Incidental Mutation 'R4701:Dab1'
| ID |
386360 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dab1
|
| Ensembl Gene |
ENSMUSG00000028519 |
| Gene Name |
disabled 1 |
| Synonyms |
C630028C02Rik |
| MMRRC Submission |
041949-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.877)
|
| Stock # |
R4701 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
103476556-104602041 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 104588948 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Valine
at position 524
(A524V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000102443
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106830]
[ENSMUST00000146078]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106830
AA Change: A524V
PolyPhen 2
Score 0.289 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000102443
Gene: ENSMUSG00000028519
AA Change: A524V
| Domain | Start | End | E-Value | Type |
|---|
|
PTB
|
37 |
171 |
3.51e-36 |
SMART |
|
low complexity region
|
254 |
267 |
N/A |
INTRINSIC |
|
low complexity region
|
470 |
487 |
N/A |
INTRINSIC |
|
low complexity region
|
490 |
501 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146078
|
| SMART Domains |
Protein: ENSMUSP00000125033
Gene: ENSMUSG00000028519
| Domain | Start | End | E-Value | Type |
|---|
|
PTB
|
37 |
171 |
3.51e-36 |
SMART |
|
low complexity region
|
235 |
242 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.2232 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
96% (108/112) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]
PHENOTYPE: Homozygous null display unstable gait and whole-body tremor with a hypoplastic cerebellum devoid of folia, a probable consequence of defective neuronal migration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aarsd1 |
T |
C |
11: 101,301,986 (GRCm39) |
I196V |
probably benign |
Het |
| Aass |
T |
A |
6: 23,075,855 (GRCm39) |
K761* |
probably null |
Het |
| Abca13 |
A |
G |
11: 9,242,306 (GRCm39) |
T1390A |
possibly damaging |
Het |
| Abhd16a |
T |
C |
17: 35,315,582 (GRCm39) |
|
probably null |
Het |
| Acad11 |
C |
T |
9: 103,972,764 (GRCm39) |
Q486* |
probably null |
Het |
| Actl9 |
T |
C |
17: 33,652,909 (GRCm39) |
L323P |
probably benign |
Het |
| Adam12 |
T |
A |
7: 133,518,191 (GRCm39) |
I650F |
possibly damaging |
Het |
| Adgre4 |
A |
T |
17: 56,091,971 (GRCm39) |
D77V |
probably damaging |
Het |
| Ankrd26 |
A |
G |
6: 118,483,446 (GRCm39) |
F1586S |
possibly damaging |
Het |
| Anpep |
T |
C |
7: 79,489,213 (GRCm39) |
T320A |
probably benign |
Het |
| Arl15 |
T |
A |
13: 114,104,261 (GRCm39) |
C133S |
probably benign |
Het |
| Ascc3 |
A |
G |
10: 50,596,760 (GRCm39) |
N1230S |
possibly damaging |
Het |
| Atf4 |
T |
A |
15: 80,141,618 (GRCm39) |
I336K |
probably damaging |
Het |
| Atp7b |
A |
T |
8: 22,490,137 (GRCm39) |
S1044T |
probably benign |
Het |
| Atp8b4 |
A |
G |
2: 126,256,213 (GRCm39) |
F249L |
probably damaging |
Het |
| AU021092 |
G |
T |
16: 5,030,057 (GRCm39) |
N319K |
probably benign |
Het |
| Bbs4 |
A |
G |
9: 59,230,802 (GRCm39) |
V440A |
probably benign |
Het |
| Bpifb4 |
G |
T |
2: 153,792,305 (GRCm39) |
G450C |
probably damaging |
Het |
| Cadm1 |
G |
A |
9: 47,730,120 (GRCm39) |
|
probably benign |
Het |
| Ccser2 |
G |
A |
14: 36,660,654 (GRCm39) |
L500F |
probably damaging |
Het |
| Cd22 |
T |
A |
7: 30,575,578 (GRCm39) |
I155F |
probably damaging |
Het |
| Cdkl4 |
A |
T |
17: 80,851,081 (GRCm39) |
V207E |
probably damaging |
Het |
| Cfap251 |
A |
G |
5: 123,460,676 (GRCm39) |
K1213E |
probably benign |
Het |
| Cfap65 |
T |
C |
1: 74,958,067 (GRCm39) |
D947G |
probably damaging |
Het |
| Cntn6 |
T |
C |
6: 104,781,321 (GRCm39) |
V397A |
probably benign |
Het |
| Cpox |
T |
A |
16: 58,498,332 (GRCm39) |
Y388* |
probably null |
Het |
| Dda1 |
T |
A |
8: 71,926,454 (GRCm39) |
Y58N |
probably damaging |
Het |
| Dennd4a |
C |
T |
9: 64,804,639 (GRCm39) |
T1326I |
possibly damaging |
Het |
| Eps8l2 |
A |
T |
7: 140,937,173 (GRCm39) |
I338F |
probably damaging |
Het |
| Fbxo42 |
A |
G |
4: 140,927,120 (GRCm39) |
T467A |
probably benign |
Het |
| Flt4 |
T |
C |
11: 49,517,635 (GRCm39) |
F319S |
possibly damaging |
Het |
| Fmn1 |
A |
T |
2: 113,414,416 (GRCm39) |
Y895F |
possibly damaging |
Het |
| Gm6887 |
C |
A |
7: 42,114,517 (GRCm39) |
|
noncoding transcript |
Het |
| Grid2 |
A |
G |
6: 64,642,899 (GRCm39) |
D887G |
probably benign |
Het |
| Grm6 |
C |
T |
11: 50,753,837 (GRCm39) |
P714S |
probably damaging |
Het |
| Gsto2 |
A |
G |
19: 47,873,095 (GRCm39) |
I157V |
probably benign |
Het |
| Il15ra |
A |
G |
2: 11,723,156 (GRCm39) |
|
probably null |
Het |
| Impg1 |
A |
G |
9: 80,221,682 (GRCm39) |
F713L |
probably benign |
Het |
| Jag1 |
T |
A |
2: 136,936,376 (GRCm39) |
T373S |
probably benign |
Het |
| Kcnh3 |
T |
A |
15: 99,139,826 (GRCm39) |
L904Q |
probably benign |
Het |
| Kctd19 |
C |
A |
8: 106,117,061 (GRCm39) |
G356V |
possibly damaging |
Het |
| Kdm5b |
T |
A |
1: 134,533,750 (GRCm39) |
|
probably benign |
Het |
| Kif1a |
T |
C |
1: 93,006,557 (GRCm39) |
I37V |
probably damaging |
Het |
| Lama5 |
G |
A |
2: 179,833,489 (GRCm39) |
R1508C |
probably damaging |
Het |
| Lamb1 |
T |
A |
12: 31,316,847 (GRCm39) |
C65* |
probably null |
Het |
| Lingo1 |
A |
G |
9: 56,527,542 (GRCm39) |
F349S |
probably damaging |
Het |
| Loxl4 |
G |
A |
19: 42,596,052 (GRCm39) |
H147Y |
probably benign |
Het |
| Lrrn4cl |
T |
A |
19: 8,829,419 (GRCm39) |
N132K |
probably damaging |
Het |
| Med17 |
A |
T |
9: 15,181,656 (GRCm39) |
H31Q |
probably damaging |
Het |
| Med23 |
A |
T |
10: 24,769,546 (GRCm39) |
L476F |
probably damaging |
Het |
| Mgst1 |
A |
T |
6: 138,127,836 (GRCm39) |
D66V |
probably damaging |
Het |
| Mroh2a |
T |
C |
1: 88,162,334 (GRCm39) |
|
probably null |
Het |
| Mroh2a |
A |
C |
1: 88,169,340 (GRCm39) |
I672L |
probably benign |
Het |
| Muc4 |
A |
T |
16: 32,576,220 (GRCm39) |
|
probably benign |
Het |
| Myo18a |
C |
T |
11: 77,708,491 (GRCm39) |
T30M |
probably damaging |
Het |
| Ncapg2 |
G |
T |
12: 116,404,238 (GRCm39) |
R903L |
probably benign |
Het |
| Nme1 |
A |
G |
11: 93,856,734 (GRCm39) |
I9T |
probably damaging |
Het |
| Nmt2 |
T |
A |
2: 3,323,678 (GRCm39) |
I357N |
probably benign |
Het |
| Nphp4 |
T |
C |
4: 152,581,116 (GRCm39) |
F100S |
probably damaging |
Het |
| Oca2 |
C |
A |
7: 55,904,750 (GRCm39) |
T72K |
probably benign |
Het |
| Or52e4 |
A |
T |
7: 104,706,086 (GRCm39) |
D211V |
probably damaging |
Het |
| Or52e7 |
A |
T |
7: 104,684,798 (GRCm39) |
D131V |
probably damaging |
Het |
| Or52z15 |
G |
A |
7: 103,332,269 (GRCm39) |
V105M |
probably damaging |
Het |
| Or7h8 |
T |
C |
9: 20,123,921 (GRCm39) |
I92T |
probably damaging |
Het |
| Or9s15 |
C |
A |
1: 92,525,160 (GRCm39) |
D306E |
probably benign |
Het |
| Plce1 |
A |
T |
19: 38,713,451 (GRCm39) |
T1240S |
probably benign |
Het |
| Plch1 |
A |
T |
3: 63,606,917 (GRCm39) |
|
probably null |
Het |
| Plxna4 |
T |
C |
6: 32,493,623 (GRCm39) |
D331G |
probably damaging |
Het |
| Ppp1r3a |
T |
C |
6: 14,718,992 (GRCm39) |
T641A |
probably benign |
Het |
| Rab32 |
A |
G |
10: 10,426,598 (GRCm39) |
L116P |
probably benign |
Het |
| Recql4 |
C |
T |
15: 76,592,785 (GRCm39) |
C302Y |
probably damaging |
Het |
| Rorc |
G |
C |
3: 94,299,017 (GRCm39) |
E391Q |
probably null |
Het |
| Saa4 |
A |
T |
7: 46,381,051 (GRCm39) |
F24I |
possibly damaging |
Het |
| Sall1 |
T |
A |
8: 89,757,788 (GRCm39) |
K772M |
probably damaging |
Het |
| Sdk1 |
T |
G |
5: 142,170,986 (GRCm39) |
L1950V |
probably damaging |
Het |
| Sil1 |
T |
C |
18: 35,399,949 (GRCm39) |
E352G |
probably benign |
Het |
| Slc26a3 |
C |
T |
12: 31,497,773 (GRCm39) |
P59L |
probably damaging |
Het |
| Smco2 |
T |
C |
6: 146,763,440 (GRCm39) |
|
probably benign |
Het |
| Sppl3 |
A |
G |
5: 115,241,372 (GRCm39) |
|
probably null |
Het |
| St6gal2 |
T |
A |
17: 55,803,345 (GRCm39) |
V360D |
probably damaging |
Het |
| Stard9 |
G |
A |
2: 120,536,194 (GRCm39) |
R345Q |
possibly damaging |
Het |
| Susd4 |
T |
A |
1: 182,719,626 (GRCm39) |
Y414N |
probably damaging |
Het |
| Tenm4 |
T |
C |
7: 96,544,556 (GRCm39) |
Y2191H |
probably damaging |
Het |
| Tln2 |
A |
G |
9: 67,253,809 (GRCm39) |
V754A |
probably benign |
Het |
| Tmem132c |
T |
A |
5: 127,641,560 (GRCm39) |
|
probably benign |
Het |
| Tnn |
A |
T |
1: 159,975,338 (GRCm39) |
S30T |
possibly damaging |
Het |
| Trpd52l3 |
G |
T |
19: 29,981,895 (GRCm39) |
V217F |
probably damaging |
Het |
| Trpm1 |
G |
T |
7: 63,893,248 (GRCm39) |
L1033F |
probably damaging |
Het |
| Tulp2 |
A |
G |
7: 45,167,348 (GRCm39) |
E182G |
probably damaging |
Het |
| Ubr4 |
A |
G |
4: 139,198,647 (GRCm39) |
K4490R |
possibly damaging |
Het |
| Usp17la |
A |
T |
7: 104,509,856 (GRCm39) |
R154* |
probably null |
Het |
| Vmn2r17 |
T |
G |
5: 109,575,849 (GRCm39) |
M240R |
probably damaging |
Het |
| Vmn2r22 |
T |
A |
6: 123,627,428 (GRCm39) |
N56I |
probably benign |
Het |
| Zdhhc21 |
A |
T |
4: 82,738,571 (GRCm39) |
I206N |
possibly damaging |
Het |
| Zfp148 |
T |
A |
16: 33,277,278 (GRCm39) |
D122E |
probably benign |
Het |
| Zfp804a |
A |
T |
2: 82,086,926 (GRCm39) |
S252C |
probably damaging |
Het |
| Zgrf1 |
C |
T |
3: 127,392,353 (GRCm39) |
T1291I |
probably benign |
Het |
|
| Other mutations in Dab1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Dab1
|
APN |
4 |
104,535,950 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL00087:Dab1
|
APN |
4 |
104,536,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00328:Dab1
|
APN |
4 |
104,545,635 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL00756:Dab1
|
APN |
4 |
104,585,075 (GRCm39) |
missense |
probably benign |
|
|
IGL02074:Dab1
|
APN |
4 |
104,585,051 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02286:Dab1
|
APN |
4 |
104,537,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02986:Dab1
|
APN |
4 |
104,336,418 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03008:Dab1
|
APN |
4 |
104,584,777 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03133:Dab1
|
APN |
4 |
104,584,777 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL03375:Dab1
|
APN |
4 |
104,538,798 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
LCD18:Dab1
|
UTSW |
4 |
103,903,769 (GRCm39) |
intron |
probably benign |
|
|
R0027:Dab1
|
UTSW |
4 |
104,561,396 (GRCm39) |
intron |
probably benign |
|
|
R0466:Dab1
|
UTSW |
4 |
104,577,747 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0838:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0840:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1086:Dab1
|
UTSW |
4 |
104,185,769 (GRCm39) |
intron |
probably benign |
|
|
R1598:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1640:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1699:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1749:Dab1
|
UTSW |
4 |
104,185,495 (GRCm39) |
intron |
probably benign |
|
|
R1770:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1846:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1847:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1848:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1885:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1986:Dab1
|
UTSW |
4 |
104,470,412 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1990:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2006:Dab1
|
UTSW |
4 |
104,462,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2030:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2032:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2034:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2061:Dab1
|
UTSW |
4 |
104,535,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2088:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2089:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2092:Dab1
|
UTSW |
4 |
104,535,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2193:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2194:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2361:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2362:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2391:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2424:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2865:Dab1
|
UTSW |
4 |
104,537,343 (GRCm39) |
missense |
probably benign |
|
|
R3118:Dab1
|
UTSW |
4 |
104,537,266 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3716:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3718:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3740:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3742:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3965:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4057:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4393:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4396:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4418:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4607:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4608:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4648:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4693:Dab1
|
UTSW |
4 |
104,536,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4730:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4760:Dab1
|
UTSW |
4 |
104,589,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4927:Dab1
|
UTSW |
4 |
104,561,449 (GRCm39) |
missense |
probably benign |
|
|
R5173:Dab1
|
UTSW |
4 |
104,545,645 (GRCm39) |
splice site |
probably null |
|
|
R5503:Dab1
|
UTSW |
4 |
104,369,461 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6199:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6200:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6207:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6224:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6227:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6228:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6229:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6246:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6247:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6248:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6249:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6250:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6258:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6259:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6260:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6505:Dab1
|
UTSW |
4 |
104,369,461 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6817:Dab1
|
UTSW |
4 |
104,536,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7305:Dab1
|
UTSW |
4 |
104,570,987 (GRCm39) |
missense |
|
|
|
R7709:Dab1
|
UTSW |
4 |
104,577,756 (GRCm39) |
nonsense |
probably null |
|
|
R7894:Dab1
|
UTSW |
4 |
104,589,335 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8142:Dab1
|
UTSW |
4 |
104,535,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8462:Dab1
|
UTSW |
4 |
104,561,404 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8472:Dab1
|
UTSW |
4 |
104,336,439 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9138:Dab1
|
UTSW |
4 |
104,588,929 (GRCm39) |
nonsense |
probably null |
|
|
R9311:Dab1
|
UTSW |
4 |
104,369,463 (GRCm39) |
critical splice donor site |
probably null |
|
|
RF017:Dab1
|
UTSW |
4 |
104,570,849 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1088:Dab1
|
UTSW |
4 |
104,336,429 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Dab1
|
UTSW |
4 |
104,585,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Dab1
|
UTSW |
4 |
104,584,937 (GRCm39) |
missense |
probably benign |
0.05 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGGGATATAAATGGCTGTGGC -3'
(R):5'- GCAACCAGTTATTTTACAGGAGGC -3'
Sequencing Primer
(F):5'- GGATATAAATGGCTGTGGCTTATATG -3'
(R):5'- TTTACAGGAGGCTGAAACTTCCC -3'
|
| Posted On |
2016-05-19 |
Incidental Mutation