Incidental Mutation 'R4862:Prss3b'
ID 374589
Institutional Source Beutler Lab
Gene Symbol Prss3b
Ensembl Gene ENSMUSG00000029882
Gene Name serine protease 3B
Synonyms 2210010C04Rik
MMRRC Submission 043260-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R4862 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 41007202-41012443 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 41009345 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 163 (D163A)
Ref Sequence ENSEMBL: ENSMUSP00000031931 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031931]
AlphaFold Q9CPN9
Predicted Effect possibly damaging
Transcript: ENSMUST00000031931
AA Change: D163A

PolyPhen 2 Score 0.736 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000031931
Gene: ENSMUSG00000029882
AA Change: D163A

DomainStartEndE-ValueType
Tryp_SPc 24 240 3.52e-102 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 95% (40/42)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox3 A G 5: 35,747,083 (GRCm39) T167A probably benign Het
Aox1 T G 1: 58,134,316 (GRCm39) D1096E probably damaging Het
Arid4a A T 12: 71,122,721 (GRCm39) D1034V probably damaging Het
Ccdc168 G A 1: 44,097,178 (GRCm39) P1307S possibly damaging Het
Chaf1b T A 16: 93,684,022 (GRCm39) L91Q probably damaging Het
Copb2 G T 9: 98,463,320 (GRCm39) D512Y probably damaging Het
Daam1 A G 12: 71,988,981 (GRCm39) E127G unknown Het
Dhx16 A G 17: 36,194,154 (GRCm39) I422V probably benign Het
Dnah6 C T 6: 73,098,771 (GRCm39) V2043I probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dync2h1 A G 9: 7,147,717 (GRCm39) V971A probably benign Het
Elapor1 A G 3: 108,375,149 (GRCm39) S573P probably benign Het
Elmo1 A G 13: 20,633,682 (GRCm39) H448R probably benign Het
Fndc1 A T 17: 7,988,567 (GRCm39) V1165D unknown Het
Hapln1 G A 13: 89,749,571 (GRCm39) G39S possibly damaging Het
Igkv6-13 C A 6: 70,434,765 (GRCm39) V27L probably benign Het
Krt28 A T 11: 99,255,936 (GRCm39) I441N possibly damaging Het
Lgr5 A T 10: 115,298,669 (GRCm39) D286E probably damaging Het
Mapkap1 A G 2: 34,513,442 (GRCm39) Y448C probably damaging Het
Or2f1 T C 6: 42,721,489 (GRCm39) Y173H possibly damaging Het
Or5t9 T A 2: 86,659,876 (GRCm39) V260E probably damaging Het
Ppt1 A C 4: 122,738,242 (GRCm39) N89T probably damaging Het
Ptgs1 G T 2: 36,127,267 (GRCm39) R51L probably damaging Het
Slc47a2 A G 11: 61,204,520 (GRCm39) F277S possibly damaging Het
Smcr8 A G 11: 60,668,897 (GRCm39) E15G probably benign Het
Tbce A G 13: 14,173,004 (GRCm39) S476P possibly damaging Het
Tmem131l A T 3: 83,805,517 (GRCm39) probably benign Het
Unc5c T C 3: 141,495,534 (GRCm39) Y468H probably damaging Het
Ush1c A T 7: 45,878,664 (GRCm39) L117H probably damaging Het
Wdfy4 A G 14: 32,822,860 (GRCm39) probably null Het
Zfa-ps G T 10: 52,419,192 (GRCm39) noncoding transcript Het
Zfat C A 15: 68,051,959 (GRCm39) A605S probably benign Het
Zfp853 T A 5: 143,275,416 (GRCm39) Q68L unknown Het
Zfyve16 G A 13: 92,644,764 (GRCm39) T1146I probably damaging Het
Other mutations in Prss3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01120:Prss3b APN 6 41,008,607 (GRCm39) missense probably damaging 1.00
IGL01625:Prss3b APN 6 41,009,882 (GRCm39) missense probably benign 0.01
IGL02159:Prss3b APN 6 41,009,891 (GRCm39) missense probably benign 0.34
IGL03161:Prss3b APN 6 41,011,240 (GRCm39) missense probably damaging 0.96
R0419:Prss3b UTSW 6 41,011,281 (GRCm39) missense probably benign 0.05
R1715:Prss3b UTSW 6 41,009,870 (GRCm39) splice site probably null
R2057:Prss3b UTSW 6 41,009,315 (GRCm39) missense probably benign 0.06
R2059:Prss3b UTSW 6 41,009,315 (GRCm39) missense probably benign 0.06
R2136:Prss3b UTSW 6 41,012,396 (GRCm39) missense probably benign 0.28
R2446:Prss3b UTSW 6 41,008,582 (GRCm39) missense probably benign 0.15
R5068:Prss3b UTSW 6 41,009,370 (GRCm39) missense probably benign 0.35
R5369:Prss3b UTSW 6 41,009,940 (GRCm39) missense probably benign 0.00
R6392:Prss3b UTSW 6 41,009,306 (GRCm39) missense probably damaging 1.00
R7010:Prss3b UTSW 6 41,009,247 (GRCm39) missense probably benign 0.42
R7567:Prss3b UTSW 6 41,010,127 (GRCm39) missense probably benign 0.04
R7727:Prss3b UTSW 6 41,010,127 (GRCm39) missense probably benign 0.04
R7962:Prss3b UTSW 6 41,012,387 (GRCm39) missense probably benign 0.01
R8373:Prss3b UTSW 6 41,008,622 (GRCm39) missense possibly damaging 0.53
R8529:Prss3b UTSW 6 41,009,369 (GRCm39) missense probably benign 0.00
R8883:Prss3b UTSW 6 41,009,305 (GRCm39) nonsense probably null
R8916:Prss3b UTSW 6 41,010,103 (GRCm39) missense probably damaging 1.00
R9066:Prss3b UTSW 6 41,008,640 (GRCm39) missense probably benign 0.41
R9095:Prss3b UTSW 6 41,010,038 (GRCm39) missense possibly damaging 0.76
R9180:Prss3b UTSW 6 41,008,681 (GRCm39) missense probably damaging 1.00
R9389:Prss3b UTSW 6 41,010,079 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GCTTTTGAGGTACACGGTCAG -3'
(R):5'- TTGTTGAAAGCGGTGGACAC -3'

Sequencing Primer
(F):5'- AGAGATGGTTAATGTTCTCTCTCC -3'
(R):5'- GCTGGGAAAGTTGTTTCC -3'
Posted On 2016-03-17