Incidental Mutation 'R5099:Ms4a20'
ID 388197
Institutional Source Beutler Lab
Gene Symbol Ms4a20
Ensembl Gene ENSMUSG00000024729
Gene Name membrane-spanning 4-domains, subfamily A, member 20
Synonyms 1700017D01Rik
MMRRC Submission 042688-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R5099 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 11074180-11108240 bp(-) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) T to C at 11089825 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000025635 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025635]
AlphaFold G5E851
Predicted Effect probably null
Transcript: ENSMUST00000025635
SMART Domains Protein: ENSMUSP00000025635
Gene: ENSMUSG00000024729

DomainStartEndE-ValueType
Pfam:CD20 18 118 2.4e-8 PFAM
transmembrane domain 130 152 N/A INTRINSIC
low complexity region 169 185 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188756
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency 98% (41/42)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arsa A G 15: 89,359,542 (GRCm39) L80P probably damaging Het
Bdkrb1 A G 12: 105,570,533 (GRCm39) D33G probably benign Het
Ccdc178 A T 18: 22,238,648 (GRCm39) V323E probably benign Het
Ceacam5 T C 7: 17,479,513 (GRCm39) V210A probably damaging Het
Dcdc2a A G 13: 25,291,681 (GRCm39) E222G probably benign Het
Gbp9 A T 5: 105,242,379 (GRCm39) L120Q probably damaging Het
Gm4787 G C 12: 81,424,604 (GRCm39) T518S probably benign Het
Gsr T A 8: 34,161,556 (GRCm39) I121N probably damaging Het
Ift140 T A 17: 25,309,674 (GRCm39) M1068K probably damaging Het
Jakmip2 A G 18: 43,701,173 (GRCm39) I414T probably benign Het
Lpin2 G A 17: 71,550,965 (GRCm39) W708* probably null Het
Mecom A G 3: 30,039,465 (GRCm39) probably benign Het
Mff C T 1: 82,728,192 (GRCm39) probably benign Het
Neb C T 2: 52,085,460 (GRCm39) C1545Y probably damaging Het
Or5ac24 C T 16: 59,165,266 (GRCm39) G266D probably benign Het
Or5p5 A G 7: 107,413,809 (GRCm39) H6R probably benign Het
Or8k36-ps1 A T 2: 86,437,560 (GRCm39) N118K unknown Het
Ppm1n A T 7: 19,011,903 (GRCm39) L392Q possibly damaging Het
Prr22 T C 17: 57,078,467 (GRCm39) F207L probably benign Het
Ptprv T C 1: 135,046,592 (GRCm39) noncoding transcript Het
Rin2 G A 2: 145,720,821 (GRCm39) C718Y probably damaging Het
Rpgrip1l G A 8: 91,975,350 (GRCm39) T1089I probably benign Het
Scn1a A G 2: 66,108,145 (GRCm39) V1510A probably damaging Het
Slfn3 A T 11: 83,105,764 (GRCm39) Y587F probably damaging Het
Sp2 T C 11: 96,852,175 (GRCm39) K250E probably damaging Het
Ssu2 A G 6: 112,336,585 (GRCm39) S333P probably benign Het
Strbp T C 2: 37,493,030 (GRCm39) T419A probably damaging Het
Tada2b A T 5: 36,633,744 (GRCm39) M203K probably benign Het
Tmem176b T C 6: 48,811,463 (GRCm39) Y62C probably benign Het
Tox G T 4: 6,688,958 (GRCm39) Q469K probably benign Het
Trgv5 G T 13: 19,376,886 (GRCm39) C111F probably damaging Het
Tyw5 T C 1: 57,427,864 (GRCm39) N243D probably damaging Het
Ube2q2 T A 9: 55,113,307 (GRCm39) probably benign Het
Ufl1 C T 4: 25,275,914 (GRCm39) R83Q probably damaging Het
Unk A G 11: 115,949,936 (GRCm39) Q701R probably benign Het
Vmn1r60 A T 7: 5,547,816 (GRCm39) C95S probably damaging Het
Vmn1r81 A G 7: 11,994,248 (GRCm39) I120T possibly damaging Het
Other mutations in Ms4a20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02142:Ms4a20 APN 19 11,087,695 (GRCm39) nonsense probably null
IGL02182:Ms4a20 APN 19 11,074,436 (GRCm39) splice site probably benign
IGL03156:Ms4a20 APN 19 11,083,114 (GRCm39) missense possibly damaging 0.80
R0189:Ms4a20 UTSW 19 11,074,311 (GRCm39) missense possibly damaging 0.46
R0218:Ms4a20 UTSW 19 11,093,801 (GRCm39) nonsense probably null
R0464:Ms4a20 UTSW 19 11,089,801 (GRCm39) missense probably damaging 1.00
R0617:Ms4a20 UTSW 19 11,089,764 (GRCm39) missense probably damaging 1.00
R1171:Ms4a20 UTSW 19 11,089,741 (GRCm39) missense probably damaging 0.97
R2341:Ms4a20 UTSW 19 11,083,157 (GRCm39) missense probably benign
R5330:Ms4a20 UTSW 19 11,069,222 (GRCm39) unclassified probably benign
R5331:Ms4a20 UTSW 19 11,069,222 (GRCm39) unclassified probably benign
R5341:Ms4a20 UTSW 19 11,087,745 (GRCm39) intron probably benign
R6109:Ms4a20 UTSW 19 11,079,276 (GRCm39) missense possibly damaging 0.66
R6177:Ms4a20 UTSW 19 11,083,114 (GRCm39) missense possibly damaging 0.53
R6970:Ms4a20 UTSW 19 11,089,678 (GRCm39) critical splice donor site probably null
R7038:Ms4a20 UTSW 19 11,087,675 (GRCm39) missense probably benign
R7584:Ms4a20 UTSW 19 11,087,725 (GRCm39) missense possibly damaging 0.94
R7752:Ms4a20 UTSW 19 11,079,224 (GRCm39) missense probably benign 0.02
R7854:Ms4a20 UTSW 19 11,089,741 (GRCm39) missense probably benign 0.01
R8261:Ms4a20 UTSW 19 11,087,707 (GRCm39) missense probably damaging 0.97
R8723:Ms4a20 UTSW 19 11,083,055 (GRCm39) missense probably damaging 0.99
R9027:Ms4a20 UTSW 19 11,083,055 (GRCm39) missense probably damaging 0.99
R9264:Ms4a20 UTSW 19 11,093,830 (GRCm39) start codon destroyed probably benign 0.14
X0019:Ms4a20 UTSW 19 11,083,156 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGTAAGCCAGTGATCGAGCC -3'
(R):5'- GTGAACACTCACCATCCTGAAG -3'

Sequencing Primer
(F):5'- GATCGAGCCTAGTAAACTGTTGACC -3'
(R):5'- CACCATCCTGAAGCAAAAAGGGTTG -3'
Posted On 2016-06-06