Incidental Mutation 'R5046:Or4k41'
ID 394359
Institutional Source Beutler Lab
Gene Symbol Or4k41
Ensembl Gene ENSMUSG00000095586
Gene Name olfactory receptor family 4 subfamily K member 41
Synonyms MOR248-15, GA_x6K02T2Q125-72500603-72501520, Olfr1287
MMRRC Submission 042636-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # R5046 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 111279487-111280404 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 111279934 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 150 (T150S)
Ref Sequence ENSEMBL: ENSMUSP00000074850 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075390]
AlphaFold Q7TQY1
Predicted Effect probably benign
Transcript: ENSMUST00000075390
AA Change: T150S

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000074850
Gene: ENSMUSG00000095586
AA Change: T150S

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 6.7e-48 PFAM
Pfam:7tm_1 41 287 9.5e-20 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.1%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm4 C A 7: 119,302,597 (GRCm39) H241N probably damaging Het
Arhgap32 G A 9: 32,168,095 (GRCm39) A693T probably damaging Het
B4galnt3 G T 6: 120,191,759 (GRCm39) A658D probably damaging Het
Car12 G A 9: 66,653,895 (GRCm39) E84K probably benign Het
Crocc2 T A 1: 93,133,624 (GRCm39) S969T probably damaging Het
Crym A G 7: 119,794,667 (GRCm39) V184A possibly damaging Het
Cryzl2 T C 1: 157,292,583 (GRCm39) C122R probably damaging Het
Defb30 T C 14: 63,273,463 (GRCm39) E49G probably benign Het
Dnah3 A G 7: 119,550,803 (GRCm39) L3161P probably damaging Het
Dnajc5g A G 5: 31,267,036 (GRCm39) N104S probably benign Het
Fcgr1 T G 3: 96,194,302 (GRCm39) K195T probably damaging Het
Gal C T 19: 3,461,167 (GRCm39) R89H probably damaging Het
Gcfc2 C T 6: 81,925,316 (GRCm39) A577V probably benign Het
Gm5116 A C 7: 32,195,379 (GRCm39) noncoding transcript Het
Golga3 A T 5: 110,340,806 (GRCm39) Q540L probably damaging Het
Hectd1 T C 12: 51,797,171 (GRCm39) E2184G probably damaging Het
Hspa12a T C 19: 58,787,977 (GRCm39) D615G probably damaging Het
Igkv14-130 A T 6: 67,768,465 (GRCm39) Y107F probably damaging Het
Ldlr T A 9: 21,657,203 (GRCm39) probably null Het
Lin9 T A 1: 180,496,763 (GRCm39) L351I probably benign Het
Lrrc37a A T 11: 103,389,066 (GRCm39) S2120T unknown Het
Mtfmt G T 9: 65,346,897 (GRCm39) V164F probably damaging Het
Nampt T C 12: 32,883,037 (GRCm39) V74A probably damaging Het
Ndufc2 G T 7: 97,056,871 (GRCm39) R120L probably damaging Het
Neo1 A T 9: 58,801,194 (GRCm39) V1156D possibly damaging Het
Nlrp1b G A 11: 71,050,898 (GRCm39) P1065S possibly damaging Het
Nop9 A G 14: 55,983,397 (GRCm39) H56R possibly damaging Het
Or6c75 A T 10: 129,337,178 (GRCm39) M142L possibly damaging Het
Pign A T 1: 105,449,798 (GRCm39) N909K possibly damaging Het
Prex1 A G 2: 166,414,883 (GRCm39) V304A probably benign Het
Racgap1 G A 15: 99,526,643 (GRCm39) R307W probably damaging Het
Rap1gds1 C A 3: 138,661,181 (GRCm39) E399* probably null Het
Rwdd4a G A 8: 47,995,837 (GRCm39) probably null Het
Sanbr A C 11: 23,570,354 (GRCm39) M182R probably benign Het
Scp2 T C 4: 107,928,488 (GRCm39) T401A probably benign Het
Sdha A G 13: 74,475,452 (GRCm39) F526S probably damaging Het
Shroom1 T A 11: 53,354,872 (GRCm39) L264Q probably benign Het
Sorl1 T C 9: 41,907,590 (GRCm39) T1466A probably benign Het
Trpm2 C T 10: 77,801,852 (GRCm39) C71Y probably damaging Het
Ugt2b34 G A 5: 87,052,246 (GRCm39) S250L probably benign Het
Vmn2r88 A G 14: 51,650,638 (GRCm39) D117G probably benign Het
Wdr73 A T 7: 80,542,173 (GRCm39) probably benign Het
Other mutations in Or4k41
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01655:Or4k41 APN 2 111,280,234 (GRCm39) missense probably benign 0.13
IGL01748:Or4k41 APN 2 111,279,875 (GRCm39) missense probably damaging 1.00
IGL02264:Or4k41 APN 2 111,280,207 (GRCm39) missense probably benign 0.05
IGL02371:Or4k41 APN 2 111,280,354 (GRCm39) missense probably damaging 1.00
IGL02385:Or4k41 APN 2 111,279,695 (GRCm39) missense probably damaging 1.00
IGL02704:Or4k41 APN 2 111,279,492 (GRCm39) missense probably benign 0.00
R0368:Or4k41 UTSW 2 111,280,133 (GRCm39) missense probably benign 0.07
R1520:Or4k41 UTSW 2 111,279,619 (GRCm39) missense probably benign 0.00
R2036:Or4k41 UTSW 2 111,279,971 (GRCm39) missense possibly damaging 0.80
R2890:Or4k41 UTSW 2 111,279,634 (GRCm39) missense probably benign 0.12
R3757:Or4k41 UTSW 2 111,279,602 (GRCm39) missense possibly damaging 0.95
R3801:Or4k41 UTSW 2 111,279,910 (GRCm39) missense probably benign 0.07
R3958:Or4k41 UTSW 2 111,280,230 (GRCm39) missense possibly damaging 0.50
R4077:Or4k41 UTSW 2 111,279,848 (GRCm39) missense probably damaging 0.99
R4763:Or4k41 UTSW 2 111,280,023 (GRCm39) nonsense probably null
R4955:Or4k41 UTSW 2 111,279,950 (GRCm39) missense probably damaging 1.00
R4975:Or4k41 UTSW 2 111,280,028 (GRCm39) missense probably benign 0.16
R5512:Or4k41 UTSW 2 111,280,099 (GRCm39) missense probably benign 0.00
R5708:Or4k41 UTSW 2 111,280,354 (GRCm39) missense probably damaging 1.00
R5771:Or4k41 UTSW 2 111,280,406 (GRCm39) splice site probably null
R5780:Or4k41 UTSW 2 111,280,178 (GRCm39) missense probably benign 0.03
R6981:Or4k41 UTSW 2 111,279,697 (GRCm39) missense probably benign 0.00
R7073:Or4k41 UTSW 2 111,279,631 (GRCm39) missense probably benign 0.22
R7633:Or4k41 UTSW 2 111,279,967 (GRCm39) missense probably benign
R7963:Or4k41 UTSW 2 111,279,971 (GRCm39) missense possibly damaging 0.80
R8121:Or4k41 UTSW 2 111,279,505 (GRCm39) missense probably benign 0.20
R8889:Or4k41 UTSW 2 111,279,967 (GRCm39) missense probably benign
R8892:Or4k41 UTSW 2 111,279,967 (GRCm39) missense probably benign
R9036:Or4k41 UTSW 2 111,280,343 (GRCm39) missense probably damaging 1.00
RF037:Or4k41 UTSW 2 111,279,896 (GRCm39) missense not run
RF039:Or4k41 UTSW 2 111,279,896 (GRCm39) missense not run
Z1088:Or4k41 UTSW 2 111,279,802 (GRCm39) missense probably benign 0.02
Z1176:Or4k41 UTSW 2 111,280,129 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- ACAAAACCATTTCCTTTGGGG -3'
(R):5'- TGACTGGCCCAAAGAACAGC -3'

Sequencing Primer
(F):5'- CCATTTCCTTTGGGGGCTGC -3'
(R):5'- ACCACTATGATATGGGATGTGC -3'
Posted On 2016-06-15