Incidental Mutation 'R0401:Jmjd1c'
| ID |
38227 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Jmjd1c
|
| Ensembl Gene |
ENSMUSG00000037876 |
| Gene Name |
jumonji domain containing 1C |
| Synonyms |
D630035I23Rik, TRIP8, 5430433L24Rik |
| MMRRC Submission |
038606-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.655)
|
| Stock # |
R0401 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
66932189-67092105 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 67056161 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Histidine
at position 527
(R527H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134246
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051446]
[ENSMUST00000173689]
[ENSMUST00000174317]
[ENSMUST00000174408]
|
| AlphaFold |
Q69ZK6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000051446
AA Change: R814H
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000056227
Gene: ENSMUSG00000037876
AA Change: R814H
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2236 |
N/A |
BLAST |
|
JmjC
|
2264 |
2488 |
3.29e-53 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173187
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173661
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173689
AA Change: R633H
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000133700
Gene: ENSMUSG00000037876
AA Change: R633H
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
1 |
2056 |
N/A |
BLAST |
|
JmjC
|
2084 |
2308 |
3.29e-53 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000174317
AA Change: R527H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000134246
Gene: ENSMUSG00000037876
AA Change: R527H
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
1 |
744 |
N/A |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000174408
AA Change: R814H
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000134551
Gene: ENSMUSG00000037876
AA Change: R814H
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2237 |
N/A |
BLAST |
|
JmjC
|
2265 |
2489 |
3.29e-53 |
SMART |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.6%
|
| Validation Efficiency |
98% (90/92) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit an age-dependent male infertility phenotype, characterized by early loss of undifferentiated spermatogonia, and a progressive reduction in testis size/weight and male germ cells, partly due to increased male germ cell apoptosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
T |
3: 137,776,067 (GRCm39) |
H1752L |
possibly damaging |
Het |
| Abcc5 |
T |
C |
16: 20,195,308 (GRCm39) |
K730E |
probably benign |
Het |
| Ahnak |
A |
G |
19: 8,992,480 (GRCm39) |
D4588G |
probably benign |
Het |
| AI467606 |
G |
A |
7: 126,691,608 (GRCm39) |
R61H |
probably damaging |
Het |
| Apoa4 |
T |
A |
9: 46,154,356 (GRCm39) |
V319E |
probably damaging |
Het |
| Ark2n |
C |
A |
18: 77,761,658 (GRCm39) |
S218I |
probably damaging |
Het |
| Atad5 |
T |
A |
11: 80,011,525 (GRCm39) |
D1297E |
probably benign |
Het |
| BC005624 |
G |
A |
2: 30,870,021 (GRCm39) |
T62I |
probably benign |
Het |
| Bcl6 |
T |
C |
16: 23,791,344 (GRCm39) |
K337E |
probably damaging |
Het |
| Cad |
T |
A |
5: 31,231,330 (GRCm39) |
|
probably benign |
Het |
| Ccdc73 |
T |
C |
2: 104,821,634 (GRCm39) |
S528P |
probably benign |
Het |
| Ccng2 |
T |
G |
5: 93,421,272 (GRCm39) |
C261G |
possibly damaging |
Het |
| Cdh11 |
A |
T |
8: 103,400,638 (GRCm39) |
I110N |
probably damaging |
Het |
| Cgnl1 |
A |
G |
9: 71,612,521 (GRCm39) |
V767A |
probably damaging |
Het |
| Cit |
A |
G |
5: 116,123,538 (GRCm39) |
T1460A |
probably benign |
Het |
| Clec4b2 |
C |
T |
6: 123,158,259 (GRCm39) |
Q42* |
probably null |
Het |
| Clip1 |
A |
G |
5: 123,791,852 (GRCm39) |
V106A |
probably damaging |
Het |
| Crb1 |
T |
C |
1: 139,126,529 (GRCm39) |
|
probably benign |
Het |
| Cts6 |
T |
C |
13: 61,346,153 (GRCm39) |
|
probably benign |
Het |
| Cul9 |
T |
C |
17: 46,852,630 (GRCm39) |
E244G |
probably damaging |
Het |
| Dcaf8l |
C |
A |
X: 88,448,815 (GRCm39) |
R438L |
probably benign |
Het |
| Ddx55 |
A |
T |
5: 124,706,014 (GRCm39) |
I480F |
probably damaging |
Het |
| Dixdc1 |
A |
G |
9: 50,604,974 (GRCm39) |
S17P |
possibly damaging |
Het |
| Drosha |
T |
A |
15: 12,926,117 (GRCm39) |
Y1235* |
probably null |
Het |
| Dsg2 |
G |
T |
18: 20,725,565 (GRCm39) |
|
probably benign |
Het |
| E2f5 |
T |
C |
3: 14,644,085 (GRCm39) |
|
probably null |
Het |
| Epc2 |
A |
G |
2: 49,418,986 (GRCm39) |
T265A |
probably damaging |
Het |
| Etaa1 |
T |
G |
11: 17,897,514 (GRCm39) |
D201A |
probably damaging |
Het |
| Fancd2 |
T |
C |
6: 113,525,304 (GRCm39) |
I260T |
possibly damaging |
Het |
| Fhdc1 |
G |
A |
3: 84,351,931 (GRCm39) |
A1098V |
probably benign |
Het |
| Gpd2 |
G |
A |
2: 57,230,105 (GRCm39) |
V286I |
possibly damaging |
Het |
| Gpr141b |
A |
T |
13: 19,913,664 (GRCm39) |
|
noncoding transcript |
Het |
| H2-T9 |
C |
T |
17: 36,439,597 (GRCm39) |
V128M |
probably damaging |
Het |
| Herc2 |
A |
C |
7: 55,807,480 (GRCm39) |
E2523A |
probably damaging |
Het |
| Irag1 |
G |
A |
7: 110,476,104 (GRCm39) |
P757S |
probably benign |
Het |
| Kif12 |
G |
A |
4: 63,087,762 (GRCm39) |
|
probably benign |
Het |
| Lrp2 |
A |
T |
2: 69,309,492 (GRCm39) |
N2802K |
probably damaging |
Het |
| Mab21l2 |
C |
G |
3: 86,454,296 (GRCm39) |
G235R |
probably benign |
Het |
| Mapk8 |
T |
C |
14: 33,104,165 (GRCm39) |
E417G |
probably benign |
Het |
| Mapk8ip3 |
G |
A |
17: 25,128,145 (GRCm39) |
|
probably benign |
Het |
| Mettl1 |
A |
G |
10: 126,880,946 (GRCm39) |
T203A |
probably benign |
Het |
| Mettl9 |
T |
C |
7: 120,675,536 (GRCm39) |
V312A |
probably damaging |
Het |
| Mex3d |
A |
G |
10: 80,222,728 (GRCm39) |
V176A |
probably benign |
Het |
| Mmp3 |
T |
C |
9: 7,449,790 (GRCm39) |
S225P |
probably damaging |
Het |
| Neb |
G |
A |
2: 52,078,689 (GRCm39) |
|
probably benign |
Het |
| Ninj2 |
C |
T |
6: 120,175,012 (GRCm39) |
A51V |
possibly damaging |
Het |
| Nle1 |
A |
G |
11: 82,796,205 (GRCm39) |
|
probably benign |
Het |
| Nol9 |
T |
C |
4: 152,137,062 (GRCm39) |
Y532H |
probably benign |
Het |
| Nr2c1 |
T |
A |
10: 94,007,020 (GRCm39) |
V286E |
probably benign |
Het |
| Or4b1b |
A |
T |
2: 90,112,748 (GRCm39) |
M57K |
probably damaging |
Het |
| Or4c31 |
T |
G |
2: 88,292,269 (GRCm39) |
L195R |
probably damaging |
Het |
| Or52e18 |
T |
A |
7: 104,609,150 (GRCm39) |
H263L |
probably damaging |
Het |
| Or5p4 |
T |
A |
7: 107,680,079 (GRCm39) |
I26N |
possibly damaging |
Het |
| Or6c69 |
A |
G |
10: 129,747,785 (GRCm39) |
Y121H |
probably benign |
Het |
| Or6f1 |
T |
C |
7: 85,970,500 (GRCm39) |
Y220C |
probably benign |
Het |
| Or9k7 |
A |
G |
10: 130,046,489 (GRCm39) |
L170P |
probably damaging |
Het |
| Ovch2 |
A |
T |
7: 107,400,343 (GRCm39) |
V15D |
probably damaging |
Het |
| Pate8 |
G |
T |
9: 36,493,924 (GRCm39) |
A3E |
unknown |
Het |
| Pclo |
T |
G |
5: 14,731,748 (GRCm39) |
S3417A |
unknown |
Het |
| Pex1 |
T |
A |
5: 3,683,759 (GRCm39) |
M1085K |
probably damaging |
Het |
| Plscr2 |
T |
C |
9: 92,164,188 (GRCm39) |
S6P |
probably benign |
Het |
| Pogz |
C |
T |
3: 94,784,336 (GRCm39) |
P722S |
possibly damaging |
Het |
| Pom121l2 |
A |
T |
13: 22,166,395 (GRCm39) |
D222V |
probably benign |
Het |
| Prpf40a |
T |
C |
2: 53,049,325 (GRCm39) |
Y179C |
probably damaging |
Het |
| R3hdm2 |
A |
G |
10: 127,294,042 (GRCm39) |
I179V |
possibly damaging |
Het |
| Ranbp9 |
A |
C |
13: 43,576,134 (GRCm39) |
V355G |
probably damaging |
Het |
| Rims2 |
T |
C |
15: 39,373,028 (GRCm39) |
|
probably benign |
Het |
| Ryr2 |
A |
T |
13: 11,720,570 (GRCm39) |
S2693T |
probably benign |
Het |
| Sbno1 |
G |
A |
5: 124,548,348 (GRCm39) |
T111I |
probably damaging |
Het |
| Sdk1 |
A |
C |
5: 142,031,916 (GRCm39) |
N997T |
possibly damaging |
Het |
| Setx |
G |
T |
2: 29,056,301 (GRCm39) |
E39* |
probably null |
Het |
| Skint7 |
T |
A |
4: 111,837,559 (GRCm39) |
N112K |
probably damaging |
Het |
| Slc35e1 |
T |
C |
8: 73,246,415 (GRCm39) |
|
probably benign |
Het |
| Slc4a10 |
A |
T |
2: 62,021,192 (GRCm39) |
D80V |
probably benign |
Het |
| Susd2 |
C |
A |
10: 75,474,437 (GRCm39) |
|
probably benign |
Het |
| Tcam1 |
G |
A |
11: 106,174,904 (GRCm39) |
E120K |
probably benign |
Het |
| Tcf3 |
G |
T |
10: 80,256,992 (GRCm39) |
S77R |
probably damaging |
Het |
| Tdpoz3 |
T |
C |
3: 93,733,672 (GRCm39) |
Y116H |
probably benign |
Het |
| Tex26 |
C |
A |
5: 149,384,323 (GRCm39) |
D164E |
probably benign |
Het |
| Thoc5 |
G |
A |
11: 4,852,213 (GRCm39) |
|
probably benign |
Het |
| Tiparp |
A |
G |
3: 65,438,857 (GRCm39) |
R58G |
probably benign |
Het |
| Trim66 |
A |
T |
7: 109,074,471 (GRCm39) |
C597S |
probably damaging |
Het |
| Ugt2a3 |
T |
A |
5: 87,484,349 (GRCm39) |
Q225L |
probably benign |
Het |
| Vmn1r25 |
T |
A |
6: 57,955,696 (GRCm39) |
I198L |
probably benign |
Het |
| Vmn2r106 |
A |
T |
17: 20,499,281 (GRCm39) |
V210D |
possibly damaging |
Het |
| Vmn2r124 |
T |
C |
17: 18,284,407 (GRCm39) |
F483L |
probably damaging |
Het |
| Vmn2r78 |
A |
G |
7: 86,570,519 (GRCm39) |
K346E |
probably benign |
Het |
| Zfhx4 |
T |
A |
3: 5,466,221 (GRCm39) |
S2126R |
possibly damaging |
Het |
| Zfp608 |
C |
T |
18: 55,032,066 (GRCm39) |
G625R |
probably benign |
Het |
| Zkscan5 |
A |
G |
5: 145,149,385 (GRCm39) |
D234G |
probably damaging |
Het |
| Zscan10 |
T |
A |
17: 23,824,889 (GRCm39) |
V115E |
probably damaging |
Het |
|
| Other mutations in Jmjd1c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01062:Jmjd1c
|
APN |
10 |
67,062,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01604:Jmjd1c
|
APN |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01753:Jmjd1c
|
APN |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02081:Jmjd1c
|
APN |
10 |
67,055,305 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02128:Jmjd1c
|
APN |
10 |
67,079,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02134:Jmjd1c
|
APN |
10 |
67,056,171 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02215:Jmjd1c
|
APN |
10 |
67,056,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Jmjd1c
|
APN |
10 |
67,062,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02502:Jmjd1c
|
APN |
10 |
67,061,640 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02546:Jmjd1c
|
APN |
10 |
67,061,115 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02943:Jmjd1c
|
APN |
10 |
67,055,433 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03171:Jmjd1c
|
APN |
10 |
67,061,277 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03261:Jmjd1c
|
APN |
10 |
67,067,849 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Accordion
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Jmjd1c
|
UTSW |
10 |
67,065,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0126:Jmjd1c
|
UTSW |
10 |
67,055,105 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0133:Jmjd1c
|
UTSW |
10 |
67,076,587 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0201:Jmjd1c
|
UTSW |
10 |
67,054,888 (GRCm39) |
missense |
unknown |
|
|
R0396:Jmjd1c
|
UTSW |
10 |
67,055,302 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0452:Jmjd1c
|
UTSW |
10 |
67,091,261 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0488:Jmjd1c
|
UTSW |
10 |
67,076,506 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0504:Jmjd1c
|
UTSW |
10 |
67,061,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0555:Jmjd1c
|
UTSW |
10 |
67,061,568 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0673:Jmjd1c
|
UTSW |
10 |
67,062,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0718:Jmjd1c
|
UTSW |
10 |
67,054,725 (GRCm39) |
splice site |
probably null |
|
|
R0755:Jmjd1c
|
UTSW |
10 |
66,932,378 (GRCm39) |
intron |
probably benign |
|
|
R1142:Jmjd1c
|
UTSW |
10 |
67,061,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Jmjd1c
|
UTSW |
10 |
67,075,015 (GRCm39) |
splice site |
probably benign |
|
|
R1413:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1619:Jmjd1c
|
UTSW |
10 |
67,055,654 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1676:Jmjd1c
|
UTSW |
10 |
67,060,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1751:Jmjd1c
|
UTSW |
10 |
67,061,469 (GRCm39) |
missense |
probably benign |
|
|
R1950:Jmjd1c
|
UTSW |
10 |
67,075,701 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1968:Jmjd1c
|
UTSW |
10 |
67,061,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2049:Jmjd1c
|
UTSW |
10 |
66,993,777 (GRCm39) |
nonsense |
probably null |
|
|
R2061:Jmjd1c
|
UTSW |
10 |
67,054,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2203:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2256:Jmjd1c
|
UTSW |
10 |
67,061,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Jmjd1c
|
UTSW |
10 |
67,074,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2349:Jmjd1c
|
UTSW |
10 |
67,091,279 (GRCm39) |
missense |
probably benign |
|
|
R2392:Jmjd1c
|
UTSW |
10 |
67,065,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3015:Jmjd1c
|
UTSW |
10 |
66,993,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3110:Jmjd1c
|
UTSW |
10 |
67,075,863 (GRCm39) |
splice site |
probably benign |
|
|
R4043:Jmjd1c
|
UTSW |
10 |
67,055,245 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4097:Jmjd1c
|
UTSW |
10 |
67,054,787 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4118:Jmjd1c
|
UTSW |
10 |
67,055,532 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4193:Jmjd1c
|
UTSW |
10 |
66,932,460 (GRCm39) |
intron |
probably benign |
|
|
R4352:Jmjd1c
|
UTSW |
10 |
67,080,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4577:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4630:Jmjd1c
|
UTSW |
10 |
66,993,753 (GRCm39) |
nonsense |
probably null |
|
|
R4717:Jmjd1c
|
UTSW |
10 |
66,993,830 (GRCm39) |
nonsense |
probably null |
|
|
R4741:Jmjd1c
|
UTSW |
10 |
67,060,718 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R4774:Jmjd1c
|
UTSW |
10 |
67,060,571 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R4836:Jmjd1c
|
UTSW |
10 |
67,069,225 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4914:Jmjd1c
|
UTSW |
10 |
67,054,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4939:Jmjd1c
|
UTSW |
10 |
67,081,916 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5211:Jmjd1c
|
UTSW |
10 |
67,067,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5215:Jmjd1c
|
UTSW |
10 |
67,076,480 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5514:Jmjd1c
|
UTSW |
10 |
67,053,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5530:Jmjd1c
|
UTSW |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5624:Jmjd1c
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5640:Jmjd1c
|
UTSW |
10 |
67,061,857 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5654:Jmjd1c
|
UTSW |
10 |
67,065,785 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5742:Jmjd1c
|
UTSW |
10 |
67,056,112 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5764:Jmjd1c
|
UTSW |
10 |
67,062,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6118:Jmjd1c
|
UTSW |
10 |
67,075,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Jmjd1c
|
UTSW |
10 |
67,083,827 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6256:Jmjd1c
|
UTSW |
10 |
67,056,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6266:Jmjd1c
|
UTSW |
10 |
67,085,439 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6358:Jmjd1c
|
UTSW |
10 |
67,061,718 (GRCm39) |
missense |
probably benign |
|
|
R6430:Jmjd1c
|
UTSW |
10 |
67,059,939 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6455:Jmjd1c
|
UTSW |
10 |
67,061,795 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6887:Jmjd1c
|
UTSW |
10 |
67,025,599 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6895:Jmjd1c
|
UTSW |
10 |
67,052,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7041:Jmjd1c
|
UTSW |
10 |
67,056,388 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7095:Jmjd1c
|
UTSW |
10 |
67,055,411 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7113:Jmjd1c
|
UTSW |
10 |
66,993,780 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7225:Jmjd1c
|
UTSW |
10 |
67,061,844 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7249:Jmjd1c
|
UTSW |
10 |
67,025,596 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7361:Jmjd1c
|
UTSW |
10 |
67,054,143 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7383:Jmjd1c
|
UTSW |
10 |
67,025,537 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7460:Jmjd1c
|
UTSW |
10 |
67,052,815 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7475:Jmjd1c
|
UTSW |
10 |
67,061,092 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7502:Jmjd1c
|
UTSW |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7699:Jmjd1c
|
UTSW |
10 |
67,054,195 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7745:Jmjd1c
|
UTSW |
10 |
67,052,824 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7897:Jmjd1c
|
UTSW |
10 |
67,075,644 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Jmjd1c
|
UTSW |
10 |
67,061,621 (GRCm39) |
missense |
probably benign |
|
|
R7911:Jmjd1c
|
UTSW |
10 |
67,067,774 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7967:Jmjd1c
|
UTSW |
10 |
67,085,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Jmjd1c
|
UTSW |
10 |
67,090,274 (GRCm39) |
missense |
not run |
|
|
R8224:Jmjd1c
|
UTSW |
10 |
67,080,628 (GRCm39) |
missense |
noncoding transcript |
|
|
R8251:Jmjd1c
|
UTSW |
10 |
67,075,068 (GRCm39) |
missense |
noncoding transcript |
|
|
R8797:Jmjd1c
|
UTSW |
10 |
67,060,616 (GRCm39) |
missense |
probably benign |
|
|
R8833:Jmjd1c
|
UTSW |
10 |
67,054,162 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9262:Jmjd1c
|
UTSW |
10 |
67,083,793 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9354:Jmjd1c
|
UTSW |
10 |
67,059,875 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9373:Jmjd1c
|
UTSW |
10 |
66,932,495 (GRCm39) |
intron |
probably benign |
|
|
R9477:Jmjd1c
|
UTSW |
10 |
66,993,734 (GRCm39) |
nonsense |
probably null |
|
|
R9519:Jmjd1c
|
UTSW |
10 |
66,993,798 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9701:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9802:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
RF011:Jmjd1c
|
UTSW |
10 |
67,055,978 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
Z1088:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,081,904 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGTCAAGCTGTTGGTGAGCG -3'
(R):5'- ACTGCATTTTCTGGGTGAACCCAC -3'
Sequencing Primer
(F):5'- ATCCAGAGGTAGTTTCCATCCAG -3'
(R):5'- GGAGACCAAGTCCTGAGTATG -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation