Incidental Mutation 'R0243:Tnc'
| ID |
37840 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnc
|
| Ensembl Gene |
ENSMUSG00000028364 |
| Gene Name |
tenascin C |
| Synonyms |
cytotactin, C130033P17Rik, TN-C, hexabrachion, tenascin-C, Hxb, TN |
| MMRRC Submission |
038481-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0243 (G1)
|
| Quality Score |
152 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
63878022-63965252 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 63888657 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Lysine
at position 1803
(T1803K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000102995
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030056]
[ENSMUST00000107372]
[ENSMUST00000107377]
|
| AlphaFold |
Q80YX1 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000030056
AA Change: T1712K
PolyPhen 2
Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000030056
Gene: ENSMUSG00000028364
AA Change: T1712K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
121 |
138 |
N/A |
INTRINSIC |
|
EGF
|
189 |
217 |
1.87e1 |
SMART |
|
EGF_like
|
220 |
248 |
3.5e1 |
SMART |
|
EGF
|
251 |
280 |
4.89e0 |
SMART |
|
EGF
|
283 |
311 |
3.23e0 |
SMART |
|
EGF_like
|
314 |
342 |
2.98e1 |
SMART |
|
EGF
|
345 |
373 |
1.87e1 |
SMART |
|
EGF
|
376 |
404 |
3.97e0 |
SMART |
|
EGF
|
407 |
435 |
8.52e0 |
SMART |
|
EGF
|
438 |
466 |
3.01e0 |
SMART |
|
EGF
|
469 |
497 |
3.46e0 |
SMART |
|
EGF
|
500 |
528 |
3.71e0 |
SMART |
|
EGF
|
531 |
559 |
4.32e-1 |
SMART |
|
EGF
|
562 |
590 |
1.84e1 |
SMART |
|
EGF
|
593 |
621 |
3.82e-2 |
SMART |
|
FN3
|
623 |
701 |
8.9e-8 |
SMART |
|
FN3
|
712 |
794 |
1.53e-6 |
SMART |
|
FN3
|
803 |
884 |
7.23e-8 |
SMART |
|
FN3
|
893 |
974 |
1.71e-9 |
SMART |
|
FN3
|
985 |
1062 |
2.56e-8 |
SMART |
|
FN3
|
1074 |
1152 |
8.58e-1 |
SMART |
|
FN3
|
1165 |
1245 |
2.72e-3 |
SMART |
|
FN3
|
1256 |
1334 |
5.36e-2 |
SMART |
|
FN3
|
1347 |
1427 |
4.93e0 |
SMART |
|
FN3
|
1438 |
1517 |
3.4e-4 |
SMART |
|
FN3
|
1528 |
1606 |
1.55e-7 |
SMART |
|
FN3
|
1617 |
1694 |
1.53e-6 |
SMART |
|
FN3
|
1705 |
1782 |
7.75e-8 |
SMART |
|
FBG
|
1797 |
2007 |
4.08e-124 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107372
AA Change: T1803K
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000102995
Gene: ENSMUSG00000028364
AA Change: T1803K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
121 |
138 |
N/A |
INTRINSIC |
|
EGF
|
189 |
217 |
1.87e1 |
SMART |
|
EGF_like
|
220 |
248 |
3.5e1 |
SMART |
|
EGF
|
251 |
280 |
4.89e0 |
SMART |
|
EGF
|
283 |
311 |
3.23e0 |
SMART |
|
EGF_like
|
314 |
342 |
2.98e1 |
SMART |
|
EGF
|
345 |
373 |
1.87e1 |
SMART |
|
EGF
|
376 |
404 |
3.97e0 |
SMART |
|
EGF
|
407 |
435 |
8.52e0 |
SMART |
|
EGF
|
438 |
466 |
3.01e0 |
SMART |
|
EGF
|
469 |
497 |
3.46e0 |
SMART |
|
EGF
|
500 |
528 |
3.71e0 |
SMART |
|
EGF
|
531 |
559 |
4.32e-1 |
SMART |
|
EGF
|
562 |
590 |
1.84e1 |
SMART |
|
EGF
|
593 |
621 |
3.82e-2 |
SMART |
|
FN3
|
623 |
701 |
8.9e-8 |
SMART |
|
FN3
|
712 |
794 |
1.53e-6 |
SMART |
|
FN3
|
803 |
884 |
7.23e-8 |
SMART |
|
FN3
|
893 |
974 |
1.71e-9 |
SMART |
|
FN3
|
985 |
1062 |
2.56e-8 |
SMART |
|
FN3
|
1074 |
1152 |
8.58e-1 |
SMART |
|
FN3
|
1165 |
1245 |
2.72e-3 |
SMART |
|
FN3
|
1256 |
1334 |
5.36e-2 |
SMART |
|
FN3
|
1347 |
1427 |
4.93e0 |
SMART |
|
FN3
|
1438 |
1517 |
2.75e0 |
SMART |
|
FN3
|
1529 |
1608 |
3.4e-4 |
SMART |
|
FN3
|
1619 |
1697 |
1.55e-7 |
SMART |
|
FN3
|
1708 |
1785 |
1.53e-6 |
SMART |
|
FN3
|
1796 |
1873 |
7.75e-8 |
SMART |
|
FBG
|
1888 |
2098 |
4.08e-124 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000107377
AA Change: T1712K
PolyPhen 2
Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000103000
Gene: ENSMUSG00000028364
AA Change: T1712K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
121 |
138 |
N/A |
INTRINSIC |
|
EGF
|
189 |
217 |
1.87e1 |
SMART |
|
EGF_like
|
220 |
248 |
3.5e1 |
SMART |
|
EGF
|
251 |
280 |
4.89e0 |
SMART |
|
EGF
|
283 |
311 |
3.23e0 |
SMART |
|
EGF_like
|
314 |
342 |
2.98e1 |
SMART |
|
EGF
|
345 |
373 |
1.87e1 |
SMART |
|
EGF
|
376 |
404 |
3.97e0 |
SMART |
|
EGF
|
407 |
435 |
8.52e0 |
SMART |
|
EGF
|
438 |
466 |
3.01e0 |
SMART |
|
EGF
|
469 |
497 |
3.46e0 |
SMART |
|
EGF
|
500 |
528 |
3.71e0 |
SMART |
|
EGF
|
531 |
559 |
4.32e-1 |
SMART |
|
EGF
|
562 |
590 |
1.84e1 |
SMART |
|
EGF
|
593 |
621 |
3.82e-2 |
SMART |
|
FN3
|
623 |
701 |
8.9e-8 |
SMART |
|
FN3
|
712 |
794 |
1.53e-6 |
SMART |
|
FN3
|
803 |
884 |
7.23e-8 |
SMART |
|
FN3
|
893 |
974 |
1.71e-9 |
SMART |
|
FN3
|
985 |
1062 |
2.56e-8 |
SMART |
|
FN3
|
1074 |
1152 |
8.58e-1 |
SMART |
|
FN3
|
1165 |
1245 |
2.72e-3 |
SMART |
|
FN3
|
1256 |
1334 |
5.36e-2 |
SMART |
|
FN3
|
1347 |
1427 |
4.93e0 |
SMART |
|
FN3
|
1438 |
1517 |
3.4e-4 |
SMART |
|
FN3
|
1528 |
1606 |
1.55e-7 |
SMART |
|
FN3
|
1617 |
1694 |
1.53e-6 |
SMART |
|
FN3
|
1705 |
1782 |
7.75e-8 |
SMART |
|
FBG
|
1797 |
2007 |
4.08e-124 |
SMART |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.2%
- 20x: 92.0%
|
| Validation Efficiency |
98% (148/151) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
PHENOTYPE: Mice homozygous for several different targeted mutations show variable behavioral and nervous system phenotypes such as abnormal circadian rhythm, anxiety behavior, novelty-induced activity, swimming, impaired synaptic plasticity, long term potentiation and serotonin and dopamine neurotransmission. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 139 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610040J01Rik |
T |
G |
5: 64,055,806 (GRCm39) |
Y181D |
probably benign |
Het |
| 1700029H14Rik |
A |
G |
8: 13,604,715 (GRCm39) |
V196A |
possibly damaging |
Het |
| 2410004B18Rik |
A |
G |
3: 145,643,833 (GRCm39) |
D7G |
probably damaging |
Het |
| Acap1 |
A |
G |
11: 69,776,252 (GRCm39) |
V249A |
probably damaging |
Het |
| Acat2 |
A |
T |
17: 13,162,908 (GRCm39) |
D313E |
probably benign |
Het |
| Actn4 |
T |
C |
7: 28,604,823 (GRCm39) |
T325A |
probably benign |
Het |
| Adamdec1 |
C |
T |
14: 68,819,407 (GRCm39) |
|
probably null |
Het |
| Adat2 |
A |
G |
10: 13,429,037 (GRCm39) |
T10A |
probably benign |
Het |
| Aff4 |
T |
A |
11: 53,288,685 (GRCm39) |
S400R |
possibly damaging |
Het |
| Agbl2 |
C |
T |
2: 90,621,825 (GRCm39) |
P104L |
possibly damaging |
Het |
| Alox12 |
G |
T |
11: 70,133,542 (GRCm39) |
T594K |
possibly damaging |
Het |
| Als2 |
C |
A |
1: 59,254,546 (GRCm39) |
K270N |
probably benign |
Het |
| Ankhd1 |
T |
A |
18: 36,767,787 (GRCm39) |
C1235S |
probably damaging |
Het |
| Ankrd24 |
T |
A |
10: 81,470,778 (GRCm39) |
I69N |
probably damaging |
Het |
| Aox4 |
G |
A |
1: 58,252,235 (GRCm39) |
V37I |
probably benign |
Het |
| Arfgap3 |
A |
G |
15: 83,214,714 (GRCm39) |
|
probably benign |
Het |
| Arhgef4 |
T |
A |
1: 34,846,080 (GRCm39) |
|
probably null |
Het |
| Asic1 |
C |
T |
15: 99,596,498 (GRCm39) |
|
probably benign |
Het |
| Atp8b5 |
A |
G |
4: 43,366,057 (GRCm39) |
N776S |
probably benign |
Het |
| Bbs7 |
A |
G |
3: 36,659,883 (GRCm39) |
I184T |
probably benign |
Het |
| Bbs9 |
A |
T |
9: 22,425,297 (GRCm39) |
H117L |
probably damaging |
Het |
| Bnip2 |
T |
C |
9: 69,902,787 (GRCm39) |
W10R |
probably damaging |
Het |
| Brd4 |
G |
T |
17: 32,443,097 (GRCm39) |
Q175K |
probably benign |
Het |
| Bysl |
A |
T |
17: 47,917,821 (GRCm39) |
V124E |
possibly damaging |
Het |
| Cadm3 |
A |
G |
1: 173,174,140 (GRCm39) |
|
probably benign |
Het |
| Cc2d2a |
T |
C |
5: 43,853,980 (GRCm39) |
|
probably benign |
Het |
| Ccdc134 |
G |
T |
15: 82,025,147 (GRCm39) |
E215D |
probably damaging |
Het |
| Celsr3 |
G |
T |
9: 108,720,923 (GRCm39) |
|
probably benign |
Het |
| Cntn5 |
T |
A |
9: 9,781,780 (GRCm39) |
D428V |
probably damaging |
Het |
| Cog1 |
A |
G |
11: 113,547,821 (GRCm39) |
|
probably benign |
Het |
| Col11a2 |
G |
T |
17: 34,281,520 (GRCm39) |
|
probably benign |
Het |
| Cyp4f13 |
G |
A |
17: 33,143,943 (GRCm39) |
|
probably benign |
Het |
| Dffb |
T |
A |
4: 154,049,835 (GRCm39) |
K343* |
probably null |
Het |
| Dnah9 |
T |
A |
11: 65,802,678 (GRCm39) |
I224F |
possibly damaging |
Het |
| Dolk |
A |
T |
2: 30,176,031 (GRCm39) |
C5S |
probably benign |
Het |
| Dynlt2b |
A |
G |
16: 32,245,705 (GRCm39) |
D118G |
probably damaging |
Het |
| Ebf1 |
A |
T |
11: 44,759,915 (GRCm39) |
|
probably benign |
Het |
| Elac1 |
A |
G |
18: 73,875,434 (GRCm39) |
L199P |
probably damaging |
Het |
| Elmod1 |
A |
C |
9: 53,842,831 (GRCm39) |
|
probably benign |
Het |
| Ep400 |
A |
C |
5: 110,872,273 (GRCm39) |
|
probably benign |
Het |
| F10 |
A |
T |
8: 13,098,196 (GRCm39) |
N133I |
probably damaging |
Het |
| Fasn |
A |
G |
11: 120,706,141 (GRCm39) |
Y1068H |
probably benign |
Het |
| Fbxo24 |
T |
C |
5: 137,622,819 (GRCm39) |
E12G |
probably damaging |
Het |
| Fer |
G |
T |
17: 64,385,941 (GRCm39) |
L304F |
probably benign |
Het |
| Filip1 |
A |
C |
9: 79,726,285 (GRCm39) |
L778R |
probably damaging |
Het |
| Fli1 |
A |
T |
9: 32,335,277 (GRCm39) |
I385N |
probably benign |
Het |
| Fpgs |
A |
T |
2: 32,582,506 (GRCm39) |
L89* |
probably null |
Het |
| Gab2 |
T |
G |
7: 96,948,448 (GRCm39) |
I346R |
probably damaging |
Het |
| Gm10764 |
G |
A |
10: 87,126,841 (GRCm39) |
G83R |
unknown |
Het |
| Gpr83 |
G |
T |
9: 14,776,138 (GRCm39) |
C153F |
possibly damaging |
Het |
| Gtf3c3 |
A |
G |
1: 54,442,695 (GRCm39) |
L783P |
possibly damaging |
Het |
| Gys2 |
A |
G |
6: 142,418,394 (GRCm39) |
|
probably benign |
Het |
| Heatr9 |
C |
T |
11: 83,404,164 (GRCm39) |
V378I |
possibly damaging |
Het |
| Helz |
A |
T |
11: 107,528,740 (GRCm39) |
Y920F |
possibly damaging |
Het |
| Inpp5f |
A |
T |
7: 128,296,907 (GRCm39) |
Q459L |
probably damaging |
Het |
| Ints12 |
T |
C |
3: 132,814,806 (GRCm39) |
S338P |
probably benign |
Het |
| Kif13a |
T |
C |
13: 46,944,827 (GRCm39) |
T925A |
probably benign |
Het |
| Kif1a |
C |
T |
1: 92,969,815 (GRCm39) |
V1051I |
probably damaging |
Het |
| Kif7 |
T |
A |
7: 79,349,308 (GRCm39) |
H1119L |
possibly damaging |
Het |
| Kmt2d |
C |
T |
15: 98,748,018 (GRCm39) |
|
probably benign |
Het |
| Krt90 |
C |
T |
15: 101,471,110 (GRCm39) |
G51S |
possibly damaging |
Het |
| Krtap31-2 |
A |
T |
11: 99,827,572 (GRCm39) |
I135F |
possibly damaging |
Het |
| Lrp2 |
T |
C |
2: 69,258,974 (GRCm39) |
E4572G |
probably benign |
Het |
| Mapk8ip1 |
T |
C |
2: 92,216,289 (GRCm39) |
E493G |
probably damaging |
Het |
| Matk |
T |
G |
10: 81,094,326 (GRCm39) |
L28V |
probably benign |
Het |
| Mcc |
T |
A |
18: 44,892,366 (GRCm39) |
T83S |
probably benign |
Het |
| Mtch1 |
A |
T |
17: 29,559,080 (GRCm39) |
M204K |
possibly damaging |
Het |
| Muc4 |
T |
G |
16: 32,586,120 (GRCm39) |
C2622G |
possibly damaging |
Het |
| Myo5a |
G |
A |
9: 75,093,405 (GRCm39) |
|
probably null |
Het |
| Myoz3 |
T |
C |
18: 60,712,023 (GRCm39) |
Y185C |
probably damaging |
Het |
| Nnmt |
A |
G |
9: 48,503,438 (GRCm39) |
V196A |
probably benign |
Het |
| Nr2f2 |
G |
C |
7: 70,009,923 (GRCm39) |
P52R |
probably damaging |
Het |
| Nup214 |
T |
A |
2: 31,888,069 (GRCm39) |
|
probably benign |
Het |
| Or2aj4 |
T |
G |
16: 19,385,044 (GRCm39) |
E196D |
probably damaging |
Het |
| Or2y13 |
T |
C |
11: 49,414,739 (GRCm39) |
L63P |
probably damaging |
Het |
| Or4c126 |
T |
A |
2: 89,824,150 (GRCm39) |
F138I |
probably benign |
Het |
| Pank3 |
T |
C |
11: 35,672,543 (GRCm39) |
|
probably benign |
Het |
| Parm1 |
A |
T |
5: 91,742,153 (GRCm39) |
N174Y |
possibly damaging |
Het |
| Pcgf2 |
A |
T |
11: 97,583,244 (GRCm39) |
|
probably null |
Het |
| Pclo |
A |
T |
5: 14,825,434 (GRCm39) |
K4661M |
unknown |
Het |
| Pcsk7 |
A |
C |
9: 45,827,357 (GRCm39) |
S375R |
probably damaging |
Het |
| Pdzrn4 |
G |
T |
15: 92,668,200 (GRCm39) |
S784I |
possibly damaging |
Het |
| Pex6 |
T |
A |
17: 47,034,663 (GRCm39) |
|
probably null |
Het |
| Pi4ka |
C |
T |
16: 17,115,499 (GRCm39) |
V1384M |
probably benign |
Het |
| Polr3f |
T |
A |
2: 144,378,195 (GRCm39) |
|
probably benign |
Het |
| Ppp2r3d |
A |
T |
9: 101,089,483 (GRCm39) |
V280E |
probably damaging |
Het |
| Prdm14 |
C |
T |
1: 13,192,672 (GRCm39) |
G356R |
probably damaging |
Het |
| Prepl |
A |
G |
17: 85,372,466 (GRCm39) |
|
probably null |
Het |
| Primpol |
T |
C |
8: 47,052,849 (GRCm39) |
D154G |
probably damaging |
Het |
| Ptchd4 |
A |
C |
17: 42,814,307 (GRCm39) |
H736P |
probably damaging |
Het |
| Rab11fip1 |
A |
G |
8: 27,642,253 (GRCm39) |
S849P |
probably damaging |
Het |
| Rap1gap |
T |
A |
4: 137,446,662 (GRCm39) |
D405E |
probably damaging |
Het |
| Rbm26 |
T |
C |
14: 105,369,374 (GRCm39) |
T686A |
probably benign |
Het |
| Resf1 |
T |
C |
6: 149,227,739 (GRCm39) |
Y262H |
probably damaging |
Het |
| Rint1 |
A |
G |
5: 24,021,930 (GRCm39) |
|
probably benign |
Het |
| Rnasek |
G |
T |
11: 70,129,266 (GRCm39) |
Y62* |
probably null |
Het |
| Rnf17 |
T |
G |
14: 56,719,541 (GRCm39) |
N930K |
possibly damaging |
Het |
| Sap130 |
A |
G |
18: 31,813,734 (GRCm39) |
|
probably benign |
Het |
| Sectm1b |
T |
A |
11: 120,946,611 (GRCm39) |
I95F |
probably damaging |
Het |
| Sema4f |
A |
T |
6: 82,916,447 (GRCm39) |
I53N |
possibly damaging |
Het |
| Shld1 |
T |
C |
2: 132,592,559 (GRCm39) |
V202A |
probably benign |
Het |
| Siglec1 |
T |
C |
2: 130,927,396 (GRCm39) |
T137A |
probably damaging |
Het |
| Six5 |
A |
C |
7: 18,830,947 (GRCm39) |
|
probably null |
Het |
| Slc22a30 |
A |
T |
19: 8,322,721 (GRCm39) |
I345N |
probably benign |
Het |
| Slc25a27 |
A |
T |
17: 43,954,518 (GRCm39) |
M316K |
probably benign |
Het |
| Slc2a8 |
A |
T |
2: 32,870,116 (GRCm39) |
|
probably benign |
Het |
| Snx1 |
G |
A |
9: 66,008,608 (GRCm39) |
|
probably benign |
Het |
| Spag17 |
A |
G |
3: 99,992,684 (GRCm39) |
T1727A |
probably benign |
Het |
| Spata20 |
T |
C |
11: 94,372,472 (GRCm39) |
D633G |
probably benign |
Het |
| Spock1 |
C |
T |
13: 57,583,922 (GRCm39) |
|
probably null |
Het |
| Sra1 |
A |
T |
18: 36,808,759 (GRCm39) |
Y291* |
probably null |
Het |
| Sspo |
C |
A |
6: 48,470,120 (GRCm39) |
P4520T |
probably damaging |
Het |
| Stat4 |
A |
G |
1: 52,051,016 (GRCm39) |
N25S |
probably benign |
Het |
| Tbx18 |
A |
T |
9: 87,597,569 (GRCm39) |
|
probably benign |
Het |
| Tep1 |
T |
A |
14: 51,084,444 (GRCm39) |
I187F |
probably damaging |
Het |
| Tfap2b |
A |
T |
1: 19,304,347 (GRCm39) |
I368F |
probably damaging |
Het |
| Tmtc1 |
A |
T |
6: 148,148,335 (GRCm39) |
L711Q |
probably damaging |
Het |
| Tmx3 |
T |
A |
18: 90,556,613 (GRCm39) |
|
probably benign |
Het |
| Tnfrsf21 |
C |
T |
17: 43,349,104 (GRCm39) |
H239Y |
probably benign |
Het |
| Tpgs1 |
C |
T |
10: 79,511,700 (GRCm39) |
P281S |
probably benign |
Het |
| Trim45 |
A |
G |
3: 100,837,160 (GRCm39) |
R499G |
probably benign |
Het |
| Tulp3 |
A |
T |
6: 128,302,921 (GRCm39) |
Y299* |
probably null |
Het |
| Ube4a |
A |
T |
9: 44,857,476 (GRCm39) |
|
probably benign |
Het |
| Ubr3 |
T |
G |
2: 69,781,749 (GRCm39) |
S642R |
probably damaging |
Het |
| Vcpip1 |
A |
T |
1: 9,817,431 (GRCm39) |
Y317* |
probably null |
Het |
| Vmn1r115 |
G |
A |
7: 20,578,327 (GRCm39) |
T195I |
probably benign |
Het |
| Vmn1r226 |
G |
A |
17: 20,907,839 (GRCm39) |
V24I |
probably benign |
Het |
| Wdr41 |
C |
T |
13: 95,153,914 (GRCm39) |
A321V |
probably damaging |
Het |
| Wfdc5 |
T |
C |
2: 164,020,755 (GRCm39) |
N44D |
probably benign |
Het |
| Wnt7b |
C |
A |
15: 85,443,103 (GRCm39) |
|
probably null |
Het |
| Zfp108 |
T |
C |
7: 23,961,208 (GRCm39) |
S600P |
possibly damaging |
Het |
| Zfp267 |
A |
G |
3: 36,219,303 (GRCm39) |
H442R |
possibly damaging |
Het |
| Zfp385b |
A |
G |
2: 77,246,072 (GRCm39) |
|
probably null |
Het |
| Zfp395 |
T |
C |
14: 65,623,929 (GRCm39) |
S133P |
probably benign |
Het |
| Zfp407 |
T |
A |
18: 84,576,836 (GRCm39) |
M1426L |
probably damaging |
Het |
| Zfp641 |
T |
G |
15: 98,187,008 (GRCm39) |
N191T |
possibly damaging |
Het |
| Zfp687 |
T |
C |
3: 94,918,864 (GRCm39) |
S303G |
probably damaging |
Het |
| Zfp759 |
T |
A |
13: 67,286,877 (GRCm39) |
F143I |
possibly damaging |
Het |
| Zgrf1 |
G |
C |
3: 127,409,095 (GRCm39) |
E1690Q |
probably damaging |
Het |
|
| Other mutations in Tnc |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00229:Tnc
|
APN |
4 |
63,935,061 (GRCm39) |
splice site |
probably benign |
|
|
IGL00531:Tnc
|
APN |
4 |
63,889,390 (GRCm39) |
splice site |
probably benign |
|
|
IGL00674:Tnc
|
APN |
4 |
63,883,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01015:Tnc
|
APN |
4 |
63,935,571 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01090:Tnc
|
APN |
4 |
63,918,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01310:Tnc
|
APN |
4 |
63,931,314 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01331:Tnc
|
APN |
4 |
63,901,112 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01393:Tnc
|
APN |
4 |
63,932,291 (GRCm39) |
splice site |
probably benign |
|
|
IGL01411:Tnc
|
APN |
4 |
63,918,959 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01472:Tnc
|
APN |
4 |
63,924,656 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01552:Tnc
|
APN |
4 |
63,888,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01661:Tnc
|
APN |
4 |
63,888,544 (GRCm39) |
splice site |
probably benign |
|
|
IGL01669:Tnc
|
APN |
4 |
63,918,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01912:Tnc
|
APN |
4 |
63,926,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02028:Tnc
|
APN |
4 |
63,884,909 (GRCm39) |
splice site |
probably benign |
|
|
IGL02100:Tnc
|
APN |
4 |
63,918,398 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02549:Tnc
|
APN |
4 |
63,933,309 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02642:Tnc
|
APN |
4 |
63,883,816 (GRCm39) |
splice site |
probably benign |
|
|
IGL02712:Tnc
|
APN |
4 |
63,893,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02876:Tnc
|
APN |
4 |
63,933,338 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02886:Tnc
|
APN |
4 |
63,918,344 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02972:Tnc
|
APN |
4 |
63,894,715 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03073:Tnc
|
APN |
4 |
63,889,461 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL03116:Tnc
|
APN |
4 |
63,932,270 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03181:Tnc
|
APN |
4 |
63,885,543 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03358:Tnc
|
APN |
4 |
63,935,852 (GRCm39) |
nonsense |
probably null |
|
|
tancredo
|
UTSW |
4 |
63,911,534 (GRCm39) |
nonsense |
probably null |
|
|
BB009:Tnc
|
UTSW |
4 |
63,926,857 (GRCm39) |
missense |
probably benign |
|
|
BB019:Tnc
|
UTSW |
4 |
63,926,857 (GRCm39) |
missense |
probably benign |
|
|
P0020:Tnc
|
UTSW |
4 |
63,927,094 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
PIT4377001:Tnc
|
UTSW |
4 |
63,935,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4403001:Tnc
|
UTSW |
4 |
63,882,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4468001:Tnc
|
UTSW |
4 |
63,882,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0362:Tnc
|
UTSW |
4 |
63,935,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0410:Tnc
|
UTSW |
4 |
63,925,931 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0420:Tnc
|
UTSW |
4 |
63,918,396 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0540:Tnc
|
UTSW |
4 |
63,938,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0650:Tnc
|
UTSW |
4 |
63,926,971 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1019:Tnc
|
UTSW |
4 |
63,880,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1102:Tnc
|
UTSW |
4 |
63,938,705 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1126:Tnc
|
UTSW |
4 |
63,936,357 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1141:Tnc
|
UTSW |
4 |
63,932,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1142:Tnc
|
UTSW |
4 |
63,932,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1307:Tnc
|
UTSW |
4 |
63,927,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1322:Tnc
|
UTSW |
4 |
63,932,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1414:Tnc
|
UTSW |
4 |
63,883,932 (GRCm39) |
splice site |
probably benign |
|
|
R1470:Tnc
|
UTSW |
4 |
63,884,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1470:Tnc
|
UTSW |
4 |
63,884,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1499:Tnc
|
UTSW |
4 |
63,882,991 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1506:Tnc
|
UTSW |
4 |
63,925,921 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1597:Tnc
|
UTSW |
4 |
63,924,621 (GRCm39) |
missense |
probably benign |
|
|
R1750:Tnc
|
UTSW |
4 |
63,890,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1765:Tnc
|
UTSW |
4 |
63,932,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Tnc
|
UTSW |
4 |
63,936,333 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1808:Tnc
|
UTSW |
4 |
63,918,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1903:Tnc
|
UTSW |
4 |
63,918,299 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1932:Tnc
|
UTSW |
4 |
63,911,262 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1941:Tnc
|
UTSW |
4 |
63,933,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1983:Tnc
|
UTSW |
4 |
63,902,867 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2024:Tnc
|
UTSW |
4 |
63,882,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2075:Tnc
|
UTSW |
4 |
63,913,903 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2327:Tnc
|
UTSW |
4 |
63,893,475 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2444:Tnc
|
UTSW |
4 |
63,933,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2982:Tnc
|
UTSW |
4 |
63,938,756 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3874:Tnc
|
UTSW |
4 |
63,926,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4110:Tnc
|
UTSW |
4 |
63,933,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4360:Tnc
|
UTSW |
4 |
63,935,161 (GRCm39) |
missense |
probably benign |
0.35 |
|
R4371:Tnc
|
UTSW |
4 |
63,888,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4434:Tnc
|
UTSW |
4 |
63,926,066 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4438:Tnc
|
UTSW |
4 |
63,926,066 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4570:Tnc
|
UTSW |
4 |
63,913,909 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4595:Tnc
|
UTSW |
4 |
63,913,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4749:Tnc
|
UTSW |
4 |
63,913,876 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R4756:Tnc
|
UTSW |
4 |
63,885,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4824:Tnc
|
UTSW |
4 |
63,935,857 (GRCm39) |
nonsense |
probably null |
|
|
R4957:Tnc
|
UTSW |
4 |
63,894,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4977:Tnc
|
UTSW |
4 |
63,924,485 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5001:Tnc
|
UTSW |
4 |
63,918,299 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5001:Tnc
|
UTSW |
4 |
63,902,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5015:Tnc
|
UTSW |
4 |
63,924,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Tnc
|
UTSW |
4 |
63,936,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5066:Tnc
|
UTSW |
4 |
63,893,466 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5073:Tnc
|
UTSW |
4 |
63,938,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5116:Tnc
|
UTSW |
4 |
63,885,452 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5195:Tnc
|
UTSW |
4 |
63,885,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5200:Tnc
|
UTSW |
4 |
63,889,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5221:Tnc
|
UTSW |
4 |
63,911,534 (GRCm39) |
nonsense |
probably null |
|
|
R5237:Tnc
|
UTSW |
4 |
63,880,333 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5265:Tnc
|
UTSW |
4 |
63,911,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5275:Tnc
|
UTSW |
4 |
63,882,967 (GRCm39) |
nonsense |
probably null |
|
|
R5346:Tnc
|
UTSW |
4 |
63,926,892 (GRCm39) |
missense |
probably benign |
|
|
R5409:Tnc
|
UTSW |
4 |
63,925,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5409:Tnc
|
UTSW |
4 |
63,884,773 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5469:Tnc
|
UTSW |
4 |
63,932,162 (GRCm39) |
splice site |
probably null |
|
|
R5518:Tnc
|
UTSW |
4 |
63,935,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5560:Tnc
|
UTSW |
4 |
63,926,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5588:Tnc
|
UTSW |
4 |
63,924,659 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R5686:Tnc
|
UTSW |
4 |
63,925,967 (GRCm39) |
splice site |
probably null |
|
|
R5686:Tnc
|
UTSW |
4 |
63,927,032 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5837:Tnc
|
UTSW |
4 |
63,931,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5976:Tnc
|
UTSW |
4 |
63,936,403 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6156:Tnc
|
UTSW |
4 |
63,888,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6182:Tnc
|
UTSW |
4 |
63,927,033 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6360:Tnc
|
UTSW |
4 |
63,918,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6416:Tnc
|
UTSW |
4 |
63,926,053 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6778:Tnc
|
UTSW |
4 |
63,913,835 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6798:Tnc
|
UTSW |
4 |
63,883,841 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6799:Tnc
|
UTSW |
4 |
63,883,841 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6943:Tnc
|
UTSW |
4 |
63,900,982 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7027:Tnc
|
UTSW |
4 |
63,902,826 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7183:Tnc
|
UTSW |
4 |
63,931,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7204:Tnc
|
UTSW |
4 |
63,889,392 (GRCm39) |
splice site |
probably null |
|
|
R7317:Tnc
|
UTSW |
4 |
63,890,959 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7323:Tnc
|
UTSW |
4 |
63,889,469 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7327:Tnc
|
UTSW |
4 |
63,882,999 (GRCm39) |
splice site |
probably null |
|
|
R7382:Tnc
|
UTSW |
4 |
63,932,280 (GRCm39) |
nonsense |
probably null |
|
|
R7399:Tnc
|
UTSW |
4 |
63,938,894 (GRCm39) |
start gained |
probably benign |
|
|
R7479:Tnc
|
UTSW |
4 |
63,935,865 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7585:Tnc
|
UTSW |
4 |
63,938,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7932:Tnc
|
UTSW |
4 |
63,926,857 (GRCm39) |
missense |
probably benign |
|
|
R7947:Tnc
|
UTSW |
4 |
63,935,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7974:Tnc
|
UTSW |
4 |
63,918,961 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7991:Tnc
|
UTSW |
4 |
63,926,983 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8004:Tnc
|
UTSW |
4 |
63,902,894 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8080:Tnc
|
UTSW |
4 |
63,894,706 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8109:Tnc
|
UTSW |
4 |
63,927,000 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8145:Tnc
|
UTSW |
4 |
63,935,716 (GRCm39) |
missense |
probably benign |
|
|
R8340:Tnc
|
UTSW |
4 |
63,926,036 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8360:Tnc
|
UTSW |
4 |
63,885,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8671:Tnc
|
UTSW |
4 |
63,935,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8691:Tnc
|
UTSW |
4 |
63,880,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8759:Tnc
|
UTSW |
4 |
63,924,501 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8864:Tnc
|
UTSW |
4 |
63,911,296 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8927:Tnc
|
UTSW |
4 |
63,925,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8928:Tnc
|
UTSW |
4 |
63,925,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8949:Tnc
|
UTSW |
4 |
63,927,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8956:Tnc
|
UTSW |
4 |
63,918,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Tnc
|
UTSW |
4 |
63,935,331 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9049:Tnc
|
UTSW |
4 |
63,918,247 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9097:Tnc
|
UTSW |
4 |
63,888,622 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9114:Tnc
|
UTSW |
4 |
63,890,973 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9151:Tnc
|
UTSW |
4 |
63,938,686 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9488:Tnc
|
UTSW |
4 |
63,913,942 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9537:Tnc
|
UTSW |
4 |
63,884,821 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9666:Tnc
|
UTSW |
4 |
63,926,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9700:Tnc
|
UTSW |
4 |
63,933,186 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9703:Tnc
|
UTSW |
4 |
63,889,412 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9771:Tnc
|
UTSW |
4 |
63,925,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
S24628:Tnc
|
UTSW |
4 |
63,936,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Tnc
|
UTSW |
4 |
63,925,663 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Tnc
|
UTSW |
4 |
63,878,781 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGTCAGTCAGGTGGTGACACTACG -3'
(R):5'- GGGCCAATATTAGCACTCCTCAGC -3'
Sequencing Primer
(F):5'- AAAGCACTGCCGTTGATCTTG -3'
(R):5'- CACCCAGGAATATGTTGGGC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation