S541T |
probably benign |
Het |
|
| Other mutations in Vmn2r10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00816:Vmn2r10
|
APN |
5 |
109,150,451 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01618:Vmn2r10
|
APN |
5 |
109,150,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01624:Vmn2r10
|
APN |
5 |
109,154,112 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01941:Vmn2r10
|
APN |
5 |
109,143,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01959:Vmn2r10
|
APN |
5 |
109,145,571 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01973:Vmn2r10
|
APN |
5 |
109,143,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01985:Vmn2r10
|
APN |
5 |
109,154,125 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02451:Vmn2r10
|
APN |
5 |
109,143,788 (GRCm39) |
nonsense |
probably null |
|
|
IGL02503:Vmn2r10
|
APN |
5 |
109,151,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03275:Vmn2r10
|
APN |
5 |
109,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0035:Vmn2r10
|
UTSW |
5 |
109,145,467 (GRCm39) |
splice site |
probably benign |
|
|
R0395:Vmn2r10
|
UTSW |
5 |
109,149,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0454:Vmn2r10
|
UTSW |
5 |
109,151,327 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0648:Vmn2r10
|
UTSW |
5 |
109,143,782 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1251:Vmn2r10
|
UTSW |
5 |
109,143,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1580:Vmn2r10
|
UTSW |
5 |
109,154,117 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1845:Vmn2r10
|
UTSW |
5 |
109,149,861 (GRCm39) |
nonsense |
probably null |
|
|
R1986:Vmn2r10
|
UTSW |
5 |
109,154,120 (GRCm39) |
nonsense |
probably null |
|
|
R2137:Vmn2r10
|
UTSW |
5 |
109,151,410 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2495:Vmn2r10
|
UTSW |
5 |
109,143,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3932:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R3933:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4899:Vmn2r10
|
UTSW |
5 |
109,151,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r10
|
UTSW |
5 |
109,145,592 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5124:Vmn2r10
|
UTSW |
5 |
109,154,286 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5145:Vmn2r10
|
UTSW |
5 |
109,143,761 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R5265:Vmn2r10
|
UTSW |
5 |
109,143,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5311:Vmn2r10
|
UTSW |
5 |
109,154,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5321:Vmn2r10
|
UTSW |
5 |
109,143,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5666:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
|
R5670:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
|
R5872:Vmn2r10
|
UTSW |
5 |
109,151,377 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6004:Vmn2r10
|
UTSW |
5 |
109,146,944 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6108:Vmn2r10
|
UTSW |
5 |
109,143,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6332:Vmn2r10
|
UTSW |
5 |
109,151,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6599:Vmn2r10
|
UTSW |
5 |
109,143,944 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6651:Vmn2r10
|
UTSW |
5 |
109,143,488 (GRCm39) |
missense |
probably null |
0.22 |
|
R6891:Vmn2r10
|
UTSW |
5 |
109,149,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Vmn2r10
|
UTSW |
5 |
109,149,894 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7146:Vmn2r10
|
UTSW |
5 |
109,151,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7941:Vmn2r10
|
UTSW |
5 |
109,144,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Vmn2r10
|
UTSW |
5 |
109,149,955 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8478:Vmn2r10
|
UTSW |
5 |
109,143,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8526:Vmn2r10
|
UTSW |
5 |
109,145,572 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R8698:Vmn2r10
|
UTSW |
5 |
109,151,390 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8796:Vmn2r10
|
UTSW |
5 |
109,143,917 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8854:Vmn2r10
|
UTSW |
5 |
109,144,126 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8871:Vmn2r10
|
UTSW |
5 |
109,146,899 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8893:Vmn2r10
|
UTSW |
5 |
109,143,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8907:Vmn2r10
|
UTSW |
5 |
109,149,791 (GRCm39) |
missense |
probably benign |
|
|
R8957:Vmn2r10
|
UTSW |
5 |
109,149,780 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8976:Vmn2r10
|
UTSW |
5 |
109,145,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9155:Vmn2r10
|
UTSW |
5 |
109,144,212 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9308:Vmn2r10
|
UTSW |
5 |
109,145,476 (GRCm39) |
nonsense |
probably null |
|
|
R9800:Vmn2r10
|
UTSW |
5 |
109,150,404 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r10
|
UTSW |
5 |
109,143,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r10
|
UTSW |
5 |
109,149,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCATTACATTAGGCAGTGC -3'
(R):5'- CTTCCTGACAGATTCAATGAAGCC -3'
Sequencing Primer
(F):5'- CATTACATTAGGCAGTGCTGTGC -3'
(R):5'- CAAATTCTTAACCTTCAGCATGCTGG -3'
|
| Posted On |
2016-06-21 |
Incidental Mutation