Incidental Mutation 'R4965:Nav2'
| ID |
383908 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nav2
|
| Ensembl Gene |
ENSMUSG00000052512 |
| Gene Name |
neuron navigator 2 |
| Synonyms |
Rainb1, Unc53H2, 5330421F07Rik, POMFIL2, HELAD1, RAINB2 |
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.571)
|
| Stock # |
R4965 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
48608796-49259838 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 49202625 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 1470
(R1470*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139045
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064395]
[ENSMUST00000183659]
[ENSMUST00000184109]
[ENSMUST00000184945]
|
| AlphaFold |
E9Q842 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000064395
AA Change: R1470*
|
| SMART Domains |
Protein: ENSMUSP00000067448
Gene: ENSMUSG00000052512
AA Change: R1470*
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
84 |
187 |
1.58e-13 |
SMART |
|
low complexity region
|
202 |
210 |
N/A |
INTRINSIC |
|
low complexity region
|
297 |
310 |
N/A |
INTRINSIC |
|
low complexity region
|
337 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
412 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
486 |
516 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
591 |
N/A |
INTRINSIC |
|
low complexity region
|
613 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
640 |
662 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
947 |
967 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1004 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1074 |
N/A |
INTRINSIC |
|
low complexity region
|
1343 |
1360 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1385 |
N/A |
INTRINSIC |
|
low complexity region
|
1417 |
1432 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1526 |
1540 |
N/A |
INTRINSIC |
|
low complexity region
|
1614 |
1628 |
N/A |
INTRINSIC |
|
coiled coil region
|
1630 |
1717 |
N/A |
INTRINSIC |
|
low complexity region
|
1789 |
1800 |
N/A |
INTRINSIC |
|
coiled coil region
|
1841 |
1909 |
N/A |
INTRINSIC |
|
AAA
|
2093 |
2247 |
1.69e-5 |
SMART |
|
low complexity region
|
2404 |
2430 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000183659
AA Change: R1409*
|
| SMART Domains |
Protein: ENSMUSP00000139309
Gene: ENSMUSG00000052512
AA Change: R1409*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
11 |
N/A |
INTRINSIC |
|
CH
|
23 |
126 |
6.19e-16 |
SMART |
|
low complexity region
|
141 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
236 |
249 |
N/A |
INTRINSIC |
|
low complexity region
|
276 |
287 |
N/A |
INTRINSIC |
|
low complexity region
|
351 |
363 |
N/A |
INTRINSIC |
|
coiled coil region
|
425 |
455 |
N/A |
INTRINSIC |
|
low complexity region
|
519 |
530 |
N/A |
INTRINSIC |
|
low complexity region
|
552 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
579 |
601 |
N/A |
INTRINSIC |
|
low complexity region
|
785 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
859 |
883 |
N/A |
INTRINSIC |
|
low complexity region
|
886 |
906 |
N/A |
INTRINSIC |
|
low complexity region
|
929 |
943 |
N/A |
INTRINSIC |
|
low complexity region
|
1001 |
1013 |
N/A |
INTRINSIC |
|
low complexity region
|
1282 |
1299 |
N/A |
INTRINSIC |
|
low complexity region
|
1307 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1356 |
1371 |
N/A |
INTRINSIC |
|
low complexity region
|
1393 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1465 |
1479 |
N/A |
INTRINSIC |
|
low complexity region
|
1553 |
1567 |
N/A |
INTRINSIC |
|
coiled coil region
|
1569 |
1656 |
N/A |
INTRINSIC |
|
low complexity region
|
1728 |
1739 |
N/A |
INTRINSIC |
|
coiled coil region
|
1780 |
1848 |
N/A |
INTRINSIC |
|
AAA
|
2032 |
2186 |
1.69e-5 |
SMART |
|
low complexity region
|
2343 |
2369 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184109
|
| SMART Domains |
Protein: ENSMUSP00000138846
Gene: ENSMUSG00000052512
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
154 |
171 |
N/A |
INTRINSIC |
|
low complexity region
|
179 |
196 |
N/A |
INTRINSIC |
|
low complexity region
|
228 |
243 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184544
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000184945
AA Change: R1470*
|
| SMART Domains |
Protein: ENSMUSP00000139045
Gene: ENSMUSG00000052512
AA Change: R1470*
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
84 |
187 |
1.58e-13 |
SMART |
|
low complexity region
|
202 |
210 |
N/A |
INTRINSIC |
|
low complexity region
|
297 |
310 |
N/A |
INTRINSIC |
|
low complexity region
|
337 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
412 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
486 |
516 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
591 |
N/A |
INTRINSIC |
|
low complexity region
|
613 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
640 |
662 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
947 |
967 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1004 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1074 |
N/A |
INTRINSIC |
|
low complexity region
|
1343 |
1360 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1385 |
N/A |
INTRINSIC |
|
low complexity region
|
1417 |
1432 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1526 |
1540 |
N/A |
INTRINSIC |
|
low complexity region
|
1614 |
1628 |
N/A |
INTRINSIC |
|
coiled coil region
|
1630 |
1717 |
N/A |
INTRINSIC |
|
low complexity region
|
1789 |
1800 |
N/A |
INTRINSIC |
|
coiled coil region
|
1841 |
1909 |
N/A |
INTRINSIC |
|
AAA
|
2093 |
2247 |
1.69e-5 |
SMART |
|
low complexity region
|
2404 |
2430 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.2%
- 10x: 95.7%
- 20x: 90.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous null mice display impaired olfaction and hearing, increased latency in a hot plate test, degeneration of the optic nerve, decreased exploration in new environments, and weight loss. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 117 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
G |
3: 137,775,433 (GRCm39) |
T1541A |
probably benign |
Het |
| 9530002B09Rik |
T |
C |
4: 122,594,285 (GRCm39) |
M59T |
probably benign |
Het |
| Adam18 |
C |
T |
8: 25,131,827 (GRCm39) |
C428Y |
probably damaging |
Het |
| Adcy5 |
A |
G |
16: 35,098,872 (GRCm39) |
E700G |
possibly damaging |
Het |
| Adprh |
G |
T |
16: 38,266,142 (GRCm39) |
Y333* |
probably null |
Het |
| Agfg2 |
C |
A |
5: 137,665,439 (GRCm39) |
|
probably null |
Het |
| Akip1 |
A |
T |
7: 109,310,961 (GRCm39) |
E167V |
probably damaging |
Het |
| Akr1c21 |
A |
T |
13: 4,630,304 (GRCm39) |
Q199L |
probably damaging |
Het |
| Aldh9a1 |
C |
A |
1: 167,193,358 (GRCm39) |
A455E |
probably damaging |
Het |
| Amph |
G |
A |
13: 19,321,869 (GRCm39) |
S520N |
probably benign |
Het |
| Ankrd52 |
A |
G |
10: 128,226,376 (GRCm39) |
D1006G |
probably benign |
Het |
| Ap5z1 |
A |
C |
5: 142,453,431 (GRCm39) |
Q133P |
probably damaging |
Het |
| Babam1 |
C |
T |
8: 71,857,032 (GRCm39) |
A331V |
possibly damaging |
Het |
| Btc |
T |
C |
5: 91,510,160 (GRCm39) |
|
probably null |
Het |
| Cacna2d3 |
A |
G |
14: 28,704,289 (GRCm39) |
F831L |
probably benign |
Het |
| Cadm3 |
G |
A |
1: 173,164,664 (GRCm39) |
P372L |
probably damaging |
Het |
| Capn5 |
A |
T |
7: 97,775,624 (GRCm39) |
M439K |
probably damaging |
Het |
| Carf |
T |
C |
1: 60,189,796 (GRCm39) |
S639P |
probably damaging |
Het |
| Casp12 |
C |
T |
9: 5,352,250 (GRCm39) |
R81C |
probably benign |
Het |
| Ces2e |
G |
T |
8: 105,660,330 (GRCm39) |
R555M |
probably benign |
Het |
| Cfap54 |
T |
A |
10: 92,902,661 (GRCm39) |
I164F |
probably benign |
Het |
| Cltc |
C |
T |
11: 86,598,327 (GRCm39) |
V1012I |
probably damaging |
Het |
| Cmya5 |
G |
A |
13: 93,232,295 (GRCm39) |
T931I |
possibly damaging |
Het |
| Cntn6 |
A |
G |
6: 104,751,435 (GRCm39) |
I364V |
probably damaging |
Het |
| Cntnap1 |
A |
T |
11: 101,068,251 (GRCm39) |
I59F |
possibly damaging |
Het |
| Cop1 |
T |
C |
1: 159,067,167 (GRCm39) |
M80T |
probably damaging |
Het |
| Cplx2 |
A |
G |
13: 54,527,460 (GRCm39) |
S115G |
possibly damaging |
Het |
| Crtac1 |
A |
G |
19: 42,307,179 (GRCm39) |
Y195H |
probably damaging |
Het |
| Csn1s2a |
A |
C |
5: 87,929,697 (GRCm39) |
S99R |
possibly damaging |
Het |
| Csn1s2b |
T |
A |
5: 87,961,820 (GRCm39) |
D41E |
possibly damaging |
Het |
| Cul9 |
C |
T |
17: 46,849,451 (GRCm39) |
D565N |
probably damaging |
Het |
| Cux1 |
A |
T |
5: 136,340,410 (GRCm39) |
N625K |
possibly damaging |
Het |
| Cyp2c37 |
A |
T |
19: 40,000,206 (GRCm39) |
M443L |
possibly damaging |
Het |
| Cyp2s1 |
G |
A |
7: 25,508,710 (GRCm39) |
T244I |
possibly damaging |
Het |
| Dgkh |
C |
T |
14: 78,861,861 (GRCm39) |
V135M |
probably damaging |
Het |
| Dtl |
T |
C |
1: 191,278,677 (GRCm39) |
E395G |
possibly damaging |
Het |
| Dyrk1a |
G |
T |
16: 94,492,854 (GRCm39) |
G658* |
probably null |
Het |
| Erlin2 |
T |
C |
8: 27,519,623 (GRCm39) |
F117S |
probably damaging |
Het |
| Fkbp8 |
A |
G |
8: 70,984,173 (GRCm39) |
|
probably null |
Het |
| Fras1 |
T |
C |
5: 96,874,439 (GRCm39) |
F2288S |
possibly damaging |
Het |
| Frmd3 |
A |
G |
4: 74,071,837 (GRCm39) |
T240A |
probably damaging |
Het |
| H2-D1 |
A |
G |
17: 35,482,881 (GRCm39) |
Y137C |
probably damaging |
Het |
| Helz2 |
A |
G |
2: 180,882,709 (GRCm39) |
V28A |
possibly damaging |
Het |
| Hydin |
A |
G |
8: 111,124,727 (GRCm39) |
I579V |
probably benign |
Het |
| Il6 |
A |
T |
5: 30,218,491 (GRCm39) |
Y29F |
possibly damaging |
Het |
| Ildr2 |
A |
G |
1: 166,135,409 (GRCm39) |
D368G |
probably damaging |
Het |
| Junb |
T |
A |
8: 85,704,788 (GRCm39) |
I91F |
probably damaging |
Het |
| Kat2a |
C |
A |
11: 100,603,029 (GRCm39) |
|
probably benign |
Het |
| Kat2a |
A |
T |
11: 100,603,030 (GRCm39) |
|
probably benign |
Het |
| Kcnh5 |
T |
A |
12: 75,011,925 (GRCm39) |
T665S |
probably benign |
Het |
| Kdm1b |
A |
T |
13: 47,227,843 (GRCm39) |
D608V |
probably damaging |
Het |
| Krcc1 |
A |
G |
6: 71,261,621 (GRCm39) |
K218E |
probably damaging |
Het |
| Krt8 |
C |
T |
15: 101,905,386 (GRCm39) |
V488M |
probably benign |
Het |
| Lzts1 |
C |
T |
8: 69,591,414 (GRCm39) |
A245T |
probably benign |
Het |
| Mcm6 |
T |
A |
1: 128,287,223 (GRCm39) |
Q27L |
probably damaging |
Het |
| Mfsd4b3-ps |
G |
T |
10: 39,823,686 (GRCm39) |
Y191* |
probably null |
Het |
| Mgme1 |
C |
T |
2: 144,118,324 (GRCm39) |
Q199* |
probably null |
Het |
| Mgme1 |
T |
C |
2: 144,121,540 (GRCm39) |
L332P |
probably benign |
Het |
| Morc3 |
G |
T |
16: 93,657,475 (GRCm39) |
E25* |
probably null |
Het |
| Mroh7 |
G |
A |
4: 106,548,184 (GRCm39) |
A1098V |
possibly damaging |
Het |
| Mtrf1 |
G |
A |
14: 79,644,027 (GRCm39) |
R174H |
probably benign |
Het |
| Mybpc3 |
G |
A |
2: 90,949,592 (GRCm39) |
G45D |
possibly damaging |
Het |
| Mycbpap |
A |
T |
11: 94,395,764 (GRCm39) |
N733K |
probably damaging |
Het |
| N4bp1 |
T |
C |
8: 87,578,314 (GRCm39) |
I684V |
possibly damaging |
Het |
| Ndufa9 |
A |
T |
6: 126,799,026 (GRCm39) |
S364T |
probably benign |
Het |
| Nipal4 |
C |
A |
11: 46,052,837 (GRCm39) |
A43S |
possibly damaging |
Het |
| Nlrp1a |
T |
A |
11: 70,983,141 (GRCm39) |
Y1275F |
possibly damaging |
Het |
| Nova1 |
A |
T |
12: 46,767,618 (GRCm39) |
L8* |
probably null |
Het |
| Odam |
G |
T |
5: 88,037,967 (GRCm39) |
G181* |
probably null |
Het |
| Optn |
T |
A |
2: 5,026,190 (GRCm39) |
Q576L |
probably benign |
Het |
| Or2c1 |
T |
C |
16: 3,657,434 (GRCm39) |
L199P |
probably damaging |
Het |
| Or4k47 |
T |
C |
2: 111,451,879 (GRCm39) |
D180G |
probably damaging |
Het |
| Or4l1 |
C |
T |
14: 50,166,354 (GRCm39) |
V216I |
probably benign |
Het |
| Or51a39 |
A |
T |
7: 102,362,702 (GRCm39) |
I306N |
probably damaging |
Het |
| Or5as1 |
T |
A |
2: 86,981,003 (GRCm39) |
M1L |
possibly damaging |
Het |
| Or5h18 |
A |
T |
16: 58,847,696 (GRCm39) |
D191E |
probably damaging |
Het |
| Or8s2 |
T |
C |
15: 98,277,030 (GRCm39) |
|
probably benign |
Het |
| Patl2 |
G |
T |
2: 121,959,329 (GRCm39) |
S45* |
probably null |
Het |
| Pde2a |
G |
A |
7: 101,152,140 (GRCm39) |
G349E |
probably benign |
Het |
| Pdlim2 |
T |
A |
14: 70,405,464 (GRCm39) |
|
probably benign |
Het |
| Per1 |
T |
C |
11: 68,995,227 (GRCm39) |
V653A |
probably benign |
Het |
| Phlda2 |
A |
G |
7: 143,056,005 (GRCm39) |
S75P |
probably damaging |
Het |
| Poldip3 |
A |
T |
15: 83,021,706 (GRCm39) |
M167K |
possibly damaging |
Het |
| Potegl |
C |
A |
2: 23,135,127 (GRCm39) |
T312K |
probably benign |
Het |
| Prpf38a |
T |
C |
4: 108,436,278 (GRCm39) |
I12V |
probably benign |
Het |
| Prrc1 |
G |
A |
18: 57,507,622 (GRCm39) |
V259I |
possibly damaging |
Het |
| Ptges3l |
A |
T |
11: 101,315,448 (GRCm39) |
M1K |
probably null |
Het |
| Rdh5 |
A |
G |
10: 128,749,653 (GRCm39) |
Y296H |
probably damaging |
Het |
| Resf1 |
G |
T |
6: 149,229,896 (GRCm39) |
G981* |
probably null |
Het |
| Rnf2 |
T |
A |
1: 151,348,968 (GRCm39) |
K51* |
probably null |
Het |
| Rpusd3 |
C |
A |
6: 113,393,809 (GRCm39) |
R215L |
probably benign |
Het |
| Rsph4a |
A |
T |
10: 33,785,236 (GRCm39) |
E382D |
probably damaging |
Het |
| S1pr2 |
G |
A |
9: 20,879,745 (GRCm39) |
Q28* |
probably null |
Het |
| Sesn1 |
A |
T |
10: 41,771,005 (GRCm39) |
I179F |
probably damaging |
Het |
| Setd3 |
T |
A |
12: 108,079,630 (GRCm39) |
E291V |
probably benign |
Het |
| Shc1 |
G |
T |
3: 89,334,303 (GRCm39) |
R323L |
probably damaging |
Het |
| Slc22a5 |
T |
C |
11: 53,782,352 (GRCm39) |
D5G |
possibly damaging |
Het |
| Slc6a19 |
T |
C |
13: 73,848,677 (GRCm39) |
K26E |
probably benign |
Het |
| Slc9a3 |
A |
G |
13: 74,312,412 (GRCm39) |
N670D |
possibly damaging |
Het |
| Spata19 |
A |
T |
9: 27,311,761 (GRCm39) |
I127L |
probably benign |
Het |
| Speg |
G |
T |
1: 75,404,347 (GRCm39) |
V2751L |
probably damaging |
Het |
| Sptbn2 |
A |
G |
19: 4,779,337 (GRCm39) |
D298G |
probably benign |
Het |
| Srm |
T |
C |
4: 148,678,640 (GRCm39) |
V289A |
possibly damaging |
Het |
| Stip1 |
C |
T |
19: 7,012,938 (GRCm39) |
A49T |
probably benign |
Het |
| Tas2r118 |
C |
A |
6: 23,969,627 (GRCm39) |
V145F |
probably benign |
Het |
| Tbc1d12 |
A |
T |
19: 38,854,169 (GRCm39) |
K284* |
probably null |
Het |
| Tfcp2 |
T |
C |
15: 100,423,531 (GRCm39) |
H125R |
probably damaging |
Het |
| Tfdp1 |
T |
C |
8: 13,423,073 (GRCm39) |
V206A |
probably damaging |
Het |
| Tgtp2 |
A |
G |
11: 48,950,237 (GRCm39) |
W112R |
probably damaging |
Het |
| Tmem71 |
T |
G |
15: 66,410,710 (GRCm39) |
M221L |
probably benign |
Het |
| Tpcn1 |
T |
C |
5: 120,685,552 (GRCm39) |
N436S |
possibly damaging |
Het |
| Usp4 |
C |
T |
9: 108,239,819 (GRCm39) |
L183F |
probably damaging |
Het |
| Vmn2r55 |
A |
T |
7: 12,404,478 (GRCm39) |
N308K |
possibly damaging |
Het |
| Zfp106 |
T |
A |
2: 120,364,400 (GRCm39) |
D669V |
probably damaging |
Het |
| Zfp108 |
A |
T |
7: 23,959,573 (GRCm39) |
I55L |
probably benign |
Het |
| Zfp512b |
A |
T |
2: 181,228,131 (GRCm39) |
S8R |
probably damaging |
Het |
| Zfp827 |
T |
C |
8: 79,787,910 (GRCm39) |
S359P |
probably benign |
Het |
|
| Other mutations in Nav2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Nav2
|
APN |
7 |
49,220,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01150:Nav2
|
APN |
7 |
49,102,269 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01649:Nav2
|
APN |
7 |
49,225,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01662:Nav2
|
APN |
7 |
49,220,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02297:Nav2
|
APN |
7 |
49,243,977 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02313:Nav2
|
APN |
7 |
49,208,521 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02441:Nav2
|
APN |
7 |
49,102,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02472:Nav2
|
APN |
7 |
49,195,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02477:Nav2
|
APN |
7 |
49,232,623 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02725:Nav2
|
APN |
7 |
49,214,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02944:Nav2
|
APN |
7 |
49,070,004 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02953:Nav2
|
APN |
7 |
49,198,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03105:Nav2
|
APN |
7 |
49,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03234:Nav2
|
APN |
7 |
49,111,756 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03274:Nav2
|
APN |
7 |
49,011,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03294:Nav2
|
APN |
7 |
49,141,205 (GRCm39) |
nonsense |
probably null |
|
|
R0006:Nav2
|
UTSW |
7 |
49,102,978 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R0070:Nav2
|
UTSW |
7 |
49,220,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0113:Nav2
|
UTSW |
7 |
49,185,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0306:Nav2
|
UTSW |
7 |
49,195,651 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0346:Nav2
|
UTSW |
7 |
49,254,333 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0539:Nav2
|
UTSW |
7 |
49,111,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0669:Nav2
|
UTSW |
7 |
49,058,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0785:Nav2
|
UTSW |
7 |
49,070,081 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0970:Nav2
|
UTSW |
7 |
49,233,901 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1162:Nav2
|
UTSW |
7 |
49,185,788 (GRCm39) |
splice site |
probably benign |
|
|
R1274:Nav2
|
UTSW |
7 |
49,254,178 (GRCm39) |
nonsense |
probably null |
|
|
R1463:Nav2
|
UTSW |
7 |
49,185,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1464:Nav2
|
UTSW |
7 |
49,011,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1464:Nav2
|
UTSW |
7 |
49,011,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1536:Nav2
|
UTSW |
7 |
49,195,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1612:Nav2
|
UTSW |
7 |
49,220,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Nav2
|
UTSW |
7 |
49,102,213 (GRCm39) |
missense |
probably benign |
|
|
R1731:Nav2
|
UTSW |
7 |
49,197,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1734:Nav2
|
UTSW |
7 |
49,225,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1865:Nav2
|
UTSW |
7 |
49,197,943 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1945:Nav2
|
UTSW |
7 |
49,114,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1997:Nav2
|
UTSW |
7 |
49,198,219 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2061:Nav2
|
UTSW |
7 |
49,248,645 (GRCm39) |
splice site |
probably benign |
|
|
R2117:Nav2
|
UTSW |
7 |
49,114,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2174:Nav2
|
UTSW |
7 |
49,102,411 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2182:Nav2
|
UTSW |
7 |
49,247,002 (GRCm39) |
missense |
probably benign |
0.38 |
|
R2251:Nav2
|
UTSW |
7 |
49,103,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2283:Nav2
|
UTSW |
7 |
49,141,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2343:Nav2
|
UTSW |
7 |
49,248,565 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R2472:Nav2
|
UTSW |
7 |
49,058,632 (GRCm39) |
missense |
probably benign |
|
|
R2568:Nav2
|
UTSW |
7 |
49,247,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2656:Nav2
|
UTSW |
7 |
49,195,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2964:Nav2
|
UTSW |
7 |
49,206,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2966:Nav2
|
UTSW |
7 |
49,206,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3817:Nav2
|
UTSW |
7 |
49,114,310 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3834:Nav2
|
UTSW |
7 |
49,195,606 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4207:Nav2
|
UTSW |
7 |
49,246,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4207:Nav2
|
UTSW |
7 |
49,222,046 (GRCm39) |
splice site |
probably null |
|
|
R4411:Nav2
|
UTSW |
7 |
49,047,857 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4413:Nav2
|
UTSW |
7 |
49,047,857 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4440:Nav2
|
UTSW |
7 |
49,225,011 (GRCm39) |
splice site |
probably benign |
|
|
R4440:Nav2
|
UTSW |
7 |
49,201,785 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4454:Nav2
|
UTSW |
7 |
49,198,292 (GRCm39) |
splice site |
probably null |
|
|
R4729:Nav2
|
UTSW |
7 |
49,102,567 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4801:Nav2
|
UTSW |
7 |
49,195,600 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4802:Nav2
|
UTSW |
7 |
49,195,600 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4824:Nav2
|
UTSW |
7 |
49,058,749 (GRCm39) |
intron |
probably benign |
|
|
R4887:Nav2
|
UTSW |
7 |
49,198,182 (GRCm39) |
nonsense |
probably null |
|
|
R4908:Nav2
|
UTSW |
7 |
49,254,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4952:Nav2
|
UTSW |
7 |
48,954,288 (GRCm39) |
intron |
probably benign |
|
|
R5169:Nav2
|
UTSW |
7 |
49,198,231 (GRCm39) |
nonsense |
probably null |
|
|
R5224:Nav2
|
UTSW |
7 |
49,201,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5249:Nav2
|
UTSW |
7 |
49,185,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5285:Nav2
|
UTSW |
7 |
49,197,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5314:Nav2
|
UTSW |
7 |
49,058,440 (GRCm39) |
small deletion |
probably benign |
|
|
R5320:Nav2
|
UTSW |
7 |
49,141,121 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5377:Nav2
|
UTSW |
7 |
49,238,908 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5471:Nav2
|
UTSW |
7 |
49,197,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5754:Nav2
|
UTSW |
7 |
49,206,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Nav2
|
UTSW |
7 |
49,197,817 (GRCm39) |
splice site |
probably null |
|
|
R5884:Nav2
|
UTSW |
7 |
49,246,917 (GRCm39) |
nonsense |
probably null |
|
|
R5921:Nav2
|
UTSW |
7 |
48,954,324 (GRCm39) |
intron |
probably benign |
|
|
R6180:Nav2
|
UTSW |
7 |
49,107,915 (GRCm39) |
missense |
probably benign |
0.39 |
|
R6208:Nav2
|
UTSW |
7 |
49,213,851 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6373:Nav2
|
UTSW |
7 |
49,102,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6450:Nav2
|
UTSW |
7 |
49,244,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6522:Nav2
|
UTSW |
7 |
49,247,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6626:Nav2
|
UTSW |
7 |
49,244,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6695:Nav2
|
UTSW |
7 |
49,114,652 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6705:Nav2
|
UTSW |
7 |
49,201,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6842:Nav2
|
UTSW |
7 |
49,107,917 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6847:Nav2
|
UTSW |
7 |
49,141,204 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7287:Nav2
|
UTSW |
7 |
49,070,076 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7312:Nav2
|
UTSW |
7 |
49,111,672 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7315:Nav2
|
UTSW |
7 |
49,198,037 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7337:Nav2
|
UTSW |
7 |
49,201,521 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7366:Nav2
|
UTSW |
7 |
49,203,951 (GRCm39) |
splice site |
probably null |
|
|
R7451:Nav2
|
UTSW |
7 |
49,202,577 (GRCm39) |
splice site |
probably null |
|
|
R7545:Nav2
|
UTSW |
7 |
49,232,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7706:Nav2
|
UTSW |
7 |
49,244,067 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7730:Nav2
|
UTSW |
7 |
49,222,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7812:Nav2
|
UTSW |
7 |
49,246,921 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8097:Nav2
|
UTSW |
7 |
49,237,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8110:Nav2
|
UTSW |
7 |
49,201,698 (GRCm39) |
nonsense |
probably null |
|
|
R8119:Nav2
|
UTSW |
7 |
49,103,232 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8298:Nav2
|
UTSW |
7 |
49,204,009 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8306:Nav2
|
UTSW |
7 |
49,195,765 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8331:Nav2
|
UTSW |
7 |
49,102,371 (GRCm39) |
missense |
probably benign |
|
|
R8402:Nav2
|
UTSW |
7 |
49,103,185 (GRCm39) |
missense |
probably benign |
0.43 |
|
R8421:Nav2
|
UTSW |
7 |
49,102,269 (GRCm39) |
missense |
probably benign |
|
|
R8478:Nav2
|
UTSW |
7 |
49,111,733 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8724:Nav2
|
UTSW |
7 |
49,141,184 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8753:Nav2
|
UTSW |
7 |
49,102,320 (GRCm39) |
missense |
probably benign |
|
|
R8835:Nav2
|
UTSW |
7 |
49,248,551 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8933:Nav2
|
UTSW |
7 |
49,111,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8957:Nav2
|
UTSW |
7 |
49,220,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9069:Nav2
|
UTSW |
7 |
49,208,561 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9095:Nav2
|
UTSW |
7 |
49,254,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Nav2
|
UTSW |
7 |
49,202,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9261:Nav2
|
UTSW |
7 |
49,246,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Nav2
|
UTSW |
7 |
49,197,647 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
Z1177:Nav2
|
UTSW |
7 |
49,243,971 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Nav2
|
UTSW |
7 |
49,102,509 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCAGTCTGCTACAGTCTTGGG -3'
(R):5'- TTTAGCAGACAGTGGAGCAG -3'
Sequencing Primer
(F):5'- CTGCTACAGTCTTGGGGTGTGTC -3'
(R):5'- AGCAGGTCCTCACTGGCATG -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation